• Starting from the N-terminus, these units include β-ketoacyl synthase (KS), acetyl/malonyl transacylase (AT/MT), β-hydroxyacyl dehydratase (DH), enoyl reductase (ER), β-ketoacyl reductase (KR), acyl carrier protein (ACP), and thioesterase (TE). (aging-us.com)
  • Peptide epimerase-dehydratase complex responsible for biosynthesis of the linaridin class ribosomal peptides. (hokudai.ac.jp)
  • By comparison, we found that various genes associated with acyl editing, fatty acid β-oxidation, triacylglycerol assembly and oil-body formation had greater expression levels at middle developmental stage (38 DAP), which are consistent with the fast accumulation of EFA in V. galamensis developing seed, implying their fundamental roles in EFA production. (researchsquare.com)
  • The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. (nih.gov)
  • Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). (nih.gov)
  • E. faecalis has two acyl carrier proteins (ACPs), AcpA (EfAcpA), which is essential for de novo fatty acid synthesis (FAS), and EfAcpB, which plays an auxiliary role in the incorporation of exogenous fatty acids. (bvsalud.org)
  • How do Fatty Acyl-CoA's pass the mitochondrial intermembrane space? (flashcardmachine.com)
  • The biosynthetic gene clusters of these linaridins lack obvious candidate genes for the dehydratase and epimerase required to introduce dehydrobutyrine and D-amino acid residues, respectively. (hokudai.ac.jp)
  • However, we previously demonstrated that the grisemycin (grm) cluster contained cryptic dehydratase and epimerase genes by heterologous expression of this biosynthetic gene cluster in Streptomyces lividans and proposed that two genes (grmH and grmL) with unknown functions catalyze dehydration and epimerization reactions. (hokudai.ac.jp)
  • protein_coding" "AAC73960","hcp","Escherichia coli","hybrid-cluster [4Fe-2S-2O] subunit of anaerobic terminal reductases [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74319","hns","Escherichia coli","global DNA-binding transcriptional dual regulator H-NS [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74185","ptsG","Escherichia coli","fused glucose-specific PTS enzymes: IIB component/IIC component [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74323","adhE","Escherichia coli","fused acetaldehyde-CoA dehydrogenase/iron-dependent alcohol dehydrogenase/pyruvate-formate lyase deactivase [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74850","yeaD","Escherichia coli","D-hexose-6-phosphate epimerase-like protein [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74888","manY","Escherichia coli","mannose-specific enzyme IIC component of PTS [Ensembl]. (ntu.edu.sg)
  • Ribosomal protein S20 [Interproscan]. (ntu.edu.sg)
  • Ribosomal protein L35 [Interproscan]. (ntu.edu.sg)
  • Although lipids are a distinct class of biomolecules, we shall see that they often occur combined, either covalently or through weak bonds, with members of other classes of bio-molecules to yield hybrid molecules such as glycolipids , which contain both carbohydrate and lipid groups, "and lipoproteins , which contain both lipids and proteins. (medmuv.com)
  • Essential in the yeast FAS catalytic cycle is the acyl carrier protein (ACP) that actively shuttles substrates, biosynthetic intermediates, and products from one active site to another. (bvsalud.org)
  • The human FASN protein is composed of six catalytic units. (aging-us.com)
  • Bor protein [Interproscan]. (ntu.edu.sg)
  • Protein of unknown function (DUF1158) [Interproscan]. (ntu.edu.sg)
  • Protein of unknown function (DUF2526) [Interproscan]. (ntu.edu.sg)
