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  • intermediates
  • Central to FA synthesis, the ACP (acyl carrier protein) represents the cofactor protein that covalently binds all fatty acyl intermediates via a phosphopantetheine linker during the synthesis process. (biochemj.org)
  • The reaction sequence is carried out by a series of individual soluble proteins that are each encoded by a discrete gene, and the pathway intermediates are shuttled between the enzymes. (wikipedia.org)
  • Chains
  • FA (fatty acid) synthesis represents a central, conserved process by which acyl chains are produced for utilization in a number of end-products such as biological membranes. (biochemj.org)
  • The fatty acid synthetic pathway is the principal route for the production of membrane phospholipid acyl chains in bacterial and plants. (wikipedia.org)
  • pathway
  • section describes the metabolic pathway(s) associated with a protein. (uniprot.org)
  • This protein is involved in the pathway fatty acid biosynthesis, which is part of Lipid metabolism. (uniprot.org)
  • View all proteins of this organism that are known to be involved in the pathway fatty acid biosynthesis and in Lipid metabolism . (uniprot.org)
  • This protein is involved in the pathway biotin biosynthesis, which is part of Cofactor biosynthesis. (uniprot.org)
  • Organism
  • p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence. (uniprot.org)
  • structural
  • Cleavage of structural proteins during assembly of the head of bacteriophage T4. (springer.com)
  • The PDBFlex database explores the intrinsic flexibility of protein structures by analyzing structural variations of the same protein across the archive. (rcsb.org)
  • This allows for the easy identification of regions and types of structural flexibility present in a protein of interest. (rcsb.org)
  • Lipid
  • This family of enzymes is found only in the plastids of higher plant cells, unlike other desaturases such as acyl-lipid desaturases and acyl-CoA desaturases. (wikipedia.org)
  • annotation
  • p>An evidence describes the source of an annotation, e.g. an experiment that has been published in the scientific literature, an orthologous protein, a record from another database, etc. (uniprot.org)
  • be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein. (uniprot.org)
  • sequences
  • The tool works with standard single letter nucleotide or protein codes including ambiguities and can match Prosite patterns in protein sequences. (nih.gov)
  • lipid
  • Radiolabeled lipid extraction was comparable for phospholipids containing saturated acyl chains between 12 and 18 carbons but diminished significantly for oleoyl-containing phospholipids. (deepdyve.com)
  • Lipid signaling, broadly defined, refers to any biological signaling event involving a lipid messenger that binds a protein target, such as a receptor, kinase or phosphatase, which in turn mediate the effects of these lipids on specific cellular responses. (wikipedia.org)
  • As such, many lipid signaling molecules cannot circulate freely in solution but, rather, exist bound to special carrier proteins in serum. (wikipedia.org)
  • By mimicking the natural substrate of the enoyl-acyl-carrier protein reductase (ENR) enzyme, triclosan acts as a site-directed inhibitor and disrupts lipid, phospholipid, lipopolysaccharide and lipoprotein synthesis. (wikipedia.org)
  • PA acts as a signaling lipid, recruiting cytosolic proteins to appropriate membranes (e.g., sphingosine kinase 1). (wikipedia.org)
  • LPAAT activity doubles the number of acyl chains, greatly increasing the cross-sectional area of the lipid that lies 'within' the membrane while the surface headgroup remains unchanged. (wikipedia.org)
  • synthases
  • Metabolomics studies of ΔfabH β-Ketoacyl-acyl carrier protein synthases (KAS) III (KASIII) assisted in the development of the hypothesis that fabF (KASII) is involved in the survival of ΔfabH E. coli cells. (iastate.edu)
  • Christensen QH, Grove TL, Booker SJ, Greenberg EP (2013) A high-throughput screen for quorum-sensing inhibitors that target acyl-homoserine lactone synthases. (springer.com)
  • enzymes
  • a) the ABC transporter that allows the fatty acid transport across the peroxisomal membrane, b) enzymes carrying out the beta-oxidation pathway ACOX1, D-PBE, ACAA1 and SCPX, c) CROT, which transfers the carnitine to an acyl not completely oxidized, d) the thioesterases PTE1, PTE2, PTE2a and PTE2b, that regulates the acyl-CoA esterification and control the fatty acid shorting during the beta-oxidation. (216.92.14)
  • Lipoate-protein ligase catalyses the formation of an amide linkage between lipoic acid and a specific lysine residue of the lipoyl domain of lipoate dependent enzymes. (wikipedia.org)
  • These include enzymes called ceramide-activated Ser-Thr phosphatases (CAPPs), such as protein phosphatase 1 and 2A (PP1 and PP2A), which were found to interact with ceramide in studies done in a controlled environment outside of a living organism (in vitro). (wikipedia.org)
