Activity cefoxitin. Medical search. Frequent questions

Mefoxin (cefoxitin) is a cephalosporin antibiotic used to treat many kinds of bacterial infections, including severe or life-threatening forms. (rxlist.com)
Second-generation cephalosporin with activity against some gram-positive cocci, gram-negative rod infections, and anaerobic bacteria. (medscape.com)
Infections caused by cephalosporin- or penicillin-resistant gram-negative bacteria may respond to cefoxitin. (medscape.com)
Cefoxitin Sodium, USP is the sodium salt of Cefoxitin, a cephamycin β-lactam second-generation cephalosporin that is resistant to β-lactamases. (toku-e.com)
Ceftizoxime is a third-generation cephalosporin with broad-spectrum gram-negative activity. (medscape.com)
Cefoxitin sodium is a 2nd generation cephalosporin that is FDA approved for the treatment of lower respiratory tract infections , urinary tract infection , gynecological infections , septicemia , bone and joint infections , and skin infections . (wikidoc.org)
Available data from published prospective cohort studies, case series, and case reports over several decades with cephalosporin use, including cefoxitin, in pregnant women have not established drug-associated risks of major birth defects, miscarriage, or adverse maternal or fetal outcomes (see Data) . (medlibrary.org)
While available studies cannot definitively establish the absence of risk, published data from prospective cohort studies, case series, and case reports over several decades have not identified an association with cephalosporin use, including cefoxitin, during pregnancy, and major birth defects, miscarriage, or other adverse maternal or fetal outcomes. (medlibrary.org)
Currently, the MABC treatment recommendations include the use of the -lactam cefoxitin (a cephalosporin) or imipenem (a carbapenem) (22,C24). (spierarchitecturalarts.com)

Briefly, to screen for ESBL enzymatic activity, a double-disk diffusion method was used: a clavulanic acid-containing disk was placed adjacent to a disk containing one of several cephalosporins such as ceftazidime and cefotaxime. (cdc.gov)
The second-generation cephalosporins (cefamandole, cefaclor, cefotetan, cefoxitin, and cefuroxime) have an extended antibacterial spectrum that includes greater activity against additional species of gram-negative rods. (britannica.com)
Cephalosporins are grouped into generations according to their spectrum of antimicrobial activity. (medscape.com)
In randomized comparative studies, Cefoxitin for injection, USP and cephalothin were comparably safe and effective in the management of infections caused by gram-positive cocci and gram-negative rods susceptible to the cephalosporins. (wikidoc.org)
Many infections caused by aerobic and anaerobic gram-negative bacteria resistant to some cephalosporins respond to cefoxitin for injection, USP. (wikidoc.org)
II generation cephalosporins have enhanced activity against gram-negative bacteria and a broad spectrum of activity compared with the drugs I generation. (silicongroup.net)
Cefoxitin (30 mg/kg SQ q8h for dogs) and cefotetan (30 mg/kg SQ q12h for dogs) are second generation cephalosporins with good spectrum including anaerobes. (vin.com)
Cefotetan, like other cephalosporins, has no activity against Chlamydia trachomatis. (globalrph.com)

Cefoxitin and cefotetan have increasing rates of resistance in Bacteroides species and would not be used as monotherapy. (hopkinsguides.com)
Many recommend cefazolin + metronidazole, cefotetan , cefoxitin or ampicillin/sulbactam as surgical prophylaxis when anaerobic bacteria leakage is likely. (hopkinsguides.com)
CEFOTAN™ (cefotetan for Injection, USP) is supplied in vials containing 80 mg (3.5 mEq) of sodium per gram of cefotetan activity. (globalrph.com)
Each 1 gram vial contains cefotetan disodium equivalent to 1 gram cefotetan activity. (globalrph.com)

However, cefoxitin is a better substrate than imipenem for beta-lactamases. (wikipedia.org)
However, because the patient responded poorly to empiric vancomycin and imipenem therapy and because of the elevated MIC to meropenem for isolate 7184, further laboratory testing was conducted to rule out the possibility of carbapenemase activity. (cdc.gov)
Type cultures produced low levels of β-lactamase and were susceptible to cefoxitin, latamoxef, imipenem and the combination of benzylpenicillin and clavulanic acid. (microbiologyresearch.org)
ThnS appears as a MBL enzyme with multiple activities including a specialised ß-lactamase activity toward imipenem. (bvsalud.org)
Surprisingly, despite the poor activity of ceftazidime with or without avibactam, the dual -lactam mixtures of ceftazidime with either ceftaroline or imipenem showed promising synergistic activities against the MABC strains. (spierarchitecturalarts.com)
Imipenem ertapenem and cefoxitin had been from Merck Clear & Dohme (Rome Italy). (mdm2-inhibitors.com)

