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Leukemia, Myeloid, AcuteLeukemiaLeukemia, Basophilic, AcuteLeukemia, MyeloidLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLeukemia, Biphenotypic, AcuteLeukemia, ExperimentalPrecursor Cell Lymphoblastic Leukemia-LymphomaLeukemia, LymphoidLeukemia, Lymphocytic, Chronic, B-CellAcute DiseaseLeukemia, Monocytic, AcuteBasophilsGene Expression Regulation, LeukemicCytarabineLeukemia Virus, MurineMyeloid-Lymphoid Leukemia ProteinFusion Proteins, bcr-ablBone MarrowRemission InductionHL-60 Cellsfms-Like Tyrosine Kinase 3Leukemia, T-CellDaunorubicinLeukemia, Myelomonocytic, AcuteKaryotypingAntineoplastic AgentsLeukemia, B-CellLeukemia, Radiation-InducedLeukemia, Myeloid, Chronic-PhaseMyelodysplastic SyndromesCytogenetic AnalysisBlast CrisisTumor Cells, CulturedMoloney murine leukemia virusReceptors, IgECore Binding Factor Alpha 2 SubunitBenzamidesK562 CellsIdarubicinLeukemia, Hairy CellLeukemia L1210Leukemia, Megakaryoblastic, AcuteBone Marrow TransplantationPyrimidinesLeukemia Virus, BovineLeukemia Virus, FelinePiperazinesChromosome AberrationsPrognosisNeoplasm ProteinsAntineoplastic Combined Chemotherapy ProtocolsTreatment OutcomeTranslocation, GeneticCytogeneticsRecurrenceLeukemia, Myeloid, Accelerated PhaseLeukemia-Lymphoma, Adult T-CellImmunophenotypingTransplantation, HomologousLeukemic InfiltrationPhiladelphia ChromosomeOncogene Proteins, FusionHematopoietic Stem CellsSialic Acid Binding Ig-like Lectin 3Chromosomes, Human, Pair 21Precursor B-Cell Lymphoblastic Leukemia-LymphomaHematopoietic Stem Cell TransplantationCell LineDrug Resistance, NeoplasmNeoplasm, ResidualLeukemia, Myeloid, Chronic, Atypical, BCR-ABL NegativeChromosomes, Human, Pair 11Neoplastic Stem CellsCell DifferentiationLeukemia P388PreleukemiaCell Line, TumorBase SequenceFlow CytometryGenes, ablMolecular Sequence DataLeukemia, Promyelocytic, AcuteMutationProto-OncogenesDisease-Free SurvivalApoptosisFriend murine leukemia virusSurvival AnalysisGene RearrangementCell Transformation, NeoplasticChromosomes, Human, Pair 8ArabinonucleosidesSurvival RateMast CellsMitoxantroneProtein Kinase InhibitorsGraft vs Host DiseaseProto-Oncogene ProteinsTime Factors
Monocytic leukemiaErythroid leukemiaLymphoblasticMaturationProliferations related to Down syndromeMegakaryoblastic leukemiaPromyelocyticSubtypeChronic myelomonPanmyelosis with myelofibrosisLeukaemiaTherapy-related myeloidSubtypesNeoplasmsLineageDifferentiationCytoplasmBasophilsNeoplasmMyelomonocytic leukemiaLymphomaFlow CytometryLymphocytic leukemiaMyelodysplasticDifferentiateClassificationAuerNeutropeniaMalignanciesBloodBone marrow
Monocytic leukemia2
  • Patients with acute monoblastic and monocytic leukemia may present with bleeding disorders, as well as with extramedullary masses, cutaneous and gingival infiltration, and central nervous system involvement. (medscape.com)
  • Patients with acute monocytic leukemia also have a high incidence of clinically significant DIC. (medscape.com)
Erythroid leukemia1
  • There are two subtypes recognized: erythroleukemia and pure erythroid leukemia. (nih.gov)
Lymphoblastic8
  • Precursor Lymphoblastic Leukemia Leukemia with an acute onset, characterized by the presence of lymphoblasts in the bone marrow and the peripheral blood. (nih.gov)
  • It includes the acute B lymphoblastic leukemia and acute T lymphoblastic leukemia. (nih.gov)
  • Acute Lymphoblastic Leukemia by Gene Expression Signature Gene expression-based patient cluster groups in acute lymphoblastic leukemia. (nih.gov)
  • Acute Lymphoblastic Leukemia ROSE Cluster Unique gene expression-based patient cluster groups in high-risk B-precursor acute lymphoblastic leukemia determined by Recognition of Outliers by Sampling Ends (ROSE). (nih.gov)
  • Among them, Acute Lymphoblastic Leukemia (ALL) is the most common leukemia and accounts for 77% of childhood leukemia. (wikidoc.org)
  • [ 1 ] and French-American-British (FAB)2 classifications for acute lymphoblastic leukemia (ALL) are provided below. (medscape.com)
  • The WHO classifies ALL as B-lymphoblastic leukemia/lymphoma or T-lymphoblastic leukemia/lymphoma. (medscape.com)
