Activity transcriptional regulation replication through transcriptional. Medical search. Frequent questions

Proteins binding to PCNA via the PIP-box are mainly involved in DNA replication whereas proteins binding to PCNA via APIM are mainly important in the context of genotoxic stress. (wikipedia.org)

Within the research in Molecular Biology, one important field along the years has been the analyses on how prokaryotes regulate the expression of their genes and what the consequences of these activities are. (ibecbarcelona.eu)
To also target low expressed essential genes, we included some variant steps that were expected to overcome the non-stringent regulation of the promoter carried by the expression vector used for the shotgun antisense libraries. (biomedcentral.com)
Gametocyte/gamete differentiation requires controlled patterns of gene expression and regulation not only of stage and gender-specific genes but also of genes associated with DNA replication and mitosis. (gla.ac.uk)
This transcriptional control, described for the first time in Plasmodium, provides a mechanism by which single-copy genes can be differently modulated during parasite development. (gla.ac.uk)
Differentially expressed candidate genes for ageing previously identified in the human blood transcriptome up-regulated in PP cows were mainly associated with T-cell function ( CCR7 , CD27 , IL7R , CAMK4 , CD28 ), mitochondrial ribosomal proteins ( MRPS27 , MRPS9 , MRPS31 ), and DNA replication and repair ( WRN ). (biomedcentral.com)
In "high-FACT" cells, FACT supports expression of genes involved in the regulation of cell cycle, DNA replication, maintenance of an undifferentiated cell state and regulated by the activity of several proto-oncogenes. (oncotarget.com)
The differentially regu- many of which were not found in previous transcriptional lated genes were separately uploaded into EASE (4) to studies of other flaviviruses (3). (cdc.gov)
CHEK1-mediated phosphorylation prevents association of E2F6 with its target promoters, allowing transcription of E2F target genes whose expression is needed for resolution of stalled replication forks and restart of DNA synthesis. (reactome.org)
Inability to induce transcription of E2F target genes (due to CHEK1 inhibition or E2F6 overexpression) leads to replication stress-induced DNA damage (Bertoli et al. (reactome.org)
They are involved in a range of cellular processes, depending upon the transcriptional repressor that recruits them to DNA, and they suppress the transcription of genes that cause apoptosis (reviewed in Bergman et al, 2006a). (southampton.ac.uk)
Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. (lu.se)
INTRODUCTION broken, which in realistic situations can severly constrain the Transcriptional regulation of effector genes is a highly successful regulatory options. (lu.se)
A very natural place to study gene detecting and metabolizing lactose, it is known that the overall regulation is in the metabolism of the cell, and then specifically in effect of expressing the lac genes in vain is a drop in the growth rate the regulation of genes that code for enzymes and transporter of as much as 5% [1,6]. (lu.se)
Here, the function of regulation is quite clear: expressing energy and carbon, that a number around 0.2% would be the right genes at the right time will enable the cell to make the expected, and that the difference is more or less specific to the lac most of the resources within its reach, by maximizing the uptake operon [7]. (lu.se)

