SyndromeHemorrhageCauses of acuteParaneoplasticAtaxia causedInfarctionStrokesCause acuteVaricellaMultiple sclerosisNeurologicalPosteriorOnsetLesionSymptomsDysfunctionEncephalomyelitisGaitStrokeDisordersDiagnosisHerniationWeaknessInfectionBilateralInflammatoryViralSynapticNeuronalIschemiaEncephalopathyAffectsAbstractClinicalNeurologicTruncal ataxiaEvidenceChildhoodBrainIntracerebralPatientsTransientMovementDiseaseChildrenCommonlyExamRespiratoryCaseSuddenExposure
Syndrome13
- This study describes a patient with paraneoplastic cerebellar degeneration, who presented acute vestibular syndrome and then episodically developed horizontal gaze-evoked nystagmus and gait ataxia. (e-rvs.org)
- The acute manifestation of vertigo and imbalance in our patient made more likely a diagnosis of acute vestibular syndrome rather than degenerative or neoplastic etiologies. (e-rvs.org)
- Acute flaccid myelitis (AFM) is a serious neurologic syndrome that affects mostly children and is characterized by the acute onset of limb weakness or paralysis. (cdc.gov)
- Acute flaccid myelitis (AFM) is a serious neurologic syndrome that can cause paralysis, predominantly in previously healthy children. (cdc.gov)
- Similar to poliomyelitis-associated acute flaccid paralysis caused by poliovirus infection, AFM is a syndrome characterized by the acute onset of flaccid limb weakness accompanied by predominantly gray matter lesions in the spinal cord. (cdc.gov)
- INTRODUCTION: Inner ear decompression sickness following scuba diving is not uncommon and the characteristic features of this disorder are acute peripheral vestibular syndrome, sometimes associated with cochlear signs, requiring urgent hyperbaric oxygen therapy. (who.int)
- Tick paralysis notably resembles many symptoms of Guillain-Barré syndrome (acute inflammatory demyelinating polyneuropathy). (medscape.com)
- HINTS to Diagnose Stroke in the Acute Vestibular Syndrome. (brainblogger.com)
- Date: December 14, 2021 Time: 7:00am (PST), 10:00am (EST) Several fast-spreading variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have become the dominant circulating. (labroots.com)
- The final diagnosis was a cerebellar hemangioblastoma associated with von Hippel-Lindau syndrome (same patient as in Images 1-3). (medscape.com)
- Electrophysiological changes in the acute "axonal" form of Guillain-Barre syndrome. (medscape.com)
- Fisher M. An unusual variant of acute immune polyneuritis (syndrome of ophthalmoplegia, ataxia, and areflexia). (medscape.com)
- Acute lymphoblastic leukemia and down syndrome: 6-mercaptopurine and methotrexate metabolites during maintenance therapy. (cancercentrum.se)
Hemorrhage7
- Brain tumors, including cerebellar astrocytoma, medulloblastoma, neuroblastoma Cerebellar contusion Subdural hematoma Toxins, including ethanol or anticonvulsants Cerebellar infarction or hemorrhage Meningitis Encephalitis Acute disseminated encephalomyelitis Multiple sclerosis Supportive treatment is the only intervention for acute cerebellar ataxia of childhood. (wikipedia.org)
- Advances in neuroimaging have led to revision of treatment concepts for cerebellar hemorrhage (CH). In the pre-computed tomography (CT) era, patients with large hematomas (which were detected by angiography or at postmortem examination) were overrepresented in clinical series. (medscape.com)
- Long-standing hypertension with degenerative changes in the vessel walls and subsequent rupture is believed to be the most common cause of a typical cerebellar hemorrhage. (medscape.com)
- The hemorrhage is remote from the surgical site or anatomic defect and may result from transient occlusion or rupture of superior cerebellar bridging veins. (medscape.com)
- In acute cases, the most common cause is either stroke or hemorrhage in or around the cerebellum. (bcm.edu)
- The objective of the rFVIIa for Acute Hemorrhagic Stroke Administered at Earliest Time (FASTEST) Trial is to establish the first treatment for acute spontaneous intracerebral hemorrhage (ICH) within a time window and subgroup of patients that is most likely to benefit. (uclahealth.org)