  • ETV6-ABL1 is a rare gene fusion with oncogenic properties, reported so far in 28 patients presenting a variety of haematological malignancies associated with clinical outcome, including chronic myeloid leukaemia (CML), acute myeloid leukaemia (AML), acute lymphoblastic leukaemia (ALL) and chronic myeloproliferative neoplasm (cMPN). (biomedcentral.com)
Maturation1
Proliferations related to Down syndrome1
  • In addition, it is also important to exclude other, more specific AML categories (ie, AML with myelodysplasia-related changes, therapy-related myeloid neoplasm, AML with germline predisposition, myeloid proliferations related to Down syndrome) before classifying a condition as AML NOS. (medscape.com)
Megakaryoblastic leukemia1
  • Although patients with acute megakaryoblastic leukemia may present with evidence of bone marrow failure associated with pancytopenia, in some cases, thrombocytosis is present. (medscape.com)
Promyelocytic3
  • Cytogenetic studies performed on bone marrow provide important prognostic information and can guide treatment by confirming a diagnosis of acute promyelocytic leukemia (APL). (medscape.com)
  • Acute promyelocytic leukemia (APL), also known as M3, is the most common subtype of AML associated with DIC. (medscape.com)
  • For example, the acute promyelocytic leukemia (APL) subtype is often treated using drugs that are different from those used for other subtypes of AML. (cancer.org)
Subtype2
  • Immunophenotyping by flow cytometry of bone marrow or peripheral blood samples can be used to help distinguish AML from acute lymphocytic leukemia (ALL) and further classify the subtype of AML. (medscape.com)
  • Chronic Myelomonocytic Leukemia (CMML) is a hematologic malignancy considered a subtype of Myelodysplastic Syndrome (MDS)/Myeloproliferative Disease (MPD). (longdom.org)
Chronic myelomon2
  • 9. Dismal outcome of acute myeloid leukemia secondary to myelodysplastic syndrome and chronic myelomonocytic leukemia after azacitidine failure in a daily-life setting. (nih.gov)
  • Chronic Myelomonocytic Leukemia (CMML) is a rare clonal hematologic disorder, with a heterogeneous clinical and morphological manifestation. (longdom.org)
Panmyelosis with myelofibrosis1
Leukaemia5
  • 7. Safety and preliminary efficacy of venetoclax with decitabine or azacitidine in elderly patients with previously untreated acute myeloid leukaemia: a non-randomised, open-label, phase 1b study. (nih.gov)
  • 12. Sequential azacitidine and lenalidomide in patients with high-risk myelodysplastic syndromes and acute myeloid leukaemia: a single-arm, phase 1/2 study. (nih.gov)
  • Acute myeloid leukaemia (AML) in adults is a cancer of the blood and bone marrow. (clinicbarcelona.org)
  • In the case of acute myeloid leukaemia (AML), the myeloid stem cells are transformed into abnormal, immature cells (malignant) known as myeloid blasts. (clinicbarcelona.org)
  • Acute myeloid leukaemia (AML) is classified according to the 2006 FAB (French‑American‑British) system and the World Health Organisation (WHO) system. (clinicbarcelona.org)
Therapy-related myeloid1
Subtypes2
  • This section briefly discusses the morphologic features of the subtypes of acute myeloid leukemia (AML) not otherwise categorized (NOS). (medscape.com)
  • In the 1970s, a group of French, American, and British leukemia experts divided AML into subtypes, M0 through M7, based on the type of cell the leukemia develops from and how mature the cells are. (cancer.org)
Neoplasms4
  • Vardiman JW, Harris NL, Brunning RD. The World Health Organization (WHO) classification of the myeloid neoplasms. (medscape.com)
  • 1. Secondary basophilic leukemia in Ph-negative myeloid neoplasms: A distinct subset with poor prognosis. (nih.gov)
  • 3. Treatment of progression of Philadelphia-negative myeloproliferative neoplasms to myelodysplastic syndrome or acute myeloid leukemia by azacitidine: a report on 54 cases on the behalf of the Groupe Francophone des Myelodysplasies (GFM). (nih.gov)
  • The 2016 revision to the World Health Organization classification of myeloid neoplasms and acute leukemia. (medscape.com)
Lineage6
  • Immunophenotyping is required to determine myeloid lineage. (medscape.com)
  • Malignant C6923 Acute Bilineal Leukemia An acute leukemia of ambiguous lineage in which there is a dual population of blasts with each population expressing markers of a distinct lineage (myeloid and lymphoid or B-and T-lymphocyte). (nih.gov)
