• Autoimmune diseases may cause your body to attack and damage your liver cells. (drugs.com)
  • Heart failure, heat stroke, and blood vessel diseases such as Budd-Chiari syndrome, can also cause acute liver failure. (drugs.com)
  • H. Malhi and G. J. Gores, "Apoptosis: Mechanisms and Relevance in Liver Diseases," http://www.gastrohep.com/theliver/Apoptosis_chapter.pdf . (hindawi.com)
  • Comparisons were made with a historical control group of 17 ALF patients treated from 2000 to 2001 in the same intensive care unit (ICU) specializing in liver diseases. (nih.gov)
  • Acute liver failure from paracetamol poisoning occurs rapidly and patients can progress to deep coma and severe multiple organ failure within hours. (kcl.ac.uk)
  • The new model was externally validated against data from 412 patients with paracetamol-induced acute liver failure managed at intensive care units in the UK (London, Birmingham, and Edinburgh) and Denmark (Copenhagen), and showed excellent accuracy. (kcl.ac.uk)
  • This better reflects the real world of acute emergency care for paracetamol-induced acute liver failure. (kcl.ac.uk)
  • In view of the pleiotropic functions of critical mediators of cell death and tissue regeneration, a particular challenge will be to reduce hepatocellular death without inhibiting the regenerative capacity of the liver. (frontiersin.org)
  • Acute liver failure in adults: Etiology, clinical manifestations and diagnosis. (mayoclinic.org)
  • Indeterminate or unknown etiology of acute liver failure is established after a careful history and a series of diagnostic blood tests are still unable to identify a clear cause for the serious liver injury," Daniel R. Ganger , MD, from the Northwestern University Feinberg School of Medicine in Chicago, told Healio Gastroenterology and Liver Disease . (healio.com)
  • We found that indeterminate etiology of acute liver failure is less common in the U.S. than previously thought at 5.5% of all cases," Ganger said. (healio.com)
  • An ultrasound, abdominal computerized tomography (CT) or magnetic resonance imaging (MRI) scan to look at the liver and blood vessels may be ordered. (virginiamason.org)
  • A 48-year-old female with abdominal pain and malaise who showed delayed symptom of acute gastroenteritis came to see us. (nih.gov)
  • Abdominal ultrasound may show fat deposition in the liver, but, as the hallmark of this condition is microvesicular steatosis (see pathology below), this is not seen on ultrasound. (wikipedia.org)
  • On the one hand, massive hepatocyte cell death triggers immune cell activation and recruitment to the liver, which can stimulate immune-mediated liver damage. (bmj.com)
  • The diagnosis can be made by a frozen-section (as opposed to a specimen in formalin) that is stained with the Oil red O stain, that shows microvesicular steatosis (or small collections of fat within the liver cells). (wikipedia.org)
  • miR-15b and miR-16 regulate TNF mediated hepatocyte apoptosis via BCL2 in acute liver failure," Apoptosis , vol. 17, no. 7, pp. 702-716, 2012. (hindawi.com)
  • The regulatory role of microRNA-1187 in TNF- α -mediated hepatocyte apoptosis in acute liver failure," International Journal of Molecular Medicine , vol. 29, no. 4, pp. 663-668, 2012. (hindawi.com)
  • Shikonin attenuated ConA-induced liver injury by reducing apoptosis and autophagy through the inhibition of the JNK pathway. (hindawi.com)
  • Our results indicated that shikonin pretreatment attenuates ConA-induced acute liver injury by inhibiting apoptosis and autophagy through the suppression of the JNK pathway. (hindawi.com)
  • Apoptosis or programmed cell death is associated with liver injury caused by ConA [ 15 , 17 ]. (hindawi.com)
  • ALF occurs when the extent of hepatocyte death exceeds the regenerative capacity of the liver. (frontiersin.org)
  • Mouse models of acute liver injury revealed that liver-resident macrophages, Kupffer cells, sense hepatocyte-mediated release of alarmins, which results in Kupffer cell activation and cytokine release. (bmj.com)
  • If you have a pregnancy-related condition that caused liver failure, you may need to give birth early. (drugs.com)
  • Thus, we examined the risk of idiosyncratic acute liver injury associated with the use of moxifloxacin relative to other selected antibiotic agents. (cmaj.ca)
  • A quick worsening of consciousness and increasingly growing cerebral edema, high intracranial pressure, which leads to cerebral herniation and death, are characteristics of acute liver failure (ALF). (umontreal.ca)