Acute lung injury. Medical search. Frequent questions

It is often impossible to distinguish TRALI from acute respiratory distress syndrome (ARDS). (wikipedia.org)
Lung injury (LI) is commonly involved in 15%~60% of severe AP, and severe LI is likely to trigger acute respiratory distress syndrome (ARDS) and respiratory failure (RF). (hindawi.com)
Acute lung injury (ALI) comprises acute respiratory distress syndrome (ARDS), a grave and deadly form of acute lung injury, and other minor degrees of lung injuries. (sbwire.com)
Acute respiratory distress syndrome (ARDS) is a life-threatening, high mortality pulmonary condition characterized by acute lung injury (ALI) resulting in diffuse alveolar damage. (lu.se)
Experimental models of ALI/ARDS use different methods of injury to acutely induce lung damage in both small and large animals. (lu.se)
Therefore, semi-quantitative histological scoring systems designed to evaluate tissue-level injury in large animal models of ALI/ARDS are needed. (lu.se)
Prone position has been used to treat severe hypoxemia in patients with acute respiratory distress syndrome (ARDS) since the 1970s. (springer.com)
BACKGROUND: Multiple pharmacologic treatments have been studied for acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). (soton.ac.uk)
4] Zhou M. Acute lung injury and ARDS in acute pancreatitis: mechanisms and potential intervention. (signavitae.com)
If pathological changes were not timely curbed, acute respiratory distress syndrome (ARDS) could be developed [ 8 - 10 ] . (researchsquare.com)
The indications of HBO for the treatment of lung diseases include pulmonary edema, ARDS, etc., and the earlier the treatment is implemented, the better results will be achieved. (researchsquare.com)
Acute lung injury (ALI) can cause acute respiratory distress syndrome (ARDS), a lethal condition with limited treatment options and currently a common global cause of death due to COVID-19. (jci.org)
Acute respiratory distress syndrome (ARDS) is a life-threatening lung condition that prevents enough oxygen from getting to the lungs and into the blood. (medlineplus.gov)
ARDS can be caused by any major direct or indirect injury to the lung. (medlineplus.gov)
Acute lung injury (ALI) and its most severe form, acute respiratory distress syndrome (ARDS), cause severe endothelial dysfunction in the lung , and vascular endothelial growth factor ( VEGF ) is elevated in ARDS. (bvsalud.org)
CONTEXT: Trials comparing higher vs lower levels of positive end-expiratory pressure (PEEP) in adults with acute lung injury or acute respiratory distress syndrome (ARDS) have been underpowered to detect small but potentially important effects on mortality or to explore subgroup differences. (mcmaster.ca)
OBJECTIVES: To evaluate the association of higher vs lower PEEP with patient-important outcomes in adults with acute lung injury or ARDS who are receiving ventilation with low tidal volumes and to investigate whether these associations differ across prespecified subgroups. (mcmaster.ca)
STUDY SELECTION: Two reviewers independently screened articles to identify studies randomly assigning adults with acute lung injury or ARDS to treatment with higher vs lower PEEP (with low tidal volume ventilation) and also reporting mortality. (mcmaster.ca)
2.5 - severe lung injury ( ARDS - Acute respiratory distress syndrome ). (thecalculator.co)
Likewise, the lack of any therapeutic treatment for the most devastating clinical course of pulmonary infection, Acute Respiratory Distress Syndrome (ARDS), and an unacceptably high mortality rate, underscore an urgent need for novel, effective therapeutic approaches. (dzl.de)
Oxygen therapy was initiated, which had a favorable evolution and complete resolution of bilateral pulmonary infiltrates within 48 h from the onset of symptoms, without requiring mechanical ventilation ( Fig. 1 D). Having excluded other possible causes of ARDS, the diagnosis of acute lung injury secondary to transfusion or TRALI syndrome was made. (journalpulmonology.org)
The pathogenesis of organ injury, including acute respiratory distress syndrome (ARDS), includes the liberation of endogenous molecular structures called "danger-associated molecular patterns" that are associated with inflammation and tissue injury. (silverchair.com)
In patients with acute respiratory distress syndrome (ARDS), the lung comprises areas of aeration and areas of alveolar collapse, the latter producing intrapulmonary shunt and hypoxemia. (biomedcentral.com)

