• Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • To counterbalance oxidative stress and ensure redox homeostasis, a subgroup of non-small-cell lung cancers acquire stabilizing mutations in NFE2L2 , the gene encoding NRF2, the transcriptional regulator of the cellular antioxidant response, and inactivating mutations in its negative regulator, KEAP1. (nature.com)
  • The flow cytometry-based Pig-a assay detects cells deficient in Glycosylphosphatidylinositol (or GPI)-anchored surface markers and provides a rapid and cost-effective enumeration of cells that are presumed to contain mutations in the endogenous X-linked Pig-a gene. (fda.gov)
  • Dr. Revollo is developing NGS methods capable of directly and efficiently identifying somatic mutations in the whole genome - in any tissue, and in any species, or any established cell culture - without the need for selecting and expanding cells that have mutations in only a few specific reporter genes. (fda.gov)
  • The disease is caused by mutations affecting the gene represented in this entry. (proteopedia.org)
  • ELX-02 is currently in Phase 2 clinical trials in CF patients affected by nonsense mutations in the CFTR (CF transmembrane conductance regulator) gene. (biospace.com)
  • More than 20 mutations in the ASXL1 gene have been found to cause Bohring-Opitz syndrome, a condition that causes abnormal head size and shape, distinctive facial features, joint abnormalities, intellectual disability, and other signs and symptoms. (medlineplus.gov)
  • Most of the ASXL1 gene mutations that cause Bohring-Opitz syndrome create a premature stop signal in the instructions for making the ASXL1 protein, resulting in either an abnormally short, nonfunctional protein or a complete lack of ASXL1 protein. (medlineplus.gov)
  • These ASXL1 gene mutations are described as "loss-of-function" because they reduce the amount of functional ASXL1 protein available, which likely disrupts the regulation of the activity of HOX genes and other genes during development. (medlineplus.gov)
  • Mutations in the ASXL1 gene have been associated with cancerous conditions of blood-forming cells, such as acute myeloid leukemia, chronic myelomonocytic leukemia, and myelodysplastic syndrome. (medlineplus.gov)
  • The ASXL1 gene mutations involved in these cancers are different from the ones that cause Bohring-Opitz syndrome (described above). (medlineplus.gov)
  • Expression of p63 is almost exclusively restricted to epithelial cells, mutations in this gene are infrequent, and its expression is increased in a variety of solid tumors, particularly those of the head and neck area 12,13 . (bvsalud.org)
  • Human genetic studies have identified mutations in the sodium channel SCN5A gene causing tachyarrhythmia disorders, as well as progressive cardiac conduction system diseases, or overlapping syndromes. (medscape.com)
  • There are a myriad of mutations identified in genes encoding cardiac transcription factors, ion channels, gap junctions, energy metabolism regulators, lamins and other structural proteins. (medscape.com)
  • [ 2 , 3 , 4 ] A full list of the described mutations is available at the TBX5 Gene Mutation Database , an online locus-specific database that contains germline and somatic mutations of the TBX5 gene. (medscape.com)
  • Mutations of this gene introduce a premature stop codon and result in truncated protein versions. (medscape.com)
  • Establishing the precise evolutionary history of a gene improves prediction of disease-causing missense mutations. (lu.se)
  • At the molecular level, pitavastatin induced expression of the cyclin dependent kinase (CDK) inhibitor p21 in a cholesterol independent manner, blocked repressive phosphorylation of the Retinoblastoma tumor suppressor protein at CDK targeted sites, and reduced expression of E2F target genes required for progression through the G1/S boundary. (oncotarget.com)
  • Consistent with a reduction in ROS levels, NAC-K cells also exhibited downregulation of genes associated with antioxidant processes, in particular the target genes of NRF2 and BACH1. (nature.com)
  • p53 affects the transcription of many target genes and interacts with key cellular proteins. (molvis.org)
  • Developmental signals received by the Notch receptor cause Suppressor of Hairless (Su[H]) to mediate transcription of target genes. (sdbonline.org)
