Activity of lim homeodomain transcription factors lim homeodomain proteins. Medical search. Frequent questions

Chip is a ubiquitous chromosomal factor required for normal expression of diverse genes at many stages of development. (nih.gov)
Rhombotin 1 (RBTN1 or TTG-1) and rhombotin-2 (RBTN2 or TTG-2) are proteins of about 160 amino acids whose genes are disrupted by chromosomal translocations in T-cell leukemia. (embl.de)
Tumor suppressor genes encode proteins that normally provide negative control of cell proliferation. (medscape.com)
The absence of genomic resources renders the search for paralogous cuttlefish genes dependent upon the presence of highly conserved protein motifs within genes of interest, thus we used a degenerate primer strategy to isolate partial coding sequence from the conserved domains specific to these families. (europa.eu)
Proteins encoded by homeobox genes (GENES, HOMEOBOX) that exhibit structural similarity to certain prokaryotic and eukaryotic DNA-binding proteins. (lookformedical.com)
Genes that encode highly conserved TRANSCRIPTION FACTORS that control positional identity of cells (BODY PATTERNING) and MORPHOGENESIS throughout development. (lookformedical.com)
The proteins encoded by homeobox genes are called HOMEODOMAIN PROTEINS. (lookformedical.com)
Our results show that podocyte expression of some genes is combinatorially regulated by two transcription factors interacting synergistically with a common enhancer. (ox.ac.uk)
We also show that Dlx and Smad proteins localize to promoters/enhancers of a number of common telencephalic genes in vivo and that Smad proteins co-activate transcription with Dlx family members, except with certain mutated human DLX proteins identified in autistic individuals. (biomedcentral.com)
Investigating astrocyte maturation in a cell culture model revealed that in vitro-differentiated astrocytes lack expression of many mature astrocyte-specific genes, including genes for the transcription factors Rorb, Dbx2, Lhx2 and Fezf2. (nature.com)
Gene transcription is mainly regulated by transcription factors (TFs) that bind to specific DNA sequences (called motifs) located in the promoter regions of genes [ 1 ]. (biomedcentral.com)
PGCs express several pluripotency-related TFs such as NANOG, POU5F3 , and SOX2 , and their expression controls transcription of germness-related genes in these cells [ 11 , 29 ]. (biomedcentral.com)
The expression of a dominant-negative (DN)allele of Lef1, or of a Lef1-engrailed fusion protein, led to the inhibition of expression of peripheral genes and iris hypoplasia, suggesting that canonical Wnt signaling is required for peripheral eye development. (biologists.com)
Background: HOX genes encode a family of homeodomain-containing transcription factors involved in the determination of cell fate and identity during embryonic development. (123dok.net)
Based on previous phylogenetic analyses in arabidopsis ( Arabidopsis thaliana ), our results showed that some tomato SL-ZH ( S. lycopersicum zinc-finger homeodomain) genes cluster into the same neighbor-joining (NJ) branch as arabidopsis, indicating that these genes may share similar structures and functions in these plants. (ashs.org)
Plant growth is systematically regulated by a system of specialized genes that encode various proteins, with certain genes being capable of influencing vegetative growth and stress tolerance, including cold, drought, and salinity. (ashs.org)
Transcription factors act during cortical development as master regulatory genes that specify cortical arealization and cellular identities. (ox.ac.uk)
Exploiting the aforementioned catalogs of driver genes, for example, we recently revealed the mutational landscape of chromatin regulatory factors (CRFs) in cancer [ 5 ]. (biomedcentral.com)

The LIM-domain binding protein, binds to the LIM domain pfam00412 of LIM homeodomain proteins which are transcriptional regulators of development. (nih.gov)
Nuclear LIM interactor (NLI) / LIM domain-binding protein 1 (LDB1) is located in the nuclei of neuronal cells during development, it is co-expressed with Isl1 in early motor neuron differentiation and has a suggested role in the Isl1 dependent development of motor neurons. (nih.gov)

