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  • survival
  • Genomic analysis of adult B-ALL identifies potential markers of shorter survival. (medscape.com)
  • Despite these accomplishments, long-term survival in adults with ALL remains largely unsatisfactory, making the design of novel antileukemic drugs tailored to specific biological targets a current priority ( 4 , 6 ). (rupress.org)
  • 7 8 Long-term survival rates range from 35% to 40% in children to less than 20% in adults. (bloodjournal.org)
  • young adults
  • This is a result of a combination of factors, including low clinical suspicion among medical professionals, feelings of invincibility among young adults, and unreliable access to medical care. (ulmanfund.org)
  • Young adults are the highest uninsured and underinsured group in the United States. (ulmanfund.org)
  • In a 2006 cover story, New York Magazine noted that young adults are the fastest-growing segment of America's uninsured population. (ulmanfund.org)
  • As a result of being uninsured, young adults may not feel empowered to seek care, may not be financially capable of paying the bills that may be incurred through medical care, and may not have regular access to a general practitioner. (ulmanfund.org)
  • Statistics show young adults have the lowest participation rate in clinical trials of any age group. (ulmanfund.org)
  • This is one of the greatest contributing factors to young adults falling through the cracks in the system. (ulmanfund.org)
  • Acute lymphoblastic leukemia (ALL) has a high frequency in children and young adults [ 1 - 3 ] and is rare in adults. (biomedcentral.com)
  • Philadelphia
  • Prognostic impact of pretreatment cytogenetics in adult Philadelphia chromosome-negative acute lymphoblastic leukemia in the era of minimal residual disease. (medscape.com)
  • Some patients presenting with acute leukemia may have a cytogenetic abnormality that is cytogenetically indistinguishable from the Philadelphia chromosome (Ph1). (cancer.gov)
  • Deletion of BCR gene [ Philadelphia chromosome is created by translocation involving the BCR (breakpoint cluster region) gene on chromosome 9 and the ABL gene (named after the abelson murine leukemia virus) on chromosome 22. (spotidoc.com)
  • Absence of chromosome 22 www.medicinemcq.com Page 2 of 18 2) Pathognomonic of CML is a. t(9;22)translocation [ The Philadelphia chromosome is detected in 95% of patients with CML and in 5% of children and 15% to 30% of adults with acute lymphoblastic leukemia. (spotidoc.com)
  • In about 25% of adults with ALL, the leukemia cells have the Philadelphia (Ph) chromosome. (cancer.ca)
  • From 1994 to 2000, 154 adults with Philadelphia chromosome-positive (Ph + ) and/or BCR-ABL + acute lymphoblastic leukemia (ALL) were treated according to a prospective trial (median follow-up, 4.5 years) with the aim to study the prognostic value of early response to therapy and the role of stem cell transplantation (SCT) in first complete remission (CR). (bloodjournal.org)
  • cardiotoxicity
  • Cumulative doses above 550 mg/m 2 in adults without risk factors for cardiotoxicity and above 400 mg/m 2 in adults receiving chest irradiation are associated with an increased risk of cardiomyopathy. (drugs.com)
  • Pretreatment
  • Pretreatment leukemia samples from bone marrow or peripheral blood or both were centrally processed at the University "La Sapienza" of Rome, where mononuclear cells were isolated by density gradient centrifugation, cryopreserved with 10% dimethyl sulfoxide, and stored in vapor-phase liquid nitrogen. (bloodjournal.org)