AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsTechnology, Industry, AgricultureInformation ScienceNamed GroupsHealth Care
Myocardial Reperfusion InjuryMyocardial IschemiaL-Iditol 2-DehydrogenaseReperfusion InjuryMyocardiumIschemiaMyocardial InfarctionCold IschemiaMyocardial ReperfusionWarm IschemiaBrain IschemiaCardiotonic AgentsIschemic Preconditioning, MyocardialReperfusionIschemic PostconditioningRats, Sprague-DawleyMyocytes, CardiacDisease Models, AnimalTime FactorsOrgan PreservationIschemic PreconditioningHeartRats, WistarCreatine KinaseApoptosisL-Lactate DehydrogenaseMice, Inbred C57BLHemodynamicsCoronary CirculationPeroxidaseVentricular Function, LeftMitochondria, HeartHeart Function TestsDelayed Graft FunctionOxidative StressMyocardial ContractionMice, KnockoutWounds and InjuriesDogsGraft SurvivalCyclic S-OxidesTissue DonorsLiver TransplantationInfarction, Middle Cerebral ArteryNephrectomyIschemic Attack, TransientNitric OxideKidney TransplantationReceptor, Adenosine A3Neuroprotective AgentsRabbitsCoronary VesselsOrgan Preservation SolutionsPeroxynitrous AcidSignal TransductionCoronary DiseaseKidneyElectrocardiographyArrhythmias, CardiacBrain InjuriesTroponin ISwinePerfusionNeutrophilsTissue and Organ HarvestingHeart RateIn Situ Nick-End LabelingReactive Oxygen SpeciesCaspase 3Nitric Oxide Synthase Type IIIKATP ChannelsAntioxidantsProto-Oncogene Proteins c-aktNitric Oxide Synthase Type IIBlood PressureSpinal Cord IschemiaNecrosisBlotting, WesternHeart VentriclesRaffinoseEnzyme InhibitorsDeathProtective AgentsTissue and Organ ProcurementCells, CulturedAcute Kidney InjuryConstrictionCadaverLiving DonorsCerebral InfarctionCytoprotectionGerbillinaeExercise TestTreatment OutcomeRandom AllocationDose-Response Relationship, DrugMalondialdehydeTumor Necrosis Factor-alphaLiverAllopurinol
InfarctionMyocardiumOxidative stressNecrosisCardiacPerfusionSyndromeRenal ischemia-reperfusion injuryClinicalHypoxiaCardiovascularAbstractStrokeDysfunctionThrombolysisMorbidityElevationPatientsTissueInflammationMechanismsPercutaneousInfarctions occurOxygenMitochondrialApoptosisTherapeuticKidney injuryHeartProtectiveOnsetOccursArrhythmiasPulmonary embolismHemodynamicTissuesSevereMacrophageTreatment of acuteTransientCellularOutcomesChest painShamInflammatory responseReocclusion
Infarction47
Myocardium8
  • In the heart, IPC is an intrinsic process whereby repeated short episodes of ischaemia protect the myocardium against a subsequent ischaemic insult. (wikipedia.org)
  • Coronary thrombolysis and mechanical revascularization have revolutionized the primary treatment of acute MI, largely because they allow salvage of the myocardium when implemented early after the onset of ischemia. (medscape.com)
  • The modest prognostic benefit of an opened infarct-related artery may be realized even when recanalization is induced only 6 hours or later after the onset of symptoms, that is, when the salvaging of substantial amounts of jeopardized ischemic myocardium is no longer likely. (medscape.com)
  • GIK has now been commonly applied in patients with acute coronary syndrome (ACS) as a metabolic support to ischemic myocardium. (biomedcentral.com)
  • However, whether GRh2 has a protective effect on ischaemia/reperfusion (I/R) in the myocardium has yet to be elucidated. (spandidos-publications.com)
  • These studies will not only extend our understanding of the fundamental mechanism by which these protein adducts are regulated in the myocardium but will also provide a solid rationale towards the specific putative binding sites available on AIFm2 in regulating NADH oxidoreductase activity during I/R injury-induced mitochondrial oxidative stress. (lsuhs.edu)
  • w3 The associated ischaemic injury and subsequent myocardial necrosis spreads from the subendocardial to the subepicardial myocardium in a time span of several hours. (bmj.com)
  • Native T1 mapping can characterise the injured myocardium and has been shown to characterise viable myocardium in the acute setting [ 8 ]. (biomedcentral.com)
Oxidative stress10
  • In conclusion, the present study confirmed that GRh2 could reduce oxidative stress and inflammation in cardiomyocytes after reperfusion, and its mechanism of action may be related to its regulation of the Nrf2/HO‑1/NLRP3 signalling pathway. (spandidos-publications.com)
  • Meng X, Zhang L, Han B and Zhang Z: PHLDA3 inhibition protects against myocardial ischemia/reperfusion injury by alleviating oxidative stress and inflammatory response via the Akt/Nrf2 axis. (spandidos-publications.com)
  • Remote effect of kidney ischemiareperfusion injury on pancreas: role of oxidative stress and mitochondrial apoptosis. (phypha.ir)
  • Myocardial antioxidant and oxidative stress changes due to sex hormones. (phypha.ir)
  • Inhibition of oxidative stress in renal ischemia-reperfusion injury. (phypha.ir)
  • Accumulated evidence indicates that oxidative stress in mitochondria plays a vital role in cardiac injury, but how mitochondrial redox mechanisms are involved in cardiac dysfunction remains unclear. (lsuhs.edu)
  • One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
