• carbonyl reductase 4 / 3-oxoacyl-[acyl-carrier protein] reductase beta subunit [EC:1.1.1. (kegg.jp)
  • 14478 3-oxoacyl-[acyl-carrier protein] reductase fabG BBZA01000001 CDS ARMA_0014 complement(14430. (go.jp)
  • Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant [Interproscan]. (ntu.edu.sg)
  • use 3-HYDROXYACYL COA DEHYDROGENASES 1981-2013 MH - 3-Oxoacyl-(Acyl-Carrier-Protein) Reductase UI - D064431 MN - D8.811.682.47.820.196 MS - A 3-oxoacyl reductase that has specificity for ACYL CARRIER PROTEIN-derived FATTY ACIDS. (nih.gov)
  • Based on genomic analyses, it was previously predicted that Saccharibacteria are anaerobic fermenters, despite the documentation of one genome encoding a single-subunit of NADH: ubiquinone dehydrogenase and a complete ubiquinol oxidase, which was explained as an oxygen-scavenging mechanism [ 8 ]. (biomedcentral.com)
  • Functional replacement of the essential linker of the biotinylated subunit of acetyl-CoA carboxylase with a linker from the lipoylated subunit of pyruvate dehydrogenase. (wikigenes.org)
  • protein_coding" "Cz03g11040.t1","No alias","Chromochloris zofingiensis","Ribosomal protein/NADH dehydrogenase domain [Interproscan]. (ntu.edu.sg)
  • Maple syrup urine disease is caused by a deficiency of the branched-chain alpha-keto acid dehydrogenase (BCKD) enzyme complex, which catalyses the decarboxylation of the alpha-keto acids of leucine, isoleucine, and valine to their respective branched-chain acyl-CoAs. (medscape.com)
  • 7/29/2013) TOTAL 2014 NEW DESCRIPTORS = 304 MH - 3-Hydroxyacyl-CoA Dehydrogenase UI - D063988 MN - D8.811.682.47.820.150.207 MS - An NAD-dependent 3-hydroxyacyl CoA dehydrogenase that has broad specificity with regards to the acyl chain length of the substrate. (nih.gov)
  • Long-chain hydroxyacyl-CoA dehydrogenase (LCHAD) deficiency and trifunctional protein (TFP) deficiency are caused by impairment of mitochondrial TFP. (nih.gov)
  • Genes for the putative A and B subunits of H.pylori CoA-transferase were introduced into the bacterial expressionvector pKK223-3 and expressed in Escherichia coli JM105 cells. (embl.de)
  • Search of the protein database with the aflatoxin pathway polyketide synthase (PKS) revealed putative PKSs in the pathogenic fungi Coccidioides immitis and Coccidioides posadasii that could require partnerships with a pair of fatty acid synthase (FAS) subunits for the biosynthesis of fatty acid-polyketide hybrid metabolites. (nih.gov)
  • protein_coding" "CRO36835","rlmN_2","Pseudomonas aeruginosa","putative dual-specificity RNA methyltransferase RlmN [Ensembl]. (ntu.edu.sg)
  • 10614) putative ABC transport system permease protein BBZA01000001 CDS ARMA_0010 complement(10625. (go.jp)
  • 11353) putative ABC transport system ATP-binding protein BBZA01000001 CDS ARMA_0011 complement(11350. (go.jp)
  • Fatty-acyl-CoA Synthase, or more commonly known as yeast fatty acid synthase (and not to be confused with Long Chain fatty acyl-CoA synthetase), is an enzyme complex responsible for fatty acid biosynthesis, and is of Type I Fatty Acid Synthesis (FAS). (wikipedia.org)
  • acyl-CoA synthetase long chain family me. (gsea-msigdb.org)
  • The two FabA-like DH domains in the E. huxleyi PUFA synthase function as 3-hydroxyacyl-acyl carrier protein dehydratase in E. coli . (biomedcentral.com)
  • protein_coding" "Cz01g39150.t1","No alias","Chromochloris zofingiensis","RNA polymerase subunit RPB4/RPC9 [Interproscan]. (ntu.edu.sg)
  • 4628 hypothetical protein BBZA01000001 CDS ARMA_0005 5077. (go.jp)
  • 5685 hypothetical protein BBZA01000001 CDS ARMA_0006 5873. (go.jp)
  • 7021 hypothetical protein BBZA01000001 CDS ARMA_0007 complement(7097. (go.jp)