  • In Drosophila, the majority of Notch target genes known so far is located in the Enhancer of split complex , encoding small basic helix-loop-helix (bHLH) proteins that presumably act as transcriptional repressors. (sdbonline.org)
  • The products of target genes it activates are required for differentiation and mitogenesis . (wikipedia.org)
  • The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. (nih.gov)
  • Most genes considered master regulators code for transcription factor proteins, which in turn alter the expression of downstream genes in the pathway. (wikipedia.org)
  • Other genes reported as master regulators code for SR proteins, which function as splicing factors, and some noncoding RNAs. (wikipedia.org)
  • Previous studies have shown that a person's genes can influence relative levels of these proteins. (asbmb.org)
  • The protein encoded by this gene is a member of the phosphatase and actin regulator family of proteins. (nih.gov)
  • Following this analysis, Jacob and Monod proposed a series of new concepts, those of messenger RNA, regulator genes, operons and allosteric proteins. (nobelprize.org)
  • In this sense, we aim to characterize the behaviour of different promoters of genes involved in biofilm regulation under different conditions and to search for possible new DNAbinding proteins associated with their promoter regions. (usp.br)
  • All genes in the ANTP-C and BX-C code for homeodomain proteins. (sdbonline.org)
  • The five genes described in this paper are arrayed between mbeta and m7 , both coding for bHLH proteins. (sdbonline.org)
  • The protein encoded by this gene belongs to the EGR family of Cys 2 His 2 -type zinc finger proteins. (wikipedia.org)
  • The switches flip when master-regulator proteins bind to them, or when chemical "tags" are attached to them by enzymes. (latimes.com)
  • Compared with individual exposures, co-exposure aerosols produced greater acellular and cellular oxidants detected by electron paramagnetic resonance (EPR) spectroscopy, and in vivo immune-spin trapping (IST), as well as synergistically increased lavage neutrophils, lavage proteins and inflammation related gene/protein expression. (cdc.gov)
  • Some inherited arrhythmias are caused by a malfunction of proteins that are related to the initiation or propagation of electrical activity. (medscape.com)
  • In genetics, a master regulator gene is a regulator gene at the top of a gene regulation hierarchy, particularly in regulatory pathways related to cell fate and differentiation. (wikipedia.org)
  • Gene expression analysis suggested that the differences derived from repression of PPARdelta gene regulation activity. (anl.gov)
  • Given the complexity of human transcriptional regulation in vivo and the multitude of potential epigenetic mechanisms cooperating to regulate transcriptional activity, questions remain about the interplay of regulatory mechanisms in patients with CMML. (nature.com)
  • Indole-3-carbinol (I3C), a compound occurring naturally in cruciferous vegetables, exhibits a potent antitumor activity via its regulation of estrogen activity and metabolism. (nih.gov)
  • These results further suggest that antitumor activities of I3C are associated not only with its regulation of estrogen activity and metabolism, but also its modulation of ER transcription activity. (nih.gov)
  • Mapping transcriptional regulation of biofilm-related genes promoters in Pseudomonas. (usp.br)
  • Most of this regulation is carried out directly by transcription factors that modulate the activity of promoters aimed at expressing virulence factors. (usp.br)
  • Research in the Lu Lab utilizes a broad range of advanced research techniques and experimental models to discover novel aspects of NF-κB regulation and new genes for drug resistance, with the hope of identifying innovative biomarkers, therapeutic targets in cancer and other NF-κB related diseases, and ultimately, lead to the development of new medicines to treat these devastating diseases. (iu.edu)
  • These data provide the first insight into the three- dimensional (3D) structure of the CFTR locus and confirm the contribution of intronic cis-acting elements to the regulation of CFTR gene expression. (duke.edu)
  • A huge chunk of that activity is wrapped up with gene regulation - dictating whether the instructions each gene carries for making a unique protein will be executed or not. (latimes.com)
  • Such regulation is key, because pretty much every cell in the human body carries the entire set of 21,000 protein-making genes. (latimes.com)