- CT revealed stable age-related atrophy without evidence of acute ischemia or hemorrhage. (acponline.org)
Causes of acute1
- Truncal ataxia with deterioration of gait Slurred speech and nystagmus Afebrile Possible causes of acute cerebellar ataxia include varicella infection, as well as infection with influenza, Epstein-Barr virus, Coxsackie virus, Echo virus or mycoplasma. (wikipedia.org)
Paraneoplastic6
- Acute cerebellar ataxia of childhood is a childhood condition characterized by an unsteady gait, most likely secondary to an autoimmune response to infection, drug induced or paraneoplastic. (wikipedia.org)
- Paraneoplastic cerebellar degeneration is a rare neurological manifestation of nonmetastatic malignancy. (e-rvs.org)
- There have been only a few cases of paraneoplastic cerebellar degeneration with acute presentation. (e-rvs.org)
- Paraneoplastic cerebellar degeneration refers to a rare neurological manifestation of nonmetastatic malignancy. (e-rvs.org)
- This study aims to describe a patient with paraneoplastic cerebellar degeneration, who initially presented as acute vertigo mimicking unilateral vestibulopathy. (e-rvs.org)
- Subacute onset of ataxia is usually seen in paraneoplastic cerebellar degeneration. (bcm.edu)
Ataxia caused1
- Cerebellar ataxia caused by a recent viral infection may not need treatment. (medlineplus.gov)
Infarction4
- Cerebellar infarction can also mimic isolated peripheral vestibulopathy. (who.int)
- Normal videonystagmography and delayed onset of occipital headache finally led to brain MRI that confirmed the presence of recent ischaemic infarction in the territory of the medial branch of the posterior inferior cerebellar artery. (who.int)
- DISCUSSION/CONCLUSION: Cerebellar infarction can present clinically with features of inner ear decompression sickness following scuba diving. (who.int)
- 1 - 4 Consequent thalamic, brain stem, and cerebellar infarction can result in herniation, hydrocephalus, and death. (ajnr.org)
Strokes1
- Introduction: This article explores the use of music and multisensory stimuli in the construction of compensatory neural networks for motoric functioning in a patient recovering from cerebellar strokes (CS). (jyu.fi)
Cause acute2
- Bacteria or viruses can cause acute inflammation of the labyrinth in conjunction with either local or systemic infections. (medscape.com)
- In children, bacterial or viral infections can cause acute ataxia and this usually improves with time. (bcm.edu)
Varicella2
- Cases of acute cerebellar ataxia have been reported as a consequence of several viral and bacterial infections as well as immunizing agents, such as varicella, influenza, hepatitis B, and diphtheria-pertussis-tetanus vaccines. (univr.it)
- Conclusion Natural mumps and varicella infections are associated with acute cerebellar ataxia. (vaccinesafety.edu)
Multiple sclerosis4
- Where such a disorder fits in the spectrum from acute disseminating encephalomeylitis to multiple sclerosis is discussed. (researchgate.net)
- Patients with multiple sclerosis are classified according to their clinical phenotype, with ~85% following a relapsing-remitting course (relapsing-remitting multiple sclerosis) characterized by recurrent, acute neurological deficits punctuating periods of latency or remission (Lublin and Reingold, 1996). (medscape.com)
- [ 37 , 46 , 48 ] ADEM bears a striking clinical and pathological resemblance to other acute demyelinating syndromes (ADS) of childhood, including multiple sclerosis (MS). ADEM in children is readily distinguishable from alternative diagnoses on the basis of clinical features and findings on neuroimaging and laboratory investigations. (medscape.com)
- Multiple sclerosis (MS) and acute disseminated encephalomyelitis (ADEM) bear a close pathological resemblance, each resembling the pathology of experimental allergic encephalomyelitis (EAE). (medscape.com)
Neurological2
- Although immunization with meningococcal group C conjugate vaccines has been associated with several neurological side effects, acute cerebellar ataxia has not been previously reported. (univr.it)
