• Cytokine binding to the cell surface leads to phosphorylation of the receptor complex by receptor associated Janus kinases (JAKs) at tyrosine residues. (nature.com)
  • The positions of highlighted regulatory phosphorylations observed in (B) below are indicated, as are the amino acids included in the NMR structure deposited as PDB 4X8Y, and the amino acid residues used to obtain crystal and NMR structures [ 4 ]. (oncotarget.com)
  • Phosphorylation on tyrosine residues, which are localized on membrane proteins, stimulates a cascade of signaling pathways that control cell proliferation, migration, and adhesion. (wikipedia.org)
  • Phosphorylation of serine residues in the N-terminus modulates the activity of ACA8, a plasma membrane Ca2+-ATPase of Arabidopsis thaliana / S. Giacometti, C.A. Marrano, M.C. Bonza, L. Luoni, M. Limonta, M.I. De Michelis. (unimi.it)
  • However, whether phosphorylation at these residues enhances or protects against α-syn toxicity in vivo remains unknown. (jneurosci.org)
  • demonstrated that overexpression of parkin protects against α-syn-induced toxicity by reducing the levels of both pS87 and pS129 in vivo , suggesting that phosphorylation at these residues is a pathological event. (jneurosci.org)
  • One of the regulatory mechanisms that modulate the Cdk5 kinase activity is phosphorylation of conserved residues ( Dhavan and Tsai, 2001 ). (frontiersin.org)
  • Phosphorylation of receptor serine/threonine residues has been proposed to exert an inhibitory influence on receptor tyrosine kinase activity and Ser 1327 and Thr 1348 have been identified as specific sites of phosphorylation in the insulin receptor COOH terminal domain. (jci.org)
  • To address the potential negative regulatory role of phosphorylation of these residues in vivo, we assessed the extent of phosphorylation of each site in insulin receptor isolated from the skeletal muscle of 12 NIDDM patients and 13 nondiabetic, control subjects. (jci.org)
  • The c-JUN proto-oncoprotein is phosphorylated at four residues within its transactivation domain (TAD) by the JNK family kinases, but the functional significance of c-JUN multisite phosphorylation has remained elusive. (crick.ac.uk)
  • Three sequential phosphorylation events on specific residues of p27, regulate the activity of these complexes and ultimately control cell cycle proliferation or arrest. (lu.se)
  • O-GlcNAcylation regulates the transcriptional activity of p53, c-Myc, FoxO1 and CREB, as well as components of the basal transcription machinery, for example, the C-terminal domain of RNA polymerase II. (nature.com)
  • p27 regulates G1 /S transition by abrogating the activity of cyclin/CDK complexes. (umass.edu)
  • Here, we show that in the mouse striatum, dopamine receptor stimulation negatively regulates phosphorylation of Tyr15-Cdk5 most likely through a D2R-mediated mechanism. (frontiersin.org)
  • The phosphorylation of MLC primarily regulates the force production and maintenance in the smooth muscle [ 6 ]. (hindawi.com)
  • Here, we show that cyclindependent kinase 5 (Cdk5), a protein kinase that regulates cell migration and invasion, phosphorylates PIPKIγ90 at S453, and that Cdk5-mediated PIPKIγ90 phosphorylation is essential for cell invasion. (arizona.edu)
  • Moreover, Cdk5-mediated phosphorylation down-regulates the activity of PIPKIγ90 and the secretion of fibronectin, an extracellular matrix protein that regulates cell migration and invasion. (arizona.edu)
  • These data suggest that Cdk5-mediated PIPKIγ90 phosphorylation regulates cell invasion by controlling PIPKIγ90 activity and fibronectin secretion. (arizona.edu)
  • Protein phosphorylation is the most common post-translation modification of proteins and regulates many biological processes. (lu.se)
  • Together, these findings provide a strong biophysical basis for the use of the S87E and S87A mutants to elucidate the role of phosphorylation at S87 in vivo . (jneurosci.org)
  • In the present study, we investigated the role of phosphorylation of Tm1 in regulating its tumor suppressor properties. (scirp.org)
  • These data underscore the structural flexibility of the NTD of PR, and the ability of steroid ligands together with interacting proteins to affect the conformation and activity of the NTD. (nih.gov)
  • Ushiro and Cohen (1980) discovered the important role of the phosphorylation of tyrosine as a regulator of intracellular processes and revealed changes in the tyrosine kinase activity of proteins in mammalian cells. (wikipedia.org)