  • Protein of unknown function (DUF441) [Interproscan]. (ntu.edu.sg)
  • LysR substrate binding domain, Bacterial regulatory helix-turn-helix protein [Interproscan]. (ntu.edu.sg)
  • YebO-like protein [Interproscan]. (ntu.edu.sg)
  • Protein of unknown function (DUF2511) [Interproscan]. (ntu.edu.sg)
  • Copper resistance protein D [Interproscan]. (ntu.edu.sg)
  • Protein of unknown function (DUF520) [Interproscan]. (ntu.edu.sg)
  • Further, the "HomoloGene" function of the NCBI was used to conduct conserved functional domain analysis of the FASN protein in different species. (aging-us.com)
  • The structural information suggests that each FAS functional unit could accommodate exogenous proteins to incorporate various enzymatic activities, and we show proof-of-concept experiments where ectopic proteins are used to modulate FAS product profiles. (bvsalud.org)
  • In this study, we confirmed that both GrmH and GrmL, which were shown to constitute a protein complex by a co-purification experiment, were required to catalyze the dehydration, epimerization, and proteolytic cleavage of a precursor peptide GrmA by in vivo experiments. (hokudai.ac.jp)
  • Additionally, several features (e.g., gene expression, survival prognosis, genetic alteration, DNA methylation, protein phosphorylation, immune cells, or relevant cellular pathways) were gathered to evaluate the regulatory mechanism of FASN in the tumorigenesis of cancers. (aging-us.com)
  • Rapid whole-genome sequencing identifies a homozygous novel variant, His540Arg, in HSD17B4 resulting in D-bifunctional protein deficiency disorder diagnosis. (nih.gov)
  • PFmulDL: a novel strategy enabling multi-class and multi-label protein function annotation by integrating diverse deep learning methods. (ecust.edu.cn)
  • N-Formimidoylation/-iminoacetylation modification in aminoglycosides requires FAD-dependent and ligand-protein NOS bridge dual chemistry. (hokudai.ac.jp)
  • 14478 3-oxoacyl-[acyl-carrier protein] reductase fabG BBZA01000001 CDS ARMA_0014 complement(14430. (go.jp)
  • This bacterial family of Acyl transferases (ACT or myristoyl-acp-specific thioesterases) catalyses the first step in the bioluminescent fatty acid reductase system, which is required for aldehyde biosynthesis. (inra.fr)
  • Together with acyl-protein synthetase (LuxE) and reductase (LuxC), it belongs to a multienzyme complex. (inra.fr)
  • It is demonstrated that 1,3,4-oxadiazole hybridization with other anticancer pharmacophores have different mechanisms of action by targeting various enzymes (thymidylate synthase, HDAC, topoisomerase II, telomerase, thymidine phosphorylase) and many of the proteins that contribute to cancer cell proliferation. (bvsalud.org)
  • protein_coding" "CRN79955","hcnC_1","Pseudomonas aeruginosa","Hydrogen cyanide synthase subunit HcnC precursor [Ensembl]. (ntu.edu.sg)
  • protein_coding" "CRO31224","fabH_1","Pseudomonas aeruginosa","3-oxoacyl-[acyl-carrier-protein] synthase 3 [Ensembl]. (ntu.edu.sg)
  • 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal [Interproscan]. (ntu.edu.sg)
  • revealed that the ß-ketoacyl-acyl carrier protein synthase KasB (encoded by the kasB gene)-deficient mutant strain synthesized mycolates with shorter chain lengths. (medscape.com)
  • The dehydratase (DH) domain of a PUFA synthase plays a crucial role in double bond positioning in fatty acids. (biomedcentral.com)
  • The two FabA-like DH domains in the E. huxleyi PUFA synthase function as 3-hydroxyacyl-acyl carrier protein dehydratase in E. coli . (biomedcentral.com)
  • Finally, we also tested the deletion of two potential medium-chain acyl-CoA depleting reactions catalyzed by the thioesterase Tes1 and the medium-chain fatty acyl CoA synthase Faa2. (biomedcentral.com)
