Acyl coa acetyl coa c acyltransferase. Medical search. Frequent questions

Yeast microsomes expressing EaDAcT possessed acetyl-CoA diacylglycerol acetyltransferase activity but lacked long-chain acyl-CoA diacylglycerol acyltransferase activity. (nih.gov)
Searching for up to 100 curated homologs for Pf1N1B4_5133 3-ketoacyl-CoA thiolase (EC 2.3.1.16) @ Acetyl-CoA acetyltransferase (EC 2.3.1.9) (394 a.a. (lbl.gov)

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. (wikipedia.org)
The systematic name of this enzyme class is acyl-CoA:1-O-alkyl-2-acetyl-sn-glycerol O-acyltransferase. (wikipedia.org)
This enzyme is also called 1-hexadecyl-2-acetylglycerol acyltransferase. (wikipedia.org)
The Acyl CoA:diacylglycerol (DGAT) is a membrane enzyme that catalyses the final step in TAG biosynthesis. (usda.gov)
Studies on specificities of the DGAT enzyme for substrates demonstrated that the DGAT had pronounced selectivities for acyl donors and acyl acceptors with both 'common' and 'uncommon' fatty acids. (usda.gov)
The investigation involving LsTAT1 enzyme action in the cell-free method revealed that the particular chemical displayed task to the acetylation involving taraxasterol, ψ-taraxasterol, β-amyrin, α-amyrin, lupeol, and taraxerol employing acetyl-CoA as an acyl contributor however absolutely no task with regard to triterpene acylation by using a fatty acyl contributor. (hormonessignaling.com)
The enzyme undergoes a multistage conformational change upon binding of acyl-CoA, thus allowing the uploading of Tei pseudoaglycone to enable the acyl-transfer reaction to take place in the occlusion between the N- and C-halves of the protein. (nycu.edu.tw)
This process is catalyzed by the enzyme acetyl-CoA synthetase. (medscape.com)
A human metabolite involved in the fatty acid elongation in the mitochondrial pathway, its formation from acetyl-CoA is catalysed by the enzyme acetyl-CoA C-acyltransferase. (ebi.ac.uk)

Carnitine acyltransferase (CAT) transports free fatty acids into the mitochondria and therefore regulates their entry into the oxidative pathway. (medscape.com)

These are acyl CoAs where the group acylated to the coenzyme A moiety is a long aliphatic chain of 13 to 21 carbon atoms. (ymdb.ca)
Acetic acid (an acyl group carrier) is linked with coenzyme A (a thiol) to produce Acetyl-CoA. (medscape.com)
An oxo-fatty acyl-CoA that results from the formal condensation of the thiol group of coenzyme A with the carboxylic acid group of 3-oxolauroic acid. (ebi.ac.uk)
Long-chain acyl coenzyme A dehydrogenase (ACADL) is the first step in catalytic fatty acid oxidation and plays an important role in long-chain fatty acid oxidation including expression regulation and activity regulation. (animbiosci.org)

ATP-citrate lyase/succinyl-CoA ligase [Interproscan]. (ntu.edu.sg)

The expression of regulatory molecules, TGF-β1/2, phospho-Akt (Ser473), PPARα, sterol regulatory element-binding protein 1 (SREBP-1), fatty acid synthase (FASN), hormone-sensitive lipase (HSL), and acyl dehydrogenases was analyzed in virus-infected hepatocytes. (academic-accelerator.com)

Functional annotation resulted in the identification of almost all genes involved in diverse lipid-metabolic pathways, including the novel fatty acid desaturase/epoxygenase, diacylglycerol acyltransferase 1 and 2, and phospholipid:diacylglycerol acyltransferases. (researchsquare.com)

Oil biosynthesis in plant is a complicated process, more than 30 reactions are required to convert acetyl-CoA to triacylglycerol. (usda.gov)
By comparison, we found that various genes associated with acyl editing, fatty acid β-oxidation, triacylglycerol assembly and oil-body formation had greater expression levels at middle developmental stage (38 DAP), which are consistent with the fast accumulation of EFA in V. galamensis developing seed, implying their fundamental roles in EFA production. (researchsquare.com)

The deduced amino series regarding LsTAT1 revealed the phylogenetic romantic relationship (43% identity) together with that relating to sterol O-acyltransferase (AtSAT1) of Arabidopsis thaliana coupled with catalytic protein elements (Asn and his awesome) which can be typically preserved in membrane-bound O-acyltransferase (MBOAT) household protein. (hormonessignaling.com)