Similarly, many infections caused by aerobic and anaerobic bacteria resistant to some penicillin antibiotics (ampicillin, carbenicillin, penicillin G) respond to treatment with cefoxitin for injection, USP. (wikidoc.org)

Like many cephamycins, Cefoxitin is particularly effective against anaerobic bacteria. (toku-e.com)
Many infections caused by mixtures of susceptible aerobic and anaerobic bacteria respond to treatment with cefoxitin for injection, USP. (wikidoc.org)

In the presence of cefoxitin, bacteria that make beta-lactamases will increase their production and secretion to cleave the beta lactam ring. (wikipedia.org)
Limited data from published literature report the presence of cefoxitin in human milk. (medlibrary.org)

Interpretive criteria for determining susceptibility to cefoxitin via disk diffusion are greater than or equal to 22mm resulting in a "susceptible" result for Staphylococcus aureus and greater than or equal to 25mm for coagulase-negative staphylococci to be considered susceptible. (wikipedia.org)
The cefoxitin disk diffusion method can be used in addition to routine susceptibility test methods or as a back-up method. (cdc.gov)
Variations in susceptibility to latamoxef (moxalactam) and cefoxitin within the Bacteroides fragilis group. (microbiologyresearch.org)
Cefoxitin Sodium is commonly used in clinical in vitro microbiological antimicrobial susceptibility tests (panels, discs, and MIC strips) against Gram-positive and Gram-negative microbial isolates. (toku-e.com)
Appropriate culture and susceptibility studies should be performed to determine the susceptibility of the causative organisms to Cefoxitin for injection, USP. (wikidoc.org)
The validation of these strains as MRSA was done using cefoxitin disc susceptibility testing according to the CLSI standards and by the PCR amplification and sequencing of 16S rRNA and mec-A genes. (gov.pk)

MEFOXIN (cefoxitin for injection) is a semi-synthetic, broad-spectrum cepha antibiotic sealed under nitrogen for intravenous administration. (rxlist.com)
Azithromycin is a relatively new member macrolide antibiotic that possesses activity against various different bacterial organisms. (medscape.com)
Erythromycin is a macrolide antibiotic with a large spectrum of activity. (medscape.com)
Amoxicillin is a penicillin antibiotic with activity against gram-positive and some gram-negative bacteria. (medscape.com)
Cefoxitin is a second-generation cephamycin antibiotic developed by Merck & Co., Inc. from Cephamycin C in the year following its discovery, 1972. (wikipedia.org)
Cefoxitin is a beta-lactam antibiotic which binds to penicillin binding proteins, or transpeptidases. (wikipedia.org)
Due, in part, to the unavailability of methicillin in the United States, cefoxitin has replaced methicillin for disk diffusion tests, which determine the sensitivity of a bacterial specimen to a given antibiotic. (wikipedia.org)
Cefoxitin is a broad-spectrum antibiotic effective against several Gram-positive and Gram-negative bacteria. (toku-e.com)
Activity of antibiotic admixtures subjected to different freeze-thaw treatments. (stabilis.org)

comparison with benzylpenicil-lin, cephalothin and cefoxitin. (microbiologyresearch.org)