  • oxidative stress that occurs during reperfusion injury has been shown to induce apoptosis, over and above that induced by ischemia. (latestfashiontips.com)
  • The authors carried out tests on an animal model to investigate the individual and combined effects of melatonin and NMN on myocardial function, mitochondrial activity, and oxidative stress status following ischemia/reperfusion injury in aged rat hearts. (prohealth.com)
  • The ischemic injury underlying these illnesses is complex, involving intricate interplays among many biological functions including energy metabolism, vascular regulation, hemodynamics, oxidative stress, inflammation, platelet activation, and tissue repair that take place in a context- and time-dependent manner. (cdc.gov)
Necrosis5
  • For the end point infarct size, estimated by biomarkers of myocardial necrosis, an overall pooled effect was SMD =−0.58, 95% CI: −0.96 to −0.19. (dovepress.com)
  • MI may also manifest itself as sudden cardiac death, which may not be apparent on autopsy (because necrosis takes time to develop). (medscape.com)
  • HNE mediates necrosis, apoptosis, and autophagy within the area rendered ischemic over the first 6 to 24 hours. (lsuhs.edu)
  • and release of BIOMARKERS of myocardial NECROSIS (e.g., elevated TROPONIN levels). (nih.gov)
  • The mechanism for localized hypercoaguability in granulomatous sarcoidosis may be due to the localized increase in Tumor Necrosis Factor alpha (TNF alpha) and interleukin-6 (IL-6) which can cause " microvascular damage leading to thrombosis ," and " ischemia . (transcendingsquare.com)
Cardiac15
  • The scRNA-seq analysis was used to characterize the dynamic changes associated with fibroblast differentiation and identified Gpx3 as a factor that might be involved in the regulation of myocardial fibrosis under cardiac pressure overload. (hindawi.com)
  • Glucose-insulin-potassium (GIK) has long been advocated as an adjunctive treatment for patients with cardiac dysfunction during episodes of ischemia and reperfusion. (biomedcentral.com)
  • Short-term cardiac stress, induced by ischemia-reperfusion (I/R) injury resulted in impaired left ventricular (LV) recovery and increased infarct size in heterozygous Hmox1-deficient (Hmox1 +/− ) mice [ 55 ]. (springer.com)
  • Gender difference in the development of cardiac lesions following acute ischemic-reperfusion renal injury in albino rats. (phypha.ir)
  • However, the molecular mechanisms involved in AIFm2 translocation that mediates cardiac injury remain unknown. (lsuhs.edu)
  • In this application, we present the first evidence that HNE upregulation following cardiac I/R injury activates the translocation of AIFm2 from the mitochondria to the nucleus. (lsuhs.edu)
  • Specific Aim # 2: Determine the cytosolic transport protein involved in the translocation of the HNE-adducted AIFm2 complex from the cytosol to the nucleus following cardiac injury. (lsuhs.edu)
  • Specific absence of homeostatic, monocyte-independent macrophages altered the immune cell crosstalk in response to injury and induced proinflammatory neutrophil polarization, resulting in impaired cardiac remodelling without influencing infarct size. (elifesciences.org)
  • In summary, resident macrophages orchestrate inflammatory responses improving cardiac remodelling, while recruited macrophages determine infarct size after I/R injury. (elifesciences.org)
  • This study provides important findings on the distinct functions of resident and recruited macrophages during cardiac healing after myocardial ischemia. (elifesciences.org)
  • This group was evaluated for the risk factors, presenting symptoms, killip class, type of acute coronary syndrome (STEMI vs NSTEMI), time to presentation to hospital, treatment received (medical management/thrombolysis/PCI/CABG), cardiac arrhythmias, mean ejection fraction, HRCT chest (CORADS grading), any complications and immediate outcome. (scialert.net)
  • Cardiac surgery-associated multiorgan dysfunction (CSA-MOD) is well recognized and includes acute kidney injury (AKI), hepatic impairment, myocardial damage, and postoperative neurologic deficit. (silverchair.com)
  • Cardiac cells that survive this first wave of injuries will often have their mitochondrial functions compromised, and this can lead to further dysfunction and even cellular death. (prohealth.com)
  • However, mitigation strategies to preserve cardiac function after an ischemic event have often only focused on individual therapeutic agents, and the results have not been ideal. (prohealth.com)
  • For the study, the researchers performed tests to measure the condition of cardiac tissue before and after an ischemic event and after perfusion was re-established. (prohealth.com)
Perfusion6
  • 3-4 This facilitates preservation of myocardial and cerebral perfusion while the source of bleeding is identified and fixed, and the patient's volume status and coagulopathy are corrected. (openanesthesia.org)