  • On the other hand, studies in cells have shown that ceramide-inducing agents such as tumor necrosis factor-alpha α (TNFα) and palmitate induce the ceramide-dependent removal of a phosphate group (dephosphorylation) of the retinoblastoma gene product RB and the enzymes, protein kinases B (AKT protein family) and C α (PKB and PKCα). (wikipedia.org)
  • These include large membrane-associated proteins with N-terminal ACB domains, multifunctional enzymes with both ACB and peroxisomal enoyl-CoA Delta(3), Delta(2)-enoyl-CoA isomerase domains, and proteins with both an ACB domain and ankyrin repeats. (wikipedia.org)
  • residues
  • The ligand is bound through specific interactions with residues on the protein, most notably several conserved positive charges that interact with the phosphate group on the adenosine-3'phosphate moiety, and the acyl chain is sandwiched between the hydrophobic surfaces of CoA and the protein. (wikipedia.org)
  • membranes
  • The importance of metabolic flexibility is underscored by appreciation for the fact that various substrates are more than just a fuel for the heart, serving also as building blocks for numerous cellular components (e.g., membranes, proteins), cofactors, and signaling molecules. (onlinejacc.org)
  • Proteins are also important in cell signaling, immune responses, cell adhesion, active transport across membranes, and the cell cycle. (wikipedia.org)
  • regulate
  • This led to high levels of fatty acyl-CoA being present in the liver, which shows that a diseased liver cannot regulate the amount of fatty acyl-CoA that is present versus a normal, healthy liver. (wikipedia.org)
  • amino acids
  • ACBP is a highly conserved protein of about 90 amino acids that is found in all four eukaryotic kingdoms, Animalia, Plantae, Fungi and Protista, and in some eubacterial species. (wikipedia.org)
  • biotin
  • Additionally it was revealed that M. acetivorans does not require biotin or any detectable biotinylated protein to survive and maintain growth. (iastate.edu)
  • Biotin protein ligases have an additional C-terminal domain which participates in biotin adenylation and dimerization. (wikipedia.org)
  • Biotin protein ligases may also have an additional N-terminal domain required for DNA binding, although this domain is not always present. (wikipedia.org)
  • lipoyl
  • In Bacillus subtilis, the transfer is from the glycine cleavage system H protein, GcvH, to other lipoyl domains. (wikipedia.org)
  • yeast
  • The former yeast protein is present in the plasma membrane and pumps arsenite and antimonite, but not arsenate, tellurite, cadmium or phenylarsine oxide out of the cell in response to the proton motive force (pmf). (wikipedia.org)
  • family
  • This interest has been fueled in part by the recent discovery of a family of highly conserved pattern recognition receptor proteins known as Toll-like receptors (TLRs) believed to be involved in innate immunity as receptors for pathogen- associated molecular patterns (PAMPs). (allindianpatents.com)
  • Two proteins of the ACR3 family have been functionally characterized. (wikipedia.org)
  • While the nomenclature of the ARC3 ArsB protein overlaps with ArsB of E. coli (ArsB family), it is important to note they are not related. (wikipedia.org)
  • secondary
  • Based on operon analyses, ARC3 homologues may function either as secondary carriers or as primary active transporters, similarly to the ArsB and ArsAB families. (wikipedia.org)
  • type
  • These AT domains are the only domains present on MmpC, while the other three type I PKS proteins contain no AT domains. (wikipedia.org)
  • Elastases form a subfamily of serine proteases, characterized by a distinctive structure consisting of two beta barrel domains converging at the active site that hydrolyze amides and esters amongst many proteins in addition to elastin, a type of connective tissue that holds organs together. (wikipedia.org)
  • highly
  • The ACB domain consists of four alpha-helices arranged in a bowl shape with a highly exposed acyl-CoA-binding site. (wikipedia.org)
  • domains
  • The mupirocin cluster exhibits an atypical acyltransferase (AT) organization, in that there are only two AT domains, and both are found on the same protein, MmpC. (wikipedia.org)
  • Although ACBP occurs as a completely independent protein, intact ACB domains have been identified in a number of large, multifunctional proteins in a variety of eukaryotic species. (wikipedia.org)
  • function
  • DRS-1, a human protein of unknown function that contains a N-terminal ACB domain and a C-terminal enoyl-CoA isomerase/hydratase domain. (wikipedia.org)
  • shape
  • Other proteins have structural or mechanical functions, such as those that form the cytoskeleton, a system of scaffolding that maintains the cell shape. (wikipedia.org)