The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. (wikipedia.org)
This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. (arigobio.com)
The human papillomavirus (HPV) E2 protein is a multifunctional protein essential for the control of virus gene expression, genome replication and persistence. (microbiologyresearch.org)
Upon co-expression in keratinocytes, L1 reduces nucleolar association of E2 protein, and when co-expressed with E1 and E2, L1 is partially recruited to viral replication factories. (microbiologyresearch.org)
Poly(ADP ribose) polymerase 1 (PARP1) is a multifunctional DNA repair protein of the base excision repair pathway and plays a major role in the repair of DNA strand breaks and in replication and transcriptional regulation among other functions. (nist.gov)
Moreover, we uncover a 26-residue region unique to EF-G2 that is essential for protein synthesis, EF-G2 dissociation from the ribosome, and responsible for the absence of GTPase activity. (yale.edu)
Transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. (embl.de)
We describe the residue-specific methylation of E2F-1 by the asymmetric dimethylating protein arginine methyltransferase 1 (PRMT1) and symmetric dimethylating PRMT5 and relate the marks to different functional consequences of E2F-1 activity. (embl.de)
The Tudor domain protein p100-TSN reads the symmetric methylation mark, and binding of p100-TSN downregulates E2F-1 apoptotic activity. (embl.de)
PRMT6 is a protein arginine methyltransferase that has been implicated in transcriptional regulation, DNA repair, and human immunodeficiency virus pathogenesis. (embl.de)
The assembly of PRMT6 protein network allowed us to formulate functional hypotheses which led to the discovery of new molecular partners for the architectural transcription factor HMGA1a, a known substrate for PRMT6, and to provide evidences for a modulatory role of HMGA1a on the methyltransferase activity of PRMT6. (embl.de)
Chromatin target of Prmt1 (Chtop) is a vertebrate-specific chromatin-bound protein that plays an important role in transcriptional regulation. (embl.de)
Whereas the recombinant HIV-1 IN protein is sufficient to catalyze the 3' processing and strand transfer activities for in vitro integration, functional interactions between IN and host cell factors are required during the early events of HIV-1 replication in vivo [ 10 - 12 ]. (biomedcentral.com)
Serine/arginine-rich protein-specific kinases (SRPKs) 1 and 2 phosphorylate and regulate serine/arginine-rich (SR) proteins that bind and regulate mRNA splicing, playing an important role in post-transcriptional regulation (1). (cellsignal.jp)
SRPK dysregulation can alter SR protein activity and promote expression of splicing isoforms, leading to increased viral infection or tumorigenic processes. (cellsignal.jp)
Replication of the Epstein-Barr virus (EBV) genome within latently infected cells is dependent on the EBV EBNA-1 protein. (psu.edu)
We observed no effect of gamma interferon on Qp activity in transfection assays, whereas we observed a moderate but significant repression of Qp activity in response to alpha interferon, possibly mediated by either the interferon consensus sequence binding protein or IRF-7, a novel alpha interferon-inducible factor identified in this study. (psu.edu)
Multiple proteins are involved in p53 regulation but one of the most critical negative regulators of p53 is the protein MDM2. (oncotarget.com)
Whereas transcription elements and epigenetic systems are in Prinaberel charge of transcriptional control, posttranscriptional legislation (splicing, mRNA editing, balance, translatability, and localization) frequently depends upon RNA-binding protein (RBP) [4]. (iassist2012.org)
The NAD-dependent histone deacetylase Sir2 controls ribosomal DNA (rDNA) silencing by inhibiting recombination and RNA polymerase II-catalyzed transcription in the rDNA of Saccharomyces cerevisiae Sir2 is recruited to nontranscribed spacer 1 (NTS1) of the rDNA array by interaction between the RENT ( RE: gulation of N: ucleolar S: ilencing and T: elophase exit) complex and the replication terminator protein Fob1. (omicsdi.org)
Replication fork arrest and rDNA silencing are two independent and separable functions of the replication terminator protein Fob1 of Saccharomyces cerevisiae. (omicsdi.org)
The replication terminator protein Fob1 of Saccharomyces cerevisiae is multifunctional, and it not only promotes polar replication fork arrest at the tandem Ter sites located in the intergenic spacer region of rDNA but also loads the NAD-dependent histone deacetylase Sir2 at Ter sites via a protein complex called RENT (regulator of nucleolar silencing and telophase exit). (omicsdi.org)
Protein-mediated "chromosome kissing" between two DNA sites in trans (or in cis) is known to facilitate three-dimensional control of gene expression and DNA replication. (omicsdi.org)
Here, we show that the replication terminator protein Fob1 of Saccharomyces cerevisiae promoted chromosome kissing that initiated rDNA recombination and controlled the replicative life span (RLS). (omicsdi.org)
Geminiviral V2 Protein Suppresses Transcriptional Gene Silencing through Interaction with AGO4. (ncsu.edu)
We have a long-standing interest in the p53 protein, a stress-activated transcriptional activator. (southampton.ac.uk)
Moreover, we show that the Polycomb protein BMI1 interacts with CDC6, an essential regulator of DNA replication in eukaryotic cells. (plos.org)
Upon senescence, Jmjd3 is overexpressed and the MLL1 protein is recruited to the locus provoking the dissociation of Polycomb from the INK4/ARF locus, its transcriptional activation and its replication during early S-phase. (plos.org)

