DiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPsychiatry and PsychologyPhenomena and ProcessesHealth Care
Acute Chest SyndromeAnemia, Sickle CellChest PainEmbolism, FatHemoglobin SC DiseaseAntisickling AgentsSyndromeLung DiseasesSickle Cell TraitAcute DiseaseHydroxyureaHemoglobin, SicklePainBlood TransfusionFetal HemoglobinRespiratory InsufficiencyPulmonary EmbolismHemolysisFeverLeukocytosisRetrospective StudiesTriageCohort StudiesAcute Coronary SyndromeEmergency Service, HospitalTomography, X-Ray Computed
Myocardial InfarctionVaso-occlusStrokeSevereDetected duringPneumoniaComplicationAnemiaRespiratorySymptomsAmong patients with acuteShortness of breDiagnosisPatients with sickleRadiographyInfectionCardiovascularTransfusionsSickle-cell anCoronary heart dHydroxyureaCardiacHemolyticPainfulPresenting with chest painClinicalDiagnosticOrganDiseaseCrisisDiscomfortHospitalizationLungThoracicInhibitorAbdomenBone marrowIllnessArterialAsthmaAnginaInterstitialBloodMETHODS
Myocardial Infarction8
  • The main outcome was whether the patients received objective evaluation for coronary artery disease after adjustment for cardiac risk, including race, age, total number of risk factors, Thrombolysis in Myocardial Infarction (TIMI) score, ECG, and whether the patient sustained an acute myocardial infarction on index hospitalization. (cdc.gov)
  • Models adjusting for acute myocardial infarction or death, high-risk initial clinical impression, or emergency department disposition found similar results for increased likelihood of cardiac catheterization in men but no difference in stress testing between men and women. (cdc.gov)
  • We did not perform acute coronary syndrome, coronary elevation myocardial infarction, whereas angioplasty because the obstruction embolism should be kept in mind in the rest present with non-ST elevation was in the distal portion of the vessel those with prosthetic valves even in the myocardial infarction [8]. (who.int)
  • Participants 21 482 patients with acute myocardial infarction in England between January 2003 and March 2009, identified in four prospectively collected, linked electronic health record sources: Clinical Practice Research Datalink (primary care data), Hospital Episode Statistics (hospital admissions), the disease registry MINAP (Myocardial Ischaemia National Audit Project), and the Office for National Statistics mortality register (cause specific mortality data). (bmj.com)
  • Main outcome measures Recording of acute myocardial infarction, incidence, all cause mortality within one year of acute myocardial infarction, and diagnostic validity of acute myocardial infarction compared with electrocardiographic and troponin findings in the disease registry (gold standard). (bmj.com)
  • Immediate all cause mortality was highest among patients with acute myocardial infarction recorded in primary care, which (unlike hospital admission and disease registry sources) included patients who did not reach hospital, but at one year mortality rates in cohorts from each source were similar. (bmj.com)
  • 5561 (31.0%) patients with non-fatal acute myocardial infarction were recorded in all three sources and 11 482 (63.9%) in at least two sources. (bmj.com)
  • The crude incidence of acute myocardial infarction was underestimated by 25-50% using one source compared with using all three sources. (bmj.com)
Vaso-occlus4
  • The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in people with sickle cell anemia. (wikipedia.org)
  • Painful Vaso-occlusive Crisis as a Prodromal Phase of Acute Chest Syndrome. (cuni.cz)
  • In contrast, we found that a simple PTS for HbF that includes only six variants explained a large fraction of the phenotypic variation (20.5-27.1%), associated with acute chest syndrome and stroke risk, and improved the statistical modeling of the vaso-occlusive crisis rate. (haematologica.org)
  • 1 SCD patients present a wide range of complications such as vaso-occlusive crisis (VOC), acute chest syndrome (ACS), stroke, and end-organ dysfunction, and their life expectancy is reduced when compared to the general population. (haematologica.org)
Stroke5
  • Current management strategies include prophylactic penicillin and immunizations to decrease the occurrence of pneumococcal infections, hydroxyurea (a disease-modifying agent), blood transfusions (for symptomatic acute anemia, stroke management, preoperative optimization), and bone marrow transplant. (ccjm.org)
  • This can cause pain and other serious problems including infection, acute chest syndrome, and stroke. (cdc.gov)
  • Encounters for complicated VOCs such as acute chest syndrome and stroke were excluded. (confex.com)
