Acyl carrier proteins are critical components of fatty acid and polyketide biosynthesis. (rsc.org)
Here, transcriptome analysis and fatty acid profiling from developing V. galamensis seeds were integrated to uncover the critical metabolic pathways responsible for high EFA accumulation and identify the targets that could be used in assembly of EFA biosynthesis pathway in existing oilseed crops. (researchsquare.com)
However, like many bacteria and plants, its metabolism does depend upon the type II fatty-acid synthesis (FAS) pathway for lipogenesis, whereas the predominant form of fatty-acid biosynthesis in humans is via the type I pathway. (rcsb.org)
Transcriptome sequencing revealed that all homologs induced the same general patterns with a drastic shift in gene expression profiles of leaves from that of a typical source tissue to a source-limited sink-like tissue: Transcripts encoding enzymes for plastid uptake and metabolism of phosphoenolpyruvate, fatty acid and oil biosynthesis were up-regulated, as were also transcripts encoding starch degradation. (biomedcentral.com)
Carrier of the growing fatty acid chain in fatty acid biosynthesis. (cusabio.com)
Built YchM deletion exhibited artificial lethality with multiple fatty acidity biosynthesis genes, as well as the YchM polypeptide bodily interacted numerous proteins from the fatty acidity biosynthetic pathway. (exposed-skin-care.net)
Backbone chemical shift assignments of the acyl-acyl carrier protein intermediates of the fatty acid biosynthesis pathway of Plasmodium falciparum. (bmrb.io)
Synthesis8
β-Ketoacyl-(acyl carrier protein) reductase (FabG) catalyzes the key reductive reaction in the elongation cycle of fatty acid synthesis (FAS), which is a vital metabolic pathway in bacteria and a promising target for new antibiotic development. (rcsb.org)
Palmitic acid is the first fatty acid produced during fatty acid synthesis and is the precursor to longer fatty acids. (hmdb.ca)
Acyl carrier protein (ACP) is an essential cofactor in the synthesis of fatty acids by the fatty acid synthetases systems in bacteria and plants. (embl.de)
Moreover, transcripts representing fatty acid degradation were up-regulated indicating that fatty acids might be degraded to feed the increased need to channel carbons into fatty acid synthesis creating a futile cycle. (biomedcentral.com)
To be available for TAG synthesis, carbons from sucrose must first be converted to pyruvate through cytosolic or plastidic glycolytic pathways and at some point be imported into the plastid to yield acetyl-coenzyme A (CoA) which feeds fatty acid (FA) synthesis with carbon backbones. (biomedcentral.com)
This product represents a full-length Acyl carrier protein (ACP), a vital component involved in the initiation and elongation steps of fatty acid synthesis in Staphylococcus aureus, an organism known for its robust resistance mechanisms and implications in human health. (cusabio.com)
Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty a. (yeastrc.org)
2010). ACP and fatty acyl-coA transferases may also be needed at multiple levels of microbial polyketide synthesis. (exposed-skin-care.net)
Acids14
In catabolism, water is used to break bonds in order to generate smaller molecules (e.g. glucose, fatty acids and amino acids to be used for fuels for energy use or other purposes). (hmdb.ca)
Palmitic acid, or hexadecanoic acid, is one of the most common saturated fatty acids found in animals, plants, and microorganisms. (hmdb.ca)
When grown on 1% propionic acid, lipid A also contains the odd-chain fatty acids tridecanoic acid, pentadecanoic acid, hydroxytridecanoic acid, and hydroxypentadecanoic acid. (cathdb.info)
Through a series of minimally complex analogs, we determined non-proteinogenic amino acids and the N-acyl fatty acid moiety are essential for bioactivity. (duke.edu)
Proteins are composed of 20 canonical amino acids whose unique arrangements predefine a protein's structure and function. (uni-goettingen.de)
Originated from the Staphylococcus aureus strain Mu50 / ATCC 700699, this recombinant acpP protein is expressed in an E.coli system and includes the complete sequence of 1-77 amino acids. (cusabio.com)
Even if amino acids are biologically present in a place, no protein can form spontaneously. (questionsonislam.com)
Fatty acids are the simplest fats synthesized in cells and they participate in the structure of complex fats that are to perform specific tasks in cells. (questionsonislam.com)
The most important feature that distinguishes fish oil from the fats of other living things is the long-chain polyunsaturated fatty acids. (questionsonislam.com)
Fatty acids are synthesized by considering special factors such as the physiology of the fish and the state of its environment. (questionsonislam.com)