  • Tyrosine phosphorylation of certain target proteins is required for ligand stimulation of their enzymatic activity. (wikipedia.org)
  • The insulin-stimulated phosphoinositide 3-kinase (PI 3-kinase)/3-phosphoinositide-dependent kinase-1 (PDK1)/protein kinase B (PKB) kinase cascade is believed to play a critical role in metabolic control and cell survival, largely mediated through PKB phosphorylation of many proteins. (dundee.ac.uk)
  • Click on one of the biological effects of VEGF-VEGF R2 signaling shown in the Explore Pathways box below to see the specific molecules involved in promoting each effect and the phosphorylation sites on VEGF R2 that are necessary for recruitment of key downstream adaptor proteins or kinases. (rndsystems.com)
  • These roles could potentially be reciprocally regulated by phosphorylation/dephosphorylation at Y113. (oncotarget.com)
  • In isolated nerve terminals, rapid changes in synapsin I phosphorylation were observed after Ca2+ entry, namely, a Ca2+-dependent phosphorylation of P-sites 1, 2, and 3 and a Ca2+-dependent dephosphorylation of P-sites 4, 5, and 6. (ucl.ac.uk)
  • Inhibition of calcineurin activity by cyclosporin A resulted in a complete block of Ca2+-dependent dephosphorylation of P-sites 4, 5, and 6 and correlated with a prominent increase in ionomycin-evoked glutamate release. (ucl.ac.uk)
  • EA caused a significant increase in the MLC dephosphorylation and MLCK phosphorylation levels in the group compared to the sham EA and model groups. (hindawi.com)
  • It is suggested that the phosphorylation of MLC catalyzed by Ca 2+ -calmodulin- (CAM-) dependent MLCK and dephosphorylation catalyzed by MLCP help regulate the contraction and relaxation of smooth muscle [ 8 , 9 ]. (hindawi.com)
  • This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. (sigmaaldrich.com)
  • Cyclin-dependent kinases are regulated by phosphorylation and dephosphorylation events. (bvsalud.org)
  • Subsequently, the change in protein tyrosine kinase activity was shown to underlie the Ras-MAPK signaling pathway regulated by mitogen-activated protein (MAP) kinases. (wikipedia.org)
  • activation of Ras phosphorylation and activation of MAP kinases transmission of signal into genome. (wikipedia.org)
  • We then generated consensus phosphorylation motifs for each of the kinases and integrated this information, along with information about in vivo phosphorylation sites determined by MS, to construct a high-resolution map of phosphorylation networks that connects 230 kinases to 2591 in vivo phosphorylation sites in 652 substrates. (johnshopkins.edu)
  • The phosphorylation of IκBα by IκB kinase family have been so many identified, but the phosphorylation sites of IκBα by other kinases remain poorly understood. (researchsquare.com)
  • Does not affect the activity of a wide panel of kinases, receptors, enzymes, and ion channels even at concentrations as high as 1 µM. (sigmaaldrich.com)
  • Protein kinases that control cell cycle progression in all eukaryotes and require physical association with CYCLINS to achieve full enzymatic activity. (bvsalud.org)
  • The level of myosin light chain (MLC) phosphorylation is an important determinant of smooth muscle contraction. (hindawi.com)
  • Myosin light chain phosphatase (MLCP) activity is associated with mammalian bladder function, and it is speculated that a change in MLC may play an important role in the nervous and myogenic control of the bladder [ 7 ]. (hindawi.com)
  • The function of striated or smooth muscle is regulated by the balance of myosin light chain kinase (MLCK) and MLCP activity. (hindawi.com)
  • Intestinal edema decreases intestinal contractile activity via decreased myosin light chain phosphorylation. (tamu.edu)
  • Edema development, basal contractile activity, maximum agonist-induced contractile response (measured as total force generation during the first 2 mins after carbachol treatment), and myosin light chain phosphorylation were measured in the distal small intestine. (tamu.edu)
  • CONCLUSION: We conclude that edema decreases myosin light chain phosphorylation, leading to decreased intestinal contractile activity. (tamu.edu)
  • and protein tyrosine kinase activity. (nih.gov)
  • The tyrosine kinase activity of insulin receptor isolated from the skeletal muscle of NIDDM patients has previously been found to be decreased compared with the activity of receptor from nondiabetic subjects but the mechanism underlying this defect is unknown. (jci.org)