  • The ASXL1 protein may have an additional role in gene regulation by signaling to molecules to add a methyl group (a process called methylation) to an area near a gene called the promoter region, which controls gene activity. (medlineplus.gov)
  • Researchers believe that the overactive ASXL1 protein leads to poor regulation of gene activity. (medlineplus.gov)
  • It is unclear how this altered gene regulation plays a role in the development of cancer, but it is likely that overactive genes promote the growth of cancers by allowing abnormal blood cells to grow and divide uncontrollably. (medlineplus.gov)
  • p53 E3 ubiquitin protein ligase homolog (Mdm2) is an important negative regulator of p53. (molvis.org)
  • Mdm2 is a key negative regulator of p53 activity. (molvis.org)
  • MiRNA-378a-3p acts as a negative regulator of mitochondrial metabolic and biogenesis pathways. (cdc.gov)
  • We found a significantly lower expression of key autophagy- (ATG-) related genes in primary AML as compared to healthy granulocytes, an increased autophagic activity during all- trans retinoic acid- (ATRA-) induced neutrophil differentiation, and an impaired AML differentiation upon inhibition of ATG3, ATG4D, and ATG5. (hindawi.com)
  • Our data clearly suggest that granulocytic AML differentiation relies on noncanonical autophagy pathways and that restoring autophagic activity might be beneficial in differentiation therapies. (hindawi.com)
  • Genes of the E(spl)-C and AS-C regulate neurogenesis and related differentiation pathways. (sdbonline.org)
  • The expression patterns suggest that both genes are under the same regulatory control as are the E(spl) bHLH genes and thus, might play a part in Notch mediated cell differentiation. (sdbonline.org)
  • In order to assess these predictions, we compute the Shannon entropy for time- resolved single-cell gene expression data in two different experimental set-ups of haematopoietic differentiation. (lu.se)
  • Single cells in these populations exhibit different com- binations of regulator activity that suggest the presence of multiple configurations of a potential differentiation network as a result of multiple entry points into the committed state. (lu.se)
  • Therefore, the entire oligodendroglial differentiation, diffuse astrocytomas, oligoastrocytomas, coding sequence of the LATS1 gene in IDH1 Mutation, and 1P/19q loSS and oligodendrogliomas. (who.int)
  • The master regulator concept has been criticized for being a "simplified paradigm" that fails to account for the multifactorial influences on some cell fates. (wikipedia.org)
  • Defining this hive of activity is essential, scientists said, because it transforms our picture of the human blueprint from a static list of 3 billion DNA building blocks into the dynamic master-regulator that it is. (latimes.com)
  • These genes were selected based on their role in asthmatic inflammatory processes and History previously reported associations with asthma phenotypes. (cdc.gov)
  • Of these mediators, cytokines play a single nucleotide polymorphisms (SNP) in pro-inflammatory cytokine genes and asthma phenotypes (Che et al. (cdc.gov)
  • The authors also enabled normalization of hippocampal gene expression in specific pathways associated with AD and neuroinflammation, which enabled memory improvements. (news-medical.net)
  • In 1958 the remarkable analogy revealed by genetic analysis of lysogeny and that of the induced biosynthesis of ß-galactosidase led François Jacob, with Jacques Monod , to study the mechanisms responsible for the transfer of genetic information as well as the regulatory pathways which, in the bacterial cell, adjust the activity and synthesis of macromolecules. (nobelprize.org)
  • Conservation of the genes belonging to the photoperiod, gibberellin and autonomous pathways was observed, while orthologues of the key genes found in the vernalisation pathway (FRI, FLC) were absent from the quinoa genome. (springer.com)
  • However, current knowledge of the molecular basis of quinoa flowering is limited and the details of flowering genes and associated pathways in quinoa remain elusive (Jarvis et al. (springer.com)
  • Plays a role as a positive regulator of the sonic hedgehog pathway, acting downstream of PTCH1. (proteopedia.org)
  • [7] Removing DNA methylation marks allows the activation of downstream genes. (wikipedia.org)