The number and amount of fatty acids in fish oil varies according to many factors such as species, season, habitat and nutritional status. (questionsonislam.com)
Bacterial decomposition of apocrine secretions yields ammonia and short-chain fatty acids, with their characteristic strong odors. (medscape.com)
The most abundant of these acids is (E)-3-methyl-2-hexanoic acid (E-3M2H), which is brought to the skin surface bound by 2 apocrine secretion odor-binding proteins, ASOB1 and ASOB2. (medscape.com)
Ligase2
Through a series of bioactivity assays, we found the transfer to the acyl carrier protein (ACP) in a fatty acyl-AMP ligase (FAAL)-dependent manner determined the specificity of lipids selected in the biosynthetic process. (duke.edu)
Here, the structure of the third enzyme in the FAS pathway, 3-ketoacyl-(acyl-carrier-protein) reductase, is reported at a resolution of 2.25 Å. (rcsb.org)
Polyketide1
These enzymes are found in a variety of biosynthetic contexts, which include fatty-acid activating enzymes, type I or type III polyketide synthases, dialkylresorcinol-generating enzymes, monooxygenases or Rieske proteins. (biomedcentral.com)
Predicted malonyl-CoA1
Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synt. (yeastrc.org)
Holo2
Selectivity for the holo over apo -form of acyl carrier proteins is demonstrated indicating that only the phosphopantetheine - thiol is modified. (rsc.org)
Phosphopantetheine is attached to a serine residue in these proteins. (embl.de)
Enzyme5
Some enzymes are made of just one component protein that works on its own, but others are made of multiple proteins that are all required for the enzyme to work properly. (elifesciences.org)
However, many enzymes can bind to different combinations of proteins to form groups (or 'complexes') with a variety of three-dimensional shapes, so there may be a variety of enzyme complexes in the solution. (elifesciences.org)
Further experiments used a mutant form of the TERT protein that cannot interact with other TERT molecules and found that complexes that contain this mutant protein still have normal enzyme activity. (elifesciences.org)
GapMind searches the predicted proteins for candidates by using ublast (a fast alternative to protein BLAST) to find similarities to characterized proteins or by using HMMer to find similarities to enzyme models (usually from TIGRFams ). (lbl.gov)
Candidates for each step are identified by using ublast (a fast alternative to protein BLAST) against a database of manually-curated proteins (most of which are experimentally characterized) or by using HMMer with enzyme models (usually from TIGRFam ). (lbl.gov)
Pathway1
This Review summarizes the more recent biochemical, cellular and mouse model studies that underscore the importance of the ER acetylation process in maintaining protein homeostasis and autophagy within the secretory pathway, and its impact on developmental and age-associated diseases. (biologists.com)
Genes5
Functional annotation resulted in the identification of almost all genes involved in diverse lipid-metabolic pathways, including the novel fatty acid desaturase/epoxygenase, diacylglycerol acyltransferase 1 and 2, and phospholipid:diacylglycerol acyltransferases. (researchsquare.com)
By comparison, we found that various genes associated with acyl editing, fatty acid β-oxidation, triacylglycerol assembly and oil-body formation had greater expression levels at middle developmental stage (38 DAP), which are consistent with the fast accumulation of EFA in V. galamensis developing seed, implying their fundamental roles in EFA production. (researchsquare.com)
Owing to its small genome (about 800 protein-coding genes), it relies on the host for many basic biosynthetic processes, hindering the identification of potential antipathogenic drug targets. (rcsb.org)
The obvious next step is to integrate this information and learn how genes, proteins, and/or epigenetic factors influence the phenotype of a disease in context of the system. (rsc.org)
In addition to the host regulatory mechanisms response to disease, the microbiome can make changes to the expression of the host features such as their genes, proteins, and/or PTMs. (rsc.org)
Sequences1
Open up in another window Physique 1 Phylogenetic romantic relationship of BIIE 0246 supplier human being SLC26 polypeptides generated with Jalview (http://www.jalview.org) using NCBI proteins sequences listed in Desk 1. (exposed-skin-care.net)
Molecules2
Small molecules capable of acylating this prosthetic group will provide a simple and reversible means of introducing novel functionality onto carrier protein domains. (rsc.org)
