Acute optic neuritis. Medical search. Frequent questions

To identify clinical and demographic features associated with the severity and recovery from acute optic neuritis (AON) episodes in patients with multiple sclerosis (MS). (neurology.org)
Optic neuritis (ON) is a demyelinating inflammation of the optic nerve that often occurs in association with multiple sclerosis (MS) and, much less commonly, neuromyelitis optica (NMO). (medscape.com)
Optic neuritis and multiple sclerosis. (bmj.com)
Pediatric optic neuritis and risk of multiple sclerosis: Meta-analysis of observational studies. (medscape.com)
Risk factors for developing multiple sclerosis after childhood optic neuritis. (medscape.com)
Optic neuritis (ON) is a common manifestation of multiple sclerosis (MS), and refers to inflammation of the optic nerve. (clevelandclinic.org)
Multiple sclerosis (MS) and acute disseminated encephalomyelitis (ADEM) are autoinflammatory demyelinating diseases of the central nervous system (CNS). (biomedcentral.com)
The most common cause is multiple sclerosis (MS) or ischemic optic neuropathy due to thrombosis or embolism of the vessel that supplies the optic nerve. (wikipedia.org)
Optic neuritis is often the presenting manifestation of multiple sclerosis. (msdmanuals.com)
This patient fulfilled the criteria for both clinically definite multiple sclerosis and acute zonal occult outer retinopathy (AZOOR). (bmj.com)
ON occurs in half of patients with relapsing-remitting multiple sclerosis (MS) and is the presenting demyelinating event in 15% to 20% of all patients with MS. Visual recovery typically begins within 30 days of symptom onset, reflecting resolution of optic nerve inflammation, but corticosteroids can hasten recovery to begin as early as 1 week. (medscape.com)
We searched PubMed and Medline for studies published during the last 10 years with the general term "optic neuritis" and specific terms like "typical optic neuritis," "atypical optic neuritis," "multiple sclerosis," "neuromyelitis optic neuritis," and "myelin oligodendrocyte glycoprotein antibody. (lww.com)
Where such a disorder fits in the spectrum from acute disseminating encephalomeylitis to multiple sclerosis is discussed. (researchgate.net)
Neuroinflammation is a central pathological feature of several acute and chronic brain diseases, including Alzheimer disease (AD), Parkinson disease (PD), amyotrophic lateral sclerosis (ALS), and multiple sclerosis (MS). It induces. (koreamed.org)
While optic neuritis (ON) can occur with both myelin oligodendro-cyte glycoprotein antibody-associat-ed disease (MOGAD) and multiple sclerosis (MS), treatment of the two demyelinating diseases differs. (aao.org)
Optic neuritis: Clinical considerations and the relationship to multiple sclerosis. (medscape.com)
Optic neuritis as onset manifestation of multiple sclerosis: a nationwide, long-term survey. (medscape.com)
Optic neuritis can occur as an isolated disease or can be associated with multiple sclerosis (MS) . Not everyone with MS will develop optic neuritis. (chop.edu)
Treatment of acute exacerbations of multiple sclerosis in adults. (mallinckrodt.com)
Risk Factors for Multiple Sclerosis Development After Optic Neuritis Diagnosis Using a Nationwide Health Records Database. (cdc.gov)

Optic neuritis (ON) represents inflammation of the optic nerve. (bmj.com)
Inflammation of the optic nerve causes loss of vision, usually because of the swelling and destruction of the myelin sheath covering the optic nerve. (wikipedia.org)
General references Optic neuritis is inflammation of the optic nerve. (msdmanuals.com)
Primary idiopathic inflammation of the optic nerve. (medscape.com)
Optic neuritis is caused by inflammation of the optic nerve, which is located between the back of the eye and the brain. (chop.edu)

This review article tends to provide an update on the approach and management of optic neuritis. (lww.com)
In a recent Lancet Neurology publication, Raftopoulos and colleagues report the potential benefits of phenytoin in the acute management of optic neuritis. (neuroophthalmology.ca)

