Acute renal allograft rejection. Medical search. Frequent questions

We found marked induction of HO mRNA and protein in renal allografts at day 5 after transplantation. (elsevierpure.com)
She has made significant contributions to the field of organ transplantation, including conducting the first successful complete steroid avoidance trial in the US and the first dosing safety trial for Rituximab in pediatric renal transplantation. (wikipedia.org)
In January 2016, Sarwal delivered a Personalized Medicine World Conference talk describing her lab's development of molecular diagnostics techniques in organ transplantation to better detect rejection, improve the management of transplant patients, and proactively preserve organ function. (wikipedia.org)
Two cohorts of mice underwent renal transplantation with either a syngeneic isograft or allograft kidney. (hindawi.com)
The notion of allografts is explored in specialty areas ranging from orthopedics and thoracic surgery to kidney and liver transplantation, in an effort to identify certain common themes having to do with the immunological response to the allograft and the various methods to avoid rejection. (novapublishers.com)
Chapters in this book present current challenges in the use of bone allografts in complex orthopedic procedures, in addition to dealing in depth with the use of hepatic and renal allografts in liver and kidney transplantation. (novapublishers.com)
Greer M, Werlein C, Jonigk D. Surveillance for acute cellular rejection after lung transplantation. (smw.ch)
This study aimed to compare the efficacy of valganciclovir and valacyclovir prophylaxis for CMV after renal transplantation with the focus on chronic histologic damage within the graft. (biomedcentral.com)
Valganciclovir prophylaxis, as compared with valacyclovir, was associated with a reduced risk of moderate-to-severe interstitial fibrosis and tubular atrophy in patients after renal transplantation. (biomedcentral.com)
Strategies to improve long-term outcomes after renal transplantation. (medigraphic.com)
Johnson RW, Kreis H, Oberbauer R, Brattstr m C, Claesson K, Eris J. Sirolimus allows early cyclosporine withdrawal in renal transplantation resulting in improved renal function and lower blood pressure. (medigraphic.com)
Renal transplantation is the most effective treatment for end-stage renal disease, with advanced immunosuppressive therapy and better surgical techniques resulting in better survival of the graft. (thieme-connect.de)
This pictorial essay aims to classify the complications of renal transplantation, describe the various imaging modalities used to detect complications, and provide a brief overview of the role of interventional radiology in their management. (thieme-connect.de)
Radiological imaging in renal transplantation. (thieme-connect.de)
Scholars@Duke publication: Early and limited use of tacrolimus to avoid rejection in an alemtuzumab and sirolimus regimen for kidney transplantation: clinical results and immune monitoring. (duke.edu)
CT10 Chapter 1: Evolution of Graft Survival in Kidney Transplantation: An Analysis of the OPTN/UNOS Renal Transplant Registry. (terasaki.org)
Evolution of Graft Survival in Kidney Transplantation: An Analysis of the OPTN/UNOS Renal Transplant Registry. (terasaki.org)
The marked decline in acute rejection episodes in the early transplantation period mainly contributed to the improvement of shortterm graft survival. (terasaki.org)
Global cardiovascular risk under early corticosteroid cessation decreases progressively in the first year following renal transplantation. (shengsci.com)
Transplantation is a widely recognized method of treatment at the terminal stages of many renal, cardiac, hepatic and pulmonary diseases. (annalsoftransplantation.com)
Di Cocco P, Fratti A, Kaylan KB, Tzvetanov IG, Benedetti E. Treatment Strategies for Antibody-mediated Rejection in Kidney Transplantation and Its Prevention. (lidsen.com)
This article reviews the current treatment strategies of antibody-mediated rejection in kidney transplantation, which is increasingly recognized as the leading immunological cause of graft failure. (lidsen.com)
Nevertheless, in most countries, priority is given to transplantation over other types of renal replacement therapies, since patients with a functioning transplant leave longer, with a better quality of life and less comorbidities. (mdmsignaling.com)
Sgambat K, Moudgil A. Optimization of Bone Health in Children before and after Renal Transplantation: Current Perspectives and Future Directions. (ctsicn.org)
Although kidney transplantation has been an important means for the treatment of patients with end stage of renal disease, the long-term survival rate of the renal allograft remains a challenge. (biomedcentral.com)
Due to ageing of the society, including patients with end-stage renal disease, kidney transplantation in individuals over 65 years of age becomes more and more common. (czytelniamedyczna.pl)
Kidney transplantation is a recognised and efficacious method of renal replacement therapy in patients with end-stage renal disease (ESRD), cheaper than dialysis therapy and allowing for longer survival. (czytelniamedyczna.pl)
Post-transplantation anemia is common among renal transplant recipients (RTR). (medpharmres.com)
This case report describes two male renal transplant recipients who infected HPV B19 after kidney transplantation with severe anemia. (medpharmres.com)
Consequently, dermatologic manifestations of renal disease may be divided into 3 general categories including: (1) dermatologic manifestations of diseases associated with the development of ESRD, (2) dermatologic manifestations of uremia, and (3) dermatologic disorders associated with renal transplantation. (medscape.com)