Regulated by malonyl CoA. (flashcardmachine.com)

Palmityl-CoA is a strong basic compound (based on its pKa). (ymdb.ca)

An uncharacterized membrane-bound O-acyltransferase (MBOAT) family member was the most abundant acyltransferase in the endosperm but was absent from the aril. (nih.gov)

Vancomycin/synthetic acyl-N-acetyl cysteamine was not expected to be able to serve as a surrogate for an acyl acceptor/donor, respectively. (nycu.edu.tw)
Any donor that can transfer acyl groups between molecular entities. (ebi.ac.uk)

The aim of this study was to clone the mRNA sequence of the Acyl-CoA dehydrogenase long chain ( ACADL ) gene of goats and explore the effect of ACADL on the differentiation of subcutaneous fat cells on this basis. (animbiosci.org)

Palmityl-CoA, also known as palmitoyl CoA or CoA, palmitoyl, belongs to the class of organic compounds known as long-chain fatty acyl coas. (ymdb.ca)

Most strikingly, NAT can catalyze formation of 2-N,6-O-diacylated or C6→C2 acyl-substituted Tei analogues through an unusual 1,4-migration mechanism under stoichiometric/solvational reaction control, wherein selected representatives showed excellent biological activities, effectively counteracting major types (VanABC) of VRE. (nycu.edu.tw)

In addition, DGATs from several plant species showed pronounced selectivities for DAG and acyl-CoA, and this selectivity of the DGAT greatly influenced the type of TAG species formed in cells. (usda.gov)

The presence of the sn-3 acetyl group imparts acTAGs with different physical and chemical properties, such as a 30% reduction in viscosity, compared to lcTAGs. (nih.gov)

This class of antibiotics is powered by the N-acyltransferase (NAT) Orf11/Dbv8 through N-acylation on glucosamine at the central residue of Tei/A40926 pseudoaglycone. (nycu.edu.tw)

However, oxidation of LDL is accompanied by a substantial reduction in LDL total cholesterol content and hence the amount of cholesterol delivered by oxidatively modified LDL may be less than that delivered by scavenger receptor ligands such as acetyl LDL which results in massive cholesterol accumulation in cultured macrophages. (elsevierpure.com)

Even after correction for the amount of intact cholesterol delivered to the cells, acetyl LDL was twofold more efficient at stimulating cholesterol esterification than oxidized LDL. (elsevierpure.com)

Integrated transcriptome and metabolome network analysis showed 2 major gene-metabolite clusters, 1 centered on the transcript for the bidirectional glucose transporter 2 (Glut2) and the other centered on the transcripts for carnitine-palmitoyl transferase 2 (Cpt2) and acetyl-CoA acyltransferase (Acaa1). (nih.gov)
Acyl CoA with carnitine gives acylcarnitine, and the enzyme is carnitine acyl transferase 1 (rate-limiting enzyme). (prepladder.com)
CoA-transferase family III [Interproscan]. (ntu.edu.sg)

Step 2: Conversion of Acetyl-CoA to CoA - In this step, the acetyl-CoA formed in the previous step is converted into an active form of CoA by the enzyme known as Acetyl-CoA synthetase. (coalitionbrewing.com)
acyl-CoA synthetase long chain fam. (gsea-msigdb.org)
As soon as fatty acid gets into any cell, irrespective of the final fate of fatty acid, the 1st enzyme to act on this fatty acid will be acetyl CoA synthetase. (prepladder.com)
This acetyl CoA synthetase uses 1 ATP which gets converted to AMP + PPI. (prepladder.com)
This step uses two high energy phosphate and successfully converts fatty acid into acetyl CoA The purpose of acyl CoA synthetase is to trap fatty acid within the cell.Fatty acids are nonpolar substances. (prepladder.com)
1. Formation of a reactive xenobiotic-CoA thioester intermediate, catalyzed by an ATP-dependent acid:CoA synthetase (ACSM). (youarethehealer.org)
Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. (nih.gov)

Carnitine acyltransferases catalyze the reversible exchange of acyl groups between coenzyme A (CoA) and carnitine. (proteopedia.org)
Coenzyme A (CoA) is synthesized in a two-step process, beginning with the synthesis of pantethine from cysteine. (coalitionbrewing.com)
CoA is a coenzyme of acyltransferase reactions and is important in the formation of acyl-CoA compounds. (coalitionbrewing.com)
These are acyl CoAs where the group acylated to the coenzyme A moiety is a long aliphatic chain of 13 to 21 carbon atoms. (ymdb.ca)
The conjugation reactions of amino acid acyltransferases use the cofactor acetyl-coenzyme A (acetyl-CoA), which is synthesized from vitamin B5, using enzymes that themselves depend on multiple B vitamins. (youarethehealer.org)