For the purposes of detecting bacterial strains with the mecC gene, which like mecA codes for a different PBP, cefoxitin is more reliable than oxacillin because mecC does not correlate as strongly with oxacillin resistance. (wikipedia.org)
Major bacterial strains susceptible to cefoxitin include: methicillin-susceptible Staphylococcus aureus Streptococcus sp. (wikipedia.org)
Double-blind trials have reported faster recovery from athletic injuries, including sprains and strains, and earlier return to activity using eight tablets daily of trypsin/chymotrypsin, four to eight tablets daily of papain, eight tablets of bromelain (single-blind only), or a combination of these enzymes. (mottchildren.org)
Cefoxitin for injection, USP is indicated for the treatment of serious infections caused by susceptible strains of the designated microorganisms in the diseases listed below. (wikidoc.org)
There have been studies reporting infections caused by tolerant strains more difficult to eradicate and antimicrobial regimens with bactericidal activity superior to that of bacteriostatic regimens in the treatment of serious S.aureus infections. (biomedcentral.com)
A total of 110 actinobacterial strains were isolated and were tested for antimicrobial activity, among them 30 strains showed inhibitory effects against MRSA, which were selected for further studies. (gov.pk)
In biological screening, the actinobacterial strains exhibited significant antiMRSA activity in the range of 20-32mm inhibitory zones. (gov.pk)
On the basis of anti-MRSA activity and significant chemical profile, the strains were prioritized for preparative screening for the purification and identification of the active compounds and for genomic studies. (gov.pk)

Yet only cefoxitin retained its previous effectiveness against Gram negative bacteria, developed effectiveness against Gram positive bacteria, and resisted breakdown by beta-lactamase. (wikipedia.org)

Staphylococci that are resistant to methicillin and oxacillin should also be considered clinically resistant to cefoxitin even if they test susceptible by in vitro methods. (wikipedia.org)
The efficacy of vancomycin against methicillin resistant S.aureus (MRSA) has been reported to be inferior to that of beta-lactams against methicillin susceptible S.aureus (MSSA) due to its slower in vitro bactericidal activity with a lower clinical response [ 4 - 6 ]. (biomedcentral.com)

Our Mefoxin (cefoxitin) Side Effects Drug Center provides a comprehensive view of available drug information on the potential side effects when taking this medication. (rxlist.com)
MEFOXIN contains approximately 53.8 mg (2.3 milliequivalents) of sodium per gram of cefoxitin activity. (rxlist.com)
Cefoxitin requires a prescription and as of 2010 is sold under the brand name Mefoxin by Bioniche Pharma, LLC. (wikipedia.org)

Cephamycin C was the first cephem discovered but while it was highly resistant to several beta-lactamases, as is its derivative cefoxitin, it was almost only effective against Gram negative bacteria. (wikipedia.org)
Cefoxitin, and the cephamycin family as a whole, served as a branching point and impulsed the discovery of more classes of beta-lactams. (wikipedia.org)
As a cephamycin, cefoxitin is highly resistant to hydrolysis by some beta-lactamases, in part due to the presence of the 7-alpha-methoxy functional group (see skeletal formula above). (wikipedia.org)
Cefoxitin was discovered in 1972 and developed by Merck & Co. and Lilly from Cephamycin C. It was synthesized in order to broaden its spectrum. (toku-e.com)

Cefoxitin's spectrum of in vitro antimicrobial activity includes a broad range of gram-negative and gram-positive bacteria, including anaerobes. (wikipedia.org)
Of all tested concentrations, direct antimicrobial activity of the two ethanolic Andrographis paniculata extracts was observed for only two human pathogens, Legionella pneumophila and Bordetella pertussis . (scialert.net)
Given that the TLC of Andrographis paniculata extracts showed that andrographolide was present in all the three Andrographis paniculata extracts, it was concluded that the observed antimicrobial activity was due to other active principle(s) present in the extracts used in this investigation. (scialert.net)
New sources, especially natural products from plants, are being investigated because medicinal plants have been widely used for treatment of many types of acute and chronic diseases in Asia and many plants with antimicrobial activity have been reported (Cowan, 1999). (scialert.net)
To date, bactericidal activity has been regarded as a desirable characteristic in antimicrobial agents when treating patients with endocarditis, while, routine MBC testing is not recommended because of the technical difficulties associated with these tests [ 11 - 15 ]. (biomedcentral.com)

found in a 2009 study that cefoxitin disk assays correctly identified all 60 mecA-positive Staphylococcus aureus, or MRSA isolates, to be resistant to cefoxitin. (wikipedia.org)
We studied bactericidal activity of oxacillin, vancomycin and teicoplanin against Staphylococcus aureus isolates in patients with endocarditis and then we sought to determine if there was a relationship between in vitro bactericidal activity and clinical outcome. (biomedcentral.com)