Of note, recent study identified that miR-127 expression was aberrant in the inflammation-related pulmonary disorders [ 36 ] and further revealed that enhanced expression of miR-127 could promote the development of inflammatory macrophages and contribute to the exaggerated lung inflammation and injury [ 37 ]. (hindawi.com)
and Zhang M, Wang L, Dong M, Li Z and Jin F: Endothelial semaphorin 7A promotes inflammation in seawater aspiration-induced acute lung injury. (spandidos-publications.com)
Chen X, Wang H, Jia K, Wang H and Ren T: [Retracted] Anti‑Semaphorin‑7A single chain antibody demonstrates beneficial effects on pulmonary inflammation during acute lung injury. (spandidos-publications.com)
In this model, we demonstrate that inhibitors of PTP1B, a protein tyrosine phosphatase that regulates signaling pathways of fundamental importance to homeostasis and inflammation, prevented lung injury and increased survival. (jci.org)
Notably, dipyridamole-dependent attenuation of lung inflammation was abolished in mice with alveolar epithelial Adora2b gene deletion. (ozgene.com)
This may involve medicines to treat infections, reduce inflammation, and remove fluid from the lungs. (medlineplus.gov)
Extracellular deoxyribonucleic acid (DNA) forms neutrophil extracellular traps (NET), which act like a danger-associated molecular pattern in that they are associated with inflammation and tissue injury. (silverchair.com)
Acute lung injury (ALI) is a common clinical manifestation of COVID-19, and this mainly manifests through lung inflammation and epithelial cell damage. (xiahepublishing.com)
Acute lung injury (ALI) induces inflammation that disrupts the normal alveolar-capillary endothelial barrier which impairs gas exchange to induce hypoxemia that reflexively increases respiration. (unmc.edu)
Molecular markers of acute upper airway inflammation in workers exposed to fuel-oil ash. (cdc.gov)

Transfusion-related acute lung injury (TRALI) is the serious complication of transfusion of blood products that is characterized by the rapid onset of excess fluid in the lungs. (wikipedia.org)
Objective: Acute lung injury (ALI) is a well known complication following the transfusion of blood products and is commonly referred to as transfusion-related acute lung injury (TRALI). (mednemo.it)
This syndrome known as transfusion-related acute lung injury (TRALI), is considered the most common and serious complication associated with the transfusion of blood products. (mednemo.it)
The lack of a consensus definition of TRALI contributed to its under-recognition as a cause of lung injury. (mednemo.it)
A definition emerged from the TRALI consensus conference in 2004 and from the US National Heart, Lung, and Blood Institute. (mednemo.it)
Transfusion-related acute lung injury (TRALI) is one of the most serious blood transfusion complications. (journalpulmonology.org)