MRI is indicated to evaluate demyelinating brain lesions rather than the optic nerves, while "routine" brain protocols typically include axial FLAIR and DWI. (umn.edu)
Additional limitations include possible referral bias, possible lack of generalizability outside academic tertiary care centers, and absence of optical coherence tomography, which might have detected subclinical axonal attrition in the optic nerves known to limit expected visual recovery. (medscape.com)
MRI brain revealed bilaterally swollen optic nerves and diffuse high signal intensities in the region of the optic nerves and optic chiasma on T2 weighted images suggestive of optic neuritis. (pediatriconcall.com)
Fig. 1) Visual Evoked Potential (VEP) showed bilateral demyelination of the optic nerves. (pediatriconcall.com)
MOG antibodies damage the protective covering (myelin sheath) that surrounds nerve fibres in the brain, optic nerves, and spinal cord, so messages cannot pass along these nerves effectively, causing symptoms such as vision loss, muscle weakness, and pain. (eurekalert.org)
A demyelinating disease is any condition that causes damage to the protective covering (myelin sheath) that surrounds nerve fibers in your brain, the nerves leading to the eyes (optic nerves) and spinal cord. (mayoclinic.org)

Mitra S, Samanta M, Sarkar M, Chatterjee S. Isolated Demyelinating Optic Neuritis in Neurotuberculosis. (pediatriconcall.com)
Isolated demyelinating optic neuritis is a rare presenting feature of neurotuberculosis in the pediatric population. (pediatriconcall.com)
He was diagnosed with demyelinating optic neuritis with evidence of neurotuberculosis and was managed successfully with anti-tubercular drug therapy and corticosteroids. (pediatriconcall.com)
Being an endemic country, neurotuberculosis should be considered as a potential cause of demyelinating optic neuritis in the pediatric population. (pediatriconcall.com)

The clinical profile of optic neuritis: experience of the Optic Neuritis Treatment Trial. (bmj.com)
The clinical features, MRI findings, and outcome of optic neuritis in children. (medscape.com)
What are the typical clinical features of optic neuritis? (clevelandclinic.org)
Imaging modalities used in the diagnosis of optic neuritis include orbital MRI and optical coherence tomography (OCT). These tools can be particularly helpful if the clinical history or physical examination findings are atypical for ON. (clevelandclinic.org)
BACKGROUND: Contrast-enhanced, fat-suppressed T1-weighted imaging (CET1WI) magnetic resonance imaging (MRI) is quite sensitive in detecting acute optic neuritis (ON), but ON remains a clinical diagnosis. (umn.edu)
PURPOSE: To evaluate the accuracy of axial, fat-suppressed FLAIR and DWI sequences used for our routine brain imaging in detecting acute ON, as compared to CET1WI and the clinical diagnosis. (umn.edu)
We sought to compare the sensitivity of 3.0 Tesla (T) MRI to that of 1.5 T MRI in detecting acute demyelinating ON.Methods:A retrospective chart review was performed on patients with a clinical diagnosis of optic neuritis at Mayo Clinic Health System from January 2010 to April 2020. (elsevierpure.com)
Clinical criteria to diagnose ON are acute visual loss, dyschromatopsia, and pain of the eye [ 8 ]. (hindawi.com)
Clinical phenotype, radiological features, and treatment of myelin oligodendrocyte glycoprotein-immunoglobulin G (MOG-IgG) optic neuritis. (msdmanuals.com)
This single-blind, randomized clinical trial examined whether visual recovery in acute ON after treatment with a high-dose IV corticosteroid was superior to that with a bioequivalent dose of an oral corticosteroid. (medscape.com)
Antiaquaporin4 antibodies and antimyelin oligodendrocytes antibodies are now considered as distinct entities of optic neuritis with their specific clinical presentation, neuroimaging characteristics, treatment options, and course of the disease. (lww.com)
The Optic Neuritis Treatment Trial (ONTT) was a carefully performed, randomized, clinical trial that yielded useful information. (medscape.com)
Optic neuritis is diagnosed by clinical presentation as well as visualization of the optic disc using an ophthalmoscope. (chop.edu)
Optic neuritis was the most common clinical manifestation of MOGAD. (bvsalud.org)