  • Moreover, within each group there was no correlation between the level of tyrosine kinase activity and the extent of serine/threonine phosphorylation. (jci.org)
  • It is concluded that the stoichiometry of serine/threonine phosphorylation of insulin receptor in vivo is low, and that increased phosphorylation of Ser 1327 or Thr 1348 is not responsible for the decreased insulin receptor tyrosine kinase activity observed in the skeletal muscle of NIDDM patients. (jci.org)
  • Integrin-mediated RON growth factor receptor phosphorylation requires tyrosine kinase activity of both the receptor and c-Src. (123dok.org)
  • Using two different methods it was possible to detect constitutive activity of p38 mitogen-activated protein kinase (p38) in newly isolated neutrophils. (lu.se)
  • Further to the published interpretation, we suggest that phosphorylation of PGRMC1 at position Y113 may promote the attested membrane trafficking function of PGRMC1. (oncotarget.com)
  • Several lines of evidence suggest that phosphorylation of α-synuclein (α-syn) at S87 or S129 may play an important role in regulating its aggregation, fibrillogenesis, Lewy body formation, and neurotoxicity in vivo . (jneurosci.org)
  • Liu, P, Kevrekidis, Y & Shvartsman, SY 2011, Substrate-induced oscillatory activity of an enzyme regulated by multisite phosphorylation . (princeton.edu)
  • The major phosphopeptides derived from biosynthetically labeled c-Fos correspond to phosphopeptides generated after phosphorylation of c-Fos in vitro with both RSK and MAP kinase. (nih.gov)
  • Cooperative phosphorylation at these sites by both enzymes was observed in vitro and reflected in vivo by the predominance of the peptide phosphorylated on both sites, as opposed to singly phosphorylated peptides. (nih.gov)
  • We conclude that interferon alpha-2b possesses greater therapeutic activity in vitro than ribavirin, with a potentially greater therapeutic ratio in humans. (cdc.gov)
  • ERK-mediated S98 phosphorylation inhibits assembly of G-actin complexes on the MRTF-A regulatory RPEL domain, promoting nuclear import. (elifesciences.org)
  • Together, our data demonstrate, for the first time, that mimicking phosphorylation at S87 inhibits α-syn aggregation and protects against α-syn-induced toxicity in vivo , suggesting that phosphorylation at this residue would play an important role in controlling α-syn neuropathology. (jneurosci.org)
  • Glutamate inputs activate Cdk5, which inhibits postsynaptic dopamine D1 receptor (D1R)-mediated signaling by phosphorylating DARPP-32 at Thr75 (Thr75-DARPP-32) in the striatum, since DARPP-32 with Thr75 phosphorylation (DARPP-32-pThr75) functions as an inhibitor of cAMP-dependent protein kinase A (PKA). (frontiersin.org)
  • Phosphorylation thus plays positive and negative roles in regulation of MRTF-A. (elifesciences.org)
  • We describe here how the PGRMC1 structure also enables important new insights into the possible regulation of PGRMC1 function by phosphorylation. (oncotarget.com)
  • Moreover, PGRMC1 has been attributed with controlling diverse functions including neuronal guidance, membrane trafficking, modulation of cytochrome P450 activity, progesterone-responsiveness, steroidogenesis and regulation of the mevalonate pathway, etc. [ 1 - 3 ]. (oncotarget.com)
  • Tyrosine phosphorylation is a key step in signal transduction and the regulation of enzymatic activity. (wikipedia.org)
  • Background: The phosphorylation of NF-kappaB inhibitor alpha (IκBα) protein is pivotal to the regulation of NF-κB transcription factor activity in the cell. (researchsquare.com)
  • and positive regulation of protein phosphorylation. (nih.gov)
  • Zerradi, M. , Houle, F. and Huot, J. (2015) Regulation of Breast Cancer Progression by Phosphorylation of the Tumor Suppressor Tropomyosin-1 Alpha. (scirp.org)
  • Simoneau, B., Houle, F. and Huot, J. (2012) Regulation of Endothelial Permeability and Transendothelial Migration of Cancer Cells by Tropomyosin-1 Phosphorylation. (scirp.org)
  • Regulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylation. (bvsalud.org)
  • In this study, we examined whether H1R desensitization contributes to regulating the decay rate of TRPC6 activity upon receptor stimulation. (mdpi.com)