  • 10614) putative ABC transport system permease protein BBZA01000001 CDS ARMA_0010 complement(10625. (go.jp)
  • 11353) putative ABC transport system ATP-binding protein BBZA01000001 CDS ARMA_0011 complement(11350. (go.jp)
  • protein_coding" "CRO36835","rlmN_2","Pseudomonas aeruginosa","putative dual-specificity RNA methyltransferase RlmN [Ensembl]. (ntu.edu.sg)
  • protein_coding" "CRO31458","clpP_1","Pseudomonas aeruginosa","ATP-dependent Clp protease proteolytic subunit precursor [Ensembl]. (ntu.edu.sg)
  • protein_coding" "Cz01g39150.t1","No alias","Chromochloris zofingiensis","RNA polymerase subunit RPB4/RPC9 [Interproscan]. (ntu.edu.sg)
  • Phenazine biosynthesis-like protein [Interproscan]. (ntu.edu.sg)
  • This reaction terminates acyl chain elongation of fatty acid biosynthesis, and in plant seeds it is the biochemical determinant of the fatty acid compositions of storage lipids. (iastate.edu)
  • These acyl-ACP TEs can potentially be used to diversify the fatty acid biosynthesis pathway to produce novel fatty acids. (iastate.edu)
  • Pyridoxal-phosphate dependent enzyme, C-terminal regulatory domain of Threonine dehydratase [Interproscan]. (ntu.edu.sg)
  • Several novel acyl-ACP TEs act on short-chain and unsaturated acylACP or 3-ketoacyl-ACP substrates, indicating the diversity of enzymatic specificity in this enzyme family. (iastate.edu)
  • The crystal structure of a myristoyl acyl carrier protein specific thioesterase (C14ACP-TE) from a bioluminescent bacterium, Vibrio harveyi, was solved by multiple isomorphous replacement methods and refined to an R factor of 22% at 2.1-A resolution. (inra.fr)
  • Regulates E3 ubiquitin-protein ligase activity of RNF19A (By similarity). (nih.gov)
  • Bacterial regulatory proteins, Aminotransferase class I and II [Interproscan]. (ntu.edu.sg)
  • Sigma-54 interaction domain, Bacterial regulatory protein, Propionate catabolism activator [Interproscan]. (ntu.edu.sg)
  • Bacterial regulatory proteins, Response regulator receiver domain [Interproscan]. (ntu.edu.sg)
  • So the E. coli have to survive under the presence of ROS and RNS that can specifically damage bacterial lipids, proteins, and DNA. (sciendo.com)
  • Recombinant, E. coli recombinant proteins are genetic recombinations in Escherichia coli, supplied as white sterile powder lyopillized. (gentaur.com)
  • protein_coding" "AAC73502","phoB","Escherichia coli","response regulator in two-component regulatory system with PhoR [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73720","dpiB","Escherichia coli","sensory histidine kinase in two-component regulatory system with CitB [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC73789","kdpD","Escherichia coli","fused sensory histidine kinase in two-component regulatory system with KdpE: signal sensing protein [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74078","torS","Escherichia coli","hybrid sensory histidine kinase in two-component regulatory system with TorR [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74079","torT","Escherichia coli","periplasmic sensory protein associated with the TorRS two-component regulatory system [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74080","torR","Escherichia coli","response regulator in two-component regulatory system with TorS [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74155","flgM","Escherichia coli","anti-sigma factor for FliA (sigma 28) [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74158","flgC","Escherichia coli","flagellar component of cell-proximal portion of basal-body rod [Ensembl]. (ntu.edu.sg)