Myelin Oligodendrocyte Glycoprotein Serepositive Demyelinating disease (MOG IgG+) is a recently discovered cause of optic neuritis. (medscape.com)

Other remarkable differences between the presentation of adult optic neuritis as compared to pediatric cases include more often unilateral optic neuritis in adults, while children much predominantly present with bilateral involvement. (wikipedia.org)
Direct ophthalmoscopy revealed diffuse hyperemia and edema of the optic disc in both the eyes with a normal macula and retina, suggestive of bilateral papillitis. (pediatriconcall.com)
Monteiro ML, Borges WI, do Val Ferreira Ramos C, Lucato LT, Leite CC. Bilateral optic neuritis in wegener granulomatosis. (medscape.com)
Siddiqui J, Rouleau J, Lee AG, Sato Y, Voigt MD. Bilateral optic neuritis in acute hepatitis C. J Neuroophthalmol . (medscape.com)
Optic neuritis can be unilateral (affecting only one eye) or bilateral (affecting both eyes). (chop.edu)

Funduscopic examination can appear normal acutely, but disc edema can be present in approximately one-third of patients (particularly those with anterior optic neuritis).1, 2 Optic disc pallor is generally seen weeks to months following onset of typical optic neuritis. (clevelandclinic.org)

0.029 logMAR) with placebo with progressive chronic optic neuropathy (p = 0.45) in the subgroup of patients with PON. (deepdyve.com)

Patient presentation for optic neuritis has been found to have a bimodal distribution with younger patients less than 9 years of age exhibiting MOG-IgG in association with ADEM and older children with clinically isolated optic neuritis or NMO-SD phenotype. (medscape.com)
McKinney, AM 2013, ' Accuracy of routine fat-suppressed FLAIR and diffusion-weighted images in detecting clinically evident acute optic neuritis ', Acta radiologica (Stockholm, Sweden : 1987) , vol. 54, no. 4, pp. 455-461. (umn.edu)

OCT evaluates the optic nerve axonal integrity by measurement of the retinal nerve fiber layer (RNFL), and is generally used to evaluate for evidence of prior ON. (clevelandclinic.org)
In the study, optic nerve edema was assessed with OCT-derived peripapil-lary retinal nerve fiber layer (pRNFL) thickness and shown to be more severe in eyes with MOGAD-ON than in eyes with MS-ON. (aao.org)
Progressive outer retinal necrosis presenting with isolated optic neuropathy. (medscape.com)

Idiopathic ON, the most common form of ON, is an inflammatory optic neuropathy in the absence of evidence of a systemic inflammatory disease. (bmj.com)
The presence of hemorrhages or exudates on funduscopic examination is more suggestive of other, non-demyelinating etiologies of optic neuropathy and warrants ophthalmology evaluation. (clevelandclinic.org)
Anterior ischemic optic neuropathy (AION), arteritic or nonarteritic. (clevelandclinic.org)
Background:Optic neuritis (ON) is the most common optic neuropathy in young adults. (elsevierpure.com)
acute optic neuritis (AON) or slowly progressive optic neuropathy (PON). (deepdyve.com)

Optic neuritis (ON) may involve the retrobulbar (retrobulbar neuritis) or the intrabulbar (papillitis) portion of the optic nerve, or both. (bmj.com)
It is also known as optic papillitis (when the head of the optic nerve is involved), neuroretinitis (when there is a combined involvement of the optic disc and surrounding retina in the macular area) and retrobulbar neuritis (when the posterior part of the nerve is involved). (wikipedia.org)