She has successfully commercialized blood testing for early diagnosis of both acute rejection and operational tolerance in kidney transplant patients, providing tools for proactive and predictive immunosuppression monitoring for transplant recipients. (wikipedia.org)
When analyzed in 45 kidney transplant recipients at the time of late for-cause biopsy, the T1/T2 ratio was independently associated with allograft dysfunction over the next 5 years. (whiterose.ac.uk)
The authors report two cases of isolated gastro-intestinal tuberculosis in renal transplant recipients that illustrates the difficulty of making this diagnosis and a brief review of the literature on its clinical presentation, diagnosis, and therapeutic approach. (hindawi.com)
In transplant recipients, MT infection can be due to primary infection, reactivation of latent TB foci favored by immunosuppression (IS), or, in a lesser extent (4%), it can be transmitted by the allograft [ 3 , 5 , 6 ]. (hindawi.com)
Cytomegalovirus (CMV) prophylaxis may prevent CMV indirect effects in renal transplant recipients. (biomedcentral.com)
From November 2007 through April 2012, adult renal transplant recipients were randomized, in an open-label, single-center study, at a 1:1 ratio to 3-month prophylaxis with valganciclovir ( n = 60) or valacyclovir ( n = 59). (biomedcentral.com)
A worldwide, phase III, randomized, controlled, safety and efficacy study of a sirolimus/cyclosporine regimen for prevention of acute rejection in recipients of primary mismatched renal allografts. (medigraphic.com)
Sirolimus in de novo heart transplant recipients reduces acute rejection and prevents coronary artery disease at 2 years: a randomized clinical trial. (medigraphic.com)
Current safety of renal allograft biopsy with indication in adult recipients: an observational study. (thieme-connect.de)
Alemtuzumab induction with 60 days of tacrolimus treatment and continuous sirolimus treatment prevented acute rejection in nine of 10 consecutive renal allograft recipients. (duke.edu)
In contrast, DSBT given to backcrossed recipients expressing the RT1c/c (c/c) phenotype elicited a transient IgM response that switched to a very low IgG response and was associated with renal allograft acceptance. (duke.edu)
Analysis of IgG isotypes demonstrated that DSBT prevented production of IgG1 and IgG2a, and to a lesser extent IgG2b and IgG2c alloantibodies in c/c but not u/c renal allograft recipients. (duke.edu)
Indeed, chronic allograft dysfunction is a growing problem among renal transplant recipients and together with death from cardiovascular disease, infection and malignancy is the leading cause of graft failure. (benthamscience.com)
Calcitriol started in the donor, expands the population of CD4+CD25+ T cells in renal transplant recipients. (shengsci.com)
In conclusion, when anemia develops rapidly and severely in renal transplant recipients in the absence of rejection and hemolysis, parvovirus B19 infection should be considered. (medpharmres.com)
Solid organ transplant recipients, who are medically immunosuppressed to prevent graft rejection, have increased melanoma risk, but risk factors and outcomes are incompletely documented. (cdc.gov)

Renal biopsy remains the gold-standard for detecting allograft rejection but is associated with significant morbidity and mortality. (hindawi.com)
There is no imaging modality available to measure the development of graft fibrosis and current practice involves a biopsy when renal function deteriorates [ 8 ]. (hindawi.com)
The recipient had a fever 8 days after receiving the renal allograft, and a biopsy of it showed acute rejection. (cdc.gov)
In kidney transplant patients without increased risk of acute rejection and baseline renal function, renal allograft biopsy is not required prior to reducing immunosuppression. (guidelinecentral.com)
In kidney transplant patients with sustained BKPyV‐DNAemia and biopsy‐proven acute rejection as evidenced by intimal arteritis or positive C4d stain (with or without proven PyVAN), antirejection therapy should be given first followed by reducing immunosuppression in a second step. (guidelinecentral.com)
Clinical data extracted from the charts were CsA dosage, CsA trough levels (whole blood, HPLC method), biopsy findings to confirm acute rejections, and serum creatine to determine clearance by the Jelliffe method. (tmu.edu.tw)
The cause of late renal allograft loss, once known as chronic allograft nephropathy, has been renamed "interstitial fibrosis and tubular atrophy" (IF/TA) to reflect the histologic pattern seen on biopsy. (biomedcentral.com)