MRSA, or methicillin-resistant Staphylococcus aureus is a strain that has acquired resistance to cefoxitin via this gene. (wikipedia.org)
Major bacteria resistant to cefoxitin include: methicillin-resistant Staphylococcus aureus Enterococci Listeria monocytogenes Enterobacter sp. (wikipedia.org)
Like many cephamycins, Cefoxitin is resistant to β-lactamases. (toku-e.com)

Each conventional vial contains sterile cefoxitin sodium, USP equivalent to 1 g, 2 g or 10 g cefoxitin. (rxlist.com)

didemnin b (db) is a cyclic peptide with potent immunosuppressive activity in vitro and in the murine graft-versus-host-reaction (gvhr), the only measure of in vivo immunity tested in our prior studies. (liverpool.ac.uk)
There is no clear relationship between in vitro bactericidal activity tests and clinical outcome. (biomedcentral.com)

Therefore, when Cefoxitin for injection, USP is used in the treatment of patients with pelvic inflammatory disease and C. trachomatis is one of the suspected pathogens, appropriate anti-chlamydial coverage should be added. (wikidoc.org)
Cefoxitin for injection, USP has a high degree of stability in the presence of bacterial beta-lactamases, both penicillinases and cephalosporinases. (wikidoc.org)
Cefoxitin for injection, USP is indicated for the prophylaxis of infection in patients undergoing uncontaminated gastrointestinal surgery, vaginal hysterectomy, abdominal hysterectomy, or cesarean section. (wikidoc.org)
In patients with a reduced creatinine clearance the dose of Cefoxitin Injection and Dextrose Injection should be adjusted to compensate for the slower rate of renal elimination. (medlibrary.org)

However, on the basis of ceftriaxone's activity against N. gonorrhoeae, its pharmacokinetics, and the results in clinical trials of doses as low as 62.5 mg, the 125 mg dose appears to have a therapeutic reserve at least as large as that of other accepted treatment regimens. (cdc.gov)
The developmental and health benefits of breastfeeding should be considered along with the mother's clinical need for cefoxitin and any potential adverse effects on the breastfed infant from cefoxitin or from the underlying maternal condition. (medlibrary.org)
In a published clinical lactation study, the concentration of cefoxitin ranged from 11.6 ± 0.8 to 0.49 ± 0.01 mcg/mL and 1.71 ± 0.08 to 0.57 ± 0.02 mcg/mL in human plasma and breast milk, respectively, at 1, 1.5, 2 or 2.5 hours following IV administration of 1 g cefoxitin twice daily. (medlibrary.org)
Of the 1,775 subjects who received cefoxitin in clinical studies, 424 (24%) were 65 and over, while 124 (7%) were 75 and over. (medlibrary.org)

Cefoxitin also yields more accurate results for disk diffusion tests. (wikipedia.org)

determined that cefoxitin serves as an appropriate replacement for methicillin in determining if some bacteria display methicillin resistance. (wikipedia.org)

It has a limited spectrum of bacterial activity but is effective in treating chlamydial infections. (medscape.com)

Another more efficient form of resistance to cefoxitin is provided by the mecA gene in bacteria. (wikipedia.org)

This in turn causes the bacteria to lyse due to ongoing activity of cell wall autolytic enzymes. (medscape.com)
It has activity against several Gram-positive and Gram-negative bacteria. (toku-e.com)

Cefoxitin Sodium is freely soluble in aqueous solution. (toku-e.com)
2003) with no antibacterial activity observed with the aqueous extract tested against E. coli , S. aureus , S. typhi or Shigella species (Leelarasamee et al . (scialert.net)

Recent studies show that, unlike additional promoted -lactamase inhibitors, the new non-lactam agent avibactam efficiently inhibits BlaMab and significantly enhances the activity of additional -lactams against transpeptidases, these results suggest that dual -lactam regimens with or without avibactam may have greater activity than a solitary agent (7, 17, 28). (spierarchitecturalarts.com)

Moreover, like most MBL fold enzymes, additional enzymatic activities of ThnS were detected such as hydrolysis of ascorbic acid, single strand DNA, and ribosomal RNA. (bvsalud.org)
two possible consequences of crystal lattice formation were studied with glyceraldehyde-3-phosphate dehydrogenases isolated from lobster (palinurus vulgaris) and pig muscle: changes in the microenvironment of the nadh-binding site as detected by fluorescence polarization, and differences in the maximal activities of the microcrystalline enzymes as compared to those in solution. (liverpool.ac.uk)
At 30°C 40 and 50°C after 120 min of incubation the residual activity seen with all three enzymes ranged between 90% and 100% (data not shown). (mdm2-inhibitors.com)