HIV entry in CD4 T lymphocytes was known to critically rely on the interaction of the HIV envelope glycoproteins (surface subunit gp120) with CD4, a viral receptor and a critical determinant of viral tropism, in that gp120 binding to CD4 eventually leads to viral/target cell membrane fusion and entry of viral replication machinery. (hal.science)
Viral replication leads to the host entering an immune-compromised state, evolving towards subsequent bacteraemia by opportunistic bacteria. (nature.com)
HIV-1 IN also binds the karyopherin TNPO3, however the significance of this interaction during viral replication remains to be explored. (biomedcentral.com)

PCNA is also involved in the DNA damage tolerance pathway known as post-replication repair (PRR). (wikipedia.org)
In this study, we found that C. albicans Hom6p has a homoserine dehydrogenase activity and is probably involved in the pathway for threonine and methionine biosynthesis. (ncl.edu.tw)
Here we outline the current status of the viral evasion mechanism underlying the regulation of the cGAS-STING pathway, focusing on how post-transcriptional modifications, viral proteins, and non-coding RNAs involve innate immunity during viral infection, attempting to inspire new targets discovery and uncover potential clinical antiviral treatments. (frontiersin.org)
Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. (cusabio.com)
Within the project using next generation sequencing technology and signal transduction pathway activity profiling technology, we have identified novel pathways and biomarkers implicated in cervical carcinogenesis. (europa.eu)

The present study investigated the methylation of CpG sites in the cyclooxygenase (COX)‑2 promoter via nuclear factor (NF)‑κB transcriptional regulation and elucidated its effect on the COX‑2 transcriptional expression in a ketamine‑induced ulcerative cystitis (KIC) animal model. (spandidos-publications.com)
Moreover, DNA hypomethylation of the COX‑2 promoter region located from ‑1,522 to ‑829 bp might contribute to transcriptional regulation of COX‑2 expression and induce a pro‑inflammatory response in KIC. (spandidos-publications.com)
The mechanism of epigenetic regulation involves the CpG site methylation of promoter regions and the modification of DNA and histones by altering chromatin structure ( 9 - 11 ). (spandidos-publications.com)
In ookinetes both promoters exhibit a basal activity, while in the oocysts the gametocyte-specific promoter is silent and the reporter gene is only transcribed from the constitutive promoter. (gla.ac.uk)
The objective of this study was to identify transcriptional regulatory proteins that mediate EBNA- 1 expression via the viral promoter Qp, which is active in EBV-associated tumors such as Burkitt lymphoma and nasopharyngeal carcinoma. (psu.edu)
KSRP continues to be described to modify c-myc transcription by binding towards the significantly upstream sequence from Prinaberel the myc promoter [8] and to regulate TNF-promoter activity [9]. (iassist2012.org)
a transcriptional cis regulatory region that when located between an enhancer and a gene's promoter prevents the enhancer from modulating the expression of the gene. (insdc.org)

Recently, we have identified ULTRAVIOLET-B-INSENSITIVE4 (UVI4) as a plant-specific component of the APC/C. Here, we demonstrate that UVI4 uses conserved APC/C interaction motifs to counteract the activity of the CELL CYCLE SWITCH52 A1 (CCS52A1) activator subunit, inhibiting the turnover of the A-type cyclin CYCA2;3. (ugent.be)
Further investigation indicated that the transcriptional activator IRF-1 and the closely related IRF-2, a repressor of interferon-induced gene expression, are both capable of activating Qp. (psu.edu)