Vertebrate homeobox proteins lim-1, lim-2 (lim-5) and lim3. (embl.de)
Homeobox proteins are master regulators of develop-ment and control many cellular processes, including proliferation, apoptosis, cell shape, and cell migration. (123dok.net)
A hallmark of events observed during segmentation was the induction of multiple transcription factors, including a large group of homeobox proteins in pace with decay of a large fraction of maternal transcripts. (biomedcentral.com)

Insulin gene enhancer protein ISL-1 is a protein that in humans is encoded by the ISL1 gene. (wikipedia.org)
LIM domains coordinate one or more zinc atoms, and are named after the three proteins (LIN-11, Isl1 and MEC-3) in which they were first found. (embl.de)
LIM-homeodomain component responses LHX2, LHX3, LHX4, LHX9 and ISL1 encode previously then reduced established in a host polymerase SLC17 cytokine of ROBO1, ROBO2, ROBO3 and SLIT2( Wilson et al. (erik-mill.de)

The Drosophila protein Chip is required for segmentation and activity of a remote wing margin enhancer. (nih.gov)
Drosophila melanogaster (Fruit fly) protein apterous, required for the normal development of the wing and halter imaginal discs. (embl.de)
Mutations in the gene for the antennapedia homeodomain protein are associated with the conversion of antenna to leg or leg to antenna DROSOPHILA. (lookformedical.com)
Proteins that originate from insect species belonging to the genus DROSOPHILA. (lookformedical.com)
The proteins from the most intensely studied species of Drosophila, DROSOPHILA MELANOGASTER, are the subject of much interest in the area of MORPHOGENESIS and development. (lookformedical.com)
The splicing co-factor Barricade/Tat-SF1, is required for cell cycle and lineage progression in Drosophila neural stem cells. (unibas.ch)
The EBF transcription factor Collier directly promotes Drosophila blood cell progenitor maintenance independently of the niche. (sdbonline.org)
In the lymph gland , an hematopoietic organ in Drosophila larva, a group of cells called the Posterior Signaling Centre (PSC), whose specification depends on the EBF transcription factor Collier (Col) and the HOX factor Antennapedia (Antp), has been proposed to form a niche required to maintain the pool of hematopoietic progenitors (prohemocytes). (sdbonline.org)
Collier, the single Drosophila COE (Collier/EBF/Olf-1) transcription factor, is required in several developmental processes, including head patterning and specification of muscle and neuron identity during embryogenesis. (sdbonline.org)
Blood cell production in the Drosophila hematopoietic organ, the lymph gland , is controlled by intrinsic factors and extrinsic signals. (sdbonline.org)

This entry represents LIM-type zinc finger (Znf) domains. (embl.de)
Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. (embl.de)
Mammalian cysteine-rich intestinal protein (CRIP), a small protein which seems to have a role in zinc absorption and may function as an intracellular zinc transport protein. (embl.de)
The plant homeodomain (PHD) finger is a C4HC3 zinc-finger-like motif found in nuclear proteins thought to be involved in epigenetics and chromatin-mediated transcriptional regulation. (embl-heidelberg.de)
In similarity to the RING finger and the LIM domain, the PHD finger is thought to bind two zinc ions. (embl-heidelberg.de)
these include the LIM domain protein LIN-11 , the Pax2/5/8 protein EGL-38 , the zinc finger protein LIN-29 , and the Nkx6.1/6.2 protein COG-1. (wormbook.org)
Members of the zinc-finger homeodomain (ZF-HD) family play a key role in the control of plant growth and development, which are involved in plant responses to stress. (ashs.org)

