Activity of intracellular. Medical search. Frequent questions

Predictions concerning the feedback of soil heterotrophic respiration to a warming climate often do not differentiate between the extracellular and intracellular steps involved in soil organic matter decomposition. (reading.ac.uk)
This study examined the temperature sensitivities of intracellular metabolic processes and extracellular soil enzyme activities and how they are influenced by previous temperatures. (reading.ac.uk)
Pre-incubation temperature effects on temperature sensitivity were subtle and restricted to extracellular activities, perhaps because of the short (60 day) duration of the pre-incubation at temperatures that were below the initial optimum (~30 °C) for the mesophilic soil community. (reading.ac.uk)
However, we found that the intracellular and extracellular steps differ in their temperature sensitivity and this observation differs depending on the range of temperature used for Q10 estimates of temperature sensitivity. (reading.ac.uk)
Between 5 °C and 15 °C intracellular and extracellular enzyme processes show equal temperature sensitivity, but between 15 °C and 26 °C intracellular metabolic processes were more temperature sensitive than extracellular enzyme activity and between 26 °C and 37 °C extracellular enzyme activity was more temperature sensitive than intracellular metabolic processes. (reading.ac.uk)
Nevertheless, since climate change predictions currently indicate that there will be a greater frequency and severity of hot summers and heatwaves, it is possible that global warming may reduce the importance of extracellular depolymerisation relative to intracellular metabolic processes as the rate limiting step of soil organic matter mineralization. (reading.ac.uk)
We conclude that extracellular and intracellular steps are not equally sensitive to changes in soil temperature and that the previous temperature a soil is exposed to may influence the potential activity, but not temperature sensitivity, of extracellular and intracellular processes. (reading.ac.uk)
Describing the activity of immune systems by intra-and extracellular infections. (uib.no)
The effects on cellular viability, resting and zymosan stimulated chemiluminescence used as a marker for reactive oxygen species generation, total ATPase and sodium, potassium dependent ATPase (Na,KATPase) activity, leakage of lipid peroxides, reduced glutathione (GSH), protein, and potassium ion (K+) into the extracellular medium, and intracellular and extracellular taurine concentrations were determined. (cdc.gov)
Adding taurine to the extracellular medium resulted in increasing intracellular taurine concentrations. (cdc.gov)
For normal neuromuscular activity, humans need normal concentration of extracellular calcium and magnesium. (medscape.com)

We observed the proteins internalization within macrophages and their capacity to eradicate the intracellular mycobacterial infection at a low micro-molar range. (frontiersin.org)
Recently, intracellular microbial sensors have also been identified, including NOD-like receptors and the helicase-domain-containing antiviral proteins RIG-I and MDA5. (nature.com)
We describe how these are activated, which are their target proteins, and how their proteolytic activity modulates platelet functions. (frontiersin.org)
New assays to investigate competition of polymer-cargo complexes by intracellular proteins were introduced and revealed that competition of xii polymer-cargo is influenced by initial binding strength. (umass.edu)
CLIC proteins might have several biochemical functions including intracellular chloride channel activity, modulation of transforming growth factor (TGF)-β signaling, and regulation of ryanodine receptors and A-kinase anchoring proteins. (nih.gov)
Processing and intracellular location of human astrovirus non-structural proteins. (surrey.ac.uk)
A class of intracellular signaling proteins that were originally identified as inhibitors of ANGIOSTATIN activity. (bvsalud.org)

A human apolipoprotein L with detergent-like activity kills intracellular pathogens. (discovery.com)

Describe mechanisms of intracellular killing of pathogens. (uib.no)

Background: Chloride intracellular channel-1 (CLIC1) activity controls glioblastoma proliferation. (unimi.it)
Using an integrated approach that combined the power of the Drosophila, Caenorhabditis elegans and mouse model systems with bioinformatics analyses, we established a novel, conserved role for chloride intracellular channels (CLICs) in alcohol-related behavior. (nih.gov)

Changes in intracellular free calcium concentration ([Ca 2+ ] i ) are known to influence a variety of events in developing neurons. (jneurosci.org)
Modulation of intracellular free calcium concentration ([Ca 2+ ] i ) may be part of the signaling pathway by which both local environmental factors and cell autonomous developmental programs influence corticogenesis. (jneurosci.org)
Thus, our discovery of the role of functional interaction between intracellular signaling pathways mediated by calcium ions (Ca 2+) and cyclic adenosine monophosphate (cAMP) (Ca 2+ /cAMP signaling interaction) in these cellular responses, opened a great avenue for the development of new antitumor therapeutic strategies. (researchgate.net)
is a genetic disorder affecting intracellular calcium regulation in cardiac tissue. (msdmanuals.com)