Given the complexity of human transcriptional regulation in vivo and the multitude of potential epigenetic mechanisms cooperating to regulate transcriptional activity, questions remain about the interplay of regulatory mechanisms in patients with CMML. (nature.com)
Finally, we demonstrate that Polycomb proteins and associated epigenetic marks are crucial for the control of the replication timing of the INK4a/ARF locus during senescence. (plos.org)
Agherbi H, Gaussmann-Wenger A, Verthuy C, Chasson L, Serrano M, Djabali M (2009) Polycomb Mediated Epigenetic Silencing and Replication Timing at the INK4a/ARF Locus during Senescence. (plos.org)

We have previously shown that the forkhead transcription factor FoxO1 is a prominent transcriptional effector of GLP-1 signaling in the β-cell. (diabetesjournals.org)

Ewing sarcoma, a tumor of children and young adults, is characterized by a chromosomal translocation that creates a transcriptional regulator that gains chromatin remodeling activity. (unc.edu)
Some Example Projects: Regulation of HDM2 and HDMX proteins The HDM2 oncoprotein is the major negative regulator of p53 function in the cell. (southampton.ac.uk)

Proliferating cell nuclear antigen (PCNA) is a DNA clamp that acts as a processivity factor for DNA polymerase δ in eukaryotic cells and is essential for replication. (wikipedia.org)

Slide nucleosomes away from DNA ends.Putative regulatory component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. (bomiprot.org)
Here we show that in young proliferating embryonic fibroblasts (MEFs) the Polycomb Repressive Complex 2 (PRC2) member EZH2 together with PRC1 members BMI1 and M33 are strongly expressed and localized at the INK4/ARF regulatory domain (RD) identified as a DNA replication origin. (plos.org)
Optimizing the parameters of the regulatory system allows us to quantify the fitness benefit of regulation. (lu.se)
In unicellular organisms like E. coli and yeast, the benefits of between potential cost and benefit, regulation can make the most a well-adapted regulatory system are readily quantified, as the difference to the long-term growth rate if the resource in question fitness of an individual can be estimated by its growth rate in is only available a similarly small fraction of the time. (lu.se)
Over evolutionary time scales, regulation must provide a fitness benefit that offsets the costs of maintaining the regulatory system. (lu.se)

Contributing to the interest of the present topic is the fact that modulation of gene activity involves the sensing of intra- and inter-cellular conditions, DNA binding and DNA dynamics, and interaction with the replication/transcription machinery of the cell. (ibecbarcelona.eu)
Taken together, our findings suggest that the interaction between E2 and L1 is important for the regulation of E2 function during the late events of the HPV life cycle. (microbiologyresearch.org)
With a minimalist model of metabolism, cell growth and transcriptional regulation in a microorganism, we explore how the interaction between environmental conditions and gene regulation set the growth rate of cells in the phase of exponential growth. (lu.se)

On the other hand, the study of the dynamics of replication and repair in living cells can be done by introducing translational fusions of PCNA. (wikipedia.org)
We investigated combinatorial translational regulation by Drosophila Pumilio (Pum) and Nanos (Nos), which control development, fertility, and neuronal functions. (elifesciences.org)

A protocol for genome-wide analysis of DNA replication timing in intact root tips. (ncsu.edu)

CtBP activity is modified by UV radiation and glycolytic metabolism, suggesting that CtBPs regulate cell survival in response to cellular stress. (southampton.ac.uk)

Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. (arigobio.com)
In addition, using invitro methylation assay we identified 4 new substrates for PRMT6, extending the involvement of this enzyme to other cellular processes beyond its well-established role in gene expression regulation. (embl.de)
The models of most immune evasion during innate immune responses are conserved, including altering the post-transcriptional modifications (PTMs) of vital proteins to inactivate or degrade these components, eluding DNA sensing from PRRs, decreasing cyclic GMP-AMP (cGAMP) cellular abundance, and modifying metabolism approach in host cells ( Eaglesham and Kranzusch, 2020 ). (frontiersin.org)
Faithful regulation of chromatin processes is central to normal cellular function and development. (unc.edu)
Transcriptional responses to pathways: roles in the causes and treatment of cancer Intra-cellular stress-response pathways are activated in response to potentially deleterious conditions in the cell's environment. (southampton.ac.uk)

The latter binds to its cognate sites, called replication termini (Ter) or replication fork barriers (RFB), that are located in each copy of NTS1. (omicsdi.org)

SIMC1 uses its SIMs and Nse5-like domain to localize SMC5/6 to polyomavirus replication centers (PyVRCs) at SUMO-rich PML nuclear bodies. (elifesciences.org)
Topoisomerase II activity in nuclear extracts Topoisomerase II activity in nuclear extracts, either vehicle controlled or incubated for different times with SP600125, was assayed using an assay kit based on the decatenation of kinetoplast DNA. (alk-inhibitors.com)
Chromatin, the assembly of DNA and its associated proteins, constitutes the template for most nuclear processes, including transcription, replication and DNA damage repair. (unc.edu)

In single celled organisms these pathways are generally involved in ensuring the survival and replication of the individual cell. (southampton.ac.uk)
Citation: Troein C, Ahre´n D, Krogh M, Peterson C (2007) Is Transcriptional Regulation of Metabolic Pathways an Optimal Strategy for Fitness? (lu.se)
A number of studies have explored how regulation of generally, and at least to a first approximation, it is obvious that metabolic pathways affects the growth rate of microorganisms, gene regulation only is useful if the environmental conditions vary both in the steady state and in response to changes in the local with time. (lu.se)

DNA replication: semi-conservative replication, DNA polymerases, events at the replication form, replication of the lagging strand, telomeres, consequences of defects in telomerase. (manchester.ac.uk)

DNA meth-ylation represses transcription by interfering with transcription factor binding and indirectly by recruiting methyl-CpG-binding proteins and reducing chromatin remodeling activities ( 12 ). (spandidos-publications.com)
It also stimulates insulin gene expression and insulin biosynthesis ( 6 ), in part via increased expression and activity of the β-cell-specific transcription factor Pdx1 ( 7 , 8 ). (diabetesjournals.org)

PCNA is a homotrimer and achieves its processivity by encircling the DNA, where it acts as a scaffold to recruit proteins involved in DNA replication, DNA repair, chromatin remodeling and epigenetics. (wikipedia.org)
Together, these results provide a unified model that integrates replication, transcription and epigenetics at the INK4/ARF locus. (plos.org)

Thus, by usurping both IRF-1 and its transcriptional antagonist IRF-2 to activate Qp, EBV has evolved not only a mechanism to constitutively express EBNA-1 but also one which may sustain EBNA-1 expression in the face of the antiviral effects of interferon. (psu.edu)
Mechanism of Regulation of Intrachromatid Recombination and Long-Range Chromosome Interactions in Saccharomyces cerevisiae. (omicsdi.org)
Mechanism of regulation of 'chromosome kissing' induced by Fob1 and its physiological significance. (omicsdi.org)
The results provide novel insights into a mechanism of regulation of Fob1-mediated chromosome kissing. (omicsdi.org)

We conclude that UVI4 regulates the temporal inactivation of APC/C during DNA replication, allowing CYCA2;3 to accumulate above the level required for entering mitosis, and thereby regulates the meristem size and plant growth rate. (ugent.be)

Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase activity and catalyzes the replication-independent deposition of histone H3.3 in pericentric DNA repeats outside S-phase and telomeres, and the in vitro remodeling of H3.3-containing nucleosomes. (arigobio.com)

These cells also develop specific strategies to increase ROS resistance and to express the enzymatic activities necessary for ROS detoxification. (hindawi.com)
To eliminate the need for transfection and bypass the problem of difficult to transfect and/or short lived cells, cell permeable replication and/or repair markers can be used. (wikipedia.org)
These peptides offer the distinct advantage that they can be used in situ in living tissue and even distinguish cells undergoing replication from cells undergoing repair. (wikipedia.org)
Our findings prove the existence of a divergent scaffolding role of KDM1A splice variants, independent of their enzymatic activity, during hESC differentiation into cardiac cells. (ibecbarcelona.eu)
Here, we characterize the role of this alarmone in the regulation of the hlyCABD(II) operon of the UPEC isolate J96, encoding the toxin alpha-hemolysin that induces cytotoxicity during infection of bladder epithelial cells. (ibecbarcelona.eu)
Among them, nicotinamide significantly inhibited HAV HA11-1299 genotype IIIA replication in Huh7 cells. (bvsalud.org)
Our initial interest in chemokines was based on our hypothesis that they could act both as chemoattractants for HIV-1 target cells and inducers of HIV-1 transcription and replication. (hal.science)
Our data show that GLP-1 increases FoxO1 acetylation, decreases the binding of SirT1 to FoxO1, and stunts SirT1 activity in β-INS832/13 cells. (diabetesjournals.org)
GLP-1 decreases both the NAD + -to-NADH ratio and SirT1 expression in INS cells and isolated islets, thereby providing possible mechanisms by which GLP-1 could modulate SirT1 activity. (diabetesjournals.org)
Our study shows for the first time that the glucoincretin hormone GLP-1 modulates SirT1 activity and FoxO1 acetylation in β-cells. (diabetesjournals.org)
Initially distinct transcriptional profiles of BrCa cells became similar upon equalizing FACT expression. (oncotarget.com)
However, the major QRE-2-specific binding activity detected within extracts of Burkitt lymphoma cells was attributed to IRF-2, suggesting that interferon-independent activation of Qp is largely mediated by IRF-2 in these cells. (psu.edu)
Involved in activated KRAS-mediated transcriptional activation of USP28 in colorectal cancer (CRC) cells. (cusabio.com)
Comparing DNA replication programs reveals large timing shifts at centromeres of endocycling cells in maize roots. (ncsu.edu)
Other trophic factors, such as IL-2, TNF-α, and granulocyte-macrophage stimulating factor, cause activated T cells to produce interferon-γ, TNF-α, and TNF-β, leading to stimulation of macrophages and further up-regulation of leukocyte adhesion molecules. (medscape.com)

Based on the tight relationship between T cell activation and HIV replication, the blockade of HIV infection by these factors was in an apparent contradiction with the strong and recently reported potent antigen-independent activation in T lymphocytes by RANTES. (hal.science)
These cytokines possess pleiotropic functions, like the regulation of immune cell activation and differentiation [1]. (iassist2012.org)

May also include enhancer-blocking activity. (insdc.org)

Our data further support the role of ppGpp participating in the coordinated regulation of the expression of bacterial factors required during infection. (ibecbarcelona.eu)
Vector acquisition and co-inoculation of two plant viruses influences transmission, infection, and replication in new hosts. (ncsu.edu)

The top three clusters from modules more highly expressed in the PP cows all involved regulation of gene transcription, particularly zinc fingers. (biomedcentral.com)

Albeit not strictly essential for replication, LEDGF/p75 tethers PIC-associated IN to chromatin to presumably stimulate its enzymatic activity at the site of integration [ 31 , 32 ]. (biomedcentral.com)

Replication of genomes: origins of replication, control of DNA replication. (manchester.ac.uk)

Viruses have optimized their evading tactics for superior replication and spreading to counteract host immunity. (frontiersin.org)

These disparate functions likely require distinct mechanisms of SMC5/6 regulation. (elifesciences.org)

Since 1986, the beginning of our involvement in HIV research, our major interest was focused on the regulation of HIV-1 replication by the transcriptional host cell machinery. (hal.science)

PCNA is clamped to DNA through the action of replication factor C (RFC), which is a heteropentameric member of the AAA+ class of ATPases. (wikipedia.org)
Studies in both commensal and UPEC isolates demonstrate that no UPEC specific factor is strictly required for the ppGpp-mediated regulation described. (ibecbarcelona.eu)
We have reported that extent of proliferation of atypical hepatocytes (POAH) in non-cancerous liver in hepatocellular carcinoma and chromatin licensing and DNA replication factor 1 (CDT1) are associated with postoperative recurrence. (bvsalud.org)
We identified the replication licencing factor CDC6 as a new partner of the Polycomb group member BMI1. (plos.org)

SirT1 activity was evaluated using an in vitro deacetylation assay and correlated with the NAD + -to-NADH ratio. (diabetesjournals.org)
Dose-dependent suppression of hepatitis C virus replication by the inhibitor SRPIN340 has been seen in vitro (1). (cellsignal.jp)

Restricted regulation of cytokine expression is essential in order to avoid an damaging and overpowering immune system response. (iassist2012.org)

Our results define an exquisite level of precision in the reader-writer interplay that governs the biological outcome of E2F-1 activity. (embl.de)

Role of CtBP transcriptional repressors in cancer cell proliferation and survival In common with p53, CtBP1 and CtBP2 proteins were discovered through their physical association with a viral oncoprotein. (southampton.ac.uk)

Molecular regulation of the autophagic process in normal and starvation conditions is presented. (hindawi.com)

ppGpp is required for the expression of the alpha-hemolysin encoded in hlyCABD(II) by stimulating its transcriptional expression. (ibecbarcelona.eu)
Using cell-based assays, we show that co-expression of L1 and E2 results in enhanced transcription and virus origin-dependent DNA replication. (microbiologyresearch.org)
However, the gene expression and activity of antioxidative enzymes had no differences between wild type and the zcf29zcf29 mutant. (ncl.edu.tw)
Since expression of IRF-1 and IRF-2 is increased in response to interferons, the Qp activity observed in the presence of interferon likely represented an equilibrium between IRF factors that activate and those that repress gene expression in response to interferon. (psu.edu)

The main function of CtBPs is as transcriptional co-repressors. (southampton.ac.uk)

Here, we discovered a temporal modulation of ubKDM1A and KDM1A+2a during human and mice fetal cardiac development and evaluated their impact on the regulation of cardiac differentiation. (ibecbarcelona.eu)

We conducted a glob- ing to prevent skew in the results due to bias in CyDye al transcriptional analysis of human glioblastoma cell incorporation. (cdc.gov)

This work provides new mechanistic insights into the regulation of rDNA silencing and intrachromatid recombination by showing that Sir2 recruitment is stringently regulated by Fob1 phosphorylation at specific sites in its C-terminal domain (C-Fob1), which also regulates long-range Ter-Ter interactions. (omicsdi.org)

To ensure correct cell cycle progression, accurate timing of APC/C activity is important, which is obtained through its association with both activating and inhibitory subunits. (ugent.be)

CHEK1 (Chk1), activated by ATR in response to replication stress (stalled replication forks), phosphorylates E2F6 on serine residue S12 and possibly also on serine residue S52. (reactome.org)

FoxO1 activity is subject to a complex regulation by Akt-dependent phosphorylation and SirT1-mediated deacetylation. (diabetesjournals.org)

The transcriptional activity of Zcf29p was induced after menadione treatment, revealed by one-hybrid assay. (ncl.edu.tw)

Anatomy23

Organisms16

Diseases1

Chemicals and Drugs86

Analytical, Diagnostic and Therapeutic Techniques and Equipment31

Phenomena and Processes109

Disciplines and Occupations1

Information Science4

Health Care2

Involved in DNA r1

Genes14

Protein28

Viral replication3

Pathway5

Promoter7

Activator2

Epigenetic3

Effector1

Regulator2

Eukaryotic cells1

Regulatory5

Interaction3

Translational2

Genome1

Regulate1

Cellular5

Binds1

Nuclear3

Pathways3

Telomerase1

Transcription factor2

Epigenetics2

Mechanism4

Mitosis1

Histone1

Cells15

Activation2

Enhancer1

Infection2

Gene transcription1

Enzymatic activity1

Control1

Counteract1

Distinct1

Machinery1

Factor4

Vitro2

Essential1

Interplay1

Role1

Molecular1

Expression4

Function1

Differentiation1

Incorporation1

Regulates1

Cell cycle1

Response1

Complex1

Assay1