  • 7504) hypothetical protein BBZA01000001 CDS ARMA_0008 complement(7590. (go.jp)
  • 11958) hypothetical protein BBZA01000001 CDS ARMA_0012 12170. (go.jp)
  • 578 hypothetical protein BBZA01000002 CDS ARMA_0016 684. (go.jp)
  • 2342 hypothetical protein BBZA01000002 CDS ARMA_0017 2339. (go.jp)
  • 3094 hypothetical protein BBZA01000002 CDS ARMA_0018 3478. (go.jp)
  • 4371 hypothetical protein BBZA01000002 CDS ARMA_0019 complement(4468. (go.jp)
  • 5751) hypothetical protein BBZA01000002 CDS ARMA_0021 complement(5880. (go.jp)
  • 6020) hypothetical protein BBZA01000002 CDS ARMA_0020 6069. (go.jp)
  • 7490 hypothetical protein BBZA01000002 CDS ARMA_0022 complement(7569. (go.jp)
  • 10130) hypothetical protein BBZA01000002 CDS ARMA_0023 10363. (go.jp)
  • 12985 hypothetical protein BBZA01000002 CDS ARMA_0025 13067. (go.jp)
  • 13828 hypothetical protein BBZA01000002 CDS ARMA_0026 13840. (go.jp)
  • 15584 hypothetical protein BBZA01000003 CDS ARMA_0028 complement(2147. (go.jp)
  • 2662) hypothetical protein BBZA01000003 CDS ARMA_0030 complement(2909. (go.jp)
  • 3070) hypothetical protein BBZA01000003 CDS ARMA_0029 3089. (go.jp)
  • 3247 hypothetical protein BBZA01000003 CDS ARMA_0031 3817. (go.jp)
  • 11054 hypothetical protein BBZA01000003 CDS ARMA_0036 11082. (go.jp)
  • 11983 hypothetical protein BBZA01000003 CDS ARMA_0038 complement(11960. (go.jp)
  • 12616) hypothetical protein BBZA01000003 CDS ARMA_0039 12726. (go.jp)
  • 13859 hypothetical protein BBZA01000003 CDS ARMA_0040 13859. (go.jp)
  • 14554 hypothetical protein BBZA01000003 CDS ARMA_0041 14582. (go.jp)
  • 15289 hypothetical protein BBZA01000003 CDS ARMA_0042 15306. (go.jp)
  • 15746 hypothetical protein BBZA01000003 CDS ARMA_0043 complement(15750. (go.jp)
  • 16253) hypothetical protein BBZA01000003 CDS ARMA_0044 complement(16376. (go.jp)
  • 16723) hypothetical protein BBZA01000003 tRNA ARMA_tRNA01 complement(16745. (go.jp)
  • 17762 hypothetical protein BBZA01000003 CDS ARMA_0046 17875. (go.jp)
  • 19373 hypothetical protein BBZA01000003 CDS ARMA_0048 complement(19431. (go.jp)
  • 20651) hypothetical protein BBZA01000003 CDS ARMA_0049 20873. (go.jp)
  • 21793 hypothetical protein BBZA01000003 CDS ARMA_0050 21812. (go.jp)
  • 24549 hypothetical protein BBZA01000003 CDS ARMA_0052 24709. (go.jp)
  • 25812 hypothetical protein BBZA01000003 CDS ARMA_0053 25854. (go.jp)
  • 27638 hypothetical protein BBZA01000003 CDS ARMA_0054 27690. (go.jp)
  • 29561 hypothetical protein BBZA01000003 CDS ARMA_0055 29551. (go.jp)
  • 30963 hypothetical protein BBZA01000003 CDS ARMA_0056 30956. (go.jp)
  • 32158 hypothetical protein BBZA01000003 CDS ARMA_0057 32158. (go.jp)
  • 35130 hypothetical protein BBZA01000003 CDS ARMA_0058 35127. (go.jp)
  • 35501 hypothetical protein BBZA01000003 CDS ARMA_0059 35523. (go.jp)
  • 38051 hypothetical protein BBZA01000003 CDS ARMA_0060 38048. (go.jp)
  • 38443 hypothetical protein BBZA01000003 CDS ARMA_0061 38445. (go.jp)
  • 40466 hypothetical protein BBZA01000003 CDS ARMA_0063 complement(40556. (go.jp)
  • 42784) hypothetical protein BBZA01000004 CDS ARMA_0066 23. (go.jp)
  • 493 hypothetical protein BBZA01000004 CDS ARMA_0067 664. (go.jp)
  • The catalytic activities of this enzyme complex involves a coordination system of enzymatic reactions between the alpha and beta subunits. (wikipedia.org)
  • The enzyme catalyzes the reaction: Acetyl-CoA + n malonyl-CoA + 4n NADPH + 4n H+ ⇌ {\displaystyle \rightleftharpoons } long-chain-acyl-CoA + n CoA + n CO2 + 4n NADP+ The 4 substrates of this enzyme are acetyl-CoA, malonyl-CoA, NADPH, and H+, whereas its 4 products are Acyl-CoA, CoA, CO2, and NADP+. (wikipedia.org)
  • The 3D protein structure of the enzyme can be found here:PDB. (wikipedia.org)