A total of 1113 King County residents undergoing mechanical ventilation met the criteria for acute lung injury and were 15 years of age or older. (nih.gov)
Although there was no significant difference in the primary outcome of 60-day mortality, the conservative strategy of fluid management improved lung function and shortened the duration of mechanical ventilation and intensive care without increasing nonpulmonary-organ failures. (nih.gov)
Ongoing research in the area of fluid conservation and lung-protective ventilation strategies have demonstrated improvements in survival rate of patients. (sbwire.com)
This leads to stiffening of the lungs and eventually triggering mismatch in ventilation-perfusion. (sbwire.com)
Prone position ventilation is a widely used lung protection ventilation strategy. (springer.com)
Due to the precise mechanism of improving oxygenation function, development of pediatric prone ventilation technology has been largely focused on children with acute respiratory distress syndrome. (springer.com)
The purpose of this study is to evaluate the feasibility and effectiveness of prone position ventilation in infants who develop postoperative acute lung injury after surgery for congenital heart disease. (springer.com)
A single-center, randomized controlled trial of pediatric patients with acute lung injury after surgery for congenital heart disease who will receive prone position ventilation or usual care (control group). (springer.com)
This study will investigate the feasibility and effectiveness of prone position ventilation techniques in children who develop postoperative acute lung injury after surgery for congenital heart disease. (springer.com)
Prone position ventilation refers to placement of the patient in the prone position during mechanical ventilation to facilitate lung expansion in the atelectatic area and improve the ventilation-perfusion ratio. (springer.com)
Prone position ventilation promotes lung recruitment and improves gas exchange through its effects on pleural pressure and lung compression [ 2 ]. (springer.com)
Prone position ventilation can reduce the difference between the dorsal and ventral pleural pressure, thereby improving the uniformity of lung ventilation and reducing alveolar hyperinflation and alveolar collapse. (springer.com)
Marini, JJ 1993, ' Pressure-targeted mechanical ventilation of acute lung injury ', Seminars in Respiratory Medicine , vol. 14, no. 4, pp. 262-269. (umn.edu)
This Murray score for Acute Lung Injury calculator assesses the need for extracorporeal membrane oxygenation (EMCO) instead of ventilation in severe acute respiratory failure. (thecalculator.co)
Acute respiratory failure is currently treated through ventilation techniques and treatments with steroids, bronchoscopy or nitric oxide. (thecalculator.co)
Mechanical ventilation practice has changed over the past few decades, with tidal volumes (VT) decreasing significantly, especially in patients with acute lung injury (ALI). (elsevierpure.com)
The purpose of this study was to investigate the role of the chemoreflex in mediating abnormal ventilation during acute (early) and recovery (late) stages of ALI. (unmc.edu)
Mechanical ventilation is indispensable for the survival of patients with acute lung injury and acute respiratory distress syndrome. (biomedcentral.com)
As in the adult with acute lung injury and acute respiratory distress syndrome, the use of lung-protective ventilation has improved outcomes for neonatal lung diseases. (biomedcentral.com)
Current protective lung ventilation strategies commonly involve hypercapnia. (biomedcentral.com)

Other contributory factors which are likely to lead to acute lung injury comprise pneumonia, sepsis, major trauma, and inhalation of noxious fumes. (sbwire.com)
Considering that dysregulated activation of neutrophils has been implicated in sepsis and causes collateral tissue damage, we demonstrate that PTP1B inhibitors improved survival and ameliorated lung injury in an LPS-induced sepsis model and improved survival in the cecal ligation and puncture-induced (CLP-induced) sepsis model. (jci.org)
Background: Pre-B-cell colony-enhancing factor (PBEF) is a potential biomarker for acute lung injury (ALI) in sepsis. (elsevierpure.com)
Elevated PBEF levels significantly correlated with higher APACHE (Acute Physiology and Chronic Health Evaluation) III scores (R2 = 0.08, P = .003) and failure to reach early sepsis goals within 6 h of severe sepsis (P = .003). (elsevierpure.com)
Conclusions: In this study, elevated PBEF did not correlate with lung injury in sepsis. (elsevierpure.com)
Lee, KA & Gong, MN 2011, ' Pre-B-cell colony-enhancing factor and its clinical correlates with acute lung injury and sepsis ', Chest , vol. 140, no. 2, pp. 382-390. (elsevierpure.com)

Pathogenesis of the condition is explained by injuries to both the alveolar and endothelium epithelium. (sbwire.com)
Initial pathological changes that could be noted were alveolar internal homorrhage, atelectasis, edema and parenchymatous degeneration, which could be reversible at early stage and within 12-24 hours after injury they could be progressive. (researchsquare.com)
Our newly identified crosstalk pathway between ENT2 and alveolar epithelial Adora2b in lung protection during ALI opens possibilities for combined therapies targeted to this protein set. (ozgene.com)
Acute lung injury (ALI) is an important cause of mortality in critically ill patients and is associated with alveolar oedema. (bmj.com)
In normal lung, sst2A was expressed by alveolar macrophages, epithelial bronchial cells, arterial and bronchial smooth muscle cells, some endothelial cells and some type 2 pneumocytes (inset). (bmj.com)
Acute exposure to higher vapor concentrations may cause severe pulmonary edema and injury to the alveolar walls of the lung and death. (cdc.gov)

