Palmitoyl-protein thioesterase 1 (PPT-1), also known as palmitoyl-protein hydrolase 1, is an enzyme that in humans is encoded by the PPT1 gene. (wikipedia.org)
mouse-adcl3 Mus musculus (Mouse) Arylacetamide deacetylase-like 3 , mouse-adcl4 Mus musculus (Mouse) Arylacetamide deacetylase-like 4 Hypothetical esterase/lipase/thioesterase family active site containing protein , mouse-aryla Mus musculus (Mouse) arylacetamide deacetylase and 5033417e09rik protein , mouse-Q8BLF1 Mus musculus (Mouse) KIAA1363 NCEH1 neutral cholesterol ester hydrolase 1 B230106I24RIK , mouse-b1avu7 Mus musculus (Mouse). (inra.fr)
also, measured were medium chain acyl-CoA dehydrogenase (MCAD) and citrate synthase activities plus uncoupling protein 3 (UCP3), mitochondrial thioesterase 1 (MTE-1), adenine nucleotide translocase (ANT) and ATP synthase protein levels. (ox.ac.uk)
Recent reports have also indicated that TMEM4 is a mitochondrial protein whose overexpression is associated with an increase in mitochondrial membrane depolarization and caspase-3 and PARP cleavage, suggesting that THEM4 is involved in the apoptotic program. (mitokor.com)
How do Fatty Acyl-CoA's pass the mitochondrial intermembrane space? (flashcardmachine.com)
Longer-term (24 and 48 h) treatment reduced the expression of lipogenic markers (FA synthase and sterol regulatory element-binding protein-1) and increased the expression of lipolytic [hormone-sensitive lipase (HSL) and adipose triglyceride lipase (ATGL)] and mitochondrial (peroxisome proliferator-activated receptor γ coactivator-1α and carnitine palmitoyltransferase 1) markers. (academic-accelerator.com)
Elevated levels of cardiac mitochondrial uncoupling protein 3 (UCP3) and decreased cardiac efficiency (hydraulic power/oxygen consumption) with abnormal cardiac function occur in obese, diabetic mice. (ox.ac.uk)
Lysosomal2
PPT-1 is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. (wikipedia.org)
The CLN3 gene encodes a 438 ̶ amino acid protein that is thought to be a part of the lysosomal membrane. (medscape.com)
Cysteine residues of proteins2
S-palmitoylation refers to reversible covalent modification of cysteine residues of proteins by saturated fatty acids. (pasteur.fr)
Fatty acylation is a type of protein lipidation with the attachment of saturated and unsaturated fatty acids to the glycine, serine, lysine, or cysteine residues of proteins. (life-science-alliance.org)
Transferases2
In vivo, palmitoylation is regulated by concerted activities of DHHC palmitoyl acyl transferases (DHHC PATs) and acyl protein thioesterases (APTs), which are enzymes responsible for protein palmitoylation and depalmitoylation, respectively. (pasteur.fr)
In mammalian cells, S-palmitoylate is added by a family of 23 transmembrane zinc finger DHHC (Asp-His-His-Cys)-containing protein acyl transferases and is removed by fatty acyl protein thioesterases ( Malgapo & Linder, 2021 ). (life-science-alliance.org)
Find PPT1 Proteins for a variety of species such as anti-Human PPT1, anti-Mouse PPT1, anti-C. elegans PPT1. (antibodies-online.com)
Find PPT1 Proteins validated for a specific application such as ELISA, WB, SDS, AbP. (antibodies-online.com)
PPT1, which removes fatty acyl groups from cysteine residues on fatty-acid modified proteins, remains in the endoplasmic reticulum, where it is inactive, causing saposins A and D to accumulate in the lysosomes. (medscape.com)
Superfamily1
Description: THEM2 Antibody: THEM2, also known as ACOT13, belongs to the hotdog-fold superfamily and possesses thioesterase activity, with greater activity observed with longer chain acyl-CoAs such as myristoyl- and palmitoyl-CoA. (mitokor.com)
HORMONE-SENSIT1
The expression of regulatory molecules, TGF-β1/2, phospho-Akt (Ser473), PPARα, sterol regulatory element-binding protein 1 (SREBP-1), fatty acid synthase (FASN), hormone-sensitive lipase (HSL), and acyl dehydrogenases was analyzed in virus-infected hepatocytes. (academic-accelerator.com)
Enzyme2
This enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. (wikipedia.org)
Nasu, S., Wicks, F.D. and Gholson, R.K. L -Aspartate oxidase, a newly discovered enzyme of Escherichia coli , is the B protein of quinolinate synthetase. (enzyme-database.org)
Although lipids are a distinct class of biomolecules, we shall see that they often occur combined, either covalently or through weak bonds, with members of other classes of bio-molecules to yield hybrid molecules such as glycolipids , which contain both carbohydrate and lipid groups, "and lipoproteins , which contain both lipids and proteins. (medmuv.com)
There are at least six types of lipids including fatty acids, isoprenoids, sterols, phospholipids, glycosylphosphatidylinositol anchors, and lipid-derived electrophiles, which can be covalently attached to proteins ( Chen et al, 2018 ). (life-science-alliance.org)
Palmitate1
Palmitoylation is a process involving the covalent attachment of the 16-carbon palmitate to proteins ( Linder & Deschenes, 2007 ). (life-science-alliance.org)
Serine1
Palmitoylation targets several protein residues, including serine (O-palmitoylation) and cysteine (S-palmitoylation or N-palmitoylation when it occurs at the N-terminal of the protein). (life-science-alliance.org)
Genes1
To achieve this, the fatty acid desaturase 2 (FAD2) and palmitoyl-acyl carrier protein thioesterase (PAT) genes, both of which are associated with fatty acid metabolism biosynthesis pathways in oil palm, need to be knocked out. (bvsalud.org)
Moreover, using acyl biotin exchange chemistry (ABE) and confocal imaging, we demonstrate that a calcium dependent protein kinase, PfCDPK1, an essential regulator of key invasion processes such as motility and microneme secretion, undergoes dynamic palmitoylation and localizes to the merozoite membrane. (pasteur.fr)
Though, excessive relative oxygen varieties are generated, it can PTZ-343 cause, mutations in DNA, damage to proteins and oxidation of membrane phospholipids. (enmd-2076.com)
Protein S-Palmitoylation Is Responsive to External Signals and Plays a Regulatory Role in Microneme Secretion in Plasmodium falciparum Merozoites. (pasteur.fr)
Protein S-palmitoylation is an important post-translational modification (PTM) in blood stages of the malaria parasite, Plasmodium falciparum. (pasteur.fr)
Here, we investigate the role of protein palmitoylation in red blood cell (RBC) invasion by P. falciparum merozoites. (pasteur.fr)
Posttranslational protein S-palmitoylation regulates the localization and function of its target proteins involved in diverse cellular processes including meiosis. (life-science-alliance.org)
Together, these results highlight the versatility of the cellular processes in which protein S-palmitoylation participates. (life-science-alliance.org)