Antitumor therapies targeted to reduce the induction, recruitment, or suppressive activities of the immune cells have been investigated. (researchgate.net)
New antitumor strategies using drugs targeted to intracellular signaling involved in cell proliferation and survival, angiogenesis, and metastasis have become promising in recent years. (researchgate.net)
Liposomes loaded with antibiotics eliminate intracellular bacteria in a colorectal cancer model, unleashing antitumor T cell immunity. (nature.com)
Metformin exerts antitumor effects in glioblastoma stem cells (GSCs) inhibiting CLIC1 activity, but its low potency hampers its translation in clinical settings. (unimi.it)

abstract = "Intracellular Na activity, a(i)(Na), was measured in voltage-clamped sheep cardiac Purkinke fibres. (manchester.ac.uk)

Acquisition and synthesis of folates by obligate intracellular bacteria of the genus Chlamydia. (jci.org)
Intracellular sensors of bacteria, viruses and danger signals. (nature.com)

Evidences suggest that Ca 2+ channels TRP and Orai participate in the intracellular Ca 2+ signaling involved the physiological angiogenesis processes [17]. (researchgate.net)
Experts in the research fields of intracellular transportation processes, statistical tracking, and biomathematical modeling made 20-minute presentations followed by a 10-minute discussion. (nimbios.org)

Recently, more attention has been focused on changes in intracellular Cl - and its role in ischemia-induced neuronal death. (jneurosci.org)
The net effect was a marked reduction in neuronal excitability that could impact on network activity. (nih.gov)
The oligomer-induced fall in neuronal excitability has the potential to impact both network activity and cognitive processing. (nih.gov)
Here, we show that KRas, but not HRas, acutely translocates from the plasma membrane (PM) to the Golgi complex and early/recycling endosomes in response to neuronal activity. (rupress.org)
At the level of the primary afferent nerve, the site at which thermal stimuli are converted into neuronal activity, temperature-sensitive members of the TRP channel family are found. (nih.gov)
BACKGROUND: Amyloid-β (Aβ) is a normal product of neuronal activity, including that of the aggregation-prone Aβ42 variant that is thought to cause Alzheimer's disease (AD). (lu.se)

The work presented herein connects a fundamental understanding of polymer-protein complexation with intracellular internalization and cargo activity. (umass.edu)
The role of polymer self-assembly was observed to impact not only initial binding interactions with protein cargo, but also internalization and intracellular activity. (umass.edu)

Mtb is an intracellular pathogen able to survive indefinitely under unfavorable conditions inside primary host immune cells, preferably residing in human alveolar macrophages ( 5 , 6 ). (frontiersin.org)
We evaluated the antimicrobial activity of Gran1 against the major human pathogen Mycobacterium tuberculosis ( Mtb ) and a panel of clinically relevant non-tuberculous mycobacteria which are notoriously difficult to treat. (uni-ulm.de)

Autophagy is a process of intracellular catabolism. (hindawi.com)

These data support a mechanism wherein the nicotinamide glycolate ester serves as a lipophilic precursor that efficiently translocates into the intracellular neutrophil space to liberate the active acid form of the pharmacophore, which then acts at an intracellular site. (aspetjournals.org)
Our data thus define a novel signaling mechanism that differentially regulates KRas and HRas localization and activity in neurons. (rupress.org)
It is a common mechanism that exists in the development and aging of organisms to eliminate redundant or damaged intracellular organelles. (hindawi.com)

Two DNA nanodevices, RatiNa and pHlicker, provide precise mapping of sodium levels in acidic organelles and potassium activity at a single-organelle resolution. (nature.com)

While plasma membrane ion channels have been extensively studied, much less is known about the identity and physiology of intracellular channels because they are less accessible to direct electrophysiological characterization. (elifesciences.org)

KRas translocation was accompanied by partial intracellular redistribution of its activity. (rupress.org)