Furthermore, 3-hydroxyacyl-CoA dehydrogenase is inhibited by NADH and thiolase is inhibited by acetyl-CoA, so that fatty acids wil not be oxidized when there are plenty of energy-yielding substrates in the cell. (ufp.pt)

It may be involved as well in the transport of acetyl-CoA into mitochondria. (proteopedia.org)
Acetyl-CoA is formed after glycolysis when pyruvate from the glycolytic pathway is transported into the mitochondria and converted into acetyl CoA. (coalitionbrewing.com)
Is acetyl-CoA formed in the mitochondria? (coalitionbrewing.com)
Carnitine acyltransferase (CAT) transports free fatty acids into the mitochondria and therefore regulates their entry into the oxidative pathway. (medscape.com)

Palmityl-CoA, also known as palmitoyl CoA or CoA, palmitoyl, belongs to the class of organic compounds known as long-chain fatty acyl coas. (ymdb.ca)

citric acid cycle (Krebs' cycle) - acetyl-CoA oxidation in order to obtain GTP and valuable intermediates. (ufp.pt)
Pyruvate carboxilase is activated by acetyl-CoA, which signals the abundance of citric acid cycle intermediates, i.e. , a decreased need of glucose. (ufp.pt)
It is also inhibited by NADH and succinyl-CoA (which signal the abundance of citric acid cycle intermediates). (ufp.pt)
In particular, CoA is used in the oxidation of fatty acids and in the production of acetyl-CoA, which can then be used in the citric acid cycle to generate energy. (coalitionbrewing.com)
The product of this reaction is acetyl CoA, which is then used to enter the citric acid cycle, where energy is ultimately produced. (coalitionbrewing.com)
The acetyl CoA molecule also carries a two carbon acetyl group, which it donates to oxaloacetate, the first substrate of the citric acid cycle. (coalitionbrewing.com)
Once these three steps have been completed, pyruvate is successfully converted into Acetyl-CoA, which can then be used in the Citric Acid Cycle to produce energy. (coalitionbrewing.com)
2nd phase: Every acetyl CoA Enters into citric acid Cycle every acetyl CoA molecule. (prepladder.com)

Bile acids are conjugated with amino acids, glycine and taurine in the liver, catalyzed by two enzymes, bile acid CoA ligase (BAL) and bile acid CoA:amino acid N-acyltransferase (BAT). (youarethehealer.org)
Enzymes that catalyze the synthesis of FATTY ACIDS from acetyl-CoA and malonyl-CoA derivatives. (lookformedical.com)

Malonyl-CoA (which is present in the cytoplasm in high amounts when metabolic fuels are abundant) inhibits carnitine acyltransferase, thereby preventing acyl-CoA from entering the mitochondrion. (ufp.pt)
What will inhibit Malonyl CoA? (flashcardmachine.com)
Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA, in the presence of NADPH, into long-chain saturated fatty acids. (nih.gov)

What is the importance of succinyl CoA in Oxidation of fatty as? (flashcardmachine.com)

12558 2-aminobenzoate-CoA ligase abmG BBZA01000002 CDS ARMA_0024 12542. (go.jp)
genetic variation in the ATP dependent acid: CoA ligase (ACSM2B) (encoding HXMA) and glycine N-acyltransferase (GLYAT) (encoding GLYAT) genes as well as variable expression of HXMA and GLYAT. (youarethehealer.org)

Two molecules of acetyl CoA are produced from each glucose molecule, and these molecules of acetyl coA are then passed into the electron transport chain. (coalitionbrewing.com)
In the electron transport chain, acetyl coA is combined with oxygen to form two molecules of water and the energy-carrying molecule called ATP. (coalitionbrewing.com)
During beta-oxidation, two-carbon molecules are removed from the fatty acids, and these two-carbon molecules are combined to form one molecule of Acetyl CoA. (coalitionbrewing.com)
Step 1: Oxidation of Pyruvate - In this step, pyruvate is oxidized and a carbon dioxide molecule is released, while the remaining two-carbon molecule is converted into Acetyl-CoA. (coalitionbrewing.com)
Acetyl-CoA is a key molecule involved in the metabolism of carbohydrates, fats, and proteins. (coalitionbrewing.com)

inhibited by ATP, alanine, free fatty acids and acetyl-CoA. (ufp.pt)