  • Therefore, spinal AMPA receptor phosphorylation contributes to the mechanisms underlying stress-induced pain transition. (jneurosci.org)
  • Our data show that O-GlcNAcylation of STAT5 is an important process that contributes to oncogenic transcription through enhanced STAT5 tyrosine phosphorylation and oligomerization driving myeloid transformation. (nature.com)
  • Conclusion: Phosphorylation of Tm1 at Ser283 contributes to its anti-tumor properties, and this effect results mainly from an increase in cell adhesion associated with a decrease in their migratory and invasive potentials. (scirp.org)
  • Integrin engagement by ECM can modulate growth factor signaling pathways, increasing the activity of growth factor RTKs (7, 8) and their downstream intracellular mediators (9, 10). (123dok.org)
  • However, intracellular accumulation and phosphorylation of ribavirin may account for its therapeutic effect in mice ( 4 ) . (cdc.gov)
  • Moreover, in the 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine (MPTP) mouse model, dopamine deficiency caused increased phosphorylation of both Tyr15-Cdk5 and Thr75-DARPP-32 in the striatum, which could be attenuated by administration of L-3,4-dihydroxyphenylalanine and imatinib (STI-571), a selective c-Abl inhibitor. (frontiersin.org)
  • Moreover, XAV939, an inhibitor of tankyrase PARP activity, decreased viral titers to 2 to 5% of control values. (bris.ac.uk)
  • The PI 3-Kγ Inhibitor, also referenced under CAS 648450-29-7, controls the biological activity of PI 3-Kγ. (sigmaaldrich.com)
  • Furthermore, inhibition of PIPKIg activity with the chemical inhibitor UNC3230 suppresses fibronectin secretion in a dose-dependent manner, whereas depletion of Cdk5 enhances fibronectin secretion. (arizona.edu)
  • Activated receptors directly or indirectly regulate cellular biochemical processes (eg, ion conductance, protein phosphorylation, DNA transcription, enzymatic activity). (msdmanuals.com)
  • abstract = "The landscape of human phosphorylation networks has not been systematically explored, representing vast, unchartered territories within cellular signaling networks. (johnshopkins.edu)
  • Upon cytokine stimulation, STAT5 tyrosine phosphorylation (pYSTAT5) is transient, while in diverse neoplastic cells persistent overexpression and enhanced pYSTAT5 are frequently found. (nature.com)
  • We here report that Cdk5 with Tyr15 phosphorylation (Cdk5-pTyr15) is enriched in the mouse striatum, where dopaminergic stimulation inhibited phosphorylation of Tyr15-Cdk5 by acting through the D2 class dopamine receptors. (frontiersin.org)
  • This study suggests a role for nuclear RSK and MAP kinase in modulating newly synthesized c-Fos phosphorylation and downstream signaling. (nih.gov)
  • However, phosphorylation of the FK linker appears to be an important regulatory determinant of FKBP52-mediated potentiation of steroid receptor activity. (unboundmedicine.com)
  • The phosphorylation of smooth muscle regulatory light chain by MLCK is the basic requirement for smooth muscle contraction and hollow organ physiological activities [ 10 ]. (hindawi.com)
  • Protein phosphorylation is a major regulatory mechanism of cellular signalling. (crick.ac.uk)
  • When stimulated by agonists of the histamine H1 receptor (H1R), TRPC6 activity decays to the baseline despite the continuous presence of the agonist. (mdpi.com)
  • Jun dimerization protein-2 (JDP-2) is a progesterone receptor (PR) coregulatory protein that acts by inducing structure and transcriptional activity in the disordered amino-terminal domain (NTD) of PR. (nih.gov)
  • Here we showed that social defeat stress enhanced plantar incision-induced AMPA receptor GluA1 phosphorylation at the Ser831 site in the spinal cord and greatly prolonged plantar incision-induced pain. (jneurosci.org)
  • In addition, stress hormones enhanced GluA1 phosphorylation and AMPA receptor-mediated electrical activity in the spinal cord. (jneurosci.org)
  • Two important classes of tyrosine kinase in tyrosine phosphorylation are receptor tyrosine kinase and nonreceptor tyrosine kinase. (wikipedia.org)
  • Binding of PLCγ to the activated receptor facilitates its efficient tyrosine phosphorylation by the RTK. (wikipedia.org)
  • Phosphorylation of Ser 1327 and Thr 1348 was determined using antibodies that specifically recognize insulin receptor phosphorylated at these sites. (jci.org)
  • In addition, a phosphotyrosine-specific antibody was used to monitor receptor tyrosine phosphorylation. (jci.org)