Acute pancreatitis (AP) is a life-threatening inflammatory disease characterized by significant morbidity and mortality [ 1 - 3 ]. (hindawi.com)
Acute lung injury, a common condition characterized by acute severe hypoxia without evidence of hydrostatic pulmonary edema, remains a key source of mortality and morbidity in critically ill patients. (sbwire.com)
Acute lung injury (ALI) remains an important cause of illness and mortality among the critically ill patient population. (sbwire.com)
2 - 5 In patients with combined injury, the lung is the critical organ and the progressive respiratory failure associated with pulmonary edema is a pivotal determinant of mortality. (mhmedical.com)
Acute lower respiratory tract infections represent an increasing public health problem worldwide, resulting in a disease burden greater than that of any other infection with mortality rates unchanged over the past 50 years. (dzl.de)
Allergic reactions The most common complications of transfusion are Febrile nonhemolytic reactions Chill-rigor reactions The most serious complications, which have very high mortality rates, are Acute hemolytic. (msdmanuals.com)

Adhikari, Neill K.J. , Burns, Karen E.A. , Meade, Maureen O. and Ratnapalan, Mohana (2004) Pharmacologic therapies for adults with acute lung injury and acute respiratory distress syndrome. (soton.ac.uk)

Here, microRNA-127 (miR-127) is one of the miRNAs that focuses on lung diseases [ 31 - 33 ]. (hindawi.com)
Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990-2017: a systematic analysis for the global burden of disease study 2017. (signavitae.com)
3] Steer ML. Relationship between pancreatitis and lung diseases. (signavitae.com)
The main features of acute lung injury (ALI) are acute, progressive respiratory failure and hypoxemia, which are typical clinical manifestations of thoracic diseases. (xiahepublishing.com)
IL-1beta is one of a family of proinflammatory cytokines thought to be involved in many acute and chronic diseases. (ox.ac.uk)

We report a patient with chronic GBL abuse who presented with a high anion gap metabolic acidosis and acute lung injury (ALI), a clinical syndrome that has not been described before. (njmonline.nl)
NIV has gained the dignity of first line intervention for acute exacerbation of chronic obstructive pulmonary dise. (biomedcentral.com)
Transient expression of IL-1beta induces acute lung injury and chronic repair leading to pulmonary fibrosis. (ox.ac.uk)

Acute lung injury is a critical illness syndrome consisting of acute hypoxemic respiratory failure with bilateral pulmonary infiltrates that are not attributed to left atrial hypertension. (nih.gov)

Acute transfusion reactions present as adverse signs or symptoms during or within 24 hours of a blood transfusion. (medscape.com)
The onset of red urine during or shortly after a blood transfusion may represent hemoglobinuria (indicating an acute hemolytic reaction) or hematuria (indicating bleeding in the lower urinary tract). (medscape.com)
Acute transfusion reactions may present in complex clinical situations when the diagnosis requires distinguishing between a reaction to the transfused blood product and a coincidental complication of the illness being treated that occurs during or immediately after a blood transfusion. (medscape.com)
The prevalence of an acute hemolytic reaction from a blood transfusion is approximately 1 in 70,000 transfusions . (healthline.com)

Pulmonary endothelial cell -specific (EC-specific) overexpression of miR-1 protected the lung against cell death and barrier dysfunction in both murine and human models and increased the survival of mice after pneumonia -induced ALI. (bvsalud.org)
Lung inflammatory reaction and oxidative stress are promoted in the initiation of radiation-induced pneumonia. (biomedcentral.com)