  • Abstract: DESCRIPTION (provided by applicant): Sickle cell disease (SCD) is characterized by acute clinical manifestations, including painful crisis, acute chest syndrome, priapism, and stroke, as well as chronic irreversible damage to the heart, lungs, kidneys, eyes, spleen and femoral heads. (nih.gov)
  • These cardiovascular complications following a stroke are known as Stroke-Heart Syndrome. (kvia.com)
Severe8
  • Thus, persons with SCD could be at higher risk for development of severe disease if infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease (COVID-19). (cdc.gov)
  • A patient in their 60s presented to the emergency department with approximately 20 minutes of acute, severe precordial chest pain radiating to their left arm at night, accompanied by dyspnea, dizziness, and sweating. (ama-assn.org)
  • Additionally, during VOC, patients are often in severe pain, resulting in shallow breathing with minimal chest wall expansion, and together with high doses of opioids, it could lead to hypoventilation, with the formation of atelectasis, and increase risk for the development of ACS [ 6 ]. (hindawi.com)
  • Sporadic cases of hantavirus pulmonary syndrome (HPS), a severe cardiopulmonary illness first identified in 1993, continue to be recognized in the United States (1,2). (cdc.gov)
  • The ASH guideline panel suggests automated RCE or manual RCE over simple transfusions in patients with SCD and severe acute chest syndrome. (guidelinecentral.com)
  • The medicine can help certain types of sickle cell diseases, like hemoglobin SS, pain crises, acute chest syndrome, severe anemia needing blood transfusions, and tiny blockages without pain. (consultantlive.com)
  • Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has spread worldwide for more than a year. (frontiersin.org)
  • Acute respiratory distress syndrome (ARDS) is caused by a severe inflammatory response in the body when there is a severe infection or after there has been trauma to the body. (nationaljewish.org)
Detected during1
  • An increase in acute phase reactants and inflammatory markers can be detected during crises and predict severity [ 9 , 10 ]. (hindawi.com)
Pneumonia3
  • citation needed] The diagnosis of acute chest syndrome is made difficult by its similarity in presentation with pneumonia. (wikipedia.org)
  • Patients with SCD often have various complications, including acute chest syndrome (ACS), a life-threatening condition similar to pneumonia but unique to SCD. (cureswithinreach.org)
  • Treated children needed fewer hospitalizations and blood transfusions and had fewer episodes of a pneumonia-like complication called acute chest syndrome. (nih.gov)
Complication2
  • Acute chest syndrome (ACS) is a life-threatening complication in people living with SCD that can result in lung injury, breathing difficulty, and low oxygen to the rest of the body. (cdc.gov)
  • A fever may be the first sign of an infection or other SCD-related complication, such as acute chest syndrome , that can be life-threatening. (cdc.gov)
Anemia1
Respiratory5
  • The presence of fevers, low oxygen levels in the blood, increased respiratory rate, chest pain, and cough are also common in acute chest syndrome. (wikipedia.org)
  • Conclusion This patient with prior treatment for coronary artery disease status post CABG x4 in 2003 presented with chest pain, acute respiratory distress requiring ventilator support was found to h. (aapc.com)
  • For patients with acute respiratory distress syndrome lung functions improved faster during the first six months. (nature.com)
  • What are the signs and symptoms of acute respiratory distress syndrome (ARDS)? (nationaljewish.org)
  • Because acute respiratory distress syndrome involves internal fluid that fills the lungs' air sacs, doctors look for common signs (things that are observed) and symptoms (things that are experienced). (nationaljewish.org)
Symptoms4
Among patients with acute1
Shortness of bre1
Diagnosis5
  • Chest radiography for the diagnosis of acute aortic syndrome. (qxmd.com)
  • Since a definitive diagnosis is required in any patient with clinically suspected acute aortic syndrome, routine chest radiography should be replaced by tomographic aortic imaging. (qxmd.com)
  • The most common symptom prompting diagnosis of ACS is chest pain , often radiating to the left arm or angle of the jaw , pressure-like in character, and associated with nausea and sweating . (wikidoc.org)
  • To view the detailed differential diagnosis of chest pain click here . (wikidoc.org)
  • Control subjects ( n = 70) were identified among patients admitted for acute chest pain and in which a diagnosis of ATE was excluded. (thieme-connect.com)