Early identification of chronic allograft damage remains challenging but is crucial to allow intervention with immunosuppressive therapy. (hindawi.com)
Only physicians experienced in immunosuppressive therapy and management of renal, cardiac or hepatic transplant patients should prescribe mycophenolate mofetil. (nih.gov)
The goal of immunosuppressive therapy is to balance the beneficial effects of reducing acute rejection while minimizing adverse effects from over-immunosuppression such as infections, malignancy, and cardiovascular disease. (benthamscience.com)
It has a primary role in immunosuppressive regimens and is associated with improved outcomes owing to its efficacy and beneficial effect on renal allograft function ( 2 ). (frontierspartnerships.org)
The exact mechanism of immunosuppressive drug-mediated renal toxicity is not fully understood. (biomedcentral.com)
The most frequent causes are erythropoietin deficiency, acute allograft rejection, iron deficiency, hemolytic anemia, adverse effects of immunosuppressive therapy, and virus infection. (medpharmres.com)

The kidneys and the heart are the organs whose acute humoral rejection has been thoroughly investigated and defined, and the role of C4d and C3d fragments of the complement system has been confirmed by numerous studies. (annalsoftransplantation.com)

Donor-specific blood transfusion (DSBT) in animals and humans can either promote subsequent renal graft survival or lead to sensitization and graft rejection. (duke.edu)
One-year graft survival of renal grafts increased progressively in the last two decades and can be now considered excellent, but long-term outcomes has not improved proportionally in the last years. (benthamscience.com)
Eid L, Tuchman S, Moudgil A. Late acute rejection: incidence, risk factors, and effect on graft survival and function. (ctsicn.org)
IF/TA is associated with decreased graft survival, especially when it is accompanied by transplant vasculopathy, subclinical rejection, or transplant glomerulopathy. (biomedcentral.com)
It has been shown to be a significant predictor of transplantkidney graft survival and is an aid in treating acute rejection. (samatashkhis.com)

The Acute Kidney Injury Network (AKIN) has developed specific criteria for the diagnosis of AKI. (medscape.com)
For the diagnosis of acute rejection and concurrent PyVAN, the presence of endarteritis, fibrinoid vascular necrosis, glomerulitis, or C4d deposits along peritubular capillaries should be documented. (guidelinecentral.com)
Diagnosis of renal allograft rejection and acute tubular necrosis by 99mTc-mononuclear leukocyte imaging. (shengsci.com)
This review will provide insights into the roles of exRNA in pathogenesis, diagnosis and therapy of renal diseases. (biomedcentral.com)
However, there are currently no reliable biomarkers for renal impairment diagnosis, prognosis, or staging in DKD patients. (bvsalud.org)
Identifying the mediators and factors that trigger IF/TA may be useful in early diagnosis and development of novel therapeutic strategies for improving long-term renal allograft survival and patient outcomes. (biomedcentral.com)