Quantitative analysis of these movements is necessary to gain a full understanding of intracellular dynamics and their regulation. (nimbios.org)
Can comprehensive analysis of all movements reveal a global regulation of intracellular dynamics? (nimbios.org)

However, correlations of the protein binding-delivery relationship or the role of polymer-protein complexation on intracellular activity of protein cargo are understudied. (umass.edu)
Studies that facilitate understanding in CPPM-mediated intracellular protein delivery provide unprecedented insight for how non-covalently bound carriers deliver cargo. (umass.edu)
Taurine at 100microM significantly countered the effects on Na,KATPase activity and protein leakage. (cdc.gov)
Boosting endoplasmic reticulum folding capacity reduces unfolded protein response activation and intracellular accumulation of human kidney anion exchanger 1 in Saccharomyces cerevisiae. (bvsalud.org)
Our findings not only demonstrate a promising strategy for preventing intracellular kAE1 accumulation and improving kAE1 plasma membrane targeting but also highlight the versatility of yeast as model to investigate kAE1-related research questions including the analysis of structural features, protein degradation and trafficking. (bvsalud.org)

Upon prolonged high intracellular rises in Ca 2+ , platelets develop a procoagulant phenotype that is characterized by the surface membrane exposure of phosphatidylserine and by the inactivation of integrin α IIb β 3 (procoagulant platelet population) ( 5 ). (frontiersin.org)
Ras activity relies on proper anchoring to the cytoplasmic leaflet of the plasma membrane (PM) by means of a lipid-based PM targeting motif. (rupress.org)
Recent electron microscopy analyses in yeast demonstrate that heterologous expression of several kAE1 variants causes a massive accumulation of the anion transporter in intracellular membrane structures. (bvsalud.org)

We demonstrated that in the HIV-1 transduced CHME-5 microglial cell range also, this cytoprotective phenotype can be induced by intracellular manifestation of HIV-1 Tat, which takes on a primary part in the transcriptional activation from the HIV-1 LTR [4,5]. (demotivate.org)

We conclude that the polybasic-prenyl motif acts as a Ca 2+ /CaM-regulated molecular switch that controls PM concentration of KRas and redistributes its activity to internal sites. (rupress.org)

Summary Since HIV-1 contaminated macrophages screen raised Akt activity extremely, our outcomes collectively display that PI3K/Akt inhibitors could be a book therapy for interfering using the establishment of long-living HIV-1 contaminated reservoirs. (demotivate.org)

RESULTS: In healthy Wistar rats, we find intracellular Aβ42 (iAβ42) in neurons throughout the brain at all ages, but levels vary greatly between brain regions. (lu.se)

He's been taught that IV bicarbonate increases the serum pH but paradoxically causes intracellular acidosis. (medscape.com)
IV bicarbonate can lead to intracellular acidosis, hypercapnia, hypocalcemia, and a reduction in oxygen delivery via the Bohr effect. (medscape.com)
Furthermore, our data indicate that UPR activation is dose dependent and uncoupled from the bicarbonate transport activity. (bvsalud.org)

Despite the antimicrobial activity of macrophages, Mtb has been able to establish a series of strategies to handle the host immune machinery, interfere with, and arrest the phagosome maturation, counteract mycobactericidal molecules and ultimately survive in a hostile intracellular environment ( 8 - 10 ). (frontiersin.org)
Under normal conditions, the dynamic balance of T helper type 1 (Th1) and Th2 activities maintains the immune homeostasis of the body. (hindawi.com)

Magnesium is one of the major intracellular cations. (medscape.com)
Intracellular magnesium is an important cofactor for various enzymes, transporters, and nucleic acids that are essential for normal cellular function, replication, and energy metabolism. (medscape.com)

Signal transduction and perception regulates biological activities to adapt to changing environments. (phys.org)

In both studies, the changes in intracellular Cl - were reversible, and there was complete recovery of electrophysiological parameters measured during reoxygenation. (jneurosci.org)

Our results demonstrate that the hypothesis-driven design of AMPs is a powerful approach for the identification of small bioactive compounds with specific antimicrobial activity. (uni-ulm.de)

Gran1 is a promising component for the design of AMP-containing nanoparticles with selective activity and favorable pharmacokinetics to be pushed forward into experimental in vivo models of infectious diseases, most notably tuberculosis. (uni-ulm.de)

