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LeukemiaLeukemia, LymphoidPrecursor Cell Lymphoblastic Leukemia-LymphomaLeukemia, Myeloid, AcuteLeukemia, Basophilic, AcuteAcute DiseaseLeukemia, Lymphocytic, Chronic, B-CellLeukemia, ExperimentalLeukemia, B-CellBasophilsMyeloid-Lymphoid Leukemia ProteinLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, MyeloidBone MarrowBlast CrisisLeukemia Virus, MurineRemission InductionTumor Cells, CulturedLeukemia, T-CellLeukemia, Monocytic, AcuteLymphocytesMoloney murine leukemia virusReceptors, IgELeukemia, Hairy CellPolymerase Chain ReactionLeukemia L1210Leukemia Virus, BovineLeukemia Virus, FelineGene Expression Regulation, LeukemicLeukemia, Radiation-InducedLeukemia P388CytarabineLeukemia, Biphenotypic, AcuteAnemia, RefractoryAntineoplastic AgentsFriend murine leukemia virusHL-60 CellsLeukemia-Lymphoma, Adult T-CellCell LineMast CellsLeukemia, Megakaryoblastic, AcuteRefractory Period, ElectrophysiologicalTreatment OutcomeFusion Proteins, bcr-ablAKR murine leukemia virusHematologyEncyclopedias as TopicHematologic NeoplasmsTranslocation, GeneticLymphatic SystemChromosome BreakpointsLymphoid Tissue
Anemia with excess blastsCytoplasmNeoplasmsMyeloid leukaemiaHematopoieticLymphoblastic leukemiaPromyelocytic leukemiaChronicBlastsLineageLineagesMyelomonocytic leukaemiaNeutropeniaHaematopoieticRecurrentRadiation therapyDiseaseCellsMalignancyPatientsDiseasesProgressionNeoplasmLymphocyticDifferentiationTissuesLymphomaMyelodysplasticAtypicalLymphomasClassificationTreatmentCellRare
Anemia with excess blasts2
  • MDS with excess blasts ([MDS-EB], previously termed refractory anemia with excess blasts [RAEB] in the 2008 WHO Classification) is a specific MDS entity characterized by increased myeloblasts in the bone marrow and/or blood or the presence of Auer rods. (medscape.com)
  • Reportable disorder s include: MDS, refractory anemia , refractory anemia with excess blasts in transformation, refractory anemia with ring sideroblast s, refractory anemia with excess blasts, chronic myelomonocytic leukemia and acute myeloid leukemia. (symptoma.com)
Cytoplasm4
  • 5-7 Morphologically, BL involves monomorphic medium-sized B cells with basophilic cytoplasm, numerous mitotic figures, rounded nuclei with finely clumped chromatin, myriad apoptosis, and tingible body macrophages, which result in a classic "starry sky" pattern. (cancernetwork.com)
  • These blasts were large with basophilic cytoplasm and no granulation. (cambridgemedicine.org)
  • Histology indicated "ghost cells," which are adipocytes with a central clearing and dark basophilic calcium deposits in the cytoplasm. (bvsalud.org)
  • BL is characterized by monomorphic medium-sized B cells with basophilic cytoplasm and numerous mitotic figures [ 3 , 4 ]. (longdom.org)
Neoplasms1
  • 5 Hematopoietic disruptions in the myeloid lineage can lead to 3 major disease categories: acute myeloid leukemia (AML), myeloproliferative neoplasms (MPN), and myelodysplastic syndrome (MDS). (oncomine.com)
Myeloid leukaemia1
  • Following diagnosis and treatment as pre-B cell acute lymphoblastic leukaemia (pre-B ALL) the patient developed an acute myeloid leukaemia (AML) which was refractory to all available curative therapies. (cambridgemedicine.org)
Hematopoietic3
  • Tumors of the hematopoietic and lymphoid tissues (American English) or tumours of the haematopoietic and lymphoid tissues (British English) are tumors that affect the blood, bone marrow, lymph, and lymphatic system. (wikipedia.org)
  • T-cell depleted allogeneic hematopoietic cell transplants as a platform for adoptive therapy with leukemia selective or virus-specific T-cells. (nih.gov)
  • The natural process of blood cell formation, hematopoietic stem cell differentiation, and generation of myeloid and lymphoid cell lineages. (oncomine.com)
Lymphoblastic leukemia6
  • Acute lymphoblastic leukemia (ALL) is the most common malignancy diagnosed in children, representing more than a quarter of all pediatric cancers. (medscape.com)
  • The image below depicts bone marrow aspirate from a child with T-cell acute lymphoblastic leukemia. (medscape.com)
  • Also, see the Childhood Acute Lymphoblastic Leukemia: Diagnosis, Management, and Complications slideshow to help recognize and treat this disease and its associated complications. (medscape.com)
  • Children with acute lymphoblastic leukemia (ALL) often present with signs and symptoms that reflect bone marrow infiltration and/or extramedullary disease. (medscape.com)
  • See Acute Lymphoblastic Leukemia Staging for more complete information. (medscape.com)
  • Relapsed acute lymphoblastic leukemia: Is it crucial to achieve molecular remission prior to transplant? (nih.gov)