  • ACP is the only "mobile" domain of the enzyme complex, in which it moves intermediate substrates along all of the catalytic centers the enzyme, most notably the alpha and beta subunits. (wikipedia.org)
  • Quental et al identified a homozygous 1-bp deletion (117delC) in the BCKDHA gene (this gene codes for the alpha subunit of the BCKD enzyme complex, specifically E1) in Portuguese Gypsies and estimated the carrier frequency for this deletion to be as high as 1.4% (about 1 case per 71 live births). (medscape.com)
  • Disulfide interchange enzyme -- An enzyme that catalyzes the rearrangement of disulfide bonds within proteins during folding. (nih.gov)
  • The affected protein could be an enzyme, a hormone, or a specific molecule such as hemoglobin or immunoglobulin chain. (nih.gov)
  • If the affected protein is an enzyme, it will have an Enzyme Commission (EC) number. (nih.gov)
  • The enzyme consists of two different subunits. (nih.gov)
  • They act as a transient carrier of specific functional groups from enzyme to enzyme. (usiad.net)
  • Priming is performed in the β subunit, and is catalyzed by the acetyltransferase (AT, equivalent to bacterial (acyl-carrier-protein) S-acetyltransferase) domain, which initiates the process of fatty acid synthesis. (wikipedia.org)
  • ACP then moves back to the β subunit to the malonyl/palmitoyl-transacylase (MPT, equivalent to bacterial malonyl transacylase) domain and binds to a malonyl of malonyl-CoA, which will be used for elongation. (wikipedia.org)
  • The bacterial enzymes are heterodimer of two subunits (A and B) of about 25 Kd each while eukaryotic SCOT consist of a single chain which is colinear with the two bacterial subunits. (embl.de)
  • These enzymatic complexes resemble bacterial antibiotic-producing proteins known as polyketide synthases (PKS). (unican.es)
  • Bacterial regulatory proteins, Aminotransferase class I and II [Interproscan]. (ntu.edu.sg)
  • Sigma-54 interaction domain, Bacterial regulatory protein, Propionate catabolism activator [Interproscan]. (ntu.edu.sg)
  • Bacterial regulatory proteins, Response regulator receiver domain [Interproscan]. (ntu.edu.sg)
  • Thisactivity was consistently observed in different H. pylori strains.Antibodies raised against either recombinant A or B subunits recognizedtwo distinct subunits of Mr approximately 26,000 and 24, 000 that are bothnecessary for H. pylori CoA-transferase function. (embl.de)
  • In addition, the E1 component consists of 2 distinct subunits (ie, E1 alpha, E1 beta) that form an alpha-2 beta-2 heterotetramer. (medscape.com)
  • Lipid modifications on proteins might help them travel to cilia by facilitating interaction with transporter proteins. (bladeresearchinc.com)
  • The Transporter Classification Database (or TCDB ) is an International Union of Biochemistry and Molecular Biology (IUBMB)-approved classification system for membrane transport proteins , including ion channels . (wikipedia.org)
  • Furthermore, our data imply that restoring lipoylation in mtFAS deficient yeast strains is not sufficient to support respiration and that long chain acyl-ACPs generated by mtFAS are required for mitochondrial function. (nature.com)
  • Acyl-ACP-LYRM protein complexes facilitate assembly of mitochondrial respiratory complexes. (nature.com)
  • Two acyl-ACP molecules can be found associated with LYRM proteins as components of complex I in the mitochondrial RC. (nature.com)
  • Mcl1 antiapoptotic protein is produced by Mtb -infected alveolar macrophages and is important for interrupting apoptosis in infected macrophages by regulating the mitochondrial membrane and blocking the release of cytochrome C and DNA-degrading enzymes [ 7 ⎼ 9 ]. (ajgreenchem.com)
