Loading...
  • inhibitory
  • This function is the outcome of the capacity of inhibitory NK receptors to block cytotoxicity upon interaction with their MHC-I ligands expressed on target cells. (jimmunol.org)
  • The cytolytic and cytokine functions of NK cells are regulated by a complex balance between inhibitory and activating signals that are triggered via the engagement of different NK cell surface receptors with their specific ligands ( 1 , 2 , 3 ). (jimmunol.org)
  • Target cells expressing MHC class I (MHC-I) 3 molecules are protected from NK cell lysis by interactions between these molecules and inhibitory NK receptors. (jimmunol.org)
  • Sesquin, a potent defensin-like antimicrobial peptide from ground beans with inhibitory activities toward tumor cells and HIV-1 reverse transcriptase. (semanticscholar.org)
  • inhibits
  • Here, we report that indeed TA potently and specifically inhibits the chymotrypsin-like activity of purified 20S proteasome (IC 50 = 0.06 μg/ml), 26S proteasome of Jurkat T-cell extracts, and 26S proteasome of living Jurkat cells. (aacrjournals.org)
  • Our present study suggests that TA targets and inhibits the proteasome in tumor cells, which may contribute to the previously observed anticarcinogenic activity of TA. (aacrjournals.org)
  • Here, we report that ester-bond containing TA potently and selectively inhibits the chymotrypsin-like activity in purified 20S proteasome, 26S proteasome of Jurkat T-cell extracts, and 26S proteasome in intact Jurkat cells. (aacrjournals.org)
  • viruses
  • The boosting of IF and NK functions did not appear to be a result of contamination of the tumor lines by viruses because inoculation of several type C viruses into normal mice had no effect, and other viruses, like lymphocytic choriomeningitis virus and influenza, elevated IF and NK levels with a significantly later kinetics, peaking 3-4 d. (rupress.org)
  • human
  • To investigate the role of human NK cells and their various receptors in the control of MHC-I-deficient tumors, we have isolated several NK cell clones from lymphocytes infiltrating an adenocarcinoma lacking β 2 -microglobulin expression. (jimmunol.org)
  • Human triggering receptors responsible for NK cell activation have been recently identified ( 9 , 10 ). (jimmunol.org)
  • carcinoma
  • In contrast, the carcinoma cell line was partially sensitive to allogeneic healthy donor NK cells expressing high levels of NCR. (jimmunol.org)
  • growth
  • HIF-1α is often upregulated in tumors leading to more aggressive tumor growth and chemoresistance, therefore representing an important target for antitumor intervention. (sigmaaldrich.com)
  • Lastly, STA-9090 inhibited tumor growth in a mastocytoma xenograft model. (aacrjournals.org)
  • demonstrate
  • We now demonstrate that HGF induced the trafficking of lysosomes to the cell periphery, independent of HGF-induced epithelial-mesenchymal transition. (biologists.org)
  • Tumor cells demonstrate enhanced metabolism because of increased glycolytic rates, which affects cytoplasmic pH (pH i ) as a result. (biologists.org)
  • extracellular
  • After depolarization of the cell in which Na+ flows into the cell, the Na+ cannot be transported back into the extracellular membrane, causing the sodium gradient to disappear. (wikipedia.org)
  • To make muscle contraction possible, a calcium influx from the extracellular fluid into the cell is crucial. (wikipedia.org)
  • Tissue
  • When compared to normal tissue, all GC epithelia had lower levels of FOXO4 located in the nucleus, consistent with less FOXO4 effector activity and FOXO4's function as a suppressor of carcinogenic properties. (wikipedia.org)
  • indicates
  • The present study indicates that the MHC-I-deficient lung adenocarcinoma had developed mechanisms of escape from the innate immune response based on down-regulation of NCR and ligands required for target cell recognition. (jimmunol.org)
  • cytotoxicity
  • These receptors include a heterogeneous family of molecules composed of natural cytotoxicity receptors (NCRs), which are exclusively expressed by NK cells and NKG2D, which is expressed by both NK cells and CTLs. (jimmunol.org)
  • acid
  • Animal studies have demonstrated that a dietary polyphenol known as tannic acid (TA) exhibits anticarcinogenic activity in chemically induced cancers, although the involved molecular target remains unknown. (aacrjournals.org)
  • The IF induced by tumor cells was heat and acid labile, species specific, and appeared to be in the type II class, although it was susceptible to antisera against Newcastle disease virus-induced IF. (rupress.org)
  • membrane
  • Under typical physiological conditions, this results in an efflux of K+ from the cell, which leads to cell membrane hyperpolarization (an increase in the electrical potential across the cell membrane) and a decrease in cell excitability (a decrease in the probability that the cell will transmit an action potential). (wikipedia.org)
  • invasion
  • During early metastatic events in cancer, reorganization of the actin cytoskeleton must occur to allow for cell invasion and migration. (aacrjournals.org)
  • HGF-induced anterograde lysosome trafficking depended upon the PI3K pathway, microtubules and RhoA, resulting in increased cathepsin B secretion and invasion by the cells. (biologists.org)
  • EIPA treatment reduced cathepsin B secretion and HGF-induced invasion by the tumor cells. (biologists.org)
  • Together, these results suggest that the location of lysosomes is an inherently important aspect of invasion by tumor cells. (biologists.org)