Promyelocytic leukemia1
  • Prompt Initiation of Conventional Chemotherapy to Avoid Early Death in Patients with Newly Diagnosed Acute Promyelocytic Leukemia. (u-tokyo-hemat.com)
Chronic7
  • Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases are myeloid in origin. (wikipedia.org)
  • See Pathology of Myelodysplastic Syndrome With Ring Sideroblasts , Chronic Anemia , Pediatric Chronic Anemia , and Acute Anemia for more detailed information on these topics. (medscape.com)
  • See Chronic Leukemias: 4 Cancers to Differentiate , a Critical Images slideshow, to help detect chronic leukemias and determine the specific type present. (medscape.com)
  • Influence of acute and chronic graft-versus-host disease on relapse and survival after bone marrow transplantation from HLA-identical siblings as treatment of acute and chronic leukemia. (nih.gov)
  • 1,2 The 4 primary disorders of MPNs are chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). (oncomine.com)
  • Characterized by excessive, abnormal white blood cell (granulocyte) production and the presence of the Philadelphia chromosome/BCR-ABL mutation, chronic myeloid leukemia (CML) is a slow-growing cancer of the blood-forming tissue (bone marrow). (oncomine.com)
  • Enlarged spleen is characteristic of chronic myelomonocytic leukemia . (symptoma.com)
Blasts4
  • [ 1 , 2 ] Bone marrow and peripheral blood blast counts are strong prognostic indicators in MDS: Patients with increased blasts at diagnosis have a poorer survival, and an increasing blast count in patients already diagnosed with MDS is often a harbinger of transformation to acute myeloid leukemia ( AML ). (medscape.com)
  • At the end of induction the bone marrow was hypercellular with 6% myeloid blasts by flow cytometry but no excess of lymphoid blasts (Figure 2 ). (cambridgemedicine.org)
  • Two months later the bone marrow aspirate indicated refractory disease with 30-50% blasts and a reduced number of mature myeloid cells and abnormal monocytoid cells. (cambridgemedicine.org)
  • Flow cytometry found 32% myeloid blasts and immature B cells with a similar phenotype to the lymphoid blasts found at diagnosis. (cambridgemedicine.org)
Lineage1
  • Flow cytometry of the bone marrow revealed that the blast cells expressed B lymphoid lineage associated antigens (Figure 1 ) and hence the patient was diagnosed with pre-B ALL. (cambridgemedicine.org)
Lineages1
  • Hematological malignancies may derive from either of the two major blood cell lineages: myeloid and lymphoid cell lines. (wikipedia.org)
Myelomonocytic leukaemia1
  • The peripheral monocytosis leads us to believe that this patient may have transformed via a juvenile myelomonocytic leukaemia (JMML) which subsequently transformed into a refractory AML. (cambridgemedicine.org)
Neutropenia1
  • [ 12 ] is a juvenile multisystem disorder caused by deletions in mitochondrial DNA (mtDNA) and manifested as severe, refractory sideroblastic anemia, neutropenia, vacuolated cells in bone-marrow precursors, exocrine pancreas insufficiency, malabsorption, and growth failure. (medscape.com)
Haematopoietic1
  • CCDC88C-FLT3 gene fusion in CD34-positive haematopoietic stem and multilineage cells in myeloid/lymphoid neoplasm with eosinophilia. (u-tokyo-hemat.com)
Recurrent1
  • Phase I pharmacokinetic and pharmacodynamic study of temozolomide in pediatric patients with refractory or recurrent leukemia: a Children's Oncology Group Study. (nih.gov)
Radiation therapy1
  • Although the incidence of acute nonlymphocytic leukemia is increased in PV, the incidence of acute leukemia in patients not exposed to chemotherapy or radiation therapy is low. (basicmedicalkey.com)
Disease3
  • Because these tissues are all intimately connected through both the circulatory system and the immune system, a disease affecting one will often affect the others as well, making aplasia, myeloproliferation and lymphoproliferation (and thus the leukemias and the lymphomas) closely related and often overlapping problems. (wikipedia.org)
  • The present study aimed to report all the cases of children admitted to our tertiary pediatric hospital with the diagnosis of EN to evaluate the epidemiology, clinical manifestations, etiology, treatment, and the course of this disease in the pediatric age. (bvsalud.org)
  • The etiologic diagnosis of EN was made in 38 children (55.9%): 29 (42.6%) had infection-related EN (in particular EBV and ß-hemolytic streptococcus), 6 (8.8%) had Crohn's disease, 1 celiac disease, 1 Sjogren syndrome, and 1 Hodgkin lymphoma. (bvsalud.org)
Cells3
  • the lymphoid cell line produces B, T, NK and plasma cells. (wikipedia.org)