  • It is a 2.6 MDa barrel shaped complex and is composed of two, unique multi-functional subunits: alpha and beta. (wikipedia.org)
  • Five these reactions are performed in the beta subunit and two reactions are performed in the alpha subunit. (wikipedia.org)
  • The crystal structure of yeast fatty acid synthase has also been derived, showing both alpha and beta subunits. (wikipedia.org)
  • The activation of yeast FAS occurs in the alpha subunit. (wikipedia.org)
  • karyopherin subunit alpha 2 [Source:HGNC. (gsea-msigdb.org)
  • containing a basic amino group, an acidic carboxyl group, and a side chain attached to an alpha carbon atom, and that link together by peptide bonds to form proteins, or that function as chemical messengers and as intermediates in metabolism. (nih.gov)
  • 23209 ribosomal protein S12 methylthiotransferase rimO BBZA01000003 CDS ARMA_0051 23344. (go.jp)
  • ribosomal protein L5 [Source:HGNC Symbol. (gsea-msigdb.org)
  • ACP first delivers the acetate group, which had been attached during priming, to the ketoacyl synthase (KS) domain in the α subunit. (wikipedia.org)
  • Sequence analysis identified 26 open reading frames, including genes encoding the -ketoacyl synthase (KS), chain length factor (CLF), and acyl carrier protein (ACP) that make up the minimal PKS. (univ-lorraine.fr)
  • The reaction is performed by the holo-(acyl-carrier-protein) synthase (ACPS) domain. (wikipedia.org)
  • ACPS attaches the 4′-phosphopantetheine prosthetic group of CoA to the acyl carrier protein (ACP) domain, which is found in the N terminus of the α subunit. (wikipedia.org)
  • Acyl-ACPs form complexes with adapter proteins that contain a leucine-tyrosine-arginine motif (LYRM) 6 . (nature.com)
  • We are interested in studying the function of these long-chain acyl groups synthesized by mtFAS and associated with ACPs. (nature.com)
  • Acetyl CoA is produced from the metabolism of carbohydrates, proteins, and fats in a process called cellular respiration. (coalitionbrewing.com)
  • Acetyl-CoA is a key molecule involved in the metabolism of carbohydrates, fats, and proteins. (coalitionbrewing.com)
  • The enhanced P. falciparum quiescence capacity of artemisinin-resistant parasites results from an increased ability to manage oxidative damage and an altered cell cycle gene regulation within a complex network involving the unfolded protein response, the PI3K/PI3P/AKT pathway, the PfPK4/eIF2α cascade and yet unidentified transcription factor(s), with minimal energetic requirements and fatty acid metabolism maintained in the mitochondrion and apicoplast. (biomedcentral.com)
  • While other PD-associate genes, such as LRRK2 , SNCA , and GBA1 , regulate lysosomal functions, lipid metabolism, or protein aggregation, some have been shown to indirectly affect the electron transport chain. (frontiersin.org)
  • NADH is necessary for cellular development and energy pro-duction: It is essential to produce energy from food and is the principal carrier of electrons in … How do the two acetyl group molecules form? (usiad.net)
  • CD177 antigen is a protein that in humans is encoded by the CD177 gene. (cd177signaling.com)
  • Following the analysis of transposon Tn5432-induced mutants of Corynebacterium glutamicum ATCC 13032, a gene encoding a protein with a biotin-binding motif was cloned. (uni-bielefeld.de)
  • Since it was not possible to inactivate the C. glutamicum gene, the gene most likely encodes a subunit of the essential acetyl-CoA carboxylase, which catalyzes the committed step in fatty acid synthesis. (uni-bielefeld.de)