In anabolism, water is removed from molecules (through energy requiring enzymatic chemical reactions) in order to grow larger molecules (e.g. starches, triglycerides and proteins for storage of fuels and information). (hmdb.ca)
Gene4
In this review, we discuss considerations of the study design for each data feature, the limitations in gene and protein abundance and their rate of expression, the current data integration methods, and microbiome influences on gene and protein expression. (rsc.org)
The corresponding gene, AtWRINKLED1 ( AtWRI1, At3g54320), encodes a protein with two APETALA2-ethylene responsive element-binding protein (AP2/EREBP) motifs that is a signature for plant-specific transcription factors involved in a wide range of developmental processes [ 5 , 6 ]. (biomedcentral.com)
Beyond the P protein, the Henipavirus P gene also encodes the V and W proteins which share with P their N-terminal, intrinsically disordered domain (NTD) and possess a unique C-terminal domain. (sciencegate.app)
[2] For,proteins cannot come into being without software (DNA or gene). (questionsonislam.com)
Macromolecules1
In our present view, these areas are found for systems where several types of macromolecules (proteins, polysaccharides or polyelectrolytes) and/or amphiphiles interact to form a functional or destructive unit. (lu.se)
Escherichia1
LpxD from Escherichia coli prefers (R,S)-3-hydroxymyristoyl-[acyl- carrier protein] over (R,S)-3-hydroxypalmitoyl-[acyl-carrier protein]. (cathdb.info)
Precursor1
AF237571_1 malonyl CoA-acyl carrier protein transacylase precursor [Plasmo. (yeastrc.org)
Biosynthetic1
to a membrane-scaffolded organic of fatty acidity biosynthetic enzymes (Babu et al. (exposed-skin-care.net)
Transcriptome1
Recent multi-omics studies have revealed the heterogeneity and complexity of tumor features such as their genetic mutations, transcriptome, proteins, and signaling pathways. (rsc.org)
PTMs2
Protein post-translational modifications (PTMs) take many shapes, have many effects and are necessary for cellular homeostasis. (biologists.com)
The biological system is complex with many regulatory features such as DNA, mRNA, proteins, metabolites, and epigenetic features such as DNA methylation and histone post-translational modifications (PTMs). (rsc.org)
Genome1
GapMind relies on the predicted proteins in the genome and does not search the six-frame translation. (lbl.gov)
Bound1
The problem of separating thousands of proteins can be reduced by analyzing for a 'sub-proteome', such as the 'metalloproteome', defined as all proteins that contain bound metals. (sciencegate.app)
Assays1
In addition, using Congo red and Thioflavin T binding assays and negative-staining transmission electron microscopy, we show that the W proteins phase separate to form amyloid-like fibrils. (sciencegate.app)
Complexes2
The center of telomerase has a protein called TERT that forms complexes with other proteins. (elifesciences.org)
The experiments show that these complexes can contain either one or two TERT proteins. (elifesciences.org)
Structural2
Here we report the findings of structural, enzymatic, and binding studies of the FabG protein found in the causative agent of cholera, Vibrio cholerae (vcFabG). (rcsb.org)
Structural and molecular information on Henipavirus W proteins is lacking. (sciencegate.app)
Species1
The most common of these are E-3M2H and (RS)-3-hydroxy-3-methlyhexanoic acid (HMHA), which are released through the action of a specific zinc-dependent N -alpha-acyl-glutamine aminoacylase (N-AGA) from Corynebacterium species. (medscape.com)
Family1
ASOB2 has been identified as apolipoprotein D (apoD), a known member of the lipocalin family of carrier proteins. (medscape.com)
Critical1
In light of the critical role of the Henipavirus W proteins in evading the host innate immune response and of the functional role of phase separation in biology, these studies provide a conceptual asset to further investigate the functional impact of the phase separation abilities of the W proteins. (sciencegate.app)
Function1
Hits to curated proteins without experimental data as to their function are never considered high confidence. (lbl.gov)
Multiple1
70%) of vernolic acid ( cis -12-epoxyoctadeca- cis -9-enoic acid), an unusual epoxy fatty acid (EFA) with multiple industrial applications. (researchsquare.com)
Similar1
PREDICTED: similar to Malonyl CoA-acyl carrier protein transacylase, mi. (yeastrc.org)
Structure1
CATH: Protein Structure Classification Database by I. Sillitoe, N. Dawson, T. Lewis, D. Lee, J. Lees, C. Orengo is licensed under a Creative Commons Attribution 4.0 International License . (cathdb.info)
Study1
Large quantities of purified proteins were used in this study. (elifesciences.org)