- It focuses on three major neurological diseases that either present in acute or neurodegenerative forms-Parkinson's disease, cerebellar ataxia, and cortical stroke. (humankinetics.com)
Posterior3
- Acute CH should be visible on CT scan as a hyperdensity in the posterior fossa. (medscape.com)
- Numerous nuanced approaches have been used to access posterior inferior cerebellar artery (PICA) aneurysms for microsurgical clipping. (thejns.org)
- Acute basilar artery thrombosis is an infrequent but catastrophic subtype of posterior circulation ischemic stroke that carries a mortality rate of 80%-90% without treatment. (ajnr.org)
Onset4
- Medical records from persons meeting AFM clinical criterion (acute onset of flaccid limb weakness) were submitted to CDC. (cdc.gov)
- Withhold or permanently discontinue fluorouracil in patients with evidence of acute early-onset or unusually severe toxicity, which may indicate near complete or total absence of dipyrimidine dehydrogenase (DPD) activity. (nih.gov)
- Stroke" is much less useful than "RUE weakness" or "acute onset cerebellar signs. (yale.edu)
- The disorder manifests as an acute-onset encephalopathy associated with polyfocal neurologic deficits and is typically self-limiting. (medscape.com)
Lesion1
- Scans show a midline cerebellar cystic lesion with an enhancing nodule (arrow) due to cerebellar hemangioblastoma. (medscape.com)
Symptoms4
- In this patient, cerebellar symptoms started within 24 hours from the vaccination, and infective causes have been ruled out by serum and liquoral analyses. (univr.it)
- Acute cerebellar ataxia is characterized by abrupt and symmetric symptoms, with no mental status changes, no fever, no meningitis, and no headache. (medscape.com)
- For example, essential tremor is generally thought of as benign and should not shorten life, but symptoms can be disabling, and cerebellar degeneration has been detected in some neuropathologic studies. (msdmanuals.com)
- The spectrum of acute central nervous system symptoms during the treatment of childhood acute lymphoblastic leukaemia. (cancercentrum.se)
Dysfunction2
- Vascular ischemia may result in acute labyrinthine dysfunction that mimics labyrinthitis. (medscape.com)
- CASE REPORT: The authors report the case of a 47-year-old man in good general health admitted with acute left vestibular dysfunction suggestive of inner ear decompression sickness 6 hours after scuba diving. (who.int)
Encephalomyelitis1
- Acute disseminated encephalomyelitis (ADEM) is an immune-mediated inflammatory demyelinating condition that predominately affects the white matter of the brain and spinal cord. (medscape.com)
Gait1
- Acute cerebellar ataxia is the most common cause of unsteady gait in children. (wikipedia.org)
Stroke2
- Given progressive truncal ataxia, patient was admitted for suspected cerebellar stroke. (acponline.org)
- Complete evaluation for cerebellar stroke was limited as MRI could not be done due to cochlear implantation. (acponline.org)
Disorders1
- Overview of Movement and Cerebellar Disorders Voluntary movement requires complex interaction of the corticospinal (pyramidal) tracts, basal ganglia, and cerebellum (the center for motor coordination) to ensure smooth, purposeful movement. (msdmanuals.com)
Diagnosis1
- Acute Cerebellar ataxia is a diagnosis of exclusion. (wikipedia.org)
Herniation1
- This can lead to the descent of the cerebellum through the craniectomy defect, which in turn may result in cerebellar herniation through the surgical defect as well as the reestablishment of contact between the cerebellar tonsils and the brainstem. (johnshopkins.edu)
Weakness2
- Clinicians should suspect AFM in children with acute flaccid limb weakness, especially when accompanied by neck or back pain and a recent history of febrile respiratory illness. (cdc.gov)
- National surveillance for AFM was initiated in 2014, after California and Colorado reported clusters of AFM or acute limb weakness among previously healthy children, none of whom had laboratory or epidemiologic evidence of poliovirus infection ( 2 , 3 ). (cdc.gov)