in critically ill patients, renal dysfunction severity can also be evaluated by combining renal function with functional parameters of other organs (eg, the Sequential Organ Failure Assessment [SOFA] score). (medscape.com)
In a study to assess the definition of renal dysfunction in multicenter, randomized, controlled trials involving critically ill patients, the renal SOFA score is the most commonly used system to quantify renal function at baseline or as a secondary outcome. (medscape.com)
In patients with kidney injury, measuring changes in the SOFA score in the first 24 hours of renal replacement therapy (RRT) can identify patients at high risk for mortality. (medscape.com)
In these clinically quiescent patients, a low T1/T2 ratio identified a 41-patient subgroup in which 35% developed allograft dysfunction, with 25% losing their allografts. (whiterose.ac.uk)
RESULTS: 37 patients did not develop chronic lung allograft dysfunction (age 41.3 ± 15.6 years, baseline FEV1 95.5 ± 19.1% predicted) and 34 patients developed chronic lung allograft dysfunction (age 50.9 ± 13.3 years, baseline FEV1 102.2 ± 25.4% predicted). (smw.ch)
Tuberculosis is a disease relatively frequent in renal transplant patients, presenting a wide variety of clinical manifestations, often involving various organs and potentially fatal. (hindawi.com)
Gastrointestinal tuberculosis, although rare in the general population, is about 50 times more frequent in renal transplant patients. (hindawi.com)
However, unlike general population, in renal transplant (RT) patients, extrapulmonar (occurring in 15%) and disseminated diseases (33-49%) are very frequent [ 1 - 3 , 7 ]. (hindawi.com)
Researchers assessed changes in the estimated glomerular filtration rate among patients with gout with moderate renal impairment, using a treat-to-target approach for gout. (renalandurologynews.com)
Sirolimus-based therapy with or without cyclosporine: long-term follow-up in renal transplant patients. (medigraphic.com)
Quantitative scintigraphic parameters for the assessment of renal transplant patients. (thieme-connect.de)
In kidney transplant patients with proven PyVAN and the absence of BKPyV-DNAemia in blood, urine, and graft tissue, JCPyV-associated nephropathy should be considered and specific QNAT be sought on urine, blood, and allograft tissue. (guidelinecentral.com)
The primary treatment of sustained BKPyV-DNAemia/probable PyVAN, presumptive PyVAN, or proven PyVAN in kidney trans plant patients without concurrent acute rejection is reducing maintenance immunosuppression. (guidelinecentral.com)
Human CMV infection is controlled by T cell-mediated immunity and in immunosuppressed transplant patients it is associated with acute allograft rejection as well as chronic allograft vasculopathy. (aai.org)
The FcgammaRIIa polymorphism in patients with chronic kidney graft rejection. (shengsci.com)
The study and the control groups consisted of end-stage renal disease patients who underwent haemodialysis as a renal replacement treatment. (bvsalud.org)
The study group comprised patients subject to haemodialysis as a renal replacement therapy who were to work out with the use of a prototype of the NefroVR system for 20 min when undergoing haemodialysis (HD). (bvsalud.org)
It is key to encourage patients with end-stage renal disease treated with haemodialysis to exercise regularly because of the possibility of their proinflammatory parameters becoming reduced. (bvsalud.org)
A relationship was observed between the activity of all oxidoreductase isoforms in PPP and PRP, and the type of renal replacement therapy and the duration of dialysis and the age of patients. (bvsalud.org)
CONCLUSIONS: The type of renal replacement therapy used in CKD patients, age of patients, duration of dialysis, CKD causes, and stage of progression significantly affect the activity of XOR and its isoforms. (bvsalud.org)
However, most current studies on exRNA in renal diseases were derived from limited numbers of patients or in vitro data. (biomedcentral.com)
Tacrolimus is the calcineurin inhibitor of choice for preventing acute rejection episodes in kidney transplant patients. (frontierspartnerships.org)
Standard immunological risk patients with end-stage renal disease who had received a de novo kidney transplant were randomized (1:1) to LCPT (N = 200) or IR-Tac/PR-Tac (N = 201). (frontierspartnerships.org)
Exposure below the minimum therapeutic level puts patients at risk of graft rejection and graft failure (and indeed, recent trends for tacrolimus minimization are still producing unsatisfying results) ( 7 ), whilst overexposure is associated with increased toxicity, including development of delayed graft function and post-transplant diabetes mellitus ( 8 ). (frontierspartnerships.org)
The studies concerning C4d and C3d expression in patients with acute humoral lung and liver rejection conducted to date have given contradictory results. (annalsoftransplantation.com)
In this period, 114 patients reached the renal outcome. (mdmsignaling.com)
the number of elderly patients with chronic renal disease is also increasing, due to longer life as well as concomitant diseases such as diabetes mellitus and arterial hypertension which, if poorly controlled, affect kidney function. (czytelniamedyczna.pl)
Dermatologic manifestations of renal disease are not uncommon findings in patients with end-stage renal disease (ESRD). (medscape.com)
Many cutaneous disorders experienced by patients undergoing dialysis have little to do with the uremic syndrome and are related to the same underlying pathologic process that caused the renal disease. (medscape.com)
Review of the 2019 report reveals that diabetes mellitus remains the most common cause of ESRD, responsible for approximately 42% of all patients on renal replacement therapy. (medscape.com)

