• Insulin, glucose and potassium (GIK) are touted as useful metabolic adjuvant, associated with improvement of cardiac function in acute myocardial function, but the general acceptance of this therapeutic approach is limited by requirements for concomitant infusion of glucose and concerns regarding hypoglycemia. (biomedcentral.com)
  • Moreover, it seems that paracrine action of skeletal myoblasts facilitate neighboring cardiomyocytes to maintain their replicative potential and/or stimulate differentiation of native cardiac stem cells (8,9). (escardio.org)
  • Initial, CAPN3 is AZ-33 normally mostly muscle-specific (9), but is normally detectable in zoom lens, liver, human brain and cardiac muscles during advancement (10C13). (exposed-skin-care.net)
  • Atherosclerotic plaque rupture is the leading cause of cardiovascular death resulting from acute coronary syndrome (ACS) and leads to cardiac remodeling and fibrosis following ACS. (archivesofmedicalscience.com)
  • There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. (archivesofmedicalscience.com)
  • Tissues with a high energy demand (eg, brain, nerves, retina, skeletal and cardiac muscle) are particularly vulnerable to defects in oxidative phosphorylation. (msdmanuals.com)
  • AKT1 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. (cusabio.com)
  • Indeed, miRNAs have been shown to be actively involved in the coordination of almost all major cellular processes, such as differentiation ( 11 ), proliferation ( 12 ), metabolism, and apoptosis ( 13 ). (spandidos-publications.com)
  • Several unexpected findings in genetically altered mice have prompted research into the direction of intermediate metabolism of skeletal cells. (mdpi.com)
  • The manipulation of blood flow in conjunction with skeletal muscle contraction has helped us with the physiological understanding of muscle fatigue, blood pressure reflexes, and metabolism in humans. (pensummed.pro)
  • Pyruvate is an important substrate in carbohydrate metabolism. (msdmanuals.com)
  • My research focuses on investigating the mechanisms responsible for sarcopenia (the age-related loss of skeletal muscle mass and strength) and developing exercise interventions for the treatment/prevention of sarcopenia. (uncg.edu)
  • Vitamin D is also an activator of insulin-like growth factor (IGF-1) and, associated with this, poor vitamin D status is linked to sarcopenia (age related loss of skeletal muscle) which affects up to 25% of those over the age of 65 years and more than half of those over 85. (positivehomeopathy.com)
  • The power of the thiol proteinases to cleave a multitude of substrates in response to calcium mineral activation allows their involvement in a variety of cell processes offering cell motility, sign transduction, apoptosis, cell differentiation and legislation of the cytoskeleton (3). (exposed-skin-care.net)
  • Significant loss of muscle mass may occur in cachexia and sarcopenia, which are major causes of mortality and disability. (mdpi.com)
  • The co-existence of impaired bone health (osteopenia/osteoporosis), reduced muscle mass and strength (sarcopenia), and increased adiposity (obesity) in middle-aged and older people has been identified in recent studies, leading to a proposal for the existence of "osteosarcopenic obesity" as a distinct entity. (springer.com)
  • Recent basic and clinical research has revealed that hydrogen is an important physiological regulatory factor with antioxidant, anti-inflammatory and anti-apoptotic protective effects on cells and organs. (researchgate.net)
  • To date, RUNX2 has been involved in diverse physiological processes, including osteogenic differentiation of mesenchymal stem/stromal cells, chondrocyte hypertrophy, immunomodulation, vascular invasion and endothelial cell migration via modulating a variety of signaling cascades (e.g. (spandidos-publications.com)
  • Cell proliferation is a very important physiological effect for low power laser irradiation (LPLI) used in clinical practice. (biomedcentral.com)
  • BFRT exercise alters acute physiological stressors such as local muscle oxygen availability and vascular shear stress which may lead to adaptations that are not easily attained with conventional training. (pensummed.pro)
  • Skeletal muscle regeneration is regulated by coordinated activation of multiple signaling pathways. (elifesciences.org)
  • However, the role of individual arms of the UPR in skeletal muscle regeneration remain less understood. (elifesciences.org)
  • Myofiber-specific ablation of IRE1α or XBP1 in mice diminishes skeletal muscle regeneration that is accompanied with reduced number of satellite cells. (elifesciences.org)
