• The beginning of metaphase is characterized by the connection of the microtubules to the kinetochores of the chromosomes, as well as the alignment of the chromosomes in the middle of the cell. (wikipedia.org)
  • Each chromatid has its own kinetochore, and all of the microtubules that are bound to kinetochores of sister chromatids radiate from opposite poles of the cell. (wikipedia.org)
  • At the metaphase to anaphase transition, this cohesion between sister chromatids is dissolved, and the separated chromatids are pulled to opposite sides of the cell by the spindle microtubules. (wikipedia.org)
  • PI3K class I, which is essential in the regulation of cell survival, metabolism, apoptosis and cell cycle of the heterodimeric class I molecules of a catalyst composition PI3Ks regulatory subunit and are classified in class IA or IB PI3K class. (microrna1.com)
  • There will always play the PI3K catalytic subunits r No redundant in the regulation of cell biology. (microrna1.com)
  • At the metaphase to anaphase transition, this cohesion between sister chromatids is dissolved, and the separated chromatids are pulled to opposite sides of the cell by the spindle microtubules. (wikipedia.org)
  • Studies have been carried out to determine how the Tub4p complex binds to the yeast microtubule organizing center, the spindle pole body (SPB). (sdbonline.org)
  • The yeast microtubule organizing center (MTOC), known as the spindle pole body (SPB), organizes the nuclear and cytoplasmic microtubules, which are functionally and spatially distinct. (sdbonline.org)
  • The cytoplasmic microtubules have functions in nuclear positioning and nuclear movement, while the nuclear microtubules are involved in spindle formation and chromosome segregation in mitosis and meiosis. (sdbonline.org)