  • In addition, betahistine hydrochloride also has a diuretic effect, which can promote blood circulation, increase organ blood perfusion, reduce myocardial oxygen consumption, improve patient blood pressure levels and ultimately improve symptoms of cardiovascular and cerebrovascular ischemia and hypoxia. (ijpsonline.com)
  • Myocardial salvage depends on the prompt, complete, and sustained restoration of myocardial perfusion. (bmj.com)
  • At present, this can only be obtained by re-establishing coronary flow, although coronary reperfusion does not necessarily imply myocardial perfusion. (bmj.com)
  • By combining bovine hemoglobin with both PEG to improve perfusion and CO to prevent vasoconstriction and inflammation during ischemia/hypoxia, PP-007 works holistically to achieve vascular and tissue homeostasis, unlike other oxygen carrier therapeutics that only treat the symptomatic condition and not underlying root cause of a disorder (Abuchowski A. 2017). (prolongpharma.com)
  • An IABP may be placed in the emergency department (ED) as a bridge to percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG), to decrease myocardial workload, and to improve end-organ perfusion. (medscape.com)
Syndrome21
  • Despite major advances in the care of patients with acute coronary syndrome over many decades, rates of early morbidity and mortality associated with the condition remain unacceptably high. (mcw.edu)
  • Following an acute coronary syndrome, patients display an elevated inflammatory profile, promoted in part by cellular senescence. (frontiersin.org)
  • The Q-CABG study aims to explore the efficacy of quercetin to reduce inflammation, myocardial injury and senescence in patients undergoing CABG following an acute coronary syndrome. (frontiersin.org)
  • The preventive intake of quercetin supplementation may help limit the vigorous inflammatory response triggered by CABG and subsequent postoperative complications in patients suffering from an acute coronary syndrome. (frontiersin.org)
  • Glucose-insulin-potassium (GIK) has been advocated in the setting of acute coronary syndrome (ACS) to reduce ischemia-related arrhythmias and myocardial injury. (biomedcentral.com)
  • Therefore, 871 patients with a suspected acute coronary syndrome (ACS) were randomized to GIK infusion or placebo in the ambulance, thereby significantly shortening system delay. (biomedcentral.com)
  • Lung inflammation is induced by renal ischemia and reperfusion injury as part of the systemic inflammatory syndrome. (phypha.ir)
  • The ECG is the most important tool in the initial evaluation and triage of patients in whom an acute coronary syndrome (ACS), such as MI, is suspected. (medscape.com)
  • 16 Revascularization in Non-ST-Elevation Acute Coronary Syndrome: For Whom, When, and How? (physioshop.co.uk)
  • Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid deterioration of renal function. (biomedcentral.com)
  • These comorbidities include vaso-occlusive (pain) crisis, acute chest syndrome, leg ulcers, and pediatric and adult stroke. (prolongpharma.com)
  • Smoking may increase the thrombus burden in patients with acute coronary syndrome. (researchsquare.com)
  • Cigarette smoking may increase the thrombus burden in patients with acute coronary syndrome (ACS).Thrombosis results largely from platelet aggregation and fibrin formation due to rupture or ulceration of the atheroma. (researchsquare.com)
  • Management of Acute Coronary Syndrome. (nih.gov)
  • Acute coronary syndrome results from an abrupt reduction or cessation of blood flow locally within a coronary artery. (unboundmedicine.com)
  • However, it resulted in decreased hospitalization for acute coronary syndrome, delayed presentation and change in decision making. (scialert.net)
  • In this study, done at tertiary care centre, patients of acute coronary syndrome over last 4 months underwent RT-PCR for SARS-CoV-2 and HRCT chest prior to admission. (scialert.net)
  • A total of 25 (5.8%) patients with acute coronary syndrome who had evidence of COVID-19 infection were enrolled in the study. (scialert.net)
  • In this study, 5.8% patients of acute coronary syndrome had evidence of COVID-19 infection. (scialert.net)
  • More severe presentations include pneumonia and acute respiratory distress syndrome. (scialert.net)
  • An early revascularization strategy with either PCI or CABG, in collaboration between cardiologists and surgeons, is recommended for appropriate patients with suspected cardiogenic shock related to acute coronary syndrome (eg, those with uncertain neurologic status, those who received previous fibrinolysis), regardless of the time delay from MI onset. (medscape.com)
Renal ischemia-reperfusion injury3
  • Renal ischemia/reperfusion injury (IRI) may influence distance organ such as lung. (phypha.ir)
  • Nacetylcysteine prevents kidney and lung disturbances in renal ischemia/reperfusion injury in rat. (phypha.ir)
  • 15. Kher A, Meldrum KK, Wang M, Tsai BM, Pitcher JM, Meldrum DR. Cellular and molecular mechanisms of sex differences in renal ischemia-reperfusion injury. (phypha.ir)
Clinical12
  • Methods to either mimic or elicit IPC have been attempted in clinical practice in the area of coronary heart disease in an attempt to limit the injury caused to the heart via ischemia and reperfusion injury. (wikipedia.org)