Herein, we aim to further define B regulatory phenotype and determine whether B regulatory activity can serve as a prognostic marker for renal allograft dysfunction (graft loss or 2-fold fall in estimated glomerular filtration rate). (whiterose.ac.uk)
Again, the T1/T2 ratio was strongly and independently associated with allograft dysfunction over the ensuing 5 years. (whiterose.ac.uk)
INTRODUCTION: Development of chronic lung allograft dysfunction is a limiting factor for post-lung transplant survival. (smw.ch)
We evaluated whether the dose of the immunosuppressant mycophenolate mofetil or plasma concentrations of the active metabolite mycophenolic acid affect the development of chronic lung allograft dysfunction. (smw.ch)
An event-time-analytical Cox proportional-hazards regression model with time-varying-covariates (18,431 measurements for MPA, mycophenolate mofetil dosage, lymphocytes) was used to predict chronic lung allograft dysfunction, with adjustment for sociodemographic factors and lung function at baseline. (smw.ch)
0.001), but only the traditional risk factor age predicted chronic lung allograft dysfunction. (smw.ch)
Continuously measured mycophenolic acid did not predict chronic lung allograft dysfunction (hazard ratio 0.98, 95% confidence interval 0.90-1.06, p = 0.64 over a period of 382.97 patient-years). (smw.ch)
CONCLUSION: Mycophenolate mofetil dosage and mycophenolic acid were not associated with chronic lung allograft dysfunction development. (smw.ch)
Thus, the mycophenolate mofetil dose or mycophenolic acid plasma concentration are not a primary factor related to organ rejection, but chronic lung allograft dysfunction may be influenced by other components of immunosuppression or other factors. (smw.ch)
Chronic lung allograft dysfunction: Definition, diagnostic criteria, and approaches to treatment-A consensus report from the Pulmonary Council of the ISHLT. (smw.ch)
Analytical study revealed an elevated C-reactive protein (CRP = 70 mg/L), no anemia or leukocytosis, acute graft dysfunction, or other abnormalities. (hindawi.com)
Chronic nephrotoxic effects of calcineurin inhibitors may be associated with late allograft dysfunction and reduced allograft half-life. (biomedcentral.com)

This interim analysis seems to indicate the superiority of tonsillectomy with pulse methylprednisolone in terms of improving renal prognosis for the treatment of IgA nephropathy as a whole. (mdmsignaling.com)
For many years, chronic allograft nephropathy (CAN) was used to describe the progressive loss of renal function in transplanted kidneys over time not related to acute rejection. (biomedcentral.com)

Plasma cell densities and glomerular filtration rates predict renal allograft outcomes following acute rejection. (uchicago.edu)

Renal cell carcinoma (RCC), the most common kidney neoplasm, originates in renal tubular epithelial cells and accounts for 85-90% of adult renal malignancies [ 1 ]. (biomedcentral.com)

Since baseline serum creatinine level and GFRs may not be readily available, the consensus committee recommended the use of the Modification of Diet in Renal Disease (MDRD) equation to estimate the patient's GFR/1.73 mm based on serum creatinine level, age, gender, and race. (medscape.com)
Chronic kidney disease (CKD) is a commonly diagnosed condition, affecting approximately 30 million adults in the United States.1 CKD refers to a diverse group of pathologies that result in kidney function decline for at least 3 months.2,3 Kidney disease etiologies are generally classified into 3 categories: prerenal, intrinsic renal, and postrenal. (renalandurologynews.com)
A man with end-stage renal disease received the donated kidney that was transplanted. (cdc.gov)
INTRODUCTION: Chronic kidney disease and renal replacement therapy are associated with reduced motor activity, which may result in the presence of mineral bone disorders and an increase in inflammation markers. (bvsalud.org)
The purpose of this article is to integrate renal and cutaneous aspects of disease as well as highlight some important, although frequently underappreciated, clinical or laboratory findings that ally renal and skin diseases. (medscape.com)
See also Chronic Kidney Disease and Chronic Renal Failure . (medscape.com)
Because dialysis and transplant centers are required to report specific information regarding each patient diagnosed with end-stage renal disease (ESRD) to the United States Renal Data System (USRDS), data regarding the causes of ESRD are readily available in the Annual Data Report published by the USRDS. (medscape.com)