Cellular morphology, time-lapse imaging, and nuclear staining demonstrated that this activity occurred in mitotically active cells. (jneurosci.org)
Intracellular ion channels are essential regulators of organellar and cellular function, yet the molecular identity and physiological role of many of these channels remains elusive. (elifesciences.org)

How do rapid intracellular movements contribute to cell polarity? (nimbios.org)

Ozone exposure significantly decreased macrophage viability, resting and zymosan stimulated chemiluminescence, and total ATPase and Na,KATPase activity in a time dependent manner. (cdc.gov)
Taurine enrichment countered the effects of ozone on viability, lipid peroxidation, total ATPase activity, and GSH leakage in a dose dependent manner. (cdc.gov)

All three patterns of activity were dependent on the release of Ca 2+ from intracellular stores. (jneurosci.org)
However, in 3D cultures, metformin and Q48 (but not Q54) inhibited proliferation, which was dependent on the inhibition dihydrofolate reductase activity. (unimi.it)

Dihydrofolate reductase activity was also detected in reticulate body extract. (jci.org)

Cooperative activity of GR with other transcription factors and a plethora of coregulators contribute to the tissue- and context-specific response toward the endogenous and pharmacological glucocorticoids (GCs). (uni-ulm.de)

Describing the dynamics of the motion of intracellular objects. (nimbios.org)

We also describe how the proteolytic activities are determined by different platelet populations in a thrombus and conversely how proteolysis contributes to the formation of such populations. (frontiersin.org)

Patients are predisposed to atrial and/or ventricular tachyarrhythmias and sudden cardiac death, particularly during increased adrenergic activity. (msdmanuals.com)

Contribution of the enzymatic activity was discarded by site-directed mutagenesis at the RNase catalytic site. (frontiersin.org)

Previously, we demonstrated in hippocampal slices from immature rats that OGD induced an immediate increase in intracellular Cl - ( Inglefield and Schwartz-Bloom, 1998a ). (jneurosci.org)

A third and infrequently encountered pattern of activity consisted of coordinated spontaneous increases in [Ca 2+ ] i in groups of neighboring VZ cells. (jneurosci.org)
Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway. (mcw.edu)

Compounds were compared to metformin for both potency and efficacy in the inhibition of GSC proliferation in vitro (MTT, Trypan blue exclusion assays, and EdU labeling) and in vivo (zebrafish model), migration (Boyden chamber assay), invasiveness (Matrigel invasion assay), self-renewal (spherogenesis assay), and CLIC1 activity (electrophysiology recordings), as well as for the absence of off-target toxicity (effects on normal stem cells and toxicity for zebrafish and chick embryos). (unimi.it)

Furthermore, nontranscriptional activities in the cytoplasm are emerging as an additional function of GR. Over the past 40 years, the concepts of GR mechanisms of action had been constantly changing. (uni-ulm.de)

Poliovirus induces early impairment of mitochondrial function by inhibiting succinate dehydorgenase activity. (surrey.ac.uk)

Future research directions include the denoising of microscopy raw data at each time instance, accurate description of the dynamics of particle motion, and tracking schemes which should be followed depending on the type of intracellular process. (nimbios.org)
Other activities carried out by the IPCS include the development of know-how for coping with chemical accidents, coordination of laboratory testing and epidemiological studies, and promotion of research on the mechanisms of the biological action of chemicals. (inchem.org)

The majority of activity consisted of single cells that displayed independent [Ca 2+ ] i fluctuations. (jneurosci.org)

The protective effect of taurine is thought to reflect its being mobilized from intracellular stores to the free state in response to ozone exposure. (cdc.gov)

Extracellular11

Proteins7

Kills intracellular1

Pathogens1

Chloride2

Calcium4

Antitumor4

Abstract1

Bacteria2

Processes2

Neuronal6

Internalization2

Pathogen2

Autophagy1

Mechanism3

Sodium1

Physiology1

Translocation1

Regulation2

Protein5

Membrane3

Phenotype1

Conclude1

PI3K1

Neurons1

Bicarbonate3

Immune2

Magnesium2

Signal1

Reversible1

Antimicrobial activity1

Nanoparticles1

Cellular2

Rapid1

ATPase2

Dependent2

Dihydrofolate1

Tissue1

Describing1

Describe1

Ventricular1

Contribution1

Rats1

Increases2

Effects1

Cytoplasm1

Mitochondrial1

Research2

Cells1

Response1