HRS and HBO could all decrease the release of immflammatory cytokines in lung tissue, reduce accumulation of oxidative products and alleviate apoptosis of pulmoanry cells, and could produce good therapeutic effects on ALI induced by LPS. (researchsquare.com)
These findings illustrate a previously unknown role of miR-1 as a cytoprotective orchestrator of endothelial responses to acute injury with prognostic and therapeutic potential. (bvsalud.org)
Based on this knowledge, new therapeutic concepts are being developed to attenuate lung tissue damage and promote tissue repair and organ regeneration. (dzl.de)
Stephen M. Black (above) and a team of researchers have uncovered a new therapeutic target for treating acute lung injury. (stephenmblack.com)
A Novel Therapeutic Approach in Acute Respiratory Distress Syndrome? (silverchair.com)
The purposes of this communication are to call attention to this seldom considered mechanism for extending lung injury that might further justify implementation of low tidal volume/high positive end-expiratory pressure ventilatory strategies for lung protection and to suggest additional therapeutic measures implied by this broadened conceptual paradigm. (healthpartners.com)
After the administration of QFPD treatment in LPS-induced ALI mice, the therapeutic effect was evaluated through the H&E staining of lung tissues and the level of inflammatory factors in vivo . (xiahepublishing.com)
Especially, pulmonary administration of PSLipos-L-NAC could significantly reduce the inflammatory response of M1-like macrophages in lung tissue and promote lung injury repair in a bleomycin-induced acute lung injury (ALI) mouse model, providing a potential therapeutic approach for ALI. (biomedcentral.com)

Additionally, the incorporation of other clinical support devices such as MV and ECMO in large animal models can lead to further lung damage and appearance of features absent in the small animal models. (lu.se)
To investigate the effects of hydrogen-rich saline (HRS) combined with hyperbaric oxygen (HBO) on acute lung injury (ALI) and its clinical significance. (researchsquare.com)
OBJECTIVE: To describe the clinical implications of an often neglected mechanism through which localized acute lung injury may be propagated and intensified. (healthpartners.com)
Retrospective clinical studies, however, suggest that the use of large VT favors the development of lung injury in these patients. (elsevierpure.com)
This is the first edition of this document for novel coronavirus, an adaption of WHO Clinical management of severe acute respiratory infection when MERS-CoV infection is suspected publication (2019). (who.int)
Clinical profile of gas leak victims in acute phase after Bhopal episode. (cdc.gov)

It includes acute respiratory failure owing to progressive hypoxemia, diffuse bilateral pulmonary infiltration, and reduced lung compliance. (sbwire.com)
Pediatric acute lung injury (PALI) is a common complication of congenital heart disease that presents with refractory hypoxemia. (springer.com)
In the supine position, both heart and diaphragm compression may aggravate the collapse of the gravity-dependent area of the lung and worsen hypoxemia and ventilator-related lung injury [ 8 ]. (springer.com)

Despite recent advances in our understanding of the mechanism and treatment of acute lung injury, its incidence and outcomes in the United States have been unclear. (nih.gov)
Potential treatment methods such as statin therapy and nutritional strategies are also expected to gain more focus from research bodies operating in the area of treatment of acute lung injury. (sbwire.com)
Guidelines for the diagnosis and treatment of acute lung injury/acute respiratory distress syndrome (2006). (signavitae.com)