  • protein_coding" "AAC74163","flgH","Escherichia coli","flagellar protein of basal-body outer-membrane L ring [Ensembl]. (ntu.edu.sg)
  • 217. The PrpF protein of Shewanella oneidensis MR-1 catalyzes the isomerization of 2-methyl-cis-aconitate during the catabolism of propionate via the AcnD-dependent 2-methylcitric acid cycle. (wisc.edu)
  • Acyl-acyl carrier protein thioesterases (acyl-ACP TEs) catalyze the hydrolysis of the thioester bond that links the acyl chain to the sulfhydryl group of the phosphopantetheine prosthetic group of ACP. (iastate.edu)
  • 23209 ribosomal protein S12 methylthiotransferase rimO BBZA01000003 CDS ARMA_0051 23344. (go.jp)
  • protein_coding" "Cz03g11040.t1","No alias","Chromochloris zofingiensis","Ribosomal protein/NADH dehydrogenase domain [Interproscan]. (ntu.edu.sg)
  • ribosomal protein L5 [Source:HGNC Symbol. (gsea-msigdb.org)
  • hypothetical protein SAOV_0248 [Staphylococcus aureus subsp. (polygenicpathways.co.uk)
  • 4628 hypothetical protein BBZA01000001 CDS ARMA_0005 5077. (go.jp)
  • 5685 hypothetical protein BBZA01000001 CDS ARMA_0006 5873. (go.jp)
  • 7021 hypothetical protein BBZA01000001 CDS ARMA_0007 complement(7097. (go.jp)
  • 7504) hypothetical protein BBZA01000001 CDS ARMA_0008 complement(7590. (go.jp)
  • 11958) hypothetical protein BBZA01000001 CDS ARMA_0012 12170. (go.jp)
  • 578 hypothetical protein BBZA01000002 CDS ARMA_0016 684. (go.jp)
  • 2342 hypothetical protein BBZA01000002 CDS ARMA_0017 2339. (go.jp)
  • 3094 hypothetical protein BBZA01000002 CDS ARMA_0018 3478. (go.jp)
  • 4371 hypothetical protein BBZA01000002 CDS ARMA_0019 complement(4468. (go.jp)
  • 5751) hypothetical protein BBZA01000002 CDS ARMA_0021 complement(5880. (go.jp)
  • 6020) hypothetical protein BBZA01000002 CDS ARMA_0020 6069. (go.jp)
  • 7490 hypothetical protein BBZA01000002 CDS ARMA_0022 complement(7569. (go.jp)
  • 10130) hypothetical protein BBZA01000002 CDS ARMA_0023 10363. (go.jp)
  • 12985 hypothetical protein BBZA01000002 CDS ARMA_0025 13067. (go.jp)
  • 13828 hypothetical protein BBZA01000002 CDS ARMA_0026 13840. (go.jp)
  • 15584 hypothetical protein BBZA01000003 CDS ARMA_0028 complement(2147. (go.jp)
  • 2662) hypothetical protein BBZA01000003 CDS ARMA_0030 complement(2909. (go.jp)
  • 3070) hypothetical protein BBZA01000003 CDS ARMA_0029 3089. (go.jp)
  • 3247 hypothetical protein BBZA01000003 CDS ARMA_0031 3817. (go.jp)
  • 11054 hypothetical protein BBZA01000003 CDS ARMA_0036 11082. (go.jp)
  • 11983 hypothetical protein BBZA01000003 CDS ARMA_0038 complement(11960. (go.jp)
  • 12616) hypothetical protein BBZA01000003 CDS ARMA_0039 12726. (go.jp)
  • 13859 hypothetical protein BBZA01000003 CDS ARMA_0040 13859. (go.jp)
  • 14554 hypothetical protein BBZA01000003 CDS ARMA_0041 14582. (go.jp)
  • 15289 hypothetical protein BBZA01000003 CDS ARMA_0042 15306. (go.jp)
  • 15746 hypothetical protein BBZA01000003 CDS ARMA_0043 complement(15750. (go.jp)
  • 16253) hypothetical protein BBZA01000003 CDS ARMA_0044 complement(16376. (go.jp)
  • 16723) hypothetical protein BBZA01000003 tRNA ARMA_tRNA01 complement(16745. (go.jp)
  • 17762 hypothetical protein BBZA01000003 CDS ARMA_0046 17875. (go.jp)
  • 19373 hypothetical protein BBZA01000003 CDS ARMA_0048 complement(19431. (go.jp)
  • 20651) hypothetical protein BBZA01000003 CDS ARMA_0049 20873. (go.jp)
  • 21793 hypothetical protein BBZA01000003 CDS ARMA_0050 21812. (go.jp)
  • 24549 hypothetical protein BBZA01000003 CDS ARMA_0052 24709. (go.jp)
  • 25812 hypothetical protein BBZA01000003 CDS ARMA_0053 25854. (go.jp)
  • 27638 hypothetical protein BBZA01000003 CDS ARMA_0054 27690. (go.jp)