  • DNA methylation is one of the major epigenetic mechanisms, and it plays an important role in determining gene function ( Hedrich and Tsokos, 2011 ). (frontiersin.org)
  • SMCHD1 is an epigenetic regulator that normally switches off expression of a protein that destroys muscle. (edu.au)
  • They dynamically regulate the expression of genes, transposable elements, and higher-order chromatin structures. (pasteur.fr)
  • We performed a multi-omics interrogation to define gene expression and chromatin remodeling associated with ASXL1 MT in chronic myelomonocytic leukemia (CMML). (nature.com)
  • Chromatin remodeling of promoters and enhancers is strongly associated with gene expression and heterogenous among overexpressed genes. (nature.com)
  • In parallel, molecular measurements such as gene expression and chromatin activity across individuals are being collected at an unprecedented rate. (dana-farber.org)
  • My research involves identifying gene regulatory elements across the genome to help us understand how chromatin structure dictates cell function and fate. (duke.edu)
  • The ASXL1 gene provides instructions for making a protein that is involved in a process known as chromatin remodeling. (medlineplus.gov)
  • Through its role in chromatin remodeling, the ASXL1 protein regulates the expression of many genes, including a group of genes known as HOX genes, which play important roles in development before birth. (medlineplus.gov)
  • The phenomenon of a group of genes with the same function and location on the chromosome signifies a so-called gene complex. (sdbonline.org)
  • Therefore, our genetic screen has identified new regulators of key cellular states. (pasteur.fr)
  • This includes increased expression of genes involved in nerve function, neuroprotection and autophagy, a process that prevents the accumulation of damaged cellular components and protein aggregates, which are characteristic of neurodegenerative diseases such as Alzheimer's disease in humans. (drugdiscoverynews.com)
  • Expression of the SIL gene is correlated with growth induction and cellular proliferation. (proteopedia.org)
  • Therapeutic strategies for the dystrophinopathies can be categorized into 3 groups based on their approach: (1) Supportive pharmacologic therapy, (2) research gene therapy, and (3) research cellular therapy. (medscape.com)
  • Moreover, genome instability was attributed to impaired autophagy and several autophagy genes with tumor suppressor functions (e.g. (hindawi.com)
  • We also highlight the therapeutic approaches aiming at targeting these regulators to enhance anti-tumor immunity. (mdpi.com)
  • Studies suggest this is a tumor suppressor gene . (wikipedia.org)
  • Tumor-infiltrating lymphocytes (TILs) may have greater tumoricidal activity than LAK cells. (msdmanuals.com)
  • The research points to a novel regulator of nuclear receptor activity, and possibly a potential way to target PPARdelta indirectly. (anl.gov)
  • In conclusion, our study demonstrated that hypomethylation of IFN-related genes is a common feature of GD/RA/SLE/SSc patients in CD4+ T cells, and the DNA methylation profile of IFN-related genes could be promising biomarkers for the diagnosis of GD, RA, SLE, and SSc. (frontiersin.org)
  • One of those molecules, phosphatidylcholine transfer protein (PCTP), suppresses the activity of the other, PPARdelta, a gene regulator critical in burning fat and energy metabolism, under conditions of overnutrition. (anl.gov)
  • The scientists first created a whole-body PCTP knockout male mouse (meaning one in which genes have been activated or deactivated), assessing its fat metabolism under different dietary conditions, including normal and high-fat diet. (anl.gov)
  • 1] The increased oxidative stress associated with all of these factors has been shown to reduce hepatic expression of the gene encoding hepcidin, a regulator of iron absorption and metabolism, thus increasing iron absorption and iron overload. (medscape.com)
  • Our results show that all 6 candidates regulate the expression of germline genes. (pasteur.fr)
  • During PDA progression, pancreatic acinar cells lose activity of the ClassI/II bHLH factors that regulate quiescence. (oncotarget.com)
  • NimR did not directly regulate the expression of urease genes but the activity of urease requires both nimR and nikQ . (rsc.org)