In the Optic Neuritis Treatment Trial (ONTT), which followed a group of patients with acute unilateral optic neuritis, 28 percent of patients experienced a recurrence of optic neuritis within five years and 35 percent within 10 years. (chop.edu)

http://www.ncbi.nlm.nih.gov/pubmed/1841573?tool=bestpractice.com When in isolation, primary demyelinating ON is considered a forme fruste of MS. ON manifests as the subacute or acute onset of pain in the eye and pain with eye movements and loss of vision, typically with central or centrocecal scotoma that usually reaches a nadir at approximately 1 to 2 weeks. (bmj.com)
OCT at onset of ON is also potentially confounded by edema of the optic disc, which may lead to overestimates of baseline RNFL.4 Ganglion cell layer (GCL) thickness, another OCT measure, is not confounded by disc edema but declines in a similar time frame to RNFL and therefore may be more useful as a baseline measurement. (clevelandclinic.org)
generally vascular presentation (acute onset). (clevelandclinic.org)
AZOOR can have an onset with monocular visual field loss, and can be distinguished from optic neuritis. (bmj.com)
Screening criteria were 18-64 years of age, presentation within 14 days of acute ON onset, absence of any recovery at time of randomization, and lack of history of ON in the same eye. (medscape.com)
Isolated optic nerve lesion with rapid onset blindness in a case of neurotuberculosis is rarely reported in the pediatric population. (pediatriconcall.com)

What is the neurologic differential diagnosis of optic neuritis? (clevelandclinic.org)

2 3 4 5 6 ] However, a more recent population-based survey conducted in urban Mangalore has shown a prevalence of 8.3/100,000 for MS and 2.6/100,000 for neuromyelitis optic spectrum diseases (NMOSD). (lww.com)
Over the last 10 years, multiple studies have shown that several demyelinating diseases (including optic neuritis, myelitis, and acute disseminated encephalomyelitis [ADEM]) associate with the MOG-antibody biomarker, and patients affected by this group of diseases frequently improve with immunotherapy. (eurekalert.org)

A case of acute optic neuritis. (medscape.com)
We report on a case of acute disseminated encephalomyelitis with optic neuritis and periodic fever syndrome in a 12-year-old Ecuadorian Hispanic boy with several relapses over the past 10 years, always preceded by autoinflammatory manifestations and without evidence of infectious processes. (biomedcentral.com)

An algorithmic approach to identifying the aetiology of acute encephalitis syndrome in India: results of a 4-year enhanced surveillance study. (cdc.gov)
Investigations of seasonal outbreaks of acute encephalitis syndrome due to Orientia tsutsugamushi in Gorakhpur region, India: A One Health case study. (cdc.gov)
Emergence of Orientia tsutsugamushi as an important cause of Acute Encephalitis Syndrome in India. (cdc.gov)
Sen PK , Dhariwal AC , Jaiswal RK , Lal S , Raina VK , Rastogi A . Epidemiology of acute encephalitis syndrome in India: changing paradigm and implication for control. (cdc.gov)
Guidelines for surveillance of acute encephalitis syndrome (with special reference to Japanese encephalitis). (cdc.gov)
The most common causes of death are pneumonia and acute encephalitis. (cdc.gov)

Optic neuritis is an inflammatory injury of the optic nerve that causes vision loss, which is common in MS and other CNS inflammatory disorders. (medscape.com)
and OCS-05, a disease modifying candidate for acute optic neuritis (AON) and other neuro-ophtha disorders such as glaucoma, diabetic retinopathy, geographic atrophy, and neurotrophic keratitis. (biospace.com)
Renal Toxicity: Cases of acute renal failure, renal tubular disorders and increase in serum creatinine have occurred. (nih.gov)

Early reports with a small number of patients found some benefit with plasma exchange in acute, severe ON. (medscape.com)