  • Finally, targeted ablation of IRE1α also reduces Notch signaling, abundance of satellite cells, and skeletal muscle regeneration in the mdx mice, a model of Duchenne muscular dystrophy. (elifesciences.org)
  • Collectively, our experiments suggest that the IRE1α-mediated signaling promotes muscle regeneration through augmenting the proliferation of satellite cells in a cell non-autonomous manner. (elifesciences.org)
  • The findings shed new light on mechanisms of regeneration of healthy myofibers after severe tissue injury and suggest interplay between these fibers and muscle satellite cells though mechanisms remain to be elucidated. (elifesciences.org)
  • However, the mechanisms of muscle regeneration are not yet fully understood. (elifesciences.org)
  • Additionally, we are interested in mechanisms responsible for skeletal muscle recovery and regeneration after injury. (uncg.edu)
  • More specifically, my laboratory investigates the role inflammation plays in muscle atrophy, as well as during recovery and regeneration after injury. (uncg.edu)
  • Aged skeletal muscle displays increased fibrosis and impaired regeneration. (uncg.edu)
  • In aged skeletal muscle, impairments in regrowth and regeneration may be explained by a decreased responsiveness of muscle precursor cells (MPCs) to environmental cues such as growth factors. (uncg.edu)
  • The human proto-oncogene STAT3 encodes transcriptional factor that is essential for embryo- genesis, proliferation and differentiation of many cell types, in addition to organ regeneration and involu- tion. (pbkom.eu)
  • Skeletal muscle growth and regeneration involves the activity of resident adult stem cells, namely satellite cells (SC). (sdbonline.org)
  • Collectively, this study provides the first evidence that transient levels of the evolutionarily conserved factor RACK1 are critical for adult SC activation and proper skeletal muscle regeneration, favoring the efficient progression of SC from a committed to a fully differentiated state. (sdbonline.org)
  • These include bone marrow-derived cells, peripheral blood derived stem cells and skeletal myoblasts (3). (escardio.org)
  • The resistant state of skeletal myoblasts to ischemia renders these cells suitable candidates for repair of chronically infracted and failing heart (5). (escardio.org)
  • Myoblasts retain skeletal muscle properties and couple only sporadically to resident cardiomyocytes precluding synchronized contraction as mechanism of benefit (8). (escardio.org)
  • It was shown to inhibit keratinocyte proliferation and promotes terminal differentiation 17 . (nature.com)
  • It promotes cellular proliferation and provides a supporting structure to which cells or cell lysates in culture dishes adhere. (lookformedical.com)
  • Low power laser irradiation (LPLI) promotes proliferation of multiple cells, which (especially red and near infrared light) is mainly through the activation of mitochondrial respiratory chain and the initiation of cellular signaling. (biomedcentral.com)
  • The dynamics of RACK1 levels in isolated adult SC of mice, i.e., progressively high during differentiation and low compared to proliferating conditions, and RACK1 silencing indicated that RACK1 promotes both the formation of myotubes and the accretion of nascent myotubes. (sdbonline.org)
  • LIF promotes long-term maintenance of embryonic stem cells by suppressing spontaneous differentiation. (fgf-4.com)
  • It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. (fgf-4.com)
  • Moreover, the protein has been observed to interact with PTP1B to influence the MAPK pathway in acute myeloid leukemia. (wikipedia.org)
  • 6] Case reports have described AN associated with hematologic malignancies, including acute myeloid leukemia, and even benign gastrointestinal neoplasms. (medscape.com)
  • All-trans retinoic acid (RA) is the most active metabolite of vitamin A. Several studies have described a pivotal role for RA signalling in different biological processes such as cell growth and differentiation, embryonic development and organogenesis. (mdpi.com)
  • These complex events involve three overlapping phases: inflammation, proliferation and remodelling [ 1 - 4 ]. (biomedcentral.com)
  • In addition, as COPD results from inflammation and/or alterations in repair mechanisms, the "spill-over" of inflammatory mediators into the circulation may result in important systemic manifestations of the disease, such as skeletal muscle wasting and cachexia. (ersjournals.com)
  • Peripheral lung inflammation may cause a "spill-over" of cytokines, such as interlukin (IL)-6, IL-1β and tumour necrosis factor (TNF)-α, into the systemic circulation, which may increase acute-phase proteins such as C-reactive protein (CRP). (ersjournals.com)