  • It seems that the expansion of numbers of genes evolving by duplication to handle the ever increasing complexities of neurogenesis, has been matched by a similar expansion of genes, also by duplication, to suppress or regulate neurogenesis. (sdbonline.org)
  • 8] Accumulating porphyrins in hepatocytes may then further down-regulate hepcidin gene expression. (medscape.com)
  • Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML. (lu.se)
  • This gene encodes a member of the regulator of G-protein signaling family. (nih.gov)
  • This gene encodes a member of the potassium channel, voltage-gated, shaker-related subfamily. (ucsc.edu)
  • The responsible gene has been mapped to band 12q24.1, which encodes the human transcription factor TBX5. (medscape.com)
  • Polymorphisms in this gene are associated with susceptibility to myocardial infarction, coronary artery disease and cervical artery dissection. (nih.gov)
  • I3C and breast cancer susceptibility gene 1 (BRCA1) synergistically inhibited transcriptional activity of ER-alpha. (nih.gov)
  • These results suggest that genetic variations in TNF, TGFB1, PTGS1 and PTGS2 genes contribute to DA susceptibility. (cdc.gov)
  • Furthermore, understanding the underlying molecular mechanisms regarding how these novel regulators control NF-κB activity may help to devise innovative therapeutic strategies to control NF-κB activity in cancer. (iu.edu)
  • The human EGR-1 protein contains (in its unprocessed form) 543 amino acids with a molecular weight of 57.5 kDa , and the gene is located on the chromosome 5 . (wikipedia.org)
  • The overall IFN-related gene panel annotated by gene ontology (GO) showed an excellent diagnostic capacity in CD4+ T cells (Sensitivity = 0.82, specificity = 0.82 and AUC = 0.90), while IFI44L , another IFN-related gene not annotated by GO, showed high prediction ability in both CD4+ (AUC = 0.86) and CD8+ (AUC = 0.75) T cells. (frontiersin.org)
  • This regulatory protein is a fluid phase serine protease that controls proenzyme activation and enzyme activity of not only the complement system but also the contact system. (uu.nl)
  • Accumulation of the polyketide aglycone is controlled by glycosylated macrolides and optimal performance of the complex polyketide synthase enzyme requires the activity of an editing thioesterase. (nih.gov)
  • Porphyria cutanea tarda (PCT) is a term encompassing a group of acquired and familial disorders in which activity of the heme synthetic enzyme uroporphyrinogen decarboxylase (UROD) is deficient. (medscape.com)
  • 7] Excess iron facilitates formation of toxic oxygen species, thus amplifying porphyrinogenesis by catalyzing formation of oxidative inhibitors of UROD enzyme activity. (medscape.com)
  • By creating a complicated catalog of all the places along our DNA strands that are biochemically active, they offer new insight into how genes work and influence common diseases. (latimes.com)
  • Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila" (PDF). (wikipedia.org)
  • Four sequence-related potassium channel genes - shaker, shaw, shab, and shal - have been identified in Drosophila, and each has been shown to have human homolog(s). (ucsc.edu)
  • The Enhancer of split complex (E[spl]-C) includes eight genes spread over 50 kilo bases on the Drosophila third chromosome. (sdbonline.org)
  • Other examples of Drosophila gene complexes include the Antennapedia complex (ANTP-C), the bithorax complex (BX-C) and the achaete-scute complex (AS-C). The hallmark of all these gene complexes, including the E(spl)-C is that within any complex the genes are evolutionarily related and jointly regulated. (sdbonline.org)
  • For this, the upstream regions of the gacA, gacS, ladS, retS, rsmA, rsmZ and PA1611 genes were cloned separately into a miniTn7 vector and inserted into the PAO1 chromosome. (usp.br)
  • Genes are often organized by function on the chromosome. (sdbonline.org)
  • Current genetic toxicology assays can only estimate somatic-mutation rates by assaying the function of certain gene markers (e.g. (fda.gov)
  • Our group discovered that which genetic variant of the FKBP5 gene a person carries is predictive of how much post-traumatic chronic pain that individual will experience following motor vehicle collision. (asbmb.org)
  • VBIM is a powerful genetic approach for gene discovery (3, 8). (iu.edu)
  • The situation is more complex when it comes to patents that in some way claim genes isolated, extracted or derived from viruses and related genetic information, or that claim potentially new uses or applications of genes or genetic information. (who.int)