We conducted a prospective, population-based, cohort study in 21 hospitals in and around King County, Washington, from April 1999 through July 2000, using a validated screening protocol to identify patients who met the consensus criteria for acute lung injury. (nih.gov)
Optimal fluid management in patients with acute lung injury is unknown. (nih.gov)
In a randomized study, we compared a conservative and a liberal strategy of fluid management using explicit protocols applied for seven days in 1000 patients with acute lung injury. (nih.gov)
These results support the use of a conservative strategy of fluid management in patients with acute lung injury. (nih.gov)
The aim of this study was to determine the expression of microRNA-127 (miR-127) in both rat models and patients of acute pancreatitis (AP) with lung injury (LI). (hindawi.com)
In this study, we sought to determine the expressions of miR-127 in the lung tissues of sodium taurocholate-induced AP models in rats and that in plasma of AP patients and to preliminarily explore the association of miR-217 levels and LI. (hindawi.com)
It has been observed that even in patients who survive acute lung injury, the quality of life is adversely affected in the long term. (sbwire.com)
The hydrostatic pressure however remains unaffected in the patients suffering with acute lung injury (ALI). (sbwire.com)
To develop an XGBoost model to predict the occurrence of acute lung injury (ALI) in patients with acute pancreatitis (AP). (signavitae.com)
The age and laboratory tests of patients with AP combined with ALI differed from those of patients without combined acute lung injury. (signavitae.com)
Lung injury is one of the most serious injuries that are difficult to handle and is a leading cause of death in patients with thoracic trauma [ 1 , 2 ] . (researchsquare.com)
13 Here a ship exploded in a harbor and set off a chain of explosions and fires among some 50 refineries and chemical plants, resulting in over 2,000 hospital admissions of patients with smoke inhalation alone, those with burn injuries, many of whom who had simultaneously inhaled smoke as well. (mhmedical.com)
A summary of their study recently appeared in The Journal of Biological Chemistry , where they noted that a bacterial infection can throw off the equilibrium of two key proteins in the lungs and also put patients at risk of a highly lethal acute lung injury (ALI). (stephenmblack.com)
IgA deficient patients with antibodies against IgA are at greater risk of developing severe hypersensitivity and anaphylactic reactions Epinephrine should be available immediately to treat any acute severe hypersensitivity reactions. (nih.gov)
Monitor renal function, including blood urea nitrogen and serum creatinine, and urine output in patients at risk of developing acute renal failure. (nih.gov)
Figure 1 Effect of intravenous infusion of salbutamol on PiCCO permeability index in patients with acute respiratory distress syndrome. (bmj.com)
What tidal volumes should be used in patients without acute lung injury? (elsevierpure.com)
Patients without acute lung injury are still ventilated with large-and perhaps too large-VT. (elsevierpure.com)
Assuming that this will be the case in patients without ALI/acute respiratory distress syndrome too, the authors suggest that the use of lower VT should be considered in all mechanically ventilated patients whether they have ALI or not. (elsevierpure.com)
Dive into the research topics of 'What tidal volumes should be used in patients without acute lung injury? (elsevierpure.com)
By allowing patients with the acute respiratory distress sy. (biomedcentral.com)
This document is intended for clinicians taking care of hospitalised adult and paediatric patients with severe acute respiratory infection (SARI) when 2019-nCoV infection is suspected. (who.int)

To date, methods available at the bedside for estimating the physiologic correlate of pulmonary edema, extravascular lung water, often are unreliable or require invasive measurements. (csem.ch)
Interest in salbutamol therapy in ALI came after a ranodmised controlled trial showed that 7 days' treatment with intravenous salbutamol reduced extravascular lung water in ALI. (bmj.com)
The permeability index was derived from the ratio of extravascular lung water divided by pulmonary blood volume, as measured by the PiCCO system. (bmj.com)

Secondary end points included the number of ventilator-free days and organ-failure-free days and measures of lung physiology. (nih.gov)
A ventilator is used to deliver high doses of oxygen and positive pressure to the damaged lungs. (medlineplus.gov)
The CESAR study is a multicentre randomized controlled trial that aims to reveal the differences in terms of efficacy of treatment and costs between conventional ventilator support and extracorporeal membrane oxygenation for severe lung failure. (thecalculator.co)
They used a double-hit model of intratracheal lipopolysaccharide challenge followed by ventilator-induced lung injury (VILI). (silverchair.com)
Studies of ventilator-associated lung injury in subjects without ALI demonstrate inconsistent results. (elsevierpure.com)

Pulmonary disease changes the physiology of the lungs, which manifests as changes in respiratory mechanics. (biomedcentral.com)

As augmented vascular leakage is a principal occurrence in the acute lung injury and thus, therapies are being targeted towards decreasing the leakage. (sbwire.com)