  • Objective: To observe the clinical effect of Qiliqiangxin capsule combined with recombinant human brain natriuretic peptide in acute left heart failure patients 7 days after onset as well as the effects of plasma MDA and ET-1. (bvsalud.org)
  • Acute cerebrovascular diseases are a group of common clinical diseases characterized by abnormal cerebrovascular circulation. (ijpsonline.com)
  • Therefore, this article mainly reviews the treatment of acute cerebrovascular disease with betahistine hydrochloride combined with atorvastatin, providing scientific reference for clinical treatment of acute cerebrovascular disease. (ijpsonline.com)
  • Sex effects and the time of reperfusion may be the important factors to consider clinical therapeutic of renal IRI as well as its impact on remote organs. (phypha.ir)
  • Acute renal failure (ARF) is an important clinical problem with a high mortality and morbidity. (biomedcentral.com)
  • PP-007 is a clinical stage investigational medicine product being evaluated in conditions of ischemia/hypoxia. (prolongpharma.com)
  • Additionally, a prior PP-007 clinical study in patients at risk of delayed cerebral ischemia (DCI) following subarachnoid hemorrhagic stroke revealed evidence of brain tissue oxygenation at the 320 mg/kg dose level (Dhar R 2017 and Tallarico RT 2018). (prolongpharma.com)
  • However, there are still questions waiting for answers and results of large-scale randomized trials are needed for the appearance of myocardial cellular therapy as a clinical therapeutic option for patients with ischemic heart disease. (escardio.org)
  • The diagnosis of ACS is based on the ischaemic symptoms, clinical findings and ECG changes. (unboundmedicine.com)
  • Other clinical manifestations of myocardial ischaemia include acute pulmonary oedema, loss of consciousness and sudden death. (unboundmedicine.com)
  • This review will examine the clinical potential of several stem and progenitor cells that may be utilised to regenerate defunct or damaged vasculature and restore blood flow to the ischaemic tissue. (biomedcentral.com)
Hypoxia6
  • Adaptation to chronic hypoxia increases myocardial resistance to acute ischemia/reperfusion (I/R) injury, similarly to application of exogenous erythropoietin (EPO). (nusl.cz)
  • Neonatal rat cardiomyocytes were also used to evaluate the protective effect of GRh2 on hypoxia/reoxygenation (H/R)‑induced myocardial injury in vitro. (spandidos-publications.com)
  • We believe that oxygen delivery alone does very little to address the comorbidities of disorders caused by anemia or hypoxia/ischemia, such as the vaso-occlusive crisis of sickle cell disease. (prolongpharma.com)
  • AIS occurs when a blood clot blocks the blood flow (ischemia) in the brain resulting in brain injury resulting from loss of tissue oxygenation (hypoxia). (prolongpharma.com)
  • And it becomes worse, when hypoxia and apnoea ensues in patients, who are trying to conserve homeostasis while suffering from multiple trauma, sepsis or acute respiratory insufficiency. (e-journal.gr)
  • A few agents have been discovered that could offer in time protection against hypoxia. (e-journal.gr)
Cardiovascular5
  • Many patients on potent agents addressing modifiable cardiovascular risk factors, such as hypertension, hyperlipidemia or diabetes, still suffer from cardiovascular complications, including acute coronary syndromes (ACS). (frontiersin.org)
  • We will characterize for the first time how the neurogranin pathway in the endothelium could regulate the nitric oxide production and cardiovascular function. (lsuhs.edu)
  • Tipping the Scales for Older Adults: Time to Consider Body Fat Assessment and Management for Optimal Atherosclerotic Cardiovascular Disease and Stroke Prevention? (ochsner.org)
  • Looking forward, we think time-dependent analyses will be helpful to examine the temporal relationship between hypoglycemia and cardiovascular outcomes, which could shed light on hypoglycemia's contribution to CV risk. (closeconcerns.com)
  • As such, new drugs that would complement reperfusion by providing neural and cardiovascular protection and by targeting multiple abnormalities in ischemia are receiving increased attention. (cdc.gov)
Abstract1
Stroke10
  • Some research also suggests that ischemic conditioning is also beneficial following a stroke, chronic cerebral hypoperfusion, or heart attack. (wikipedia.org)
  • The release of CO by PP-007 into the microcirculation has been shown to limit/prevent vasoconstriction of the pial arteries acute ischemic stroke animal models. (prolongpharma.com)
  • We are dedicated to our mission to bring a proven therapeutic to market that can treat the debilitating impacts of ischemic stroke and help relieve physical blockage for a comprehensive treatment. (prolongpharma.com)
  • Prolong is also dedicated to aiding in multi-therapeutic situations in conditions such as hemorrhagic stroke, where PCHB was dosed several times along with other supportive therapies to stabilize (bridge) a critically ill anemic patient for lifesaving interventions without adverse effects. (prolongpharma.com)