  • Integrin-in-duced epidermal growth factor (EGF) and platelet-derived growth factor (PDGF) RTK phosphorylation depends on the kinase activity of the receptor (7, 13). (123dok.org)
  • Insulin signaling was evaluated at the levels of the insulin receptor, IRS-1-associated PI3K (IRS-1-PI3K), Akt, and GS employing kinase activity assays and phospho-specific western blotting. (ku.dk)
  • A drug's ability to affect a given receptor is related to the drug's affinity (probability of the drug occupying a receptor at any given instant) and intrinsic efficacy (intrinsic activity-degree to which a ligand activates receptors and leads to cellular response). (msdmanuals.com)
  • In endothelial cells PKA activity promotes vessel maturation and limits tip cell formation. (mdc-berlin.de)
  • Reducing PKA activity increased ATG16L1 protein levels and endothelial autophagy. (mdc-berlin.de)
  • Together these results indicate that endothelial PKA activity mediates a critical switch from active sprouting to quiescence in part through phosphorylation of ATG16L1, which in turn reduces endothelial autophagy. (mdc-berlin.de)
  • We recently reported that raised activity of the glycosylating enzyme core 2 β 1,6- N -acetylglucosaminyltransferase (GlcNAc-T) through protein kinase C (PKC)β2-dependent phosphorylation plays a fundamental role in increased leukocyte-endothelial cell adhesion and capillary occlusion in retinopathy. (diabetesjournals.org)
  • In the present study, we demonstrate that following exposure to plasma from diabetic patients, the human promonocytic cell line U937 exhibits a significant elevation in core 2 GlcNAc-T activity and increased adherence to cultured retinal capillary endothelial cells. (diabetesjournals.org)
  • Here we show that methyl-CpG-binding protein 2 (MeCP2) phosphorylation at Ser421 (pMeCP2) is essential for the sustained, but not the rapid, antidepressant effects of ketamine and scopolamine in mice. (nature.com)
  • In testis extracts from mice lacking Cdk2, there are changes in expression of PMS2, MSH2, and HEI10, which may be reflective of the loss of CDK2 phosphorylation. (lu.se)
  • We found that O-GlcNAcylation and tyrosine phosphorylation act together to trigger pYSTAT5 levels and oncogenic transcription in neoplastic cells. (nature.com)
  • PDGF-induced activation of phospholipase C activity is abrogated in cells expressing PLCγ mutated in the tyrosine phosphorylation sites. (wikipedia.org)
  • We investigated the new phosphorylation site for IκBα and identified its biological function in breast cancer cells. (researchsquare.com)
  • Conclusions: Therefore, we identified novel phosphorylation site of IκBα by AURK, and its site was related to apoptosis and necroptosis pathway in breast cancer cells. (researchsquare.com)
  • Levels of enzyme activity in plasma-treated U937 cells were closely dependent on the severity of diabetic retinopathy, with the highest values observed upon treatment with plasma of patients affected by proliferative retinopathy. (diabetesjournals.org)
  • The results indicated CuO caused a 2- fold increase in AP-1 activity in JB6 cells. (cdc.gov)
  • Metronidazole selectively radiosensitizes of metronidazole (in a range of therapeutic hypoxic cells without influencing the ra- concentrations) on PMN-generated free diation response of normal well-oxygenated radicals during phagocytosis activity in cells [ 5,7-9 ]. (who.int)
  • and fly models of PD ( Chen and Feany, 2005 ), the role of S87 phosphorylation in α-syn fibrillogenesis, LB formation and neurotoxicity in vivo remains unexplored. (jneurosci.org)
  • To mimic phosphorylation of the ACA8 N-terminus, each of the serines found to be phosphorylated in those studies (Ser19, Ser22, Ser27, Ser29, Ser57, and Ser99) has been mutated to aspartate. (unimi.it)
  • In this study, we investigated the cellular and behavioral effect of overexpression of wild-type (WT), S87A, and S87E α-syn to block or to mimic S87 phosphorylation, respectively, in the substantia nigra of Wistar rats using recombinant adeno-associated vectors. (jneurosci.org)
  • This modification was dependent on extracellular signal-regulated kinase (ERK) activity triggered by HSV infection. (bris.ac.uk)
  • Reactive oxygen species (ROS) levels were determined using dihydrodichlorofluorescein staining, and the chymotrypsin-like protease activities were measured using the Suc-LLVY-aminoluciferin substrate. (molvis.org)