Scholars@Duke publication: The association of enhancement of renal allograft survival by donor-specific blood transfusion with host MHC-linked inhibition of IgG anti-donor class I alloantibody responses. (duke.edu)
Using a rat renal allograft model, we have examined whether the effects of DSBT on renal allograft outcome and IgG alloantibody responses are linked to the host MHC. (duke.edu)
In F1 rats produced by mating PVG (RT1c), a low IgG alloantibody responder to transfused ACI (RT1a) blood, with 3 different high-IgG responders [W/F (RT1u), LOU (RT1u), and LEW (RT1l)], high IgG alloantibody production was found to be inherited as a dominant trait and associated with acute rejection of ACI renal allografts. (duke.edu)
DSBT given to offspring of (PVG x W/F)F1 rats backcrossed to W/F with either RT1u/c (u/c) or RT1u/u) (u/u) phenotype induced high-IgG-alloantibody responses that were associated with acute renal allograft rejection. (duke.edu)
The differences in the level and isotype of IgG alloantibody responses found in sera of DSBT-pretreated backcross rats of u/c and c/c phenotypes were also present in allograft eluates and splenocyte cultures. (duke.edu)
These findings demonstrate that the variable ability of DSBT to enhance renal allograft survival correlates with the inhibition of antidonor class I alloantibody responses of all IgG subclasses by a mechanism that is linked to host MHC. (duke.edu)

Endothelial changes associated with hyperacute, acute, and chronic renal allograft rejection in man. (johnshopkins.edu)
Due to its proclivity for endothelium, this component can be detected in peritubular capillaries in both chronic renal allograft rejection as well as hyperacute rejection, acute vascular rejection, acute cellular rejection, and borderline rejection. (samatashkhis.com)

Thrombotic microangiopathy and peritubular capillary C4d expression in renal allograft biopsies. (uchicago.edu)

Chronic allograft damage (CAD), characterised by interstitial fibrosis and tubular atrophy (IFTA), is the commonest cause of transplant failure following surgery [ 1 ]. (hindawi.com)
Interstitial fibrosis and tubular atrophy (IF/TA) describes the histologic characteristics of allograft destruction over time. (biomedcentral.com)

MPA prevents the glycosylation of lymphocyte and monocyte glycoproteins that are involved in intercellular adhesion to endothelial cells and may inhibit recruitment of leukocytes into sites of inflammation and graft rejection. (nih.gov)
The mechanisms leading to IF/TA in the transplanted kidney include inflammation, activation of renal fibroblasts, and deposition of extracellular matrix proteins. (biomedcentral.com)

To establish potential differences between valganciclovir and valacyclovir prophylaxis, we performed a randomized trial (2VAL Study) showing a decrease in the rates of acute rejection with valganciclovir [ 26 ]. (biomedcentral.com)

In summary, the addition of tacrolimus therapy for 2 months to a steroid-free, alemtuzumab induction and sirolimus maintenance protocol limited the previously shown acute rejection development. (duke.edu)
It is evident that both cyclosporine and tacrolimus can cause renal and systemic vasoconstriction through increased release of endothelin-1, activation of the renin-angiotensin system, increased production of thromboxane A 2 , and decreased production of vasodilators such as nitric oxide and prostacyclin [ 7 ]. (biomedcentral.com)

Monocytes and macrophages are known to play a role in chronic renal allograft damage [ 10 ] and are key promoters of fibrosis in other organs, such as the liver [ 11 , 12 ]. (hindawi.com)
9 Chhajer G, Arunachalam VK, Ramasamy R, Mehta P, Cherian M. Elastography: a surrogate marker of renal allograft fibrosis-quantification by shear-wave technique. (thieme-connect.de)

Mycophenolate mofetil has also been shown to reverse ongoing acute rejection in the canine renal and rat cardiac allograft models. (nih.gov)
Mycophenolate mofetil also inhibited proliferative arteriopathy in experimental models of aortic and cardiac allografts in rats, as well as in primate cardiac xenografts. (nih.gov)

Renal cell carcinoma (RCC) is the most common malignant kidney tumor and has a high incidence rate. (biomedcentral.com)

Overcoming Chronic Rejection-Can it B? (lww.com)
However, the precise mechanisms by which CMV exacerbates acute and chronic rejection are unknown. (aai.org)

