AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
IsoenzymesElectrophoresis, Cellulose AcetateCreatine KinaseL-Lactate DehydrogenaseAlkaline PhosphataseChromatography, Ion ExchangeKineticsClinical Enzyme TestsGlutathione TransferaseElectrophoresisLiverIsoelectric FocusingSubstrate SpecificityAspartate AminotransferasesElectrophoresis, Polyacrylamide GelChromatography, DEAE-CelluloseHomoarginineWheat Germ AgglutininsCarbonic AnhydrasesElectrophoresis, Agar GelElectrophoresis, Starch GelProtein Kinase CMolecular Sequence DataHexosaminidasesAmino Acid SequenceCytosolHydrogen-Ion ConcentrationMolecular WeightIsoamylaseAscorbate PeroxidasesIsoelectric PointMusclesPhosphoglycerate MutaseHexosaminidase BPeroxidasesChromatography, GelLevamisole3-Deoxy-7-Phosphoheptulonate Synthasebeta-N-AcetylhexosaminidasesPlacentaGroup IB Phospholipases A2AmylasesHexosaminidase ACytochrome P-450 Enzyme SystemGene Expression Regulation, EnzymologicBone and BonesPolyporaceaeImmunodiffusionHexokinaseMyocardiumAcetylglucosaminidaseChromatography, High Pressure LiquidChromatography, AffinityAlcohol DehydrogenaseEnzyme ActivationLaccase3-Oxo-5-alpha-Steroid 4-DehydrogenaseBase Sequencealpha-AmylasesAutoanalysisDatura stramoniumPhosphopyruvate HydrataseHot TemperatureCloning, MolecularLipidosesElectrophoresis, DiscCarbonic Anhydrase InhibitorsIntestinesProtein Kinase C-alphaPolygalacturonasePhosphofructokinase-1Reference ValuesMicrosomes, LiverTissue DistributionAldehyde-LyasesRNA, MessengerDinitrochlorobenzeneSequence Homology, Amino Acidbeta-GlucosidaseEnzyme InhibitorsFructose-Bisphosphate AldolaseSubcellular FractionsMyosinsCreatine Kinase, Mitochondrial FormTriethyltin CompoundsAdenylate KinaseBrainRabbitsReptilian ProteinsEsterasesKidneyOrgan SpecificityMalate Dehydrogenase3',5'-Cyclic-AMP PhosphodiesterasesAcid PhosphataseEnzyme StabilityMethodsDrug StabilityChromatographyMitochondria
Lactate dehydrogenaseCytochromeCharacterizationProteinsInhibitorsEnzyme activityAlkalinePatternsCreatineAntioxidantVitroInvestigateSubstratePotencyReactiveRegulationAnti-inflammatoryAssessmentStimulatesHumanEnzymaticDeficiencyHeartHepaticLipidDrug effectsEffectsSignificantlyTotalAssayContrastTestFormsCellsDrugsFoundReleaseSignificantModifyMainLevels
Lactate dehydrogenase4
  • lactate dehydrogenase isoenzymes were separated by agarose gel electrophoresis and quantified. (avma.org)
  • The percentage contributions of lactate dehydrogenase 1 and 2 isoenzymes to the total amount of all 5 isoenzymes at 12 and 24 months of age were significantly higher than those at 2 months of age. (avma.org)
  • Changes in the activity of hexokinase and lactate dehydrogenase isoenzymes in the three brain regions and heart were studied in the 6-Aminonicotinamide-treated rats. (ias.ac.in)
  • In addition, a significant decrease in the activities of myocardial injury markers i.e., creatine phosphokinase-MB (CK-MB isoenzyme) and lactate dehydrogenase (LDH) was also observed in the heart of ISP control group as compared to sham control. (scialert.net)
Cytochrome2
  • Historical and current examples of several extensively studied SNPs include the genes encoding for glucose-6-phosphate dehydrogenase, N -acetyltransferase, and the superfamily of cytochrome P-450 (CYP) isoenzymes. (medscape.com)
  • The pharmacogenetic differences in a number of phase-I enzymes, such as cytochrome P-450 (CYP) isoenzymes, dehydrogenases, and esterases, and phase-II (conjugating) enzymes have been extensively studied. (medscape.com)
Characterization2
Proteins2
  • Transglutamina-se(TGase) catalyses the crosslink of proteins by forming ε-(γ-glutamyl) lysine isopeptide bonds and requires the binding of Ca2+ for its activity. (biovendor.com)
  • In the Alzheimer's disease brain, the elevated tTGase activity is manifested by polymerization of a number of proteins, including Aβ peptide, β-amyloid precursor protein and the tau protein, with formation of neurofibrillary tangles. (biovendor.com)
Inhibitors3
  • Herein, we also demonstrate that compounds developed to target mutant IDH1 can be repurposed as wild-type IDH1 inhibitors, because these drugs surprisingly become potent inhibitors of wtIDH1 in cancer cells under conditions present in tumors: specifically, we found that wtIDH1 is critical for PDAC cell survival under low-glucose conditions, and allosteric IDH inhibitors effectively block wtIDH1 activity under low magnesium. (nature.com)
  • Phophodiesterase (PDE) isoenzyme profiles of human cell preparations and tissues have been analysed by a semiquantitative method using selective PDE inhibitors and activators. (ersjournals.com)
  • PKCa and PKCe activities were inhibited using isoform-specific pharmacologic inhibitors and genetically modified dominant-negative (DN) expressing cell lines. (cdc.gov)