Vertebrate insulin gene enhancer binding protein isl-1. (embl.de)
Vertebrate protein kinases LIMK-1 and LIMK-2. (embl.de)
Vertebrate paxillin, a cytoskeletal focal adhesion protein. (embl.de)
Based on recent data, a new view is emerging that vertebrate Dachshund(Dach) proteins are components of Six1/6 transcription factor-dependent signaling cascades. (biologists.com)
We focus our attention on three families of transcription factors that are known to have roles in vertebrate chondrogenesis: Sox and the Ant- and Prd- class families of the homeodomain proteins. (europa.eu)
In the vertebrate CNS, HB9/MNR2 transcription factors are specifically expressed in all somatic motoneurons and are necessary to distinguish motoneurons from interneurons, in part by repressing interneuron-specific gene expression. (jneurosci.org)
Together, vertebrate HB9/MNR2 transcription factors are expressed in all somatic motoneurons and excluded from interneurons. (jneurosci.org)

Lineage specification is governed by gene regulatory networks (GRNs) that integrate the activity of signaling effectors and transcription factors (TFs) on enhancers. (xenbase.org)
Mammalian LH-2, a transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types. (embl.de)
pRB functions as a negative regulatory transcription factor during the G1 to S phase cell cycle transition. (medscape.com)
The proximal region of the cNANOG promoter contains a positive transcriptional regulatory element (CCAAT/enhancer-binding protein ( CEBP )-binding site) in ESCs. (biomedcentral.com)
We show for the first time that different trans -regulatory elements control transcription of cNANOG in a cell type-specific manner. (biomedcentral.com)
Indeed, in the absence of PRDM9, meiotic DSBs occur at transcription regulatory regions, such as promoters and enhancers (Brick et al. (springer.com)
Transcription factors (TFs), which bind to specific nucleotide sequences, have been shown to play important roles in the regulatory networks of numerous developmental processes in plants. (ashs.org)
Gene Ontology analysis revealed a strong enrichment in proteins with DNA binding and/or transcription-regulatory properties. (sdbonline.org)

LIM domains are found in many key regulators of developmental pathways. (embl.de)
15. Denaxa M , Sharpe PT, Pachnis V. (2009) The LIM homeodomain transcription factors Lhx6 and Lhx7 are key regulators of mammalian dentition. (fleming.gr)
Furthermore, Smad proteins, transcriptional effectors of TGF-β signaling, are co-expressed and physically interact in the basal ganglia with Dlx homeodomain transcription factors, which are critical regulators of the differentiation, migration and survival of telencephalic GABAergic neurons. (biomedcentral.com)
By screening for proteins that colocalize with NHR-67 punctae, we identified new regulators of uterine cell fate maintenance: homologs of the transcriptional co-repressor Groucho (UNC-37 and LSY-22), as well as the TCF/LEF homolog POP-1. (elifesciences.org)
PRDM9 is a member of the PRDM family of transcription regulators, but unlike other family members, it contains a Krüppel-associated box (KRAB)-related domain that is predicted to be a potential protein interaction domain. (springer.com)
These data brought new evidence that Col direct control of the expression of the transcription regulators apterous and eyes-absent (eya) is critical to specifying neuronal identities. (sdbonline.org)

The PHD finger and the bromodomain are small protein domains that occur in many proteins associated with phenomena related to chromatin. (embl-heidelberg.de)
One pathway, which has been extensively studied in yeast, is mainly guided by chromatin structure and the other, analyzed in detail in mice, is driven by the sequence-specific DNA-binding PR domain-containing protein 9 (PRDM9). (springer.com)
DSB sites are preferentially located within chromatin loops, while several proteins that are required for DSB formation (Rec114, Mei4, and Mer2) localize on the chromosome axis (Blat et al. (springer.com)

Moreover, we discovered that this lncRNA positively regulates both mRNA and the protein expression of LMO7, a protein that may regulate the cell migration of normal lung epithelial cells. (bvsalud.org)
12. Neves G, Shah MM, Liodis P, Achimastou A, Denaxa M , Roalfe G, Sesay A, Walker MC, Pachnis V. (2013) The LIM homeodomain protein Lhx6 regulates maturation of interneurons and network excitability in the mammalian cortex. (fleming.gr)
Therefore, we investigated the mechanism that regulates transcription of the chicken NANOG ( cNANOG) gene in PGCs and ESCs. (biomedcentral.com)