A 53-year-old man with end-stage renal failure (ESRD) of unknown etiology was on hemodialysis (HD) since 1999. (hindawi.com)

She also spearheaded genomic and proteomics investigations into mechanisms of organ transplant injury and was the first to determine that there was substantive molecular heterogeneity in acute kidney transplant rejection. (wikipedia.org)
She has also founded biotechnology companies, inclusive of Organ-i in 2009, which was acquired by Immucor in 2014 and which successfully commercialized the kSORT blood multigene assay for predicting kidney transplant rejection. (wikipedia.org)
An uncommon but potential y lized to act as an alkylating agent, Infection with HIV-1 is the cause of dangerous side effect of immuno- causes acute myeloid leukaemia and the acquired immune deficiency syn- suppression to support organ trans- carcinoma of the urinary bladder in drome (AIDS). (who.int)

Kaplan-Meier survival curves showed tonsillectomy with pulse methylprednisolone were associated with lower incidence of renal outcome compared with conservative therapy and steroids therapy (log-rank test, P (mdmsignaling.com)

Current imaging techniques for monitoring allograft function involve the use of ultrasound to exclude ureteric obstruction or vascular compromise in the failing kidney. (hindawi.com)

In addition to assessing patient status, renal criteria can be used for prognosis. (medscape.com)

CMV infection also promotes the development of chronic allograft vasculopathy (characterized by graft vessel arteriosclerosis) that underlies late graft failure ( 6 , 11 ). (aai.org)

Sirolimus-based therapy following early cyclosporine withdrawal provides significantly improved renal histology and function at 3 years. (medigraphic.com)
To evaluate the utility of cyclosporine (CsA) trough concentrations as a monitoring tool for acute graft rejections and CsA nephrotoxicity. (tmu.edu.tw)

Native kidneys and skeletal muscle were imaged as reference tissues and renal explants analysed by histology and electron microscopy. (hindawi.com)

CMV infects endothelial cells (EC) and it is thought that CMV-specific host immune responses to infected allograft EC contribute to rejection. (aai.org)

Efficacy of sirolimus compared with azathioprine for reduction of acute renal allograft rejection: a randomised multicentre study. (medigraphic.com)

Acute kidney injury (AKI), formerly called acute renal failure (ARF), is commonly defined as an abrupt decline in renal function, clinically manifesting as a reversible acute increase in nitrogen waste products (measured by blood urea nitrogen [BUN] and serum creatinine levels) over the course of hours to weeks. (medscape.com)

In the immediate posttransplant period, there were no surgical or infectious complications, delayed graft function, or acute rejection episodes. (hindawi.com)

Renal graft was lost after 3 days, due to renal artery thrombosis. (hindawi.com)

Precision medicine and novel molecular target therapies in acute myeloid leukemia: the background of hematologic malignancies (HM)-SCREEN-Japan 01. (cdc.gov)

Meier-Kriesche HU, Schold JD, Srinivas TR, Kaplan B. Lack of improvement in renal allograft survival despite a marked decrease in acute rejection rates over the most recent era. (medigraphic.com)
Acute Kidney Injury (AKI) Acute kidney injury is a rapid decrease in renal function over days to weeks, causing an accumulation of nitrogenous products in the blood (azotemia) with or without reduction in amount of urine. (msdmanuals.com)

Its pathogenesis has not been fully elucidated and existing therapy is not effective in improving renal transplant function. (biomedcentral.com)

Anatomy5

Organisms7

Diseases9

Chemicals and Drugs15

Analytical, Diagnostic and Therapeutic Techniques and Equipment18

Psychiatry and Psychology1

Phenomena and Processes6

Named Groups1

Health Care1

Transplantation30

Recipients16

Biopsy7

Immunosuppressive6

Humoral rejection1

Graft survival5

Diagnosis6

Patients30

Dysfunction12

Nephropathy2

Outcomes1

Tubular epithelial cells1

Disease7

Alloantibody6

Hyperacute2

Biopsies1

Interstitial2

Inflammation2

Prophylaxis1

Tacrolimus2

Fibrosis2

Mycophenolate mofetil2

Cell carcinoma1

Chronic rejection2

ESRD1

Organ3

Incidence1

Vascular1

Prognosis1

Vasculopathy1

Cyclosporine2

Kidneys1

Endothelial1

Efficacy1

Serum1

Episodes1

Artery1

Myeloid1

Decrease2

Pathogenesis1