Acute disseminated encephalomyelitis is generally preceded by an infection, and it is usually self-limiting and non-recurrent. (biomedcentral.com)
However, when there are multiple attacks of acute disseminated encephalomyelitis followed by optic neuritis, it is defined as acute disseminated encephalomyelitis-optic neuritis. (biomedcentral.com)
To the best of our knowledge, there are no previous reports of acute disseminated encephalomyelitis and optic neuritis preceded by autoinflammation, triggered by periodic fever syndrome. (biomedcentral.com)
We propose that an autoinflammatory basis should be pursued in patients diagnosed as having acute disseminated encephalomyelitis and no record of infections. (biomedcentral.com)

Since there may be a delay between the optic neuritis and the myelitis, and since the treatment will be different, suspicion for neuromyelitis optica should prompt laboratory study for NMO (neuromyelitis optica) antibody. (medscape.com)

To demonstrate the relation between optic neuritis (ON) and systemic inflammation markers as neutrophil lymphocyte ratio (N/L ratio), platelet count, mean platelet volume (MPV), and red cell distribution width (RDW) and furthermore to evaluate the utilization of these markers to predict the frequency of the ON episodes. (hindawi.com)
The development of new immunosuppressant drugs and monoclonal antibodies has reduced the relapses and improved the prognosis of optic neuritis as well as an associated systemic disease. (lww.com)

Corticosteroids have a long history of use for treatment of acute demyelinating events, reducing blood-brain barrier breakdown and accelerating recovery from acute relapse. (medscape.com)

Parainfectious optic neuritis. (medscape.com)

Pediatric Optic Neuritis. (medscape.com)
Pediatric Optic Neuritis: What Is New. (medscape.com)
Pediatric Optic Neuritis Prospective Outcomes Study. (medscape.com)
Most of the optic neuritis cases that are reported in pediatric tuberculosis are usually associated with other focal neurodeficits or follow anti-tubercular therapy, especially ethambutol . (pediatriconcall.com)

Visual evoked potentials (VEPs) can also provide valuable information regarding optic nerve impairment in ON. (clevelandclinic.org)

Initially, the optic nerve head may appear normal, with disc pallor months later. (medscape.com)

It can be the initial demyelinating event in up to 20% of patients, and occurs in almost half of patients with MS.1 ON associated with demyelinating disease is generally characterized by acute to subacute, painful, and monocular vision loss. (clevelandclinic.org)
In subacute pulmonary reactions, fever and eosinophilia occur less often than in the acute form. (druglib.com)

We were not too surprised to find that the pRNFL during an acute optic neuritis attack was much thicker in MOGAD compared to MS overall, but the degree that OCT differentiated the two entities was quite striking," said John J. Chen, MD, PhD, at the Mayo Clinic in Rochester, Minnesota. (aao.org)

But based on this study, the presenta-tion of optic neuritis with significant pRNFL thickening would be suggestive of MOGAD, and such a patient should be treated with early steroids, he said. (aao.org)

however, frequently there is no abnormal appearance of the nerve head in optic neuritis (in cases of retrobulbar optic neuritis), though it may be swollen in some patients (anterior papillitis or more extensive optic neuritis). (wikipedia.org)
In about two thirds of patients, inflammation is entirely retrobulbar, causing no visible changes to the optic nerve head. (msdmanuals.com)

Visual evoked potentials often show a loss of P100 response in the acute phase. (medscape.com)
VEPs evaluate optic nerve function by calculating P100 latency and amplitude, which are generally abnormal in the setting of acute and remote optic neuritis. (clevelandclinic.org)
Prolonged P100 latency is a characteristic of remote optic neuritis. (clevelandclinic.org)
VEPs often show a loss of P100 response in the acute phase. (medscape.com)

Ophthalmological imaging studies at his first hospitalization 10 years ago were consistent with a demyelinating and axonal lesion of the left optic tract, which is compatible with ON. (biomedcentral.com)

Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) - inflammatory disorder of the central nervous system, predominantly of the optic nerve and spinal cord. (mayoclinic.org)