  • In some countries laws specifically provide that isolated genetic material, such as gene sequences, may be considered patentable inventions (as long as they meet the other criteria for the granting of a patent) even if corresponding genes occur in nature. (who.int)
  • This situation typically arises when it is considered that the isolated gene or genetic material may serve a distinct useful purpose. (who.int)
  • 9] Reduction of hepatic UROD activity to approximately 25% of normal, most often reflecting effects of multiple genetic and/or exogenous inhibitory factors, is required for clinical disease expression. (medscape.com)
  • In vitro analysis revealed that a putative switch-protein kinase regulator, RsbW, is capable of interacting directly with σ 66 , as well as phosphorylating its own antagonist, RsbV1, rendering it inactive. (plos.org)
  • Preclinical studies linked to AD have shown that poor circadian activity patterns increase the risks of dementia and precede cognitive malfunction. (news-medical.net)
  • Continuing Bodnar's research over more than 10 years now, GMGI scientists investigated age-related patterns of gene expression-the extent to which various genes are turned on and off-in tissues of the red sea urchin. (drugdiscoverynews.com)
  • malpha and m4 embyonic expression patterns are nearly indistinguishable, and appear very similar to those of E(spl)-C bHLH genes, particularly m5, m7 and m8 . (sdbonline.org)
  • Genes can maintain spatiotemporal expression patterns by long-range interactions between cis-acting elements. (duke.edu)
  • Studies in yeast have identified a series of autophagy- (ATG-) related genes forming the autophagy machinery. (hindawi.com)
  • We found that the most significant differentially methylated sites had a remarkable enrichment in type I interferon (IFN) pathway genes. (frontiersin.org)
  • We identified a significant induction of epithelial alarmin (thymic stromal lymphopoietin-TSLP)-dependent interleukin-13 pathway after co-exposure, associated with increased mucin and interferon gene expression. (cdc.gov)
  • Exome sequencing was carried out in gemistocytic astrocytomas, and homozygous deletion of genes was identified at 19q13, i.e. (who.int)
  • Deletion of the core circadian clock genes Bmal1 and Per1 in mice triggers oxidative damage and synaptic degeneration. (news-medical.net)
  • APP23 TG mice without diurnal oscillation in genes exhibited hyperexcitability and reduced sleep. (news-medical.net)
  • Efficacy of modRNA delivery of cell cycle regulators on improving ejection fraction in mice with acute myocardial infarction (MI). (ca.gov)
  • Evaluate safety parameters for modRNA delivery of cell cycle regulators in mice and rats. (ca.gov)
  • GXD's primary emphasis is on endogenous gene expression during development. (jax.org)
  • We demonstrate that recombinant as well as endogenous Vag8 enhanced contact system activity by binding C1-INH and attenuating its inhibitory function. (uu.nl)
  • Chlamydia trachomatis is an obligate intracellular human pathogen that exhibits stage-specific gene transcription throughout a biphasic developmental cycle. (plos.org)
  • Next, the importance of embryonic developmental genes such as homeobox and T-box transcription factors are highlighted in conduction system development and function. (medscape.com)
  • A complex intronic enhancer regulates expression of the CFTR gene by direct interaction with the promoter. (duke.edu)
  • The cystic fibrosis transmembrane conductance regulator gene (CFTR) is expressed primarily in epithelial cells. (duke.edu)
  • An element located within a DNase I-hypersensitive site (DHS) 10 kb into the first intron was previously shown to augment CFTR promoter activity in a tissue-specific manner. (duke.edu)
  • In this study, they show that PCTPs can repress the activity of a nuclear receptor called PPARdelta, a gene regulator critical in burning fat, maintaining energy balance, and regulating fatty acid uptake. (anl.gov)
  • Repress the gene that burns fat, and fat is stored instead, they hypothesize. (anl.gov)
  • For example, the AS-C transcription factors activate transcription of other genes, while the transcription factors of the E(spl)-C repress transcription. (sdbonline.org)
