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  • transmural ischemia
  • From ECG recordings both in a resting state (control recordings) and during percutaneous coronary intervention (PCI)-induced transmural ischemia, we developed a method for quantification of I-US, I-DS, and I-TS that incorporates dynamic. (lu.se)
  • From ECG recordings both in a resting state (control recordings) and during percutaneous coronary intervention (PCI)-induced transmural ischemia, we developed a method for quantification of I-US, I-DS, and I-TS that incorporates dynamic ECG normalization so as to improve the sensitivity in the detection of ischemia-induced changes. (lu.se)
  • These amplitude changes have been primarily described during subendocardial ischemia and ST depres-sions, but they have also been seen with transmural ischemia and ST elevations. (cheapmedicinechest.com)
  • ST segment elevations with straight (horizontal, upsloping or downsloping) or convex ST segment strongly suggest acute transmural ischemia ( Figure 1 A ). Concave ST segment elevations, on the other hand, are much less likely to be caused by ischemia ( Figure 1 B ). This is noted in both North American and European guidelines. (ecgwaves.com)
  • There are plenty of cases of transmural ischemia presenting with concave ST elevations. (ecgwaves.com)
  • Importantly, reciprocal ST segment depressions strongly suggest transmural ischemia. (ecgwaves.com)
  • Acute transmural ischemia located in the basal portions of the lateral wall of the left ventricle (referred to as the posterolateral wall) does not result in ST segment elevations on the conventional 12-lead ECG, simply because none of the leads are able to detect these injury currents. (ecgwaves.com)
  • Similarly, acute transmural ischemia located in the right ventricle is frequently missed when only using the standard leads. (ecgwaves.com)
  • onset
  • We are interested in early (relative to onset of ischemia) depression of conduction velocity, θ, which relates mostly to changes in I Na and in later, more severe depression of θ, which may still be I Na dependent and yet may also involve I Ca(L) . Our investigation focuses on acute ischemia (first 10-15 minutes) before the occurrence of gap junction uncoupling and irreversible cell damage. (ahajournals.org)
  • During the onset of an acute coronary syndrome, an immediate increase in plasma free fatty acid (FFA) concentrations presents the ischaemic underperfused myocardium with a metabolic challenge to its survival. (biomedsearch.com)
  • Hemodynamic measurements and coronary blood flow (85Kr clearance) were obtained before and after the onset of ischemia. (ahajournals.org)
  • injury
  • Despite autophagy plays a significant role in diabetes and pulmonary IR injury, the role of autophagy in ALI secondary to myocardial IR in diabetes remains largely elusive. (hindawi.com)
  • Previous studies indicated that myocardial IR could also cause injury in distant organs, and the lung can be one of the most affected organs [ 5 , 6 ]. (hindawi.com)
  • Further studies suggested that acute lung injury (ALI) induced by myocardial IR in diabetes was more serious than that in nondiabetics [ 7 ]. (hindawi.com)
  • The effects of CHD are usually attributable to the detrimental effects of acute myocardial ischemia-reperfusion injury (IRI). (jci.org)
  • Although the process of myocardial reperfusion continues to improve with more timely and effective reperfusion and with advances in PCI technology and antiplatelet and antithrombotic agents for maintaining the patency of the infarct-related coronary artery, there is still no effective therapy for preventing myocardial reperfusion injury. (jci.org)
  • syndrome
  • Acute coronary syndrome as a possible immune-related adverse event in a lung cancer patient achieving a complete response to anti-PD-1 immune checkpoint antibody. (pneumotox.com)
  • inhibitor
  • Separately, rat myocardial fibroblast was incubated with vehicle ( n = 4), low-dose chymase ( n = 4), high-dose chymase ( n = 4), or high-dose chymase plus chymase inhibitor ( n = 4). (aspetjournals.org)
  • molecular weight 526.60), a specific chymase inhibitor (CM), on a clinically relevant swine model of AMI-R. A 60-min ischemia followed by a 120-min reperfusion was chosen to assess an early effect of chymase inhibition (it is the shorter time point where necrosis can be determined with accuracy and reproducibility) and to allow comparison with previous experiments performed by our group. (aspetjournals.org)
  • detection
  • Due in part to the National Heart Lung and Blood Institute's emphasis on promoting research on rapid detection of the symptoms of acute myocardial ischemia, various types of biosensor designs, including ion-selective optical fibers, wave-guides, nanoparticle fluorescence sensors and ion-selective electrodes, have been used to detect potassium and hydrogen in the blood stream. (medgadget.com)
  • diabetic
  • We aimed to investigate pulmonary autophagy status and its roles in oxidative stress and inflammation reaction in lung tissues from diabetic rats subjected to myocardial IR. (hindawi.com)
  • In conclusion, diabetic lungs are more vulnerable to myocardial IR, which are involved in impaired autophagy. (hindawi.com)
  • Improving autophagy could attenuate ALI induced by myocardial IR in diabetic rats, possibly through inhibiting inflammatory reaction and oxidative stress. (hindawi.com)
  • However, there are little relevant reports concerning the potential mechanism of ALI induced by myocardial IR under diabetic condition. (hindawi.com)
  • During the 1st hour of ischemia in the diabetic group, the end-diastolic pressure rose from 7 +/- 1.1 (mean +/- SE) mm Hg to 23.8 +/- 2.3 without a significant increase of end-diastolic volume. (ahajournals.org)