  • The goal for the acute management of patients with stroke is to stabilize the patient and to complete initial evaluation and assessment, including imaging and laboratory studies, within 60 minutes of patient arrival. (medscape.com)
  • Not only can both produce symptoms that mimic ischemic stroke, but they can also aggravate ongoing neuronal ischemia. (medscape.com)
  • In patients with transient ischemic attacks (TIAs), failure to recognize the potential for near- term stroke, failure to perform a timely assessment for stroke risk factors, and failure to initiate primary and secondary stroke prevention exposes the patient to undue risk of stroke and exposes clinicians to potential litigation. (medscape.com)
  • Current treatments for acute ischemic stroke include IV thrombolytic therapy with tissue-type plasminogen activator ( t-PA ) and endovascular therapies using stent retriever devices. (medscape.com)
  • [ 5 ] . A 2015 update of the American Heart Association/American Stroke Association guidelines for the early management of patients with acute ischemic stroke recommends that patients eligible for intravenous t-PA should receive intravenous t-PA even if endovascular treatments are being considered and that patients should receive endovascular therapy with a stent retriever if they meet criteria. (medscape.com)
  • A specific dietary intervention to restore brain structure and function after ischemic stroke. (uni-muenster.de)
Dysfunction2
  • In response to injury, myocardial fibroblasts show abnormal activation and secrete excessive extracellular matrix, resulting in chamber wall stiffness and diastolic dysfunction [ 5 ]. (hindawi.com)
  • Around 7 (28%) patients had complications which included acute kidney injury in 1 patient, multiorgan dysfunction (MODS) in 3 patients out of which 2 patients died, ischemic hepatitis in 1 patient, lower limb DVT in 1 patient and DVT with pulmonary thromboembolism in 1 patient. (scialert.net)
Thrombolysis1
  • Such injury would occur when a patient has an acute myocardial infarct followed by reperfusion by either percutaneous coronary intervention or thrombolysis. (wikipedia.org)
Morbidity2
  • Thus it can increase morbidity from myocardial ischemia, rupture of aneurysms in the systemic and cerebral circulation, acute heart failure, pulmonary hypertension and failure of the right heart. (e-journal.gr)
  • Many important diseases are characterised by acute or chronic ischaemia, which affect millions of people each year and represent a considerable morbidity, mortality and economic cost to healthcare systems worldwide [ 2 ]. (biomedcentral.com)
Elevation2
  • Although patients presenting without ST-segment elevation (non-STE-ACS) are not candidates for immediate administration of thrombolytic agents, they should receive anti-ischemic therapy and may be candidates for PCI urgently or during admission. (medscape.com)
  • True hypertensive emergencies are characterized by a rapid elevation in blood pressure to a level above 180/120 mmHg and are associated with acute target organ damage, which requires immediate hospitalization for close hemodynamic monitoring and IV pharmacotherapy. (nursingcenter.com)
Patients18
  • Heart Healthy living i.e. attention to lipid control is less frequent than in the general population ~25% of the patients in Methadone Maintenance Programs use cocaine, which is highly ischemogenic, one or more times a year. (wikipedia.org)
  • If image quality is good and if the apex is visualized, the sensitivity and specificity of abnormal wall motion for diagnosing acute MI exceeds 90%, particularly in patients without previous MI. (medscape.com)
  • Methods: In total, 240 hospitalized patients with acute left heart failure from October 2017 to May 2021 were selected from the Department of Emergency and Critical Care Center of Beijing Anzhen Hospital, Capital Medical University and the Department of Cardiology of the Jilin Provincial People's Hospital. (bvsalud.org)
  • Resuscitative endovascular balloon occlusion of the aorta (REBOA) is a tool to temporarily halt exsanguination in trauma patients with noncompressible torso or pelvic injuries. (openanesthesia.org)
  • REBOA is a novel approach to temporarily stop exsanguination in trauma patients from noncompressible torso or pelvic injuries. (openanesthesia.org)
  • The American Association for the Surgery of Trauma's Aortic Occlusion for Resuscitation in Trauma and Acute Care Surgery (AORTA) registry recently compared the effectiveness of REBOA to open aortic occlusion (AO) in 114 patients across 8 trauma centers. (openanesthesia.org)
  • A sudden increase in afterload may cause left ventricular dilation, increased pulmonary artery pressures, and myocardial ischemia, especially in patients with coronary artery disease. (openanesthesia.org)