  • Additionally, bone and muscle closely interact with each other not only mechanically but also metabolically. (springer.com)
  • Fibroblast growth factor-21 (FGF-21) and growth differentiation factor-15 (GDF-15) are additional biomarkers that may suggest mitochondrial dysfunction. (msdmanuals.com)
  • Other activities include the stimulation of acute phase protein synthesis by hepatocytes, stimulation of differentiation of cholinergic nerves, and suppression of adipogenesis by inhibiting the lipoprotein lipase in adipocytes. (fgf-4.com)
  • Although skeletal muscle is the major carnosine depot, the role of the dipeptide in preventing skeletal muscle injury has not been studied, and it is unclear whether carnosine affects ischemic damage or post injury events underlying wound healing and tissue angiogenesis. (frontiersin.org)
  • Even though the exact mechanisms underlying ischemic injury in the muscle are not completely understood, hypoxia-inducible factor-1 alpha (HIF-1α) has emerged as an attractive target to enhance post ischemic angiogenesis. (frontiersin.org)
  • Vascular endothelial growth factor (VEGF) is important for the maintenance of the skeletal muscle capillaries. (uncg.edu)
  • Recently, we observed that muscle capillarization, vascular endothelial growth factor (VEGF) protein, and the VEGF mRNA response to acute exercise were lower in aged compared with young women. (uncg.edu)
  • Studies previously conducted show that HS negatively affects the skeletal muscle growth and development by changing its effects on myogenic regulatory factors, insulin growth factor-1, and heat-shock proteins. (frontiersin.org)
  • Simultaneously detect the levels of these cytokines, chemokines, and acute phase proteins in a single sample. (rndsystems.com)
  • Intrinsic brain RAS is an enzyme-neuropeptide system having functional components (angiotensinogen, peptidases, angiotensin, and specific receptor proteins) with important biological and neurobiological activities in the brain. (hindawi.com)
  • Recently, the signaling proteins involved in LPLI-induced proliferation merit special attention, some of which are regulated by mitochondrial signaling. (biomedcentral.com)
  • Recently, a large number of signaling proteins reported play an important key role in the process of LPLI-induced cell proliferation, probably due to the fact that the molecular events they are involved in are the basic response of the cells to extracellular stimuli. (biomedcentral.com)
  • This is supported by reduced proliferation of human dermal papilla and predominantly epithelial keratinocytes after incubation with AICAR, the agonist for AMPK signaling which activates PPARGC1a and serves as co-activator of PPARγ. (nature.com)
  • Description: EGF is a potent growth factor that stimulates the proliferation of various epidermal and epithelial cells. (fgf-4.com)
  • Osteoporosis, a systemic skeletal disease characterized by low bone mass and microarchitectural deterioration of bone tissue with a consequent increase in bone fragility, occurs frequently, particularly in older women. (springer.com)
  • Increased curiosity about CAPN3 was highly stimulated when it had been reported that mutations in its gene bring about limb-girdle muscular dystrophy (LGMD) type 2A, seen as a the continuous atrophy of hip and make muscle tissues (LGMD2A, or calpainopathy) (21). (exposed-skin-care.net)
  • The reason for its use is the higher number of platelets, which is an important source of growth factors, such TGF- β1, that hypothetically possess a stimulating effect on regulation and differentiation in mesenchymal tissue repair 10 . (bvsalud.org)
  • Several preliminary reports have demonstrated that local stem cell transplantation in patients with acute myocardial infarction is safe and may lead to improved myocardial function and perfusion. (escardio.org)
  • An acute session of HIIT induced significant increases in interleukin (IL)-6, IL-8, IL-10, tumor necrosis f. (uncg.edu)
  • The initial appeal for BFRT training was driven by studies demonstrating rapid increases in muscle size, strength, and endurance capacity, even when notably low intensities and resistances, which would typically be incapable of stimulating change in healthy populations, were used. (pensummed.pro)
  • The initial appeal for BFR training (BFRT) was driven by studies demonstrating rapid increases in muscle size, strength, and endurance capacity, even when notably low intensities and resistances were utilized. (pensummed.pro)