  • Interestingly, chemotherapy, including hydroxyurea, has been associated with acute leukemia in JAK2 V617F-negative stem cells in some PV patients. (basicmedicalkey.com)
  • Up-regulation of VEGF and its receptor in refractory leukemia cells. (nih.gov)
Malignancy1
  • citation needed] Historically, hematological malignancies have been most commonly divided by whether the malignancy is mainly located in the blood (leukemia) or in lymph nodes (lymphomas). (wikipedia.org)
Patients2
  • Sixty-eight patients with EN were included. (bvsalud.org)
  • In 30 patients (45%), no definitive diagnosis was reached, and they were defined as having idiopathic EN. (bvsalud.org)
Diseases1
  • The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases. (nih.gov)
Progression1
  • During the progression of his wounds, he developed epigastric pain and acute pancreatitis. (bvsalud.org)
Neoplasm3
  • For instance, B-cell chronic lymphocytic leukemia (CLL) and B-cell small lymphocytic lymphoma (SLL) are different manifestations of the same neoplasm, as are lymphoblastic lymphomas and T-cell acute lymphocytic leukemias. (medscape.com)
  • Lymphoplasmacytic lymphoma (LPL) is defined in the WHO Classification of Tumours of Haematopoetic and Lymphoid Tissues, fourth edition, as a small B-cell neoplasm composed of lymphocytes, plasma cells, and plasmacytoid lymphocytes, which does not meet the criteria for any of the other small B-cell lymphomas that may also exhibit plasmacytic differentiation. (paramedicalinfo.com)
  • lymphoplasmacytic lymphoma/ Waldenstrom's macroglobulinemia is an uncommon lymphoid neoplasm, representing approximately 2% of non-Hodgkin's lymphoma cases diagnosed in the United States between 1988 and 2007 according to Surveillance, Epidemiology and End Results (SEER) registry data. (paramedicalinfo.com)
Lymphocytic1
  • Lymphomas, lymphocytic leukemias, and myeloma are from the lymphoid line, while acute and chronic myelogenous leukemia, myelodysplastic syndromes and myeloproliferative diseases are myeloid in origin. (wikipedia.org)
Differentiation1
  • 14. 28-kDa mammalian heat shock protein, a novel subs tra te of a growth regulatory protease involved in differentiation of human leukemia cells. (nih.gov)
Tissues3
  • Tumors of the hematopoietic and lymphoid tissues (American English) or tumours of the haematopoietic and lymphoid tissues (British English) are tumors that affect the blood, bone marrow, lymph, and lymphatic system. (wikipedia.org)
  • Because these tissues are all intimately connected through both the circulatory system and the immune system, a disease affecting one will often affect the others as well, making aplasia, myeloproliferation and lymphoproliferation (and thus the leukemias and the lymphomas) closely related and often overlapping problems. (wikipedia.org)
  • 1] NHL usually originates in the lymphoid tissues and can spread to other organs. (medscape.com)
Lymphoma1
  • Provides a list of recurrent somatic mutations and associated pathways in small B-cell lymphoma/leukemia. (paramedicalinfo.com)
Myelodysplastic1
  • See Pathology of Myelodysplastic Syndrome With Ring Sideroblasts , Chronic Anemia , Pediatric Chronic Anemia , and Acute Anemia for more detailed information on these topics. (medscape.com)
Atypical1
  • However, in some cases acute myeloid leukemia (AML) demonstrates APL-like morphological features such as atypical promyelocytes accumulation. (bvsalud.org)
Lymphomas1
  • citation needed] Historically, hematological malignancies have been most commonly divided by whether the malignancy is mainly located in the blood (leukemia) or in lymph nodes (lymphomas). (wikipedia.org)
Classification1
  • MDS with excess blasts ([MDS-EB], previously termed refractory anemia with excess blasts [RAEB] in the 2008 WHO Classification) is a specific MDS entity characterized by increased myeloblasts in the bone marrow and/or blood or the presence of Auer rods. (medscape.com)
Treatment2
  • 19. treatment of promyelocytic blast crisis of chronic myelogenous leukemia with all tra ns-retinoic acid. (nih.gov)
  • There are no life-threatening causes of pancytopenia that require acute treatment within 24 hours. (wikidoc.org)
Cell3
  • Hematological malignancies may derive from either of the two major blood cell lineages: myeloid and lymphoid cell lines. (wikipedia.org)
  • the lymphoid cell line produces B, T, NK and plasma cells. (wikipedia.org)
  • 3. High-throughput sequencing of T-cell receptor alpha chain clonal rearrangements at the DNA level in lymphoid malignancies. (nih.gov)
Rare1
  • Mixed-phenotype acute leukemia (MPAL), a rare and heterogeneous category of acute leukemia, is characterized by cross-lineage antigen expression. (bvsalud.org)