Rapid development of severe acute respiratory distress syndrome after abatacept treatment in a patient with rheumatoid arthritis. (pneumotox.com)
a history of travel to or residence in the city of Wuhan, Hubei Province, China in the 14 days prior to symptom onset, or · patient is a health care worker who has been working in an environment where severe acute respiratory infections of unknown etiology are being cared for. (who.int)

However, the pathophysiology of acute and post-acute manifestations of COVID-19 (long COVID-19) is understudied. (nature.com)
At any rate these two disasters led to the establishments of centers for the care of burn victims and to research into the pathophysiology of burn injury. (mhmedical.com)

Acute lung injury is a part of the systemic inflammatory process where the lung demonstrates symptoms similar to other tissues such as extravascation of protein rich fluid, destruction in capillary endothelium, and interstitial edema. (sbwire.com)
MicroRNA-1 protects the endothelium in acute lung injury. (bvsalud.org)
We found that the levels of a VEGF -regulated microRNA , microRNA -1 (miR-1), were reduced in the lung endothelium after acute injury . (bvsalud.org)

Is MicroRNA-127 a Novel Biomarker for Acute Pancreatitis with Lung Injury? (hindawi.com)

OLV improves surgical exposure and operative conditions during a variety of procedures in the thorax, including lung resections, esophageal surgery, and procedures involving access to the thoracic aorta and the sympathetic chain. (medscape.com)

Excess release and over-expression of immflammatory mediators and related immflammatory cytokines could stimulate excess immflammatory reaction, resulting in damage to alvelar-cappilary membrane and increased vascular permeability and ultimately acute lung injury (ALI) [ 5 - 7 ] . (researchsquare.com)
This reaction may occur when donor plasma contains antibodies that cause damage to the immune cells in the lungs. (healthline.com)
Because fever and chills also herald a severe hemolytic transfusion reaction, all febrile reactions must be investigated as for acute hemolytic transfusion reaction, as with any transfusion reaction. (msdmanuals.com)
About 20 people die yearly in the US as a result of acute hemolytic transfusion reaction. (msdmanuals.com)
ABO incompatibility is the most common cause of acute hemolytic transfusion reaction. (msdmanuals.com)

Both microbial attack (bacteria, viruses, fungi) and non-microbial inflammatory injury (aspiration, inhalation of toxic gases) may cause Acute Lung Injury (ALI) with severe respiratory failure. (dzl.de)

The radiation-induced lung injury is a common complication from radiotherapy in lung cancer. (biomedcentral.com)

Softer PSLipos-L-NAC could resist macrophage capture, but remarkably prolong their targeting effect period on macrophages via durable binding to macrophage surface, and subsequently more effectively suppress inflammatory response in macrophages and then hasten inflammatory lung epithelial cell wound healing. (biomedcentral.com)

Scores equal to or above 3 (≥2.5 if rapid deterioration) are part of the criteria used in the referral to extracorporeal membrane oxygenation in acute lung injury. (thecalculator.co)

3 days later, we study lung pathological, the levels of inflammatory factors, and cell apoptosis in the pulmonary tissue was detected by Tunel and cell apoptosis rate was calculated accordingly. (researchsquare.com)
In our experiment, adult SD rat model of acute lung injury was established by injecting lipopolysaccharide (LPS) into treachea, and life signs and dry-wet ratio of pulmonary tissue were closely observed. (researchsquare.com)
The high expression of IL-1beta in the first week after injection was accompanied by local increase of the proinflammatory cytokines IL-6 and TNF-alpha and a vigorous acute inflammatory tissue response with evidence of tissue injury. (ox.ac.uk)
This was associated with severe progressive tissue fibrosis in the lung, as shown by the presence of myofibroblasts, fibroblast foci, and significant extracellular accumulations of collagen and fibronectin. (ox.ac.uk)
These data directly demonstrate how acute tissue injury in the lung, initiated by a highly proinflammatory cytokine, IL-1beta, converts to progressive fibrotic changes. (ox.ac.uk)