  • WHO, 2001) Malignant C4673 Acute Biphenotypic Leukemia An acute leukemia of ambiguous lineage characterized by blasts which coexpress myeloid and T or B lineage antigens or concurrent B and T lineage antigens. (nih.gov)
  • WHO, 2001) Malignant C7464 Acute Leukemia of Ambiguous Lineage Acute Leukemia of Indeterminate Lineage An acute leukemia in which the blasts lack sufficient evidence to classify as myeloid or lymphoid or they have morphologic and/or immunophenotypic characteristics of both myeloid and lymphoid cells. (nih.gov)
  • FAB M7 An acute myeloid leukemia in which at least 50% of the blasts are of megakaryocytic lineage. (nih.gov)
  • These specialized immune cells of the myeloid lineage play important roles in the defense against certain parasites, are important immune regulators, and are critically involved in some forms of allergic response (1). (forschung3r.ch)
Differentiation3
  • Patients with acute myeloid leukemia (AML) with minimal differentiation, AML without differentiation, and AML with differentiation usually present with evidence of bone marrow failure (ie, anemia , neutropenia , and/or thrombocytopenia ). (medscape.com)
  • A rare acute myeloid leukemia in which the primary differentiation is to BASOPHILS . (nih.gov)
  • Homeobox genes, such as Hoxb8, have the potential to block the differentiation of myeloid cells, which they often do in leukemias. (forschung3r.ch)
Cytoplasm3
  • and abundant, deeply basophilic cytoplasm. (medscape.com)
  • Basophilic stippling represents the spontaneous aggregation of ribosomal RNA in the cytoplasm of erythrocytes. (eclinpath.com)
  • They have basophilic cytoplasm and an eccentric nucleus with heterochromatin in a characteristic cartwheel arrangement. (wikidoc.org)
Basophils2
  • Leukemia Basophilic A rare acute myeloid leukemia in which the immature cells differentiate towards basophils. (nih.gov)
  • Basophilic granulocytes (basophils) are a rare leukocyte population within the blood, playing crucial roles in innate immune defense, immune regulation and allergic responses. (forschung3r.ch)
Neoplasm2
Myelomonocytic leukemia1
  • Lymph node swelling is rare in most types of AML, except for acute myelomonocytic leukemia (AMML). (wikipedia.org)
Lymphoma2
  • Leukemia must be differentiated from various diseases that cause weight loss , night sweats , hepatosplenomegaly , and palpable lymph nodes , such as hairy cell leukemia , prolymphocytic leukemia, follicular lymphoma , and mantle cell lymphoma . (wikidoc.org)
  • Provides a list of recurrent somatic mutations and associated pathways in small B-cell lymphoma/leukemia. (paramedicalinfo.com)
Flow Cytometry1
Lymphocytic leukemia1
  • However, Chronic Lymphocytic Leukemia (CLL) is the most common form of leukemia in adults, and it accounts for 30% of all leukemias in the United States. (wikidoc.org)
Myelodysplastic2
Differentiate1
  • The stem cell can either self-renew or differentiate into myeloid or lymphoid stem cells, which in turn can further differentiate and mature, ultimately giving rise to all the circulating blood cells. (nih.gov)
Classification1
  • Proposals for the classification of the acute leukaemias. (medscape.com)
Auer1
Neutropenia1
  • 90% of reported cases is prolonged and profound neutropenia in patients with acute leukemia ( 6 , 7 , 9 ). (cdc.gov)
Malignancies1
  • The leukemias are the most common malignancies among children younger than 15 years. (wikidoc.org)
Blood4
  • Acute myeloid leukemia (AML) is a cancer of the myeloid line of blood cells, characterized by the rapid growth of abnormal cells that build up in the bone marrow and blood and interfere with normal blood cell production. (wikipedia.org)
  • The underlying mechanism involves replacement of normal bone marrow with leukemia cells, which results in a drop in red blood cells, platelets, and normal white blood cells. (wikipedia.org)
  • It is characterized by an extreme increase of immature basophilic granulated cells in the bone marrow and blood. (nih.gov)
  • Acute anemia is usually due to acute blood loss or acute hemolysis. (medscape.com)
Bone marrow1
  • For unexplained acute anemia after exclusion of other causes, performing bone marrow biopsy is imperative to diagnose PRCA and rule out involvement of bone marrow by primary tumor. (amjcaserep.com)