Infection1
- Acute cerebellar ataxia usually follows 2-3 weeks after an infection. (wikipedia.org)
Bilateral1
- Acute bilateral deafness as the first symptom of Wernicke encephalopathy. (ima-press.net)
Inflammatory2
- Necropsies reported dilation of the left ventricle, focal fibrosis, and inflammatory infiltrates with acute myocyte loss. (nature.com)
- [ 2 ] Other boundaries of ADEM merge indistinctly with a wide variety of inflammatory encephalitic and vasculitic illnesses as well as monosymptomatic, postinfectious illnesses that should remain distinctfromADEM, such as acute cerebellar ataxia (ACA). (medscape.com)
Viral1
- The most common viruses causing acute cerebellar ataxia are chickenpox virus and Epstein-Barr virus, leading to a childhood form of post viral cerebellar ataxia. (wikipedia.org)
Synaptic5
- However, recent experimental evidence indicates that cerebellar operations are much more complex than solely predicted by anatomy, due to the crucial role played by neuronal and synaptic properties. (frontiersin.org)
- Here, we review what is known about cerebellar network organization, neural dynamics and synaptic plasticity and point out what is still missing and would require experimental assessments. (frontiersin.org)
- non-linear excitation and inhibition properties and multiple forms of synaptic plasticity that cooperate to generate the computational schemes that process incoming signals and generate the cerebellar output. (frontiersin.org)
- The presence of auto-antibodies that target synaptic machinery proteins was documented recently in immune-mediated cerebellar ataxias. (springer.com)
- GAD65 is involved in the synthesis, packaging, and release of GABA, whereas the other three play important roles in the induction of long-term depression (LTD). Thus, the auto-antibodies toward these synaptic molecules likely impair fundamental synaptic machineries involved in unique functions of the cerebellum, potentially leading to the development of cerebellar ataxias (CAs). (springer.com)
Neuronal2
- We demonstrate that PI(4,5)P 2 forms tiny clusters with a mean size of ∼1000 nm 2 rather than randomly distributed in cerebellar neuronal membranes in male C57BL/6J mice. (jneurosci.org)
- The cerebellar cortex microcircuit is characterized by a highly ordered neuronal architecture having a relatively simple and stereotyped connectivity pattern. (frontiersin.org)
Ischemia1
- Examination of the brain showed diffuse cerebral edema, and cerebellar arachnoid hemorrhages most likely due to the prolonged cerebral ischemia. (hawaii.edu)
Encephalopathy2
- Acute cerebellar ataxia in a young woman: Wernicke's encephalopathy? (ima-press.net)
- The paper describes a clinical case of acute cerebellar ataxia that is apparently caused by Wernicke's encephalopathy in a young woman. (ima-press.net)
Affects2
- Most commonly acute cerebellar ataxia affects children between age 2 and 7 years. (wikipedia.org)
- Autoimmunity affects the cerebellum, leading to the manifestations of the cerebellar ataxias (CAs), termed immune-mediated cerebellar ataxia (IMCAs). (springer.com)
Abstract1
- abstract = "Cerebellar ptosis is a rare complication following Chiari malformation decompression, and generally is the result of a very large suboccipital craniectomy. (johnshopkins.edu)
Clinical1
- The spectrum of clinical presentations included sudden unexpected death in children before the age of 2 years, mitochondrial disease leading to death in infants aged between 1 month and 2 years, sudden cardiac arrest following the ingestion of small amounts of alcohol in teenagers, and adults reporting acute sensitivity to alcohol. (nature.com)
Neurologic1
- Low GCS score did not correlate with poor neurologic outcome in patients with acute basilar artery thrombosis managed with IA therapy. (ajnr.org)
Truncal ataxia1
- There were prominent cerebellar signs in the form of truncal ataxia, impaired finger to nose and knee-heel tests, and dysdiadochokinesia. (bmj.com)
Evidence2