Diuresis or fluid restriction may improve lung function but could jeopardize extrapulmonary-organ perfusion. (nih.gov)
The fluid buildup also makes the lungs heavy and stiff. (medlineplus.gov)
Listening to the chest with a stethoscope ( auscultation ) reveals abnormal breath sounds, such as crackles, which may be signs of fluid in the lungs. (medlineplus.gov)
This lung damage results in fluid buildup in the lungs and can severely limit the ability of the lungs to supply oxygen to the body. (healthline.com)
The profibrotic cytokines PDGF and TGF-beta1 were increased in lung fluid samples 1 week after peak expression of IL-1beta. (ox.ac.uk)

However, excessive tidal volumes and inadequate lung recruitment may contrib. (biomedcentral.com)

[7-10] Acute respiratory distress immediately after the transfusion of blood and/or blood products has been increasingly recognized over the past two decades. (mednemo.it)
CONCLUSIONS: The diffuse injury that characterizes acute respiratory distress syndrome is often considered a process that begins synchronously throughout the lung, mediated by inhaled or blood-borne noxious agents. (healthpartners.com)
Acute Respiratory Distress Syndrome - Can Data from the Sick Guide Care for the Healthy? (upenn.edu)
Thereby, it may inhibit the progression of acute respiratory distress syndrome. (genomediscovery.org)

One meta-analysis demonstrated faster and more stable positioning with the use of a DLT, whereas use of BBs resulted in less postoperative sore throat and hoarseness and fewer airway injuries. (medscape.com)
Relatively little attention has been paid to possibility that inflammatory lung injury may also begin focally and propagate sequentially via the airway network, proceeding mouth-ward from distal to proximal. (healthpartners.com)
For these short fibers, which can be fully engulfed by lung cells and do not dissolve in airway fluids in less than a few weeks, their clearance will be similar to other mineral and vitreous particles. (cdc.gov)

1 investigated the role of NETs in the pathogenesis of acute lung injury in mice. (silverchair.com)
Hence, the authors propose that NETs do not contribute functionally to the pathogenesis of lung injury in this animal model. (silverchair.com)

Those who live often get back most of their normal lung function, but many people have permanent (usually mild) lung damage. (medlineplus.gov)

During the cascade events of activation of proinflammatory cytokines and mediators in AP, the injured cells of the lungs recruit immune cells and release cytokines, chemokines, growth factors, and prostaglandins, contributing to acute inflammatory response [ 4 - 7 ]. (hindawi.com)
1 - 3 During the outbreak of the 2019 novel coronavirus disease (COVID-19), SARS-CoV-2 infection induced the excessive activation of immune cells in the body's lungs, 4 , 5 and this led to the development of ALI. (xiahepublishing.com)

SARS-CoV-2 infection primarily affects the pulmonary system, but accumulating evidence suggests that it also affects the pan-vasculature in the extrapulmonary systems by directly (via virus infection) or indirectly (via cytokine storm), causing endothelial dysfunction (endotheliitis, endothelialitis and endotheliopathy) and multi-organ injury. (nature.com)
It is also indicated to protect the uninvolved lung in the setting of pulmonary hemorrhage or infection, during one-lung lavage, or in the setting of a bronchopleural fistula. (medscape.com)

1] GBD 2017 Disease and Injury Incidence and Prevalence Collaborators. (signavitae.com)

CpG ODN may reduce the injury of reactive oxygen species and adjust the serum TNF-α concentration in the mice after irradiation, which reduces the generation of the inflammatory cytokines. (biomedcentral.com)

Faron Pharmaceuticals, Ltd. is at present engaged in the development of pharmacological treatments for acute lung injury with the help of a consortium consisting European Commission, Traumakine program (University College London Hospital (UCLH) and University of Torino and University of Turku). (sbwire.com)

Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: a troublesome trio for acute pancreatitis. (signavitae.com)

Unstable Inflation Causing Injury: Insight from Prone Position and Paired CT Scans. (upenn.edu)

Anatomy16

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Analytical, Diagnostic and Therapeutic Techniques and Equipment60

Phenomena and Processes30

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