Patients with sickle2
  • De D. Acute nursing care and management of patients with sickle cell. (medscape.com)
  • Close to half of all patients with sickle cell disease (SCD) will have at least one episode of acute chest syndrome (ACS) during their lifetime. (hindawi.com)
Radiography6
  • We sought to assess the diagnostic accuracy of routine chest radiography for the acute aortic syndrome (dissection, intramural hematoma, penetrating ulcer, or nondissecting aneurysm). (qxmd.com)
  • mean [+/- SD] age, 58 +/- 17 years) underwent chest radiography for suspected acute aortic syndrome. (qxmd.com)
  • Chest radiography had a sensitivity of 64% (70/109) and a specificity of 86% (92/107) for aortic disease. (qxmd.com)
  • Chest radiography is of limited value for diagnosing the acute aortic syndrome, particularly for conditions confined to the ascending aorta. (qxmd.com)
  • A structured data instrument that included demographic information, chest pain description, history, physical examination, chest radiography, and electrocardiogram (ECG) data was completed. (cdc.gov)
  • Chest radiography indicated ground-glass opacities and consolidation at the onset of disease, with the exception of 8.9% (5/56) that showed minor changes. (nature.com)
Infection1
  • Acute chest syndrome is often precipitated by a lung infection, and the resulting inflammation and loss of oxygen saturation leads to further sickling of red cells, thus exacerbating pulmonary and systemic hypoxemia, sickling, and vaso-occlusion. (wikipedia.org)
Cardiovascular2
  • Compared with HEART-score, HET-score is simpler and appears to have similar ability to discriminate between chest pain patients with and without cardiovascular event. (nih.gov)
  • The aim of this study was to investigate the generation of NETs in different groups of patients with acute thrombotic events (ATEs) and to establish whether NETs markers can predict the risk of new cardiovascular events. (thieme-connect.com)
Transfusions3
  • Hydroxycarbamide substantially reduces episodes of pain and acute chest syndrome, admissions to hospital, and transfusions in adults with sickle-cell anaemia. (nih.gov)
  • The ASH guideline panel suggests automated RCE, manual RCE, or simple transfusions in patients with SCD and moderate acute chest syndrome. (guidelinecentral.com)
  • The investigators wrote how other studies have noted the beneficial effects of hydroxyurea treatment, how the medication reduces pain, dactylitis, acute chest syndrome, hospitalizations, and transfusions. (consultantlive.com)
Sickle-cell an2
  • Sickle-cell anaemia is associated with substantial morbidity from acute complications and organ dysfunction beginning in the first year of life. (nih.gov)
  • According to the World Health Organization, the approximate estimates of affected individuals indicate that 240 million people are heterozygous for these disorders and at least 200000 lethally affected homozygotes are born annually, approximately equally divided between sickle-cell anaemia and thalassaemia syndromes. (ukessays.com)
Coronary heart d1
  • Association of endothelial nitric oxide synthase promoter region (T-786C) gene polymorphism with acute coronary syndrome and coronary heart disease. (nih.gov)
Hydroxyurea2
Cardiac4
  • Other treatment for cardiac arrest, dysrhythmias, or acute hypertension may also be required. (medscape.com)
  • Used to treat acute hypertension and cardiac chest pain. (medscape.com)
  • More than two thirds of sudden cardiac death resulting from acute thrombus occurs in smokers (3). (who.int)
  • in different circumstances, the cardiac apex could also be situated abnormally in the left side of the chest. (ehd.org)
Hemolytic1
  • The ASH guideline panel suggests immunosuppressive therapy (intravenous immunoglobulin [IVIg], steroids, and/or rituximab) over no immunosuppressive therapy in patients with SCD (all genotypes) with an acute need for transfusion and at high risk for acute hemolytic transfusion reaction or with a history of multiple or life-threatening delayed hemolytic transfusion reactions. (guidelinecentral.com)
Painful2
  • Painful events (sickle cell crises) in the hands or feet, belly, back, or chest are the most common symptom of sickle cell disease. (peacehealth.org)
  • Acute painful vaso -occlusive crises (VOC) are the leading cause of emergency department (ED) encounters and hospital admissions for those with sickle cell disease (SCD). (confex.com)
Presenting with chest pain1
  • Patients presenting with chest pain with duration of ≥10 min and an onset of last episode ≤12 h but without ST-segment elevation on ECG at 6 emergency departments were eligible for inclusion. (nih.gov)