  • MSCs were characterized for plastic adhesion, surface markers, proliferation and differentiation capacity. (biomedcentral.com)
  • Acute hypoxia impairs posterior cerebral bioenergetics and memory in man. (waseda.jp)
  • We sought to examine the effects of acute hypoxia on central executive (selective attention and response inhibition) and non-executive (memory) performance and the extent to which impairments are potentially related to reductions in regional cerebral blood flow and oxygen delivery. (waseda.jp)
  • On the other hand, the number of circulating hEPC is increased in hypoxia or acute myocardial infarction (AMI). (intechopen.com)
  • In clinical practice, these involve the life-long immunosuppression of the organ transplantation patients, the creation of the supporting environment for engineered tissues in the mended organ, the unsolved issues of cell survival and differentiation of the cell-based therapy, and the selection and development of vectors for gene therapy. (biomedcentral.com)
  • SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. (fgf-4.com)
  • RACK1 was expressed transiently in the skeletal muscle of post-natal mice, being abundant in the early phase of muscle growth and almost disappearing in adult mature fibers. (sdbonline.org)
  • After acute injury in muscle of both mouse and the fruit fly Drosophila melanogaster (used as alternative in vivo model) this study found that RACK1 accumulated in regenerating fibers while it declined with the progression of repair process. (sdbonline.org)
  • It plays an important role during embryonal development as programmed cell death and accompanies a variety of normal involutional processes in which it serves as a mechanism to remove "unwanted" cells. (wikipedia.org)
  • MicroRNA-1/206(miRNA-1/206) is specifically expressed in skeletal muscle and play a critical role in myogenesis. (biomedcentral.com)
  • Skeletal muscle, the most abundant tissue of the body, has remarkable regenerative capacity mainly due to its resident muscle stem cells, also known as satellite cells. (elifesciences.org)
  • Myofiber-specific ablation of IRE1α dampens Notch signaling and canonical NF-κB pathway in skeletal muscle of adult mice. (elifesciences.org)
  • These multipotent cells with innate self-renewal capacity can be in vitro expanded without losing their differentiation potential. (biomedcentral.com)
  • The expression level of the SFRP1 was highly varied across numerous pig tissues and it was down-regulated during porcine skeletal muscle development. (biomedcentral.com)
  • MSCs have been isolated from various tissues such as bone marrow (BM), umbilical cord blood, skeletal muscle and brain. (biomedcentral.com)
  • Vitamin D is also involved in the regulation of cell proliferation and differentiation. (positivehomeopathy.com)
  • It has also been postulated that hypocretins play an important role in the regulation of hypothalamus-pituitary-adrenal (HPA) axis, energy homeostasis, acquisition and learning of reward system-stimulating signals. (pbkom.eu)
  • Description: TPO is a lineage-specific growth factor produced in the liver, kidney and skeletal muscle. (fgf-4.com)
  • MicroRNAs (miRNAs/miRs) are endogenous, single-stranded, small (approximately 22 nucleotides in length) noncoding RNA molecules that play an important and ubiquitous role in regulating genes expression. (spandidos-publications.com)
  • Moreover, miRNAs play a modulatory role in the development and growth of skeletal muscles [ 22 ]. (biomedcentral.com)
  • Three miRNAs, miRNA-1, −133 and −206, are specifically expressed in muscle and are considered to be myomiRs [ 23 , 24 ]. (biomedcentral.com)
  • In this paper, we discuss the current available information about the role that different phenotypes of macrophages plays after injury and during the remodelling phase in different tissue types, with particular attention to the skeletal muscle. (hindawi.com)
  • In the present study, we demonstrate that IRE1α (also known as ERN1) and its downstream target, XBP1, are activated in skeletal muscle of mice upon injury. (elifesciences.org)
  • Mice with muscle-speci?c inactive AMPK (AMPK DN) were used to invest. (uncg.edu)
  • In this review, we focus on the impact of ncRNA post-transcriptional regulatory mechanisms, especially those of microRNAs and lncRNAs, in RA signalling pathways during differentiation and disease. (mdpi.com)
  • The incorporation of BFRT exercise into the training of strength-and endurance-trained athletes has recently been shown to provide additive training effects that augment skeletal muscle and cardiovascular adaptations. (pensummed.pro)