Pharmaceutical compositions comprising a helicobacter-inhibiting anti- microbial agent and a benzimidazole derivative having gastric acid secretion inhibitory activity. (gc.ca)

Des infections microbiennes ont été observées chez 30% (155/519) de l'ensemble des malades admis au service de soins intensifs pour adultes de l'Hôpital universitaire de Jordanie à Amman en 1993. (who.int)

Tell your doctor if you are pregnant before using cefoxitin. (rxlist.com)

The scientists used chemically modified the compound to give cefoxitin, so titled due to its semi-synthetic nature. (wikipedia.org)

Much of the research conducted has used smaller amounts likely to be the equivalent (in modern units of activity) of approximately 500 MCU taken four times a day. (mottchildren.org)

The usual adult dosage range of cefoxitin is 1 gram to 2 grams every six to eight hours. (rxlist.com)

However, no antibacterial activity of andrographolide against any of the pathogens tested in this investigation was observed. (scialert.net)
These drugs are grouped according to their antibacterial activity and chemical structure. (healthline.com)

These derivatives show better activity than their parent compounds. (longdom.org)

Like β-lactams, cephamycins interfere with PBP (penicillin binding protein) activity involved in the final phase of peptidoglycan synthesis. (toku-e.com)

Findings from this study found that TiO-500C nanocomposites concentration at 100 mg/mL is cytocompatible to the fibroblast cells lines with proliferation rate/activity higher than 116% after 24 h treatment. (researchsquare.com)

17 mm) indicates AmpC-like β-lactamase activity. (cdc.gov)

By binding to PBPs, cefoxitin prevents the PBPs from forming the cross-linkages between the peptidoglycan layers that make up the bacterial cell wall, thereby interfering with cell wall synthesis. (wikipedia.org)
This PBP has a lower binding affinity for penicillin-based antibiotics such as cefoxitin and will continue to cross-link the peptidoglycan layers of the cell wall even in the presence of the beta-lactam antibiotics. (wikipedia.org)

Properly designed drug delivery systems like liposomes and nanoparticles have been reported as efficient emodin carriers and to enhance emodin activity in cancer cell inhibition. (longdom.org)

The modified Hodge test is a phenotypic test proposed to confirm the presence of carbapenemase activity such as KPC in K. pneumoniae and E. coli ( 8 ). (cdc.gov)

Other drugs may interact with cefoxitin. (rxlist.com)
Drugs in this group have close the half-life (50 - 80 min), except tsefotetan that has a higher rate (about 4 h), are distinguished mainly by the kidney, is not metabolized in the body (except cefoxitin). (silicongroup.net)

One gram of bromelain standardized to 2,000 MCU would be approximately equal to 1 gram with 1,200 GDU of activity, or 8 grams with 100,000 RU of activity. (mottchildren.org)

and Norfloxacin showed high activity against the gonococcus (95-100 per cent sensitivity). (bvsalud.org)

Organisms11

Diseases2

Chemicals and Drugs29

Analytical, Diagnostic and Therapeutic Techniques and Equipment3

Phenomena and Processes4

Information Science1

Health Care1

Cephalosporin9

Cephalosporins8

Cefotetan4

Imipenem6

Ampicillin1

Anaerobic Bacteria2

Presence of cefoxitin2

Susceptibility6

Antibiotic9

Cephalothin1

Strains8

Beta-lactamase1

Susceptible2

MEFOXIN3

Cephamycin4

Antimicrobial5

Isolates2

Resistant3

Vial contains1

Vitro2

Injection4

Clinical4

Disk diffusion1

Methicillin1

Spectrum1

Resistance1

Bacteria2

Aqueous2

Transpeptidases1

Enzymes3

Derivative1

Infections1

Pregnant1

Semi-synthetic1

Equivalent1

Adult1

Antibacterial activity2

Compounds1

Penicillin binding1

Concentration1

AmpC1

Peptidoglycan2

Inhibition1

Coli1

Drugs2

Grams1

Sensitivity1