Enzyme activity1
  • The enzyme activity rate in most patients with pyruvate kinase deficiency is 5-25% of normal, with measurement of the intermediates (2,3-diphosphoglycerol and glucose-6-phosphate) proximal to the enzyme defect helping to confirm the diagnosis. (medscape.com)
Alkaline1
Patterns3
  • The aim of this work was to investigate changes in isoenzyme patterns of enzymes related to reactive oxygen species (ROS) detoxification such as superoxide dismutase (SOD), catalase (CAT), peroxidase (POX), ascorbate peroxidase (APX), glutathione reductase (GR), and glutathione-S-transferase (GST) in cotton under Mg deficiency. (tubitak.gov.tr)
  • The most striking results were the changes in isoenzyme patterns of SOD, NOX, POX, and GST. (tubitak.gov.tr)
  • Therefore, PDE isoenzyme profiles represent dynamic patterns, which apparently adapt to pathological and environmental conditions. (ersjournals.com)
Creatine1
  • The creatine phosphokinase (CPK) isoenzymes test measures the different forms of CPK in the blood. (adam.com)
Antioxidant3
  • Antiinflammatory, antioxidant and anticancer activities reported to be possessed by these compounds might have resulted from prevention of oxidative damage [ 24 , 25 ]. (ijpsonline.com)
  • ISP-administration produced a significant decrease in the activities of endogenous antioxidant defence enzymes viz. (scialert.net)
  • The possible underlying mechanism of the cardioprotective effect of T. terrestris could be due to restoration of endogenous myocardial antioxidant status or free radical scavenging activity along with correction of the altered hemodynamic parameters and preservation of histoarchitectural and ultrastructural alterations. (scialert.net)
Vitro2
  • It was recently shown that addition of fatty acid free bovine serum albumin (BSA) significantly enhances in vitro activities of UGTs, a limiting factor in in vitro-in vivo extrapolation. (nih.gov)
  • Antimycotic activity was demonstrated in in vitro systems and in vivo experimental models. (drugs.com)
Investigate1
  • Experiments were designed to investigate the relationship between the two isoenzymes and the degree to which each is responsible for cytokine release in HBE. (cdc.gov)
Substrate1
  • isoenzymes - isoenzymes (isozymes) isoenzymes - Variants of a given enzyme, occurring within a single organism, having the same specificity for substrate, hence catalysing the same reaction, but with slight differences in molecular structure which make it possible to separate them. (knolik.com)
Potency1
  • Theophylline inhibits PDE isoenzyme activities and functions of inflammatory cells with similar potency, and exhibits higher functional efficacy as compared to rolipram. (ersjournals.com)
Reactive1
  • Mg deficiency changes the isoenzyme pattern of reactive oxygen species" by RENGİN ÖZGÜR UZİLDAY, BARIŞ UZİLDAY et al. (tubitak.gov.tr)
Regulation1
  • The activities of GR and GST were highest in plants treated with 0 μM Mg, indicating excess use of glutathione for redox regulation. (tubitak.gov.tr)
Anti-inflammatory1
  • Celecoxib is a nonsteroidal anti-inflammatory drug that exhibits anti-inflammatory, analgesic, and antipyretic activities. (pediatriconcall.com)
Assessment1
  • Assessment of hepatic FDPase isoenzyme activity is the definitive diagnostic procedure. (medscape.com)
Stimulates1
  • We found that HDE stimulates PKCa activity by 1 hour, and within 6 hours the activity returns to baseline. (cdc.gov)
Human5
  • The results shed new light on the complexity of the BSA effects on the activity and enzyme kinetics of the human UGTs. (nih.gov)
  • Changes in human placental 5α-reductase isoenzyme expression with adva" by Thi T. Vu, Jonathan J. Hirst et al. (edu.au)
  • Phospholipase D activity in human platelets is inhibited by protein kinase A, involving inhibition of phospholipase D1 translocation. (uib.no)
  • Phospholipase D in human platelets: presence of isoenzymes and participation of autocrine stimulation during thrombin activation. (uib.no)
  • O 2 − release, protein kinase C (PKC) activity, and translocation of PKC-α and -βII and p47phox were increased in THP-1 cells (human monocytic cell line) under HG (15 mmol/l glucose) conditions, whereas AT supplementation inhibited these changes. (diabetesjournals.org)
Enzymatic3
  • Enzymatic activities were measured in pairs of concurrently obtained serum and salivary samples from 32 children in good oral and systemic health (16 of each sex) with a median age of 6.4 ± 3.3 years (range 1.08 - 12.92 years). (bvsalud.org)
  • The enzymatic activities of all the studied enzymes were higher in serum than in saliva. (bvsalud.org)
  • Direct enzymatic assay of hepatic FDPase activity from hepatic specimens remains the most specific diagnostic test for this disorder. (medscape.com)