Carnitine acyltransferase 2 releases the carnitine back and converts acylcarnitine to acyl CoA. (prepladder.com)

People with carnitine/acyltransferase deficiency can't use LCFA for fuel. (flashcardmachine.com)

14478 3-oxoacyl-[acyl-carrier protein] reductase fabG BBZA01000001 CDS ARMA_0014 complement(14430. (go.jp)
2,4-dienoyl-CoA reductase 1 [Sourc. (gsea-msigdb.org)

CoA is also involved in acyl group transfers, and these reactions are important in many metabolic processes, including the synthesis of ketones, amino acids and neurotransmitters. (coalitionbrewing.com)

An autosomal recessive disorder of lipoprotein metabolism caused by mutation of LECITHIN CHOLESTEROL ACYLTRANSFERASE gene. (nih.gov)
Acetyl CoA is produced from the metabolism of carbohydrates, proteins, and fats in a process called cellular respiration. (coalitionbrewing.com)

Amino acid conjugation is a major route for a number of small aromoatic acids, and involves the formation of an amide bond between the xenobiotic acyl-CoA and the amino acid. (youarethehealer.org)
2. Linkage of the activated acyl group via an acyl-CoA:amino acid N-acyltransferase (GLYAT) to the amino group of the acceptor amino acid. (youarethehealer.org)

A sterol O-acyltransferase that catalyzes reaction of Acyl-CoA and cholesterol into CoA and cholesterol ester. (nih.gov)

This acetyl CoA then enters the Kreb's cycle and the product of ATP is the same as when Acetyl coA is produced from carbohydrates. (coalitionbrewing.com)
Acyl carnitine crosses the inner mitochondrial membrane and enters the matrix. (prepladder.com)

Pyruvate, the end-product of glycolysis, is transformed into acetyl-CoA through a three-step metabolic process known as the Pyruvate-Dehydrogenase (PDH) pathway. (coalitionbrewing.com)

601 1-acyl-sn-glycerol-3-phosphate acyltransferase plsC BBZA01000001 CDS ARMA_0002 604. (go.jp)

This acetyl group is made up of a carbon (C) and two hydrogen (H) atoms, which have been taken from pyruvate. (coalitionbrewing.com)

This multifunctional protein has 7 catalytic activities as an acyl carrier protein. (nih.gov)

The structural information provides significant new insights into the catalytic mechanism of CrAT and possibly carnitine acyltransferases in general. (proteopedia.org)

As such, CoA is essential for many cellular processes, including energy production. (coalitionbrewing.com)

During the conversion of pyruvate to acetyl CoA, electrons are also transferred to the electron transport chain, which is responsible for generating the majority of the energy in cells. (coalitionbrewing.com)
enoyl-CoA hydratase, short chain 1. (gsea-msigdb.org)
dihydrolipoamide branched chain acyltransferase activity. (yeastrc.org)

The SM concentration is also significantly increased in macrophages treated with acetyl-LDL plus an acyl-CoA:cholesterol acyltransferase inhibitor [ 11 ]. (biomedcentral.com)

They're the preferred fuel of heart and renal-- they are water soluble source of acetyl units. (flashcardmachine.com)

Anatomy15

Organisms13

Diseases5

Chemicals and Drugs161

Analytical, Diagnostic and Therapeutic Techniques and Equipment17

Phenomena and Processes38

Disciplines and Occupations1

Technology, Industry, Agriculture8

Information Science3

Health Care1

Acetyltransferase2

Enzyme9

Carnitine1

Coenzyme4

Lyase1

Synthase1

Phospholipid1

Triacylglycerol2

Protein1

Malonyl1

Compound1

MBOAT1

Donor2

SEQUENCE1

Long1

Reaction1

Species1

Group1

Class1

Results1

Cells1

Transferase3

Synthetase7

Coenzyme5

Thiolase1

Mitochondria4

Fatty acyl1

Citric8

Enzymes2

Malonyl-CoA3

Oxidation of fatty1

Ligase2

Molecule5

Free fatty1

Acylcarnitine1

Deficiency1

Reductase2

Synthesis1

Metabolism2

Amino2

Catalyzes1

Enters2

Pyruvate dehydrogenase1

Phosphate1

Carbon1

Protein1

Catalytic1

Cellular processes1

Chain3

Cholesterol1

Renal1