Both predicted proteins are highly conserved with other known homologous sequences, with the exception of two small domains present only in the Sof-RXR. (europa.eu)

It is suggested that these proteins act synergistically to enhance transcriptional efficiency by acting as co-factors for LIM homeodomain and Otx class transcription factors both of which have essential roles in development. (nih.gov)
In some cases, Sox17 and β-catenin synergistically activate transcription apparently independent of Tcfs, whereas on other enhancers, Sox17 represses β-catenin/Tcf-mediated transcription to spatially restrict gene expression domains. (xenbase.org)

3. Vassilopoulos N, Kaplanian A, Vinos M, Katsaiti Y , Christodoulou R , Denaxa M , Skaliora I. (2022) The role of selective Satb1 deletion in somatostatin expressing interneurons on endogenous network activity and the transition to epilepsy. (fleming.gr)
Endogenous substances, usually proteins, which are effective in the initiation, stimulation, or termination of the genetic transcription process. (lookformedical.com)

Within this enhancer, we identified a cis-acting element composed of two adjacent DNA-binding sites (FLAT-E and forkhead) bound by transcription factors Lmx1b and FoxC. (ox.ac.uk)
3] LMX1B, located at 9q34.1, is an LIM-homeodomain transcription factor required for the normal development of dorsal limb structures, the glomerular basement membrane, the anterior segment of the eye, and dopaminergic and serotonergic neurons. (medscape.com)
Mutations in the homeodomain of LMX1B versus LIM-A or LIM-B may be associated with proteinuria. (medscape.com)

DNA repair proteins that include the bacterial MutL protein and its eukaryotic homologs. (nih.gov)

An RNA glycolytic DNA, MSI1, processes ROBO3 mRNA and is its text, well docking ROBO3 repair proteins( Kuwako et al. (erik-mill.de)

PTEN encodes a protein kinase of the same name and functions as a tumor suppressor through regulation of cell proliferation. (medscape.com)
see RTKRas/MAP kinase signaling ), LIN-12 (see LIN-12/Notch signaling in C. elegans ), and WNT (see Wnt signaling ), as well as the functions of the SynMuv and mediator proteins (see Transcriptional regulation ). (wormbook.org)

Antennapedia homeodomain protein. (lookformedical.com)
Antennapedia homeodomain protein is a homeobox protein involved in limb patterning in ARTHROPODS. (lookformedical.com)
Four members of the mouse Dlx protein family (Dlx1, 2, 5 and 6), part of the Antennapedia class of non-Hox homeodomain transcription factors, are expressed in the embryonic subpallium (Panganiban and Rubenstein 2002 ). (biomedcentral.com)

Isl-1 binds to one of the two cis-acting protein-binding domains of the insulin gene. (embl.de)

Currently, little is known about the signaling pathways that modulate Dlx activity. (biomedcentral.com)
Transcription factors (nurr1, pitx3 and lmx1a) that promote embryonic mouse or chicken dopaminergic development were employed to determine if they would modulate lineage restriction of these adult human progenitors. (scirp.org)
A family of inhibitory proteins which bind to the REL PROTO-ONCOGENE PROTEINS and modulate their activity. (bvsalud.org)

In humans and mice, hotspots are specified by PRDM9, a meiosis-specific PRDM family protein (Baudat et al. (springer.com)
EMX1 also functions as a transcriptional activator of Nrp1 expression in vitro, and overexpression of this protein in Emx1 knockout mice rescues the midline-crossing phenotype. (ox.ac.uk)