It may occur as a monophasic illness, recurrent isolated optic neuritis, and recurrent optic neuritis in the context of multifocal inflammatory CNS disease. (medscape.com)
Acute reactions usually occur within the first week of treatment and are reversible with cessation of therapy. (druglib.com)

As an adjunct to standard measures for the treatment of acute iron intoxication. (nih.gov)

The main symptom of optic neuritis is vision loss, frequently maximal within several days and varying from a small central or paracentral scotoma to complete blindness. (msdmanuals.com)

Visual evoked potentials may be abnormal even when visual acuity is normal and when MRI of the optic nerve reveals no abnormalities. (medscape.com)

In neuromyelitis optica higher AQP4 autoantibody levels are associated with the occurrence of optic neuritis. (wikipedia.org)

These results demonstrate a novel link between neuroinflammation and vascular physiological dysfunction in the cerebral white matter, and could indicate enduring loss of vascular compliance associated with imperfect repair of blood-brain barrier damage after resolution of acute neuroinflammation. (biorxiv.org)

Optic neuritis is most common among adults 20 to 40 years. (msdmanuals.com)

Sanborn GE, Kivlin JD, Stevens M. Optic neuritis secondary to sinus disease. (medscape.com)

A. 1.5 Tesla, contrast-enhanced spin echo T1-weighted, fat-suppressed coronal MRI through the orbits shows enlargement and contrast enhancement of the left optic nerve in the retrobulbar portion (arrow). (medscape.com)

Many patients with optic neuritis may lose some of their color vision in the affected eye (especially red), with colors appearing subtly washed out compared to the other eye. (wikipedia.org)
Hospital-at-home (HaH) programmes deliver hospital-type treatments to patients located in their own homes, often in substitution for an acute inpatient admission or to support. (annals.edu.sg)
Forty-two patients with acute ON and forty healthy subjects were enrolled into the study. (hindawi.com)
Forty-two patients with acute ON whose blood samples were received before treatment with intravenous corticosteroids and randomly selected forty healthy subjects (age and sex matched) were enrolled into the study. (hindawi.com)
rheumatoid arthritis, juvenile rheumatoid arthritis and ankylosing spondylitis to tide patients over an acute episode or exacerbation. (mallinckrodt.com)
Although patients in the acute phase responded well to methylprednisolone pulse therapy, the long-term recurrence rate was high. (bvsalud.org)
Background: Acute kidney injury (AKI) commonly occurs in coronavirus disease 2019 (COVID-19) patients who have been hospitalised and is associated with a poor prognosis. (bvsalud.org)

A cut-off value of 118 μm provided a sensi-tivity of 74% and specificity of 82% for the optic neuritis being from MOGAD. (aao.org)

Anatomy4

Diseases11

Chemicals and Drugs2

Analytical, Diagnostic and Therapeutic Techniques and Equipment4

Psychiatry and Psychology1

Phenomena and Processes3

Multiple sclerosis20

Inflammation of the optic nerve5

Management of Optic Neuritis2

Nerves6

Demyelinating Optic Neuritis4

Clinical14

Cause of optic neuritis1

Bilateral5

Typical optic neuritis1

Chronic1

Clinically2

Retinal3

Neuropathy5

Retrobulbar neuritis2

Unilateral1

Onset6

Diagnosis of optic1

Diseases2

Case of acute2

Encephalitis6

Disorders3

Severe1

Encephalomyelitis4

Myelitis1

Systemic2

Recovery from acute1

Parainfectious1

Pediatric4

Regarding optic nerve1

Disc pallor1

Subacute2

Mayo Clinic1

Suggestive1

Nerve head2

P1004

Axonal1

Spinal cord1

Occur2

Treatment of acute1

Symptom1

Abnormalities1

Neuromyelitis1

Neuroinflammation1

Common1

Sinus1

Left optic1

Patients7

MOGAD1