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  • vivo
  • Six compounds showed significant cardio-cytoprotecion and the most effective compound (MMPI-1154) significantly decreased infarct size when applied at 1 μM in an ex vivo model for acute myocardial infarction. (frontiersin.org)
  • By using state-of-the-art technique, intravital imaging, we study the role of adhesion molecules in regulating blood cell-endothelial (platelet and leukocyte) interaction followed by stimulation/ injury in vivo. (uiowa.edu)
  • MAPK
  • San-Huang-Xie-Xin-Tang prevents rat hearts from ischemia/reperfusion-induced apoptosis through eNOS and MAPK pathways," Evidence-Based Complementary and Alternative Medicine , vol. 2011, Article ID 915051, 9 pages, 2011. (hindawi.com)
  • Pathophysiology
  • In this article, the pathophysiology of myocardial lRI and the emerging therapeutic strategies for protecting the heart from its detrimental effects are reviewed. (jci.org)
  • In addition, research projects uses molecular and cellular techniques, combined with genetically modified mice to investigate the role of novel molecules in the pathophysiology of acute ischemic stroke and atherosclerosis. (uiowa.edu)
  • insulin
  • Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: the roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation," Circulation , vol. 105, no. 12, pp. 1497-1502, 2002. (hindawi.com)
  • endogenous
  • In a rabbit model, the administration of ascorbate aggravates damage, likely through the abrogation of the endogenous enzymatic antioxidant response triggered by short episodes of ischemia [ 10 ]. (hindawi.com)
  • mediates
  • Endothelial Cell-Derived von Willebrand Factor Is the Major Determinant That Mediates von Willebrand Factor-Dependent Acute Ischemic Stroke by Promoting Postischemic Thrombo-Inflammation. (uiowa.edu)
  • patients
  • In 39 patients with VES 28 patients (71.8%) were characterized by mental tension and fear during PCI, and 11 cases (28.2%) happened to VES because of reperfusion arrhythmia. (alliedacademies.org)
  • cardiomyopathy
  • Sildenafil treatment significantly increased myocardial PKG activity and significantly reduced myocardial accumulation of CryAB R120G , ubiquitin conjugates, and aberrant protein aggregates in mice with CryAB R120G -based desmin-related cardiomyopathy. (ahajournals.org)
  • diabetic
  • In conclusion, diabetic lungs are more vulnerable to myocardial IR, which are involved in impaired autophagy. (hindawi.com)
  • Approach and Results- The extent of renal injury was evaluated in wild-type (WT), Adamts 13 −/− and Adamts 13 −/− Vwf −/− mice after 26 weeks of streptozotocin-induced diabetic nephropathy. (ahajournals.org)
  • model
  • Materials and Methods: A porcine model of acute liver failure induced by hepatic devascularization was used. (biomedsearch.com)