13. Denaxa M , Kalaitzidou M, Garefalaki A, Achimastou A, Lasrado R, Maes T, Pachnis V. (2012) Maturation-promoting activity of SATB1 in MGE-derived cortical interneurons. (fleming.gr)
We show that astrocyte maturation is promoted by extrinsic signals that induce multiple transcription factors that act largely independently to regulate distinct gene expression modules that together promote a mature astrocytic phenotype. (nature.com)

A L-R expression screen identified the cytoskeletally-associated gene, actin binding lim protein 1 ( Ablim1 ), as asymmetrically expressed in both the node and left lateral plate mesoderm (LPM). (biomedcentral.com)

NANOG is a core transcription factor (TF) in embryonic stem cells (ESCs) and primordial germ cells (PGCs). (biomedcentral.com)

Signaling mechanisms mediated by the Transforming Growth Factor-β (TGF-β) superfamily regulate a variety of developmental processes. (biomedcentral.com)
Here we show that components of both bone morphogenetic protein/growth differentiation factor and TGF-β/activin/Nodal branches of TGF-β superfamily signaling are expressed in the developing subpallium. (biomedcentral.com)
Together, these results suggest that TGF-β superfamily signaling plays a role in telencephalic GABAergic neuron development through functional interactions with Dlx transcription factors. (biomedcentral.com)
In that regard, recent studies in non-neural cells have suggested the existence of functional interactions between Dlx proteins and Smad transcription factors, which are critical mediators of transforming growth factor-β (TGF-β) superfamily signaling pathways (Chiba et al. (biomedcentral.com)

Some LIM domains bind protein partners via tyrosine-containing motifs. (embl.de)
They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. (embl.de)

a protein required for the differentiation of the set of six touch receptor neurons in this nematode. (embl.de)
We further provide evidence to support the hypothesis that transcription factors (TFs) required to drive induction, differentiation, and maintenance of midbrain dopaminergic neural progenitor cells which give rise to terminally differentiated SNpc neurons are uniquely involved in both developmental patterning and metabolism, a dual function unlike other TFs that program neurons in other brain regions. (frontiersin.org)

Among these candidates, motif-driven podocyte enhancer activity of CCNC and MEIS2 was functionally analyzed in vivo. (ox.ac.uk)
A disorder of biogenic proteins contain reconstituted a plasma for immunity in the feedback and motif of WNT bodies at the capability GlcNAc(2. (erik-mill.de)

Several other genetic backgrounds result in enlargement of the haltere significantly beyond the normal range of haploinsufficient phenotypes, suggesting genetic variation in cofactors that mediate homeotic protein function. (lookformedical.com)

Do not confuse with NUCLEOPROTEINS which are proteins conjugated with nucleic acids, that are not necessarily present in the nucleus. (lookformedical.com)

Our findings establish Sox17 as a tissue -specific modifier of Wnt responses and point to a novel paradigm where genomic specificity of Wnt/β-catenin transcription is determined through functional interactions between lineage-specific Sox TFs and β-catenin/Tcf transcriptional complexes. (xenbase.org)
The function of this domain is not yet known but in analogy with the LIM domain it could be involved in protein-protein interaction and be important for the assembly or activity of multicomponent complexes involved in transcriptional activation or repression. (embl-heidelberg.de)
Once activated, R-Smads accumulate in the nucleus where they associate with Smad4, a common partner for all R-Smads, to form transcription complexes. (biomedcentral.com)
These complexes function in DNA repair pathways, primarily DNA MISMATCH REPAIR , where MutL/MLH1 and the MUTS DNA MISMATCH-BINDING PROTEIN are targeted to damaged DNA . (nih.gov)

We have gained crucial insights into molecular factors and pathways of the cells generating either the supporting gonadal cells or germ cells of both sexes. (lidsen.com)

Zyxin is a low-abundance adhesion plaque protein which has been shown to interact with CRP. (embl.de)
However, the molecular mechanisms by which Otx and other transcription factors (TFs) interact with the genome to direct head formation are largely unknown. (xenbase.org)
In addition, we identified proteins that interact with the KRAB domain of PRDM9 in yeast two-hybrid assay screens, particularly CXXC1, a member of the COMPASS complex. (springer.com)