  • In addition to central injury in acute cerebrovascular diseases, which can lead to poor prognosis in patients, fluctuations in the properties and functions of local and circulating immune mediators can also trigger the body to enter an immune imbalance state, leading to poor prognosis in some patients after receiving systematic symptomatic support treatment. (ijpsonline.com)
  • In this article, we review the progress in the treatment of acute cerebrovascular disease patients using betahistine hydrochloride combined with atorvastatin. (ijpsonline.com)
  • In almost all patients, AMI is caused by an acute thrombotic coronary occlusion following the rupture of the cap of an atherosclerotic plaque. (bmj.com)
  • Initial stabilization of patients with suspected MI and ongoing acute chest pain should include administration of sublingual nitroglycerin if patients have no contraindications to it. (medscape.com)
  • In the United States, although 18% of ED patients have severely elevated blood pressure at or above 180/110 mmHg upon presentation, 3 far fewer have hypertensive emergency, as previously defined, which occurs in conjunction with acute or impending target organ damage. (nursingcenter.com)
  • Patients are divided into 4 groups Group 1 (Smokers treated by PPCI) Group 2 (Non-smokers treated by PPCI) Group 3 (Smoker treated by pharmaco-invasive strategy) Group 4 (Non-smoker treated by pharmaco-invasive strategy) TIMI flow before and after PCI, acute heart failure and death was assessed in each patient. (researchsquare.com)
  • On the other hands, many patients cannot have PPCI at its optimal time because of geographical or logistical issues. (researchsquare.com)
  • In some patients the pain may resemble the symptoms of acute abdomen (pain begins in the upper abdomen accompanied by nausea). (unboundmedicine.com)
  • Fever was present at the time of presentation in only 8 (32%) patients. (scialert.net)
  • [ 12 ] Consider placing an IABP in patients with cardiogenic shock who have acute mitral regurgitation or a ventricular septal defect, as well as select patients with severe cardiogenic shock when other MCS devices are unavailable. (medscape.com)
  • To determine whether ischemia-reperfusion injury causes this acute-phase response, we studied the temporal relation between plasma levels of CRP and ischemic episodes in 48 patients with unstable angina and 20 control patients with active variant angina, in which severe myocardial ischemia is caused by occlusive coronary artery spasm. (ox.ac.uk)
Tissue11
  • If the blood supply to an organ or a tissue is impaired for a short time (usually less than five minutes) then restored so that blood flow is resumed, and the process repeated two or more times, the cells downstream of the tissue or organ are robustly protected from a final ischemic insult when the blood supply is cut off entirely and permanently. (wikipedia.org)
  • Ischemic injury occurs when the blood supply is insufficient to meet the tissue demand for metabolism. (medscape.com)
  • Neutrophils are the first immune cells that infiltrate the damaged tissue as early as 24 h after injury. (springer.com)
  • We here investigated macrophage lineages and ablated tissue macrophages in homeostasis and after I/R injury in a CSF1R-dependent manner. (elifesciences.org)
  • The process is present during normal myocyte development and is activated in response to cell injury and results in the removal of the injured cell without damaging surrounding tissue. (latestfashiontips.com)
  • If the underlying ischaemia is not sufficiently resolved it can lead to tissue damage, with subsequent cell death. (biomedcentral.com)
  • Cells for vascular therapy must be able to home to ischaemic or damaged tissue and engage in vessel formation alone or in unison with resident vasculature to achieve a controlled and functional reperfusion event, without causing pathological angiogenesis (for example, proliferative retinopathy in the vitreous of the eye). (biomedcentral.com)
  • A cell therapy approach should be aimed at promoting revascularisation of ischaemic tissue. (biomedcentral.com)
  • During myocardial ischemia (lack of blood flow to the muscle tissue of the heart, commonly referred to as a "heart attack"), blood flow is interrupted because of damage to one or more of the coronary blood vessels that irrigate the heart. (prohealth.com)
  • In many cases, damage to heart tissue by reperfusion injury is greater than the damage done by the interruption of blood flow. (prohealth.com)
  • but reperfusion may introduce additional harm to the tissue through a process known as ischemia/reperfusion injury. (cdc.gov)
Inflammation2
  • Nevertheless, its importance in timely resolution of post-ischemic inflammation remains incompletely understood. (springer.com)
  • Thus, development of strategies targeting particular subsets of inflammatory cells and providing well-timed resolution of inflammation may be crucial for proper healing and recovery. (springer.com)
Mechanisms3
  • 2 Paradoxically, reperfusion itself can enlarge the infarct size, by complex mechanisms collectively termed ischemia/reperfusion injury. (dovepress.com)