  • We show that Rho-dependent MRTF-A phosphorylation reflects relief from an inhibitory function of nuclear actin. (elifesciences.org)
  • The Abl-related gene (Arg) requires its F-actin-microtubule cross-linking activity to regulate lamellipodial dynamics during fibroblast adhesion. (nih.gov)
  • Biochemical validation, mass spectrometry and peptide spot arrays revealed that PKA phosphorylates ATG16L1α at Ser268 and ATG16L1β at Ser269, driving phosphorylation-dependent degradation of ATG16L1 protein. (mdc-berlin.de)
  • In the summer of 1979, studies of polyomavirus middle T and v-Src associated kinase activities led to the discovery of tyrosine phosphorylation as a new type of protein modification. (wikipedia.org)
  • both EGFR and c-Src kinase activities. (123dok.org)
  • The results in this dissertation also demonstrate that the protein phosphatase type 2A (PP2A) can directly and independently decrease the phosphorylation levels of both p38 and caspase 3. (lu.se)
  • Additionally, E2 decreased the activity of complex I and oxygen consumption rate. (bvsalud.org)
  • These biochemical modifications impair the activities, and possibly also the stability, of caspase 8 and 3 and thereby weaken the capacity of these enzymes to induce apoptosis. (lu.se)
  • However, this subregion was not required for JDP-2 enhancement of the activity of progestin agonists. (nih.gov)
  • We conclude that PR bound to RU486 and associated with JDP-2 adopts an active conformation in a subregion of the NTD requiring phosphorylation of serine 400 that is distinct from that promoted by progestin agonists. (nih.gov)
  • During the transient loss of p38 activity there was a temporary Fas-induced increase in phosphatidylinositol 3-kinase (PI3K) activity, which also had a pro-apoptotic impact on the neutrophils. (lu.se)
  • This phosphorylation event is associated with increased cell proliferation and poor prognosis in patients with glioma. (umass.edu)
  • Selectively blocks MCP-1-, but not CSF-1-, dependent Akt phosphorylation and chemotaxis in primary Pik3cg +/+ murine monocytes and in a human monocytic cell line THP-1 (IC 50 = 181 nM). (sigmaaldrich.com)
  • These effects of diabetic plasma on enzyme activity and cell adhesion, mediated by PKCβ2-dependent phosphorylation of the core 2 GlcNAc-T protein, were found to be triggered by increased plasma levels of tumor necrosis factor (TNF)-α. (diabetesjournals.org)
  • We tested human recombinant interferon alpha-2b and ribavirin for activity against WNV in a primate cell system similar to that used to measure the effect of these agents on Bovine viral diarrhea virus , a cultivatable, closely related surrogate for Hepatitis C virus . (cdc.gov)
  • The induction of AP-1 activity in cultured cell lines was time and dose-dependent. (cdc.gov)
  • Phosphorylation of the C terminus of c-Fos has been implicated in serum response element-mediated repression of c-fos transcription after its induction by serum growth factors. (nih.gov)
  • Woods, YL & Rena, G 2002, ' Effect of multiple phosphorylation events on the transcription factors FKHR, FKHRLI and AFX ', Biochemical Society Transactions , vol. 30, no. 4, pp. 391-397. (dundee.ac.uk)
  • To identify the essential domains of IκBα for phosphorylation of IκBα by AURK, kinase assay was performed with a series of IκBα truncation mutants. (researchsquare.com)
  • 7 The JAKs also trigger the activation and tyrosine phosphorylation of STAT5, causing parallel dimerization, nuclear translocation and tetramerization of STAT5. (nature.com)
  • We demonstrate that the distinct FK linker sequences per se do not account for lack of potentiation activity by FKBP51. (unboundmedicine.com)
  • We previously demonstrated that phosphorylation of Threonine-308 on Akt (pAkt-T308), Akt2 activity, and GS activity in muscle were positivity associated with insulin sensitivity. (ku.dk)
  • The insulin-stimulated GS activity was positively associated with pAkt-T308 (P=0.01) and Akt2 activity (P=0.04), but not pAkt-S473 or IRS-1-PI3K activity. (ku.dk)
  • To help understand why the two FKBPs behave differently and to gain insight into FKBP52 potentiation activity, we have analyzed the loop structure that links FK1 and FK2. (unboundmedicine.com)
  • In contrast, S33 phosphorylation potentiates the activity of an autonomous Crm1-dependent N-terminal NES, which cooperates with five other NES elements to exclude MRTF-A from the nucleus. (elifesciences.org)