- Evidence to guide patient selection for IA therapy in acute basilar artery thrombosis is lacking. (ajnr.org)
- This issue reviews evidence-based approaches to emergency department management of moderate to severe acute asthma in pediatric patients. (ebmedicine.net)
Childhood3
- Acute cerebellar ataxia is the most common cause of childhood ataxia, usually resulting from infections or vaccinations. (univr.it)
- TPMT polymorphisms and minimal residual disease after 6-mercaptopurine post-remission consolidation therapy of childhood acute lymphoblastic leukaemia. (cancercentrum.se)
- Relapse risk following truncation of PEG-asparaginase in childhood acute lymphoblastic leukemia. (cancercentrum.se)
Brain2
- Treatment depends on the cause and type of tremor and may involve avoidance of triggers (physiologic), propranolol or primidone (essential), physical therapy (cerebellar), levodopa (parkinsonian), and possibly deep brain stimulation or thalamotomy (disabling and drug-refractory). (msdmanuals.com)
- In the case of assessing the potential acute neurotoxicity of MeI, the peak concentration of MeI in the brain would be the appropriate internal dose measure. (cdc.gov)
Intracerebral2
- Cerebellar hemorrhages (CHs) result from the same causes as other intracerebral hemorrhages. (medscape.com)
- An estimated 10% of intracerebral hemorrhages are believed to be cerebellar in location. (medscape.com)
Patients2
- Cerebellar hemorrhages are occasionally reported in patients following supratentorial surgery, spinal surgery, and in patients with spontaneous intracranial hypotension. (medscape.com)
- Polygenic risk score-analysis of thromboembolism in patients with acute lymphoblastic leukemia. (cancercentrum.se)
Transient1
- The acute transient neurotoxicity observed in rats exposed to MeI is best supported by a mode of action involv- ing modification of ion currents by the parent chemical in nerve cells. (cdc.gov)
Movement1
- Acute cerebellar ataxia is sudden inability to coordinate muscle movement due to disease or injury to the cerebellum. (medlineplus.gov)
Disease1
- Kawasaki disease is an acute febrile multisystem vasculitis affecting children. (hawaii.edu)
Children3
- Acute cerebellar ataxia in children, particularly younger than age 3, may occur several days or weeks after an illness caused by a virus. (medlineplus.gov)
- Acute ataxia in children has a wide differential that sends kids and families to the pediatrician or emergency department, Strunc said. (medscape.com)
- ÓG, Vaitkeviciene G, Lepik K, Forslund A, Heyman M, Harila-Saari A. Impact of body mass index on relapse in children with acute lymphoblastic leukemia treated according to Nordic treatment protocols. (cancercentrum.se)
Commonly1
- Despite their immune diversity, the majority of IMCAs is commonly associated with auto-antibodies against cerebellar autoantigens. (springer.com)
Exam1
- A cerebellar exam was within normal limits. (aao.org)
Respiratory1
- Acute effects in animals included respiratory stimulation and violent tonic convulsions, causing respiratory depression and asphyxiation. (cdc.gov)
Case1
- The authors describe a case of a 12-year-old girl exhibiting acute cerebellar ataxia following meningococcal group C conjugate vaccination. (univr.it)
Sudden1
- Within these 28 cases, 15 died of sudden cardiac arrest and 13 of acute heart failure. (nature.com)
Exposure3
- Study of the neurochemical alterations produced by acute and subchronic Pb-exposure in Meriones shawi: Immunohistochemical study of Reissner's fiber secretion by the subcommissural organ after curcumin-III treatment. (nih.gov)
- These exposures, however, are with exposure, proceeding through operational and ana- expected to be acute in nature due to its intended use, which tomical changes, and resulting in toxicity. (cdc.gov)
- An understanding of the mode(s) of action by which these with incomplete information, and because mode of action effects are produced by MeI is important to guide criti- is used to guide critical decisions, it is important to provide cal decisions used in the acute exposure risk assessment. (cdc.gov)