Clinical2
  • Medicine Central , im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688316/all/Chest_Pain_Acute_Coronary_Syndrome. (unboundmedicine.com)
  • In 2017, the US Food and Drug Administration (FDA) approved L-glutamine oral powder for reducing acute complications of SCD, and many other drugs are in development and undergoing clinical testing. (ccjm.org)
Diagnostic1
  • Acute- and convalescent-phase serum specimens from patient 2 were submitted to the South Dakota Public Health Laboratory and CDC for hantavirus diagnostic testing. (cdc.gov)
Organ1
  • In conclusion, we report here the longest prospective neonatal cohort study to date addressing acute vaso-occlusive, hematological, and extracerebral major organ complications, and providing new data about transfusion requirements in [sickle cell disease] children," the investigators wrote. (consultantlive.com)
Disease5
  • What is Hand-Foot Syndrome in Sickle Cell Disease? (cdc.gov)
  • Chest films were re-evaluated blindly for aortic disease, based on an overall impression using standard criteria such as widening of the aortic contour and mediastinal shadow. (qxmd.com)
  • LaDonna was hospitalized for three weeks with Acute Chest Syndrome (ACS), a common disorder for children with sickle cell disease. (lifesouth.org)
  • I also see patients who have acute manifestations of sickle cell disease. (reachmd.com)
  • Bronchial hyper-responsiveness may be a component of acute chest syndrome in people with sickle cell disease. (worldasthmafoundation.org)
Crisis1
  • If patients with SCD crisis are being transported by emergency medical services (EMS), they should receive supplemental oxygen and intravenous hydration en route to the hospital. (medscape.com)
Discomfort2
  • Angina is a type of chest discomfort due to poor blood flow through the blood vessels of the heart muscle. (medlineplus.gov)
  • Chest discomfort or pain - This feeling can happen when inhaling. (nationaljewish.org)
Hospitalization1
  • Few randomized controlled trials have examined the efficacy time of smoking cessation in hospitalized patients with acute coronary syndrome, either during hospitalization or after discharge. (who.int)
Lung2
  • This condition commonly manifests with a new opacification of the lung(s) on a chest x-ray. (wikipedia.org)
  • Both may present with a new opacification of the lung on chest x-ray. (wikipedia.org)
Thoracic1
  • Doppler AdsonпїЅs test: predictor of consequence of surgery in non-specific thoracic outlet syndrome. (ehd.org)
Inhibitor1
  • The use of angiotensin-converting enzyme (ACE) inhibitors was comparable between the two groups during hospital admission, and, at the time of discharge from hospital, patients who had presented without chest pain were more likely to be receiving an ACE inhibitor. (medscape.com)
Abdomen1
  • Pain develops when sickle-shaped red blood cells block blood flow through tiny blood vessels to your chest, abdomen and joints. (healthanddietblog.com)
Bone marrow1
  • First description of bone marrow failure syndrome in Spain caused by mutations in the ERCC6L2 gene. (amedeo.com)
Illness2
  • they were specifically asked to report only confirmed COVID-19 cases and to report cases after resolution of acute illness or death. (cdc.gov)
  • An acute febrile illness was diagnosed, and he was discharged to outpatient follow-up. (cdc.gov)
Arterial1
  • In conclusion, we found that increase of markers of NETosis can be observed in acute thrombotic conditions, occurring both on the arterial and venous site. (thieme-connect.com)
Asthma1
  • The main objectives of this paper were to test the hypothesis that polymorphisms in NOS1 and NOS3 genes associate with ACS in SCD patients and to characterize the association between physician-diagnosed asthma and acute chest syndrome (ACS). (nih.gov)
Angina1
  • ACS should be distinguished from stable angina , which is chest pain that develops during exertion and resolves at rest. (wikidoc.org)
Interstitial1
  • and alanine aminotransferase {ALT} 138 U/L {normal: 7-56 U/L}). Although he reported no abdominal pain and the abdominal examination on admission was normal, serum amylase and lipase levels were elevated (amylase 226 U/L {normal: 30-110 U/L} and lipase 771 U/L {normal: 23-300 U/L}). Chest radiographs at the time of admission demonstrated perihilar interstitial infiltrates. (cdc.gov)
Blood1
  • Acute coronary syndrome ( ACS ) refers to a spectrum of conditions resulting from acute myocardial ischemia and/or infarction that is most often due to an abrupt reduction in coronary blood flow . (wikidoc.org)
METHODS1