Deficiency2
  • For example, a new Cu/ZnSOD isoenzyme was induced in plants treated with 0 μM Mg. Cotton plants adapt to Mg deficiency by changing the intensity of existing isoenzymes or inducing new ones. (tubitak.gov.tr)
  • Fasting hypoglycaemia and metabolic acidosis associated with deficiency of hepatic fructose-1,6-diphosphatase activity. (medscape.com)
Heart2
  • Changes in the subcellular distribution of hexokinase activity from three brain regions and heart were studied during alloxan induced diabetes. (ias.ac.in)
  • PKC activity is increased in retina, aorta, heart, and renal glomeruli of diabetic rats as well as in cultured vascular cells or tissues exposed to HG conditions ( 6 ). (diabetesjournals.org)
Hepatic1
  • 2010. Elevated hepatic fatty acid elongase-5 activity corrects dietary fat-induced hyperglycemia in obese C57BL/6J mice. . (oregonstate.edu)
Lipid1
  • Pretreatment with T. terrestris resulted in the increased activities of SOD, CAT, GSHPx and prevention of depletion of tissue glutathione along with inhibition of lipid peroxidation. (scialert.net)
Drug effects1
  • People taking topiramate should be aware of the following risks: Avoid activities requiring mental alertness and coordination until drug effects are realized. (wikipedia.org)
Effects3
  • 5α-Reduced steroids, including allopregnanolone, suppress neuronal activity and can have neuroprotective effects in the fetus. (edu.au)
  • These results shown that crude ethanol and water extracts of Iris taochia had effective reducing effect, radical scavenging activity and metal chelating effects when compared to standard antioxidants. (ijpsonline.com)
  • 2001. The effects of inhalation exposure to bromo dichloromethane on specific rat CYP isoenzymes. (cdc.gov)
Significantly1
  • Peroxisome proliferator-activated receptor-γ coactivator-1α content was significantly increased at 24 months of age and citrate synthase activity was increased at 6 and 24 months of age, compared with findings at 2 months. (avma.org)
Total1
  • A significant rise or fall in the total CPK or CPK isoenzymes can help your health care provider diagnose certain conditions. (adam.com)
Assay1
  • PKCgamma activity was measured with a PKC assay kit. (nih.gov)
Contrast1
  • In contrast, PKC activity was enhanced by 6 hours after HDE treatment. (cdc.gov)
Test1
  • Efectos de la administración aguda y subcrónica de agmatina sobre la ansiedad evaluada en el test del laberinto elevado en cruz en ratones machos. (psicothema.com)
Forms1
  • The American Academy of Neurology (AAN) recommends that disease-modifying therapy be offered to patients with relapsing forms of MS who have had recent relapses and/or MRI activity. (drugs.com)
Cells2
  • Corresponding to isoenzyme analysis, it was demonstrated that both PDE III and PDE IV have to be inhibited for complete suppression of either tumour necrosis factor-alpha (TNF-alpha) release from macrophages, or lymphocyte proliferation (PDE III/IV cells). (ersjournals.com)
  • Biochemical assays indicated that SVEVs are functionally active, showing high metalloproteinase and fibrinogenolytic activity besides being cytotoxic against HUVEC cells. (nature.com)
Drugs1
  • Because CYP isoenzymes metabolize a large number of structurally diverse drugs and chemicals, most of the variant genotypes of the CYP2D6, CYP2C9, CYP2C19, and CYP3A families have been identified and studied. (medscape.com)
Found1
  • Toxins with hemorrhagic and myonecrotic activity are generally found in the venoms of the Viperidae family due to synergic action of proteolytic enzymes, such as metalloproteinases and serine proteinases 4 . (nature.com)
Release1
  • Release of the proinflammatory cytokines IL-6, IL-8, and TNF-a was measured and PKC isoform activities assessed. (cdc.gov)
Significant2
  • The application of pharmacogenetics in identifying single nucleotide polymorphisms (SNPs) in DNA sequences that cause clinically significant alterations in drug-metabolizing enzyme activities is discussed. (medscape.com)
  • This review introduces the concept of pharmacogenetics in the context of drug-metabolizing enzymes and highlights the polymorphisms in DNA sequences that lead to clinically significant alterations in drug-metabolizing-enzyme activities. (medscape.com)
Modify1
  • We concluded that the salivary TRAP has a potential to be use as biomarkers of pathologies and states that modify its activity in the serum. (bvsalud.org)
Main1
  • September 2004 (the main activity season water and stored at -20 ° before being of sandflies). (who.int)
Levels1
  • Placental expression of both isoenzymes increased with advancing gestation and there were marked sex differences in levels of 5α-reductase I (P (edu.au)