  • Although myocardial fibrosis is a common pathophysiological process associated with many heart diseases, the molecular mechanisms regulating the development of fibrosis have not been fully determined. (hindawi.com)
  • Many studies have revealed potential mechanisms associated with myocardial fibrosis. (hindawi.com)
Percutaneous1
  • Primary percutaneous coronary intervention (PCI) is the preferred method of reperfusion if this can be performed within recommended time frames. (dovepress.com)
Infarctions occur2
  • More than two thirds of myocardial infarctions occur in lesions that are less than 60% severe. (medscape.com)
  • In the US, about 1.0 million myocardial infarctions occur annually. (msdmanuals.com)
Oxygen5
  • Ischemic preconditioning (IPC) is an experimental technique for producing resistance to the loss of blood supply, and thus oxygen, to tissues of many types. (wikipedia.org)
  • Reperfusion injury and reactive oxygen species: the evolution of a concept. (phypha.ir)
  • A highly toxic aldehyde formed by reactive oxygen species (ROS) is 4-hydroxy-2-nonenal (HNE) through lipid peroxidation following myocardial ischemia/reperfusion (I/R) injury. (lsuhs.edu)
  • Imbalance between the myocardial oxygen need and the availability of oxygen, and consequently myocardial ischaemia may also be caused, in the absence of an acute coronary stenosis (plaque rupture), by tachycardia and bradycardia, coronary spasm, hypotension, anaemia, respiratory insufficiency or other severe disease. (unboundmedicine.com)
  • Ischaemia is characterised by a reduction in oxygen supply to tissues and organs, usually as a result of blood vessel constriction or obstruction. (biomedcentral.com)
Mitochondrial4
  • We tested the hypothesis that 8-Br is also protective under clinically relevant conditions (regional ischaemia) when applied either before ischemia or at the beginning of reperfusion, and this effect is associated with the mitochondrial permeability transition pore (MPTP). (mdpi.com)
  • Time-lapse videography of living cells captures spectacular intracellular mitochondrial movement, and this movement promotes mitochondrial connections to form a dynamic mitochondrial network [ 3 ]. (biomedcentral.com)
  • Therefore, we hypothesize that HNE adduction to AIFm2 mediates mitochondrial stress signaling through translocation of AIFm2 from mitochondria to the nucleus and contributes to the pathogenesis of heart failure following I/R injury. (lsuhs.edu)
  • Apoptotic cell death follows well-defined time-depend-ent processes, which result in changes in the plasma membrane, proteolysis of intracellular proteins, loss of mitochondrial function, and characteristic DNA cleavage. (latestfashiontips.com)
Apoptosis1
  • 11. Hassoun HT, Lie ML, Grigoryev DN, Liu M, Tuder RM, Rabb H. Kidney ischemia-reperfusion injury induces caspase-dependent pulmonary apoptosis. (phypha.ir)
Therapeutic3
  • Therefore, exploring the mechanism of myocardial fibrosis and developing new therapeutic interventions are critical. (hindawi.com)
  • In particular, we focus on the therapeutic potential of endothelial progenitor cells as an exciting new option for the treatment of ischaemic diseases. (biomedcentral.com)
  • Here we review the current literature on scutellarin to provide a comprehensive understanding of the pharmacological activity, mechanism of action, toxicity, and therapeutic potential of scutellarin for the treatment of ischemia, diabetic complications, and other chronic diseases. (cdc.gov)
Kidney injury4
Heart13
  • Protection of the heart against injury from acute ischemia remains challenging for emergency physicians and cardiologists because there are no therapies proven to directly protect the heart against the deleterious effects of ischemia in humans. (mcw.edu)
  • The cAMP analogue 8-Br-cAMP-AM (8-Br) confers marked protection against global ischaemia/reperfusion of isolated perfused heart. (mdpi.com)
  • Then, 3-4 days later inflammatory monocytes are recruited into ischemic area of the heart. (springer.com)
  • 3, 5-diiodothyropropionic acid (DITPA) have evidences of improving effects on I/R in heart through modulation of cellular signaling in response to ischemic stress. (biomedcentral.com)
  • After the end of reperfusion phase mice were sacrificed, blood samples were collected directly from the heart for determination of serum TNF-a, IL-6, urea and Creatinine. (biomedcentral.com)
  • The resistant state of skeletal myoblasts to ischemia renders these cells suitable candidates for repair of chronically infracted and failing heart (5). (escardio.org)
  • Some anesthetic agents are considered to have protective effects to the brain and the heart against ischemic - reperfusion injury. (e-journal.gr)
  • Bovenkamp PR, Brix T, Lindemann F, Holtmeier R, Abdurrachim D, Kuhlmann MT, Strijkers GJ, Stypmann J, Hinrichs KH, Hoerr V. Velocity mapping of the aortic flow at 94 T in healthy mice and mice with induced heart failure using time-resolved three-dimensional phase-contrast MRI (4D PC MRI). (uni-muenster.de)
  • Ischaemia-related diseases such as peripheral artery disease and coronary heart disease constitute a major issue in medicine as they affect millions of individuals each year and represent a considerable economic burden to healthcare systems. (biomedcentral.com)