This gene encodes a transcription factor containing two N-terminal LIM domains and one C-terminal homeodomain. (wikipedia.org)
RB1 encodes the protein pRB and was the first tumor suppressor gene to be molecularly defined. (medscape.com)
TP53 encodes the protein p53, which is known as the "guardian of the genome. (medscape.com)

The family includes proteins which bind to both double- and single-stranded DNA and also includes specific DNA binding proteins in serum which can be used as markers for malignant diseases. (lookformedical.com)
The Bcl-2 homology 3 (BH3) domain is crucial for the death-inducing and dimerization properties of pro-apoptotic members of the Bcl-2 protein family, including Bak, Bax, and Bad. (lookformedical.com)
family factor action HOXA2 lists subdivided in low complexe of ROBO2( Geisen et al. (erik-mill.de)

During mammalian development a cilia driven leftwards flow of liquid leads to the left-sided expression of Nodal , which in turn activates asymmetric expression of the transcription factor Pitx2 . (biomedcentral.com)
At the node, a previously unrecognised action of early nodal flow and Pkd2 activity, within the pit of the node, influences gene expression in a symmetric manner. (biomedcentral.com)

C. elegans homeobox protein ceh-14. (embl.de)
C. elegans homeobox protein unc-97. (embl.de)
This valuable data study presents convincing data that expression of the C. elegans transcription factor NHR-67 is sufficient to drive an invasive fate, and that the alternative proliferative fate is associated with NHR-67 transcriptional down-regulation. (elifesciences.org)

A Practical Guide to Small Protein Discovery and Characterization using Mass Spectrometry. (mpg.de)
Identification, characterization and structure analysis of a type I ribosome-inactivating protein from Sapium sebiferum (Euphorbiaceae). (shengsci.com)

These coordinates are achieved through the induction of specific sets of transcription factors in response to a variety of extrinsic cues. (biomedcentral.com)

p53 is a transcription factor whose expression is increased by DNA damage and blocks cell division at the G1 phase of the cell cycle to allow DNA repair. (medscape.com)
Homeodomain proteins are involved in the control of gene expression during morphogenesis and development (GENE EXPRESSION REGULATION, DEVELOPMENTAL). (lookformedical.com)
Forced expression of these factors in vitro induces distinct sets of mature astrocyte-specific transcripts. (nature.com)
Combinations of these factors induce unexpected alterations in root and shoot growth, root architecture and root gene expression profiles. (biomedcentral.com)
Using immunohistochemistry, we observed HOXD9 protein expression in human brain tumor tissues, including astrocytomas and glioblastomas. (123dok.net)
Transcription factor expression and the rate-limiting enzyme in dopamine synthesis tyrosine hydroxylase (TH) were detected in the transfected cells after 4 month-selection with G418, indicating transfected hONPs were stably restricted towards a dopaminergic lineage. (scirp.org)
Here, I focus on driver transcription factors and their connection to tumorigensis in several tumor types through the alteration of the expression of their targets. (biomedcentral.com)
Then, I collect a list of downstream targets of the all driver transcription factors (TFs), and identify which of them exhibit a differential expression upon alterations of driver transcription factors. (biomedcentral.com)
The oocyte is loaded with maternal mRNAs and proteins that control the cell maintenance and fate and the formation of the body plan prior to the onset of zygotic genome expression [ 3 , 4 ]. (biomedcentral.com)

Transcripts found in unfertilized oocytes also encoded a large number of proteins implicated in cell adherence, tight junction and focal adhesion, suggesting high complexity in terms of structure and cellular interactions in embryos prior to midblastula transition (MBT). (biomedcentral.com)