  • Corynebacterium glutamicum thiosulfate sulfurtransferase (thtR) gene, partial cds, acyl CoA carboxylase (accBC) gene, complete cds. (uni-bielefeld.de)
  • Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 7.9 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
  • COX Aromatic Rich Motif, Cytochrome C oxidase subunit II [Interproscan]. (ntu.edu.sg)
  • Coenzymes typically act as group transfer agents, carrying electrons and chemical groups such as acyl groups, methyl groups, etc., depending on the coenzyme. (usiad.net)
  • The genes encoding the KS and ACP subunits are transcribed constitutively but show a remarkable increase in expression after entering transition phase. (univ-lorraine.fr)
  • The molecular basis of a number of rarer HRFC syndromes remains unknown, and it is hoped that these insights might provide a rationale for the selection of candidate genes in the future, on the basis of protein function. (bmj.com)
  • We will then summarize some of the well-known and newly identified PD-associated genes and their direct or indirect influences on ETC. Finally, we discuss the OXPHOS-independent functions of ETC proteins and their possible implications in PD pathogenesis. (frontiersin.org)
  • Targeted and proximity-dependent promiscuous protein biotinylation by a mutant Escherichia coli biotin protein ligase. (wikigenes.org)
  • Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). (nih.gov)
  • HN - 2014 FX - Ammonia MH - Anaphase-Promoting Complex-Cyclosome UI - D064173 MN - D8.811.464.938.750.92 MN - D12.776.167.24 MS - An E3 ubiquitin ligase primarily involved in regulation of the metaphase-to-anaphase transition during MITOSIS through ubiquitination of specific CELL CYCLE PROTEINS. (nih.gov)
  • Phenazine biosynthesis-like protein [Interproscan]. (ntu.edu.sg)
  • 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal [Interproscan]. (ntu.edu.sg)
  • Transcriptional regulatory protein, Response regulator receiver domain [Interproscan]. (ntu.edu.sg)
  • Binding-protein-dependent transport system inner membrane component [Interproscan]. (ntu.edu.sg)
  • Periplasmic binding proteins and sugar binding domain of LacI family [Interproscan]. (ntu.edu.sg)
  • Protein of unknown function (DUF1439) [Interproscan]. (ntu.edu.sg)
  • FlgN protein [Interproscan]. (ntu.edu.sg)
  • Flagella basal body rod protein, Flagellar basal body rod FlgEFG protein C-terminal [Interproscan]. (ntu.edu.sg)
  • FlgD Ig-like domain, FlgD Tudor-like domain, Flagellar hook capping protein - N-terminal region [Interproscan]. (ntu.edu.sg)
  • Flagellar L-ring protein [Interproscan]. (ntu.edu.sg)
  • Rod binding protein, Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase [Interproscan]. (ntu.edu.sg)
  • Subunit of malonate decarboxylase, it is an acyl carrier protein to which acetyl and malonyl thioester residues are bound via a 2'-(5''-phosphoribosyl)-3'-dephospho-CoA prosthetic group and turn over during the catalytic mechanism. (string-db.org)
  • Multi-subunit acetyl-CoA carboxylases. (wikigenes.org)
  • The protein is composed of two domains, an N-terminal biotin carboxylase and a C-terminal biotin-carboxyl-carrier protein, that are highly similar to corresponding subunits from prokaryotic and eukaryotic biotin enzymes. (uni-bielefeld.de)
  • protein_coding" "AAC74079","torT","Escherichia coli","periplasmic sensory protein associated with the TorRS two-component regulatory system [Ensembl]. (ntu.edu.sg)
  • A starter unit:acyl-carrier protein transacylase (SAT) domain was discovered in the nonreducing PKS. (nih.gov)
  • protein_coding" "CRO31458","clpP_1","Pseudomonas aeruginosa","ATP-dependent Clp protease proteolytic subunit precursor [Ensembl]. (ntu.edu.sg)
