Immunosuppressive AgentsAlkylatingChemotherapyApoptosisCytotoxic drugsCyclophosphamideChemotherapeuticDrugsInhibitAnticancer agentPotentPharmacologyNitrogenAntibioticCompoundsToxicityTopoisomeraseInhibitorCell'sTumorsPrimarilyEfficacyInhibitsInhibitorsImmuneAnaloguesExhibitsTherapiesMedicationClinicalDiseaseMineralocorticoid activityInhibitionResistanceDrugDosageEffectCellVaried metabolicPancreatic cancerAdministrationEffectsWidelyAnti-inflammatoryAntimicrobialInfectious agentsAntioxidant activityAntibacterialIrinotecanCellsEnzymaticAcute
Immunosuppressive Agents1
- Antineoplastic and Immunosuppressive Agents. (wikipedia.org)
Alkylating11
- Treatment generally consists of surgical resection when possible, followed by a combination of external beam radiotherapy with concomitant administration of the orally active alkylating agent temozolomide (TMZ). (biomedcentral.com)
- Antineoplastic with alkylating activity. (cancer.gov)
- We use low-dose Cyclophosphamide (Endoxan®, CTX), a synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities, to make immune system lightly lymphodepletion. (ncl.edu.tw)
- Drugs that exert their influence during a specific phase(s) of the cell cycle are called Cell cycle -specific (CCS) drugs and include antimetabolites, some alkylating agents and vinca alkaloids. (studylib.net)
- 7. Drugs that exert their influence during any phase of the cell cycle are called Cell cycle nonspecific (CCNS) drugs and include Alkylating agents, hormones and anti-tumor antibiotics. (studylib.net)
- Cyclophosphamide/Alkylating Agent Concept/Action/Use Assessment Immunity CCNS Damage cell's DNA preventing reproduction of cancer cells. (studylib.net)
- A biologic alkylating agent that exerts its cytotoxic effects by forming DNA ADDUCTS and DNA interstrand crosslinks, thereby inhibiting rapidly proliferating cells. (lookformedical.com)
- Immunosuppressive therapies, including irradiation, antimetabolites, alkylating agents, cytotoxic drugs and corticosteroids (used in greater than physiologic doses), may reduce the immune response to cholera vaccine. (medscape.com)
- from any individual except oneself and solar radiation, and most of the leukaemia by a genotoxic mech- or an identical twin will provoke an chemical alkylating agents used in anism after its use in anticancer immune reaction against the graft- anticancer chemotherapy. (who.int)
- ed tissues, the intensity of which and chemical alkylating agents are varies with the degree of antigenic considered to cause cancer primar- Immunosuppressive difference between graft and host. (who.int)
- An uncommon but potential y lized to act as an alkylating agent, Infection with HIV-1 is the cause of dangerous side effect of immuno- causes acute myeloid leukaemia and the acquired immune deficiency syn- suppression to support organ trans- carcinoma of the urinary bladder in drome (AIDS). (who.int)
Chemotherapy5
- In 2019, Sun Pharma launched ready-to-infuse INFUGEM (gemcitabine in sodium chloride injection) in the U.S. INFUGEM, the first chemotherapy product that comes in a premixed, ready-to-infuse formulation, was approved by the U.S. Food and Drug Administration (FDA) in July 2018, in combination with other drugs, for the treatment of breast, ovarian, non-small cell lung cancers, and as a single agent to treat pancreatic cancer. (transparencymarketresearch.com)
- It is an antibiotics agent which exhibits antineoplastic activity and is used primarily in chemotherapy as an anticancer agent. (yashodahospitals.com)
- Initially used as a single agent, it has now been used in combination in chemotherapy. (yashodahospitals.com)
- i ) metal-based anticancer and imaging agents targeting specific biomarkers up-regulated in tumor cells for the targeted chemotherapy and diagnosis, and ( ii ) metal-glycoconjugates as antiviral agents against Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2). (universityofgalway.ie)
- The use of two or more chemotherapy agents is referred to as combination therapy 6. (studylib.net)
Apoptosis2
- IM-induced autophagy did not involve c-Abl or Bcl-2 activity but was associated with ER stress and was suppressed by depletion of intracellular Ca2+, suggesting it is mechanistically nonoverlapping with IM-induced apoptosis. (lu.se)
- Interestingly, leukemia MDR1-expressing cells show lower LC50 values and a higher degree of apoptosis and caspase-3 activity than their drug-sensitive counterparts. (torvergata.it)
Cytotoxic drugs1
- or may result from the systemic administration of cytotoxic drugs, e.g., antineoplastic agents, which damage not only tumor cells, but all rapidly dividing normal cell populations. (dentalcare.com)
Cyclophosphamide2
- Most patients are treated with oral prednisone, with or without a cytotoxic/immunosuppressive agent, such as methotrexate, cyclophosphamide, or chlorambