Acute ischemic reperfusion. Medical search. Frequent questions

The objective of this study was to determine whether homing of endothelial progenitor cells (EPCs) induced by ischemic preconditioning (IPC) contributed to the protection of renal acute ischemia-reperfusion injury (IRI) in male rats. (annalsoftransplantation.com)
Cerebrovascular diseases (CVDs) have become a global public health problem and ischemia‑reperfusion injury, the major cause of neurological impairment exacerbation, is closely related to excitotoxicity. (spandidos-publications.com)
The present study aimed to investigate the effects of changes in heat shock protein (HSP)90β expression and verify whether HSP90β regulates EAAT2 expression in a cerebral ischemia‑reperfusion injury model. (spandidos-publications.com)
A model of cerebral ischemia‑reperfusion was established using the MCAO method. (spandidos-publications.com)
These results suggested that HSP90β is involved in the process of cerebral ischemia‑reperfusion injury in rats and that inhibition of HSP90β expression increases EAAT2 levels, conferring a neuroprotective effect in MCAO model rats. (spandidos-publications.com)
yet at the same time it can induce ischemia-reperfusion injury, which leads to brain damage both in the ischemic core and penumbra area. (spandidos-publications.com)
An ischemic stroke consists of two related pathological injury processes: Primary ischemia-induced brain injury and secondary ischemia reperfusion injury ( 3 ). (spandidos-publications.com)
A study has shown that neurons in the ischemic penumbra may undergo apoptosis hours or days after ischemia and alleviating ischemia reperfusion injury is an achievable therapeutic goal in the early intervention of ischemic stroke aimed at limiting the amount of infarction ( 4 ). (spandidos-publications.com)
When ischemic stroke occurs, cerebral ischemia and hypoxia cause the release of excessive excitatory amino acids, mainly glutamic acid and aspartic acid, which exert excitotoxic effects on the central nervous system. (spandidos-publications.com)
Therefore, an effective therapeutic strategy is required to prevent the onset of acute stroke and manage the chronic symptoms associated with neural ischemia, i.e., long-term neuroinflammation and localized necrosis [ 8 , 9 ]. (hindawi.com)
Graphical presentation of the various stages of cerebral ischemia stroke, i.e., acute phase, subacute phase, and chronic phase and their contributing factors. (hindawi.com)
Protection of the heart against injury from acute ischemia remains challenging for emergency physicians and cardiologists because there are no therapies proven to directly protect the heart against the deleterious effects of ischemia in humans. (mcw.edu)
Tanaka M, Mokhtari GK, Terry RD, et al: Overexpression of human copper/zinc superoxide dismutase (SOD1) suppresses ischemia-reperfusion injury and subsequent development of graft coronary artery disease in murine cardiac grafts. (spandidos-publications.com)
Mao X, Ji C, Sun C, et al: Topiramate attenuates cerebral ischemia/reperfusion injury in gerbils via activating GABAergic signaling and inhibiting astrogliosis. (spandidos-publications.com)
Male C57Bl/6 mice were subjected to focal cerebral ischemia and periods of reperfusion (0, 8 and 24 h). (biomedcentral.com)
However, a de-ramified morphology was prominent when ischemia was coupled to reperfusion. (biomedcentral.com)
The extension of the necrotic core into the penumbra is influenced by additional factors such as regional differences in the composition of brain tissue, the vulnerability of different cell types to ischemia, residual tissue perfusion and additional events such as reperfusion [ 2 - 4 ]. (biomedcentral.com)
We investigated the effects of a fibrin-derived peptide Bbeta(15-42) in acute and chronic rodent models of ischemia-reperfusion at three different study centers (Universities of Dusseldorf and Vienna, TNO Biomedical Research). (bris.ac.uk)
We show that Bbeta(15-42) robustly and reproducibly reduced infarct size in all models of ischemia-reperfusion. (bris.ac.uk)
In rodents, Bbeta(15-42) inhibits proinflammatory cytokine release and is cardioprotective during ischemia-reperfusion injury. (bris.ac.uk)
Such ischemia-reperfusion injuries (IRI) are a serious complication, responsible for a variety of clinically important conditions including stroke and acute kidney injury. (tu-dresden.de)
Dr. Maria Fedorova, leader of the research group "Lipid Metabolism: Analysis and Integration" at the Center of Membrane Biochemistry and Lipid Research (ZML) at the Faculty of Medicine of TUD, is the project coordinator of the FERROPath consortium ( Ferroptosis as a common underlying pathomechanism in tissue ischemia/reperfusion injury ) that will be funded by the Bundesministerium für Bildung und Forschung (BMBF) from July 2022 for 3 years. (tu-dresden.de)
One of the primary causes of ARF is ischemia/reperfusion (I/R). Inflammatory process and oxidative stress are thought to be the major mechanisms causing I/R. MK-886 is a potent inhibitor of leukotrienes biosynthesis which may have anti-inflammatory and antioxidant effects through inhibition of polymorphonuclear leukocytes (PMNs) infiltration into renal tissues. (biomedcentral.com)
A total of 24 Adult males of Swiss albino mice were randomized to four groups: I/R group (n = 6), mice underwent 30 minute bilateral renal ischemia and 48 hr reperfusion. (biomedcentral.com)
RPI/WCS is typically defined as an acute spinal cord injury that follows cervical spine surgery where postoperative MR studies document intrinsic cord edema/ischemia, swelling, and/or hemorrhage in the absence of significant new/residual extrinsic pathology. (surgicalneurologyint.com)
The patient had severe cardiac dysfunction and atrial fibrillation and presented with acute ischemia in the right lower limb 24 h after receiving an inferior vena cava filter. (medscape.com)
30%) with acute symptoms of right lower-extremity ischemia. (medscape.com)
Migraine is likely to increase individual vulnerability to ischemic stroke during the process of acute brain ischemia and might represent, therefore, a potential new therapeutic target against occurrence and progression of the ischemic damage. (medscape.com)
Based on these premises, taking advantage of the reliability of computed tomography perfusion (CTP) imaging in the estimation of cerebral tissue viability in both clinical and research settings, [ 4 ] we conducted a case-control study comparing CTP maps of migraineurs and nonmigraineurs patients with acute ischemic stroke aimed at investigating whether a personal history of migraine is associated with vulnerability to brain ischemia. (medscape.com)

Aiming to depolarise expert opinion on the matter, Hong et al set out to investigate the association between post-stroke baseline blood pressure, collateral flow, infarct growth, and clinical outcomes in acute ischaemic stroke patients with large vessel occlusion or stenosis, using baseline CT perfusion to measure collateral flow. (neuronewsinternational.com)
Speaking to NeuroNews , Cheng commented: "ENCHANTED and our recent study raised the intriguing hypothesis that in patients with acute large vessel occlusion, maintaining higher blood pressure to sustain collateral flow before reperfusion therapy, but then aggressively lowering blood pressure to prevent haemorrhagic transformation may be beneficial. (neuronewsinternational.com)
Background: Data on outcome of endovascular treatment in patients with acute ischaemic stroke due to large vessel occlusion suffering from intravenous thrombolysis-associated intracranial haemorrhage prior to mechanical thrombectomy remain scarce. (uni-koeln.de)
Methods: A retrospective analysis of consecutive acute ischaemic stroke patients treated with mechanical thrombectomy due to large vessel occlusion despite the pre-interventional occurrence of intravenous thrombolysis-associated intracranial haemorrhage was performed at five tertiary care centres between January 2010-September 2020. (uni-koeln.de)
Bilateral renal artery occlusion (45 min) followed by reperfusion in rats was utilized as a model of ARF. (eurekamag.com)
SPAN will facilitate the testing of up to 8 promising cerebroprotective drugs or interventions to be given prior to or at the time of reperfusion in experimental models of ischemic stroke (e.g., transient middle cerebral artery occlusion, tMCAo). (nih.gov)
SPAN will support late-stage preclinical studies of putative cerebroprotectants to be given prior to or at the time of reperfusion in rodent models of transient middle cerebral artery occlusion (tMCAo), with clinically relevant long-term outcomes and in models with common stroke comorbidities (i.e., aging, hypertension, diabetes, hyperlipidemia, obesity, etc. (nih.gov)
Rationale: Early reperfusion in patients experiencing acute ischemic stroke is critical, especially for patients with large vessel occlusion who have poor prognosis without revascularization. (uni-frankfurt.de)
Background Mechanical thrombectomy (MT) has become the cornerstone of acute ischemic stroke management in patients with large vessel occlusion (LVO). (bmj.com)
Thrombolysis of an acute thrombolytic occlusion in the popliteal artery. (medscape.com)
Anteroposterior (AP) angiogram of the knee shows acute occlusion in the middle of the popliteal artery above the knee. (medscape.com)
These findings are typical of an acute thromboembolic occlusion. (medscape.com)
Thrombolysis of acute thromboembolic occlusion of the popliteal artery. (medscape.com)
Close-up angiogram of the adductor canal region shows an abrupt cut-off of the above-the-knee popliteal artery and poor collateral flow consistent with acute occlusion. (medscape.com)
Patients with ischemic stroke and cerebral arterial occlusion treated with endovascular revascularization. (who.int)

Parenchymal blood volume (PBV) mapping with flat panel detectors may provide real-time estimates of tissue perfusion during endovascular ischemic stroke procedures. (bmj.com)
To test this hypothesis, we need a well-designed randomised trial, which must include pre-treatment perfusion imaging of reperfusion status. (neuronewsinternational.com)
S olitaire™ stent retriever devices have been shown to immediately restore vascular perfusion safely, rapidly, and effectively in acute ischemic stroke patients with large vessel occlusions. (uni-frankfurt.de)
Multicenter cohort study of patients with acute ischemic stroke who underwent a brain computed tomography perfusion and were scheduled to undergo reperfusion therapy. (medscape.com)

[ 2 ] In 1958, streptokinase was first used in patients with acute myocardial infarction (AMI), and this changed the focus of treatment. (medscape.com)
Studies evaluating intracoronary administration of adenosine for prevention of microvascular dysfunction and ischemic-reperfusion injury in patients with acute myocardial infarction (AMI) undergoing primary percutaneous coronary intervention (PCI) have yielded mixed results. (nih.gov)
The present study was undertaken to evaluate the cardioprotective potential of HupA in myocardial ischemic damage using a rat model of acute myocardial infarction. (spandidos-publications.com)
These findings suggest that the cardioprotective potential of HupA is associated with its antioxidant, anti-apoptotic and anti-inflammatory properties in acute myocardial infarction in rats. (spandidos-publications.com)
Guo J, Li HZ, Wang LC, et al: Increased expression of calcium-sensing receptors in atherosclerosis confers hypersensitivity to acute myocardial infarction in rats. (spandidos-publications.com)
Ventricular septal rupture complicating acute myocardial infarction: a contemporary review. (ctsnet.org)
Mechanical Complications of Acute Myocardial Infarction: A Scientific Statement From the American Heart Association. (ctsnet.org)
Diagnosis can be made based on patient history, symptoms, electrocardiography findings, and cardiac biomarkers, which delineate between ST elevation myocardial infarction and non-ST elevation acute coronary syndrome. (aafp.org)
1 It is important for primary care physicians to be able to diagnose and manage acute coronary syndrome (ACS), which comprises two clinical presentations: ST elevation myocardial infarction (STEMI) and non-ST elevation acute coronary syndrome (NSTE-ACS). (aafp.org)
The term non-ST elevation acute myocardial infarction (NSTEMI) is no longer used in the American College of Cardiology/American Heart Association (ACC/AHA) guidelines as a broad category with separate treatment guidelines. (aafp.org)
Do not test for myoglobin or creatine kinase-MB in the diagnosis of acute myocardial infarction. (aafp.org)

The indicators were revised in 2019 to reflect changes in acute stroke care, including the increasing use of endovascular thrombectomy (removal of clots). (safetyandquality.gov.au)
The Penumbra System should only be used by physicians who have received appropriate training in interventional neuro-endovascular techniques and treatment of acute ischemic stroke. (penumbrainc.com)
There have been many studies evaluating endovascular therapy in the management of ischemic stroke published in the past few years. (rebelem.com)

The effect of vessel patency, following recombinant tissue plasminogen activator (rtPA) administration, on clinical outcome in acute ischemic stroke (AIS) has been controversial. (ajnr.org)
This study is aimed at investigating variables in combination recanalization therapies for acute, large vessel ischemic stroke that are associated with better clinical outcomes (measured by NIH stoke scale and modified Rankin Scale). (parkview.com)
As part of the PENUMBRA SYSTEM, the Reperfusion Catheters and Separators are indicated for use in the revascularization of patients with acute ischemic stroke secondary to intracranial large vessel occlusive disease (within the internal carotid, middle cerebral - M1 and M2 segments, basilar, and vertebral arteries) within 8 hours of symptom onset. (penumbrainc.com)
Confirm vessel diameter, and select an appropriate size Penumbra Reperfusion Catheter. (penumbrainc.com)

HSP90β expression coincided with astrocyte markers in the ischemic penumbra area, while no expression was observed in microglia. (spandidos-publications.com)
By contrast, the ischemic penumbra will have only moderately decreased cerebral blood flow and normal or even increased cerebral blood volume due to autoregulation. (radiopaedia.org)
As part of the PENUMBRA SYSTEM, the Penumbra Sterile Aspiration Tubing is indicated to connect the Penumbra Reperfusion Catheters to the Penumbra Aspiration Pump. (penumbrainc.com)
Do not use automated high-pressure contrast injection equipment with the Penumbra Reperfusion Catheter because it may damage the device. (penumbrainc.com)
Do not use in arteries with diameters smaller or equal to the distal outer diameter of the Penumbra Reperfusion Catheters. (penumbrainc.com)
In ischemic stroke, there is usually a core infarct and an ischemic penumbra. (rebelem.com)
The penumbra is the area that we try to salvage with reperfusion therapy. (rebelem.com)

Spectrum of acute renal failure in the intensive care unit: the PICARD experience. (bmj.com)
14. Liaño F, Pascual J. Epidemiology of acute renal failure: a prospective, multicenter, community-based study. (bmj.com)
Madrid Acute Renal Failure Study Group. (bmj.com)
Epidemiology and outcomes of acute renal failure in hospitalized patients: a national survey. (bmj.com)
17. Lameire N, Van Biesen W, Vanholder R. Acute renal failure. (bmj.com)
Hemodynamically mediated acute renal failure. (bmj.com)
Apoptotic pathways in ischemic acute renal failure. (bmj.com)
We have demonstrated an enhanced pressor response following chronic infusion of Ang II in rats after recovery from acute renal failure (ARF). (eurekamag.com)
This was complicated by residual shunt with a high gradient, causing hemolysis and acute renal failure. (ctsnet.org)
Acute renal failure (ARF) is an important clinical problem with a high mortality and morbidity. (biomedcentral.com)
Progressive AKI leads to acute renal failure (ARF)[ 1 ]. (biomedcentral.com)

Intravenous thrombolysis (IVT) is a standard procedure for the treatment of patients with acute ischemic stroke (AIS). (frontiersin.org)
Results We found high quality evidence to recommend MT plus best medical management (BMM, including intravenous thrombolysis whenever indicated) to improve functional outcome in patients with LVO related acute ischemic stroke within 6 hours after symptom onset. (bmj.com)

abstract = "BACKGROUND AND PURPOSE: Blood-brain barrier (BBB) disruption detected on magnetic resonance imaging (MRI) in acute ischemic stroke as a hyperintense acute reperfusion marker (HARM) is associated with upregulation of matrix metalloproteinase-9 (MMP-9). (johnshopkins.edu)
abstract = "Many compounds have been shown to prevent reperfusion injury in various animal models, although to date, translation into clinic has revealed several obstacles. (bris.ac.uk)

Although ideally positioned for immediate response to ischemic stroke (IS) and reperfusion, their progressive morphological transformation into activated cells has not been quantified. (biomedcentral.com)
3, 5-diiodothyropropionic acid (DITPA) have evidences of improving effects on I/R in heart through modulation of cellular signaling in response to ischemic stress. (biomedcentral.com)

Imaging biomarkers are increasingly used to provide a better understanding of the pathophysiology of acute ischemic stroke. (ajnr.org)

Cerebral reperfusion, or hyperperfusion, syndrome is a rare but serious complication that can occur following rapid revascularization of a partially or completely occluded artery with successful thrombolytic therapy, successful thrombectomy, carotid enterectomy (CEA), or carotid artery stenting (CAS). (medscape.com)
The effect of arterial recanalization following thrombolytic therapy of acute ischemic stroke (AIS) is a complicated and controversial issue. (ajnr.org)
The objective of this study was to provide a generalized critique for the role of mesenchymal stem cell therapy in ischemic stroke injury, its underlying mechanisms, and constraints on its preclinical and clinical applications. (hindawi.com)
Herein, we presented an overview of a previously published work regarding the role of stem cell therapy in ischemic stroke and its underlying molecular mechanisms. (hindawi.com)
We aim to provide the basis for establishing a future study to promote the clinical translation of stem cell therapy in ischemic brain diseases. (hindawi.com)
Reperfusion therapy, preferably primary PCI, should be administered to eligible patients with STEMI and symptom onset within the previous 12 hours. (aafp.org)
Planned projects include health economic evaluations of stroke care (Ullberg), analyses of the 3 and 5 year follow-up surveys (Ullberg), and studies on acute ischemic stroke and intracerebral hemorrhage occurring during anticoagulant therapy (Apostolaki-Hansson). (lu.se)
Currently, systematic intravenous alteplase administered within 4.5hrs after symptom onset is the mainstay of therapy, however many question its risk/benefit ratio in ischemic stroke. (rebelem.com)

No resource exists that comprehensively assesses artificial intelligence/machine learning (AI/ML)-enabled technologies indicated for the management of ischemic and hemorrhagic stroke. (mdpi.com)

The relationship between blood pressure and outcomes is highly dependent on reperfusion, conclude Lang Hong (Fudan University, Shanghai, China) and colleagues on behalf of the INSPIRE group. (neuronewsinternational.com)
Yet, Hong and colleagues acknowledge that in patients with good collateral flow, "if there is subsequent reperfusion, there may be smaller infarct volume, and hence better clinical outcomes. (neuronewsinternational.com)
Kidney disease: improving global outcomes (KDIGO) Acute Kidney Injury Work Group. (bmj.com)
Incidence and outcomes in acute kidney injury: a comprehensive population-based study. (bmj.com)
Design: The study is a global multicenter, two‐arm, prospective, randomized, open, blinded end‐point trial comparing functional outcomes in acute ischemic stroke patients who are treated with either intravenous tissue plasminogen activator alone or intravenous tissue plasminogen activator in combination with the Solitaire device. (uni-frankfurt.de)
OBJECTIVES: The purpose of this study was to estimate the prevalence, risk factors, and outcomes associated with acute cardiac events during COVID-19-associated hospitalizations among adults. (cdc.gov)
We calculated the prevalence of acute cardiac events (identified by International Classification of Diseases-10th Revision-Clinical Modification codes) by history of underlying cardiac disease and examined associated risk factors and disease outcomes. (cdc.gov)
CONCLUSIONS: Acute cardiac events were common during COVID-19-associated hospitalizations, particularly among patients with underlying cardiac disease, and are associated with severe disease outcomes. (cdc.gov)

We performed a systematic review of imaging biomarkers used in randomized controlled trials of acute ischemic stroke, in which a therapeutic intervention was trialed within 48 hours of symptom onset. (ajnr.org)
This study identifies temporal transcriptional changes in the acute phase of ischemic stroke that reflect the early response of pericytes to the ischemic insult and its secondary consequences and may constitute potential future therapeutic targets. (lu.se)
Ischemic brain injury is associated with a high rate of mortality and disability with no effective therapeutic strategy. (hindawi.com)
Ischemic stroke is attributed to a high disability rate with limited or no therapeutic options for functional recovery [ 1 - 3 ]. (hindawi.com)

Reperfusion injury in acute ischemic stroke: Tackling the irony of revascularization. (nih.gov)
In addition to central injury in acute cerebrovascular diseases, which can lead to poor prognosis in patients, fluctuations in the properties and functions of local and circulating immune mediators can also trigger the body to enter an immune imbalance state, leading to poor prognosis in some patients after receiving systematic symptomatic support treatment. (ijpsonline.com)

Conclusions MT is the standard of care in patients with LVO related acute stroke. (bmj.com)

Despite major advances in the care of patients with acute coronary syndrome over many decades, rates of early morbidity and mortality associated with the condition remain unacceptably high. (mcw.edu)
Repair of ischemic ventricular septal defect with and without coronary artery bypass grafting. (ctsnet.org)
Acute coronary syndrome continues to be a significant cause of morbidity and mortality in the United States. (aafp.org)
Family physicians need to identify and mitigate risk factors early, as well as recognize and respond to acute coronary syndrome events quickly in any clinical setting. (aafp.org)
Rapid reperfusion with primary percutaneous coronary intervention is the goal with either clinical presentation. (aafp.org)

Aggarwal R, John R, Knoper R. Anterior Ischemic VSD Repair After Failed Percutaneous Device Closure. (ctsnet.org)
The video shows an anterior approach using a single patch technique for a ventricular septal rupture presumed to be from an ischemic event after a failed percutaneous device closure. (ctsnet.org)

Tourniquet release during the late period of TKR can induce ischaemic-reperfusion injury, eliciting the activation of neutrophils, circulating pro-inflammatory cytokines, and reactive oxygen species [ 2 , 3 ]. (medsci.org)
Thirty minutes-oxygen-glucose deprivation/24 h reperfusion was used to induce excitotoxicity. (scialert.net)

In study I, arterial pressure in conscious animals was not different between ARF and sham-operated controls at 5 weeks of recovery, however ARF-rats manifested an increased pressor sensitivity to acute graded doses of Ang II. (eurekamag.com)

The extent of reperfusion injury likely depends on the extent of initial hypoperfusion, the time to collateral collapse, the volume of irreversible tissue damage, and the degree of autoregulatory and pro-inflammatory responses. (medscape.com)
Intrinsically, ischemic stroke indicates the cascade of congesting events, i.e., thrombus formation and embolism, that ultimately decreases the local blood flow and cause oxygen deprivation in affected brain tissue. (hindawi.com)
The researchers hypothesized that the lack of a treatment effect may reflect the fact that these patients had enough blood flow to the brain from secondary sources to support the brain tissue until spontaneous reperfusion occurred. (nih.gov)
When after an ischemic event reperfusion is induced, which happens for instance during organ transplantation or resuscitation after cardiac arrest, this reperfusion can paradoxically cause additional damage to the affected tissue. (tu-dresden.de)
Along with the observation that migraine mutants had an elevated minimum cerebral blood flow threshold required for tissue survival and developed larger infarcts, these findings directly support the hypothesis that brain tissue in migraineurs is more susceptible to ischemic injury. (medscape.com)

Approximately 80% of strokes are ischemic in origin leading to significant morbidity and mortality worldwide. (rebelem.com)

Certain factors may lead to an unfavorable outcome even when treatment is administered rapidly, such as reperfusion injury and hemorrhagic transformation, poor collateral circulation, dehydration, poor cardiac output, hypotension, hyperglycemia, and fever ( 1 - 5 ). (ajnr.org)

The use of an advanced imaging shortly after the onset of acute stroke failed to identify a subgroup of patients who could benefit from a clot-removal procedure, a study has found. (nih.gov)

Acute kidney injury and mortality in hospitalized patients. (bmj.com)
Predicting one-year mortality of critically ill patients with early acute kidney injury: data from the prospective multicenter FINNAKI study. (bmj.com)

The clinical presentation of cerebral reperfusion syndrome varies but generally includes components of the following triad: 1) ipsilateral headache, 2) contralateral focal neurologic deficits, and/or 3) seizures. (medscape.com)
Since reperfusion is necessary, but hyperperfusion is not required, some authors prefer use of the broader term reperfusion syndrome . (medscape.com)
Cerebral reperfusion syndrome presents with ipsilateral headache, contralateral focal neurologic deficits, and/or seizures, but a complete triad is not required for diagnosis. (medscape.com)
Acute kidney injury (AKI) is a common clinical syndrome characterized by rapid deterioration of renal function. (biomedcentral.com)
Following acute cervical spinal cord decompression, a subset of patients may develop acute postoperative paralysis due to Reperfusion Injury (RPI)/White Cord Syndrome (WCS). (surgicalneurologyint.com)
Postoperative reperfusion injury (RPI)/white cord syndrome (WCS) causing acute deficits following cervical spine surgery. (surgicalneurologyint.com)

The aim of this study was to systematically review the use of imaging biomarkers in randomized controlled trials in patients with acute ischemic stroke, exploring the purposes for which the imaging biomarkers were used. (ajnr.org)

PBV deficit normalization may occur with recanalization of the parent artery and probably represents successful reperfusion. (bmj.com)

On admission, her EKG did not show ischemic changes and her cardiac enzymes were negative. (ctsnet.org)
Note the meniscus of the acute thromboembolus, which raises the possibility of a cardiac source. (medscape.com)
RESULTS: Among 8,460 adults, 11.4% (95%CI: 10.1%-12.9%) experienced an acute cardiac event during a COVID-19-associated hospitalization. (cdc.gov)
Persons at greater risk for experiencing acute cardiac events during COVID-19-associated hospitalizations might benefit from more intensive clinical evaluation and monitoring during hospitalization. (cdc.gov)

RED Reperfusion Catheters (RED 72, RED 72 with SENDit ™ Technology, RED 68, RED 62, and RED 43) are intended for use in the revascularization of patients with acute ischemic stroke. (penumbrainc.com)

Management of acute kidney injury: core curriculum 2018. (bmj.com)

Previous report showed the protective effects of berberine on ischemic-induced excitotoxic insult in oligodendrocytes. (scialert.net)

The PIs of the awarded interventions will become part of the network and will collaborate with the SPAN Coordinating Center ( RFA-NS-22-004 ), testing laboratories ( RFA-NS-22-003 ), and other intervention contributors ( RFA-NS-22-066 , RFA-NS-22-067 ) to facilitate the parallel testing of multiple cerebroprotective interventions in experimental models of ischemic stroke. (nih.gov)

Lastly, the paper detailed a subgroup analysis carried out on patients with major reperfusion, where Hong et al report that in such patients: "Higher baseline blood pressure was associated with decreased infarct growth and a better clinical outcome. (neuronewsinternational.com)

Greater effort to prospectively use consistent imaging biomarkers should help improve the development of novel treatment strategies in acute stroke and improve comparison between studies. (ajnr.org)

The Acute Stroke Clinical Care Standard was reviewed against current guidelines in 2019. (safetyandquality.gov.au)

Treatment options for patients with acute ischemic stroke are limited. (ajnr.org)
The current treatment options for ischemic stroke aim to achieve reperfusion but are time critical. (lu.se)
Therefore, this article mainly reviews the treatment of acute cerebrovascular disease with betahistine hydrochloride combined with atorvastatin, providing scientific reference for clinical treatment of acute cerebrovascular disease. (ijpsonline.com)
In this article, we review the progress in the treatment of acute cerebrovascular disease patients using betahistine hydrochloride combined with atorvastatin. (ijpsonline.com)
A patient with ischaemic stroke for whom reperfusion treatment is clinically appropriate, and after brain imaging excludes haemorrhage, is offered a reperfusion treatment in accordance with the settings and time frames recommended in the Clinical Guidelines for Stroke Management. (safetyandquality.gov.au)
A patient with stroke is offered treatment in a stroke unit as defined in the National Acute Stroke Services Framework. (safetyandquality.gov.au)

Patients with acute postoperative neurological deficits following cervical spine surgery must undergo MR studies to rule out extrinsic cord pathology before being diagnosed with RPI/WCS. (surgicalneurologyint.com)

An insight into the biology of ischemic stroke indicates that a stream of molecular events initiates instantly after the onset of ischemic stroke, such as oxidative stress, increased level of intracellular calcium, excitotoxicity, and inflammation which results in apoptotic or necrotic neuronal cell death [ 12 - 14 ]. (hindawi.com)

External validation for acute kidney injury severity scores: a multicenter retrospective study in 14 Japanese ICUs. (bmj.com)

Systematic review and meta-analysis of the mechanical complications of ischemic heart disease: papillary muscle rupture, left ventricle rupture and post-infarct ventricular septal defect. (ctsnet.org)

KDIGO clinical practice guideline for acute kidney injury. (bmj.com)
KDOQI US commentary on the 2012 KDIGO clinical practice guideline for acute kidney injury. (bmj.com)
Acute kidney injury: prevention, detection and management. (bmj.com)
The definition of acute kidney injury and its use in practice. (bmj.com)
Epidemiology of acute kidney injury in the intensive care unit. (bmj.com)

Cardiovascular Disease (CVD) is with the cardiovascular events of Ischemic Heart Disease and Stroke, the number 1 and 2 cause of death in the world and expect to increase especially in Asia. (selectbiosciences.com)
Complications of acute ischemic heart disease include ventricular septal rupture resulting in a defect and sudden left to right shunt. (ctsnet.org)

Symptoms can include hemiplegia, aphasia, and visual field deficit and neglect and range in severity from worsening of deficits caused by the initial ischemic injury to new symptoms localizing to a larger area within the same vascular territory. (medscape.com)
The patient underwent right femoral-anterior tibial bypass with ischemic symptoms in the right lower extremity. (medscape.com)

Anatomy8

Organisms5

Diseases11

Chemicals and Drugs19

Analytical, Diagnostic and Therapeutic Techniques and Equipment14

Phenomena and Processes13

Health Care1

Ischemia29

Occlusion15

Perfusion4

Myocardial11

Endovascular3

Vessel4

Penumbra7

Renal failure11

Thrombolysis2

Abstract2

Response to ischemic2

Pathophysiology1

Therapy8

Management of ischemic1

Outcomes8

Therapeutic4

Injury in acute2

Conclusions1

Coronary5

Percutaneous2

Induce2

Rats1

Tissue5

Morbidity1

Hemorrhagic1

Onset of acute stroke1

Mortality2

Syndrome6

Randomized contro1

Recanalization1

Cardiac4

Revascularization1

20181

Protective Effects1

Intervention1

Outcome1

Biomarkers1

20191

Treatment6

Undergo1

Oxidative stress1

Retrospective1

Mechanical1

Kidney injury5

Heart disease2

Symptoms2