  • Moreover, it was observed that, PGRN protects the heart against ischemia-reperfusion injury. (biomedcentral.com)
  • Most myocardial infarctions, commonly known as heart attacks, happen in people once they get older, and aging makes it more difficult to recover from this type of injury. (prohealth.com)
  • What Happens During a Heart Attack and Reperfusion Injury? (prohealth.com)
  • Reperfusion injury increases the damage done after events such as heart attacks. (prohealth.com)
Protective1
  • The protective effect of erythropoietin on renal injury induced by abdominal aortic-ischemia-reperfusion in rats. (phypha.ir)
Onset1
  • This group exposed anesthetised open-chest dogs to four periods of 5 minute coronary artery occlusions followed by a 5-minute period of reperfusion before the onset of a 40-minute sustained occlusion of the coronary artery. (wikipedia.org)
Occurs2
  • This is an important feature of apoptotic cell death/removal that occurs during development and cellular injury. (latestfashiontips.com)
  • UA is suggested by angina pain that occurs for the first time and is then experienced with increasing frequency or that is a known symptom of previously diagnosed stable angina which is rapidly worsening (over days - in less than 2 weeks). (unboundmedicine.com)
Arrhythmias1
  • After thrombolytic therapy, reperfusion arrhythmias, such as an accelerated idioventricular rhythm (AIVR), may occur. (medscape.com)
Pulmonary embolism1
  • Better understanding of the mechanism would be helpful as localized hypercoaguability may increase risk of pulmonary embolism or other ischemic strokes. (transcendingsquare.com)
Hemodynamic1
  • Cardiogenic shock is an emergency involving acute hemodynamic instability that necessitates immediate resuscitative therapy before shock irreversibly damages vital organs. (medscape.com)
Tissues5
  • The enhanced lung and renal tissues damages were depended to reperfusion time in both genders. (phypha.ir)
  • Treating such diseases remains difficult and several strategies have been used to stimulate the growth of blood vessels and promote regeneration of ischaemic tissues, such as the use of recombinant proteins and gene therapy. (biomedcentral.com)
  • In vascular medicine, various stem cells and adult progenitors have been highlighted as having a vasoreparative role in ischaemic tissues. (biomedcentral.com)
  • The evaluation of the most suitable timing of cell delivery as well as the number of cells needed to integrate into resident vasculature and promote revascularisation of specific tissues requires careful optimisation and evaluation. (biomedcentral.com)
  • When blood flow is re-established (reperfusion), a series of inflammatory responses take place because of the damage sustained by the tissues affected by the previous lack of blood. (prohealth.com)
Severe1
  • The incidence of acute severe cerebrovascular disease is also increasing year by year with the increasing incidence of cerebrovascular diseases, which is the focus of attention in the medical community. (ijpsonline.com)
Macrophage1
  • Consequently, a greater post-MI monocyte-derived myocardial macrophage infiltration was noted in Hmox1-deficient individuals. (springer.com)
Treatment of acute1
  • Diagnosis and Treatment of Acute Coronary Syndromes: A Review. (nih.gov)
Transient2
  • Once activated, p53 coordinates multiple downstream pathways, thereby maintaining the homeostasis of the host cell or organism (if the stress is mild, transient, and repairable) or eliminating damaged cells (if the stress is acute, prolonged, and difficult to resist). (nature.com)
  • CONCLUSIONS: The normal levels of CRP in variant angina, despite a significantly larger number of ischemic episodes and greater total ischemic burden, and the failure of CRP values to increase in unstable angina indicate that transient myocardial ischemia, within the range of duration observed, does not itself stimulate an appreciable acute-phase response. (ox.ac.uk)
Cellular1
  • Through the first two compounds Hmox1 mitigates cellular injury. (springer.com)
Outcomes1
  • Outcomes are optimized if zone III occlusion times are 30-60 minutes or less. (openanesthesia.org)
Chest pain2
Sham2
  • Eighty male and female rats were assigned into 8 groups, 4 groups in each gender including: sham, renal ischemia for 45min by clamping renal vessels followed by 3, 24 or 48h reperfusion. (phypha.ir)
  • Sham group (n = 6), mice underwent same anesthetic and surgical procedures except for ischemia induction. (biomedcentral.com)
Inflammatory response2
  • Afterwards, however, the hearts of Hmox1-deficient mice undergo adverse late LV remodeling due to overactive and prolonged post-ischemic inflammatory response. (springer.com)
  • Sun W, Wang Z, Sun M, Huang W and Wang Y and Wang Y: Aloin antagonizes stimulated ischemia/reperfusion-induced damage and inflammatory response in cardiomyocytes by activating the Nrf2/HO-1 defense pathway. (spandidos-publications.com)
Reocclusion2