  • 29561 hypothetical protein BBZA01000003 CDS ARMA_0055 29551. (go.jp)
  • 30963 hypothetical protein BBZA01000003 CDS ARMA_0056 30956. (go.jp)
  • 32158 hypothetical protein BBZA01000003 CDS ARMA_0057 32158. (go.jp)
  • 35130 hypothetical protein BBZA01000003 CDS ARMA_0058 35127. (go.jp)
  • 35501 hypothetical protein BBZA01000003 CDS ARMA_0059 35523. (go.jp)
  • 38051 hypothetical protein BBZA01000003 CDS ARMA_0060 38048. (go.jp)
  • 38443 hypothetical protein BBZA01000003 CDS ARMA_0061 38445. (go.jp)
  • 40466 hypothetical protein BBZA01000003 CDS ARMA_0063 complement(40556. (go.jp)
  • 42784) hypothetical protein BBZA01000004 CDS ARMA_0066 23. (go.jp)
  • 493 hypothetical protein BBZA01000004 CDS ARMA_0067 664. (go.jp)
  • creates a toxic condition, which directly alters the stability of various lipids, proteins, enzymes of critical metabolic pathways, replication, transcription, and translation machinery, which makes it difficult for the micro organisms to survive [ 70 , 73 ]. (sciendo.com)
  • Transcriptional regulatory protein, Response regulator receiver domain [Interproscan]. (ntu.edu.sg)
  • These results indicate that Net participates in the transcriptional response to hypoxia by regulation of HIF-1alpha protein stability. (gsea-msigdb.org)
  • Accepted August 23, 2012 ABSTRACT The catabolite control protein CcpA is a pleiotropic regulator that mediates the global transcriptional response to rapidly catabolizable carbohydrates, like glucose in Gram-positive bacteria. (studyres.com)
  • These structural modification strategies have shown promising results when combined with outstanding oxadiazole scaffolds, which selectively interact with nucleic acids, enzymes, and globular proteins. (bvsalud.org)
  • The enhanced P. falciparum quiescence capacity of artemisinin-resistant parasites results from an increased ability to manage oxidative damage and an altered cell cycle gene regulation within a complex network involving the unfolded protein response, the PI3K/PI3P/AKT pathway, the PfPK4/eIF2α cascade and yet unidentified transcription factor(s), with minimal energetic requirements and fatty acid metabolism maintained in the mitochondrion and apicoplast. (biomedcentral.com)
  • Almost 2000 mutations, truncations or polymorphisms in the CFTR gene are recorded in the cystic fibrosis mutation database .run by the Cystic Fibrosis Centre at the Hospital for Sick Children in Toronto A polymutant protein comprising 20 point mutations was constructed from this unformation and used for analysis in some cases. (polygenicpathways.co.uk)
  • Probe Set ID Ref Seq Protein ID Signal Strength Name Gene Symbol Species Function Swiss-Prot ID Amino Acid Sequence 1367452_at NP_598278 7.9 small ubiquitin-related modifier 2 precursor Sumo2 Rattus norvegicus " Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. (nih.gov)
  • 601 1-acyl-sn-glycerol-3-phosphate acyltransferase plsC BBZA01000001 CDS ARMA_0002 604. (go.jp)
  • Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (By similarity). (nih.gov)
  • 41314) energy-coupling factor transport system permease protein ecfT BBZA01000003 CDS ARMA_0064 complement(41356. (go.jp)
  • protein_coding" "CRN68674","aroH_1","Pseudomonas aeruginosa","Phospho-2-dehydro-3-deoxyheptonate aldolase [Ensembl]. (ntu.edu.sg)
  • protein_coding" "CRO25849","No alias","Pseudomonas aeruginosa","cytochrome c oxidase accessory protein CcoG [Ensembl]. (ntu.edu.sg)
  • chlorate resistance protein [Ensembl]. (ntu.edu.sg)
  • Piecemeal evidence associates artemisinin resistance with increased unfolded protein response (UPR), dysregulation of the pre-replication phase and the PI3K/PI3P/AKT pathway. (biomedcentral.com)