  • Introduction: Family environment is the primary environment for adolescent growth and development, which is believed to have an important impact on the occurrence of non-suicidal self-injury (NSSI) behavior in adolescents. (bvsalud.org)
  • Dynamic Ppargc1a expression in the mouse hair cycle suggests a possible role in regulating hair growth and differentiation. (nature.com)
  • Hepatocyte growth factor receptor (c-Met), a member of tyrosine protein kinase receptors (TPKR), is phosphorylated during LPLI-induced proliferation, but tumor necrosis factor alpha (TNF-alpha) receptor has not been affected. (biomedcentral.com)
  • Introduction and Objective: Because L-PRP constitutes an important source of growth factor that is associated with osteogenesis and fibrogenesis, the aim of this study was to evaluate the effect of L-PRP on the presence of collagen III and MMP-2 and MMP-9, while comparing these results by means of a histomorphometric analysis of bone matrix and fibrous deposition on bone repair. (bvsalud.org)
  • Left ventricular remodeling after acute myocardial infarction (MI) is a complex pathological process producing alterations in topography of both the infarcted and non-infarcted regions of the ventricle leading to progressive dilatation and systolic dysfunction (2). (escardio.org)
  • When an adequate number of cells (ASCs 10 × 10 6 and BM-MSCs 3 × 10 6 , because of their low rate of proliferation) was reached, two skin wounds were surgically induced in each animal. (biomedcentral.com)
  • In Drosophila with depleted RACK1 in all muscle cells or, specifically, in SC lineage resulted in a delayed recovery of skeletal muscle after physical damage as well as the low presence of active SC in the wound area. (sdbonline.org)
  • While human LIF is active on mouse cells and is widely used in the maintenance of murine ESC to prevent spontaneous differentiation, mouse LIF is not active on human cells due to its inability to bind to the human LIF receptor. (fgf-4.com)
  • We measured substrate utilization and skeletal muscle mitochondrial respiration to determine whether these adaptations are driven by high fat or low CHO availability. (edu.au)
  • The use of a muscle creatine kinase germline knockout of the gene encoding Ire1/Ern1 shifts the focus from traditional studies of tissue repair toward the regenerating myofibers. (elifesciences.org)
  • It is a common sense that tissue injury in the younger is easily repaired and the acute injury is healed better and faster. (biomedcentral.com)
  • Acute myocardial infarction and resultant heart failure is a major cause of mortality and morbidity worldwide (1). (escardio.org)
  • Serious' effects are those that evoke failure in a biological system and can lead to morbidity or mortality (e.g., acute respiratory distress or death). (cdc.gov)
  • This cannot be the sole cause and therefore it is important for therapeutic and diagnostic purposes to identify additional pathways. (nature.com)
  • Both views have merit but imply different conceptual and important therapeutic consequences. (ersjournals.com)
  • For instance ASCs show a higher proliferative capacity and retain differentiation potential for a longer period in culture compared with human BM-MSCs. (biomedcentral.com)
  • As opposed to other styles of muscles dystrophy, where mutations take place in genes encoding structural protein, calpainopathy was the initial reported kind of dystrophy predetermined by mutations within a gene encoding a proteolytic enzyme. (exposed-skin-care.net)
  • The risk of frailty and disability in obese individuals with low muscle mass and function has been reported to be higher than that observed in non-obese counterparts with similar muscle alterations [ 11 ]. (springer.com)
  • The present review summarises recent advances in this important area and addresses possible basic mechanisms responsible for them, acknowledging that these associations have only recently begun to be studied in depth. (ersjournals.com)
  • Increased body fat can be present either as an overt overweight/obesity or fat redistributed into visceral organs and/or fat infiltrated into bone and muscle, which occurs especially with age and some chronic diseases [ 3 , 4 ]. (springer.com)
  • Carnosine (β-alanine-histidine) is an endogenous histidyl dipeptide, present in high concentration in the skeletal muscle (1-20 mM), heart (0.1-1 mM), and brain (1-2 mM). (frontiersin.org)
  • These data are discussed in terms of three exposure periods: acute (14 days or less), intermediate (15-364 days), and chronic (365 days or more). (cdc.gov)
  • MRLs can be derived for acute-, intermediate-, and chronic-duration exposures for inhalation and oral routes. (cdc.gov)