  • The ASXL1 protein can turn on (activate) or turn off (repress) HOX genes depending on when they are needed. (medlineplus.gov)
  • its long-term silencing affects cell survival and cell cycle distribution as well as decreases CDK1 activity correlated with reduced phosphorylation of CDK1. (proteopedia.org)
  • A deletion at 1p32 between STIL and TAL1 genes leads to STIL/TAL1 fusion mRNA with STIL exon 1 slicing to TAL1 exon 3. (proteopedia.org)
  • miRNA-378a as a key regulator of cardiovascular health following engineered nanomaterial inhalation exposure. (cdc.gov)
  • The transcriptional regulator BACH1 negatively controls the expression of antioxidant genes, counteracting NRF2 activity. (nature.com)
  • Melo-Hanchuk TD, Kobarg J. Polyglutamylase activity of tubulin tyrosine ligase-like 4 is negatively regulated by the never in mitosis gene A family kinase never in mitosis gene A -related kinase 5. (wjgnet.com)
  • Moreover, I3C down-regulated the expression of the estrogen-responsive genes, pS2 and cathepsin-D, and up-regulated BRCA1. (nih.gov)
  • it is distinct from NikR the Ni-responsive regulators of the ribbon-helix-helix family. (rsc.org)
  • Canonical examples of master regulators include Oct-4 (also called POU5F1), SOX2, and NANOG, all transcription factors involved in maintaining pluripotency in stem cells. (wikipedia.org)
  • Efficacious and safe intramyocardial delivery of modified mRNA encoding cell cycle regulators as a gene therapy for cardiac regeneration through resident cardiomyocyte proliferation. (ca.gov)
  • This project would provide disease-modifying gene therapy for people with heart failure due to loss of cardiac muscle, a leading cause of deaths in the US, using novel modified mRNA delivery. (ca.gov)
  • Efficacy of modRNA delivery of cell cycle regulators on improving cardiac function in chronic post-MI rats. (ca.gov)
  • We propose gene delivery mediated by modified mRNA, as used in COVID vaccines, to reprogram adult cardiomyocytes transiently into a proliferative state for cardiac regeneration, thereby improving heart function. (ca.gov)
  • Cardiac function, utilizing the Vevo 2100 Imaging System, electron transport chain complex activities, and mitochondrial respiration assessed cardiac and mitochondrial function. (cdc.gov)
  • In addition to structural genes required for tylosin production, the tyl cluster contains three resistance determinants and several regulatory genes. (nih.gov)
  • Surprisingly, m2 transcripts also accumulate in a pattern reminiscent of the transcript distribution of E(spl) bHLH genes, although there are no structural similarites with either the bHLH or the m4/malpha genes. (sdbonline.org)
  • Searching for a transcriptional driver that might be responsible for the gene enrichment led to the identification of NRF2 and BACH1. (nature.com)
  • The NAC-K cells had an increased ability to migrate and invade compared with con-K cells, which was concomitant with an enrichment of genes involved in cell motility and migration. (nature.com)
  • Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. (ucsc.edu)
  • Our study of car crash survivors showed that rare variants TG and GG in the stress response gene FKBP5 increase vulnerability to developing chronic pain. (asbmb.org)
  • Ali H, Olatubosun A, Vihinen M. Classification of mismatch repair gene missense variants with PON-MMR. (lu.se)
  • These regulators may have great potential to serve as new biomarkers and therapeutic targets for cancer. (iu.edu)
  • Ethanol intake, estrogen therapies, hemochromatosis genes, and hepatitis and human immunodeficiency viral infections are among these contributory factors. (medscape.com)
  • The tylosin-biosynthetic (tyl) gene cluster occupies about 1% of the genome of Streptomycesfradiae and includes at least 43 open reading frames. (nih.gov)
  • Here, we use a computational approach to perform genome-wide identification and analysis of 611 orthologues of the Arabidopsis thaliana flowering genes. (springer.com)
  • When a promoter region is methylated, gene activity is repressed, and when a promoter region is not methylated, the gene is active. (medlineplus.gov)
  • A Torkamani, N J. Schork, (2007) Distribution analysis of nonsynonymous polymorphisms within the human kinase gene family. (lu.se)
  • Master regulators involved in development and morphogenesis can also appear as oncogenes relevant to tumorigenesis and metastasis, as with the Twist transcription factor. (wikipedia.org)