  • Chymotrypsin -- A protease that catalyses the hydrolysis (the breakdown) of proteins into peptides or amino acids in the small intestine. (nih.gov)
  • It consists entirely of pentameric α7 subunits expressed in the CNS, autonomic nervous system, vascular system, lymphocytes and spleen. (nih.gov)
  • protein_coding" "CRO25849","No alias","Pseudomonas aeruginosa","cytochrome c oxidase accessory protein CcoG [Ensembl]. (ntu.edu.sg)
  • Like UQCRC1 in preventing cytochrome c from release, functions of ETC proteins beyond oxidative phosphorylation might also contribute to the pathogenesis of PD. (frontiersin.org)
  • ETC is composed of transmembrane complexes I (cI) to V (cV) and two electron carriers, the ubiquinone (i.e. (frontiersin.org)
  • MtFAS follows the prokaryotic type II mode where individual enzymatic steps are carried out by separate enzymes (Fig. 1a ) Acyl groups synthesized by mtFAS are linked to 4-phosphopantetheine moiety of the acyl carrier protein (ACP) via a thioester bond. (nature.com)
  • Lipid modifications likely have a role more than just tethering the proteins to membrane. (bladeresearchinc.com)
  • Lipid modifications can also regulate protein stability and abundance. (bladeresearchinc.com)
  • Future studies focusing on role of lipid modifications in cilia biology will help understand how cilia maintain a complement of specific proteins that allows for specific functions. (bladeresearchinc.com)
  • These enzymes catalyse the transfer of acyl carrier protein (ACP) with a covalently bound CoA derivative, but can accept free CoA thioesters as well. (embl.de)
  • CoA is a coenzyme of acyltransferase reactions and is important in the formation of acyl-CoA compounds. (coalitionbrewing.com)
  • One of the PUFA synthase subunits is a conserved large protein (PfaA in marine proteobacteria) that contains three to nine tandem acyl carrier protein (ACP) domains as well as condensation and modification domains. (unican.es)
  • These results, together with the structural organization predicted for PfaA, suggest that this protein plays a key role at early stages of the anaerobic pathway of PUFA synthesis. (unican.es)
  • There are two steps to using this system: cloning and expression of the protein of interest as a SNAP-tag® fusion, and labeling of the fusion with the SNAP-tag substrate of choice. (neb.com)
  • 601 1-acyl-sn-glycerol-3-phosphate acyltransferase plsC BBZA01000001 CDS ARMA_0002 604. (go.jp)
  • Yeast fatty acyl synthase, of Type I FAS, is composed of a α6β6 complex in which an αβ unit forms one functional center for fatty acid synthesis. (wikipedia.org)
  • Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. (nih.gov)
  • The ternary complex containing UFD1L, VCP and NPLOC4 binds ubiquitinated proteins and is necessary for the export of misfolded proteins from the ER to the cytoplasm, where they are degraded by the proteasome. (nih.gov)
  • The trafficking of proteins to cilia is complex and many mechanisms have been put forward to explain the phenomenon. (bladeresearchinc.com)
  • Piecemeal evidence associates artemisinin resistance with increased unfolded protein response (UPR), dysregulation of the pre-replication phase and the PI3K/PI3P/AKT pathway. (biomedcentral.com)
  • SNAP- and CLIP-tag protein labeling systems enable the specific, covalent attachment of virtually any molecule to a protein of interest. (neb.com)
  • Encodes a germin-like protein with possible oxalate oxidase activity (based on GenBank record). (or.jp)
  • Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). (nih.gov)
  • protein_coding" "CRO31224","fabH_1","Pseudomonas aeruginosa","3-oxoacyl-[acyl-carrier-protein] synthase 3 [Ensembl]. (ntu.edu.sg)