Neuronal ribosomes exhibit dynamic and context-dependent exchange of ribosomal proteins. (mpg.de)
This study suggests that specific transcription factors and treatment with morphogens can restrict human adult olfactory-derived progenitors to a dopaminergic neuronal lineage. (scirp.org)
Although numerous transcription factors have been identified as being crucial for cortical development, little is known about their downstream targets and how they mediate the emergence of specific neuronal connections via selective axon guidance. (ox.ac.uk)

Any of the processes by which nuclear, cytoplasmic, or intercellular factors influence the differential control of gene action during the developmental stages of an organism. (lookformedical.com)
Nuclear acid depurine experiment showed that SEBIN had rRNA N-Glycosidase activity. (shengsci.com)

Serum insulin-like growth factor (IGF)-I and IGF-binding protein-3 concentrations and prostate cancer risk: results from the European Prospective Investigation into Cancer and Nutrition. (mdc-berlin.de)

Proteins found in the nucleus of a cell. (lookformedical.com)
In the CYTOPLASM, I-kappa B proteins bind to the transcription factor NF-KAPPA B. Cell stimulation causes its dissociation and translocation of active NF-kappa B to the nucleus. (bvsalud.org)

Neurons induced in explants derived from plate at the time that these two cell groups exhibit theirboth diencephalic and telencephalic levels of the neu- inductive activities (Riddle et al. (fliphtml5.com)
The anchor cell induces nearby epidermal precursor cells to generate vulval cells via an epidermal growth factor (EGF) signaling pathway. (wormbook.org)
Furthermore, small interfering RNA-mediated knockdown demonstrated that POU5F3 , SOX2 , and CEBP played a role in cell type-specific transcription of cNANOG . (biomedcentral.com)
Cytokinesis in animal cells relies on a centralspindlin complex consisting of male germ cell RacGap (MgcRacGAP) and mitotic kinesin-like protein 1 (MKLP1). (shengsci.com)
In the nuclei of VU cells, residual NHR-67 protein is compartmentalized into discrete punctae that are dynamic over the cell cycle and exhibit liquid-like properties. (elifesciences.org)
Conclusions: Our results suggest that HOXD9 may be a novel marker of GCSCs and cell proliferation and/or survival factor in gliomas and glioma cancer stem-like cells, and a potential therapeutic target. (123dok.net)
Proteomics-Based Discovery of First-in-Class Chemical Probes for Programmed Cell Death Protein 2 (PDCD2). (stanford.edu)
The maintenance of stem or progenitor cell fate relies on intrinsic factors as well as local cues from the cellular microenvironment and systemic signaling. (sdbonline.org)
Together, this study shows that the PSC is dispensable for blood cell progenitor maintenance and reveals the key role of the conserved transcription factor Col as an intrinsic regulator of hematopoietic progenitor fate. (sdbonline.org)
Initial analysis of Collier/Early B Cell Factor function in the lymph gland revealed the role of the Posterior Signaling Center (PSC) in mounting a dedicated cellular immune response to wasp parasitism. (sdbonline.org)

Anatomy5

Organisms1

Chemicals and Drugs20

Analytical, Diagnostic and Therapeutic Techniques and Equipment2

Phenomena and Processes18

Information Science3

Genes18

Domain-binding2

Homeobox proteins3

ISL13

Drosophila10

Zinc7

Vertebrate7

Regulatory8

Regulators6

Chromatin3

Regulates3

Highly conserved1

Synergistically2

Endogenous2

Lmx1b3

Eukaryotic1

Repair proteins1

Kinase2

Antennapedia3

Binds1

Modulate3

Mice2

Maturation2

Actin1

Embryonic1

Superfamily4

Motifs2

Differentiation2

Motif2

Genetic1

Nucleic1

Complexes4

Pathways1

Interact3

Encodes3

Family3

Nodal2

Elegans3

Characterization2

Extrinsic1

Expression9

Focal adhesion1

Neuronal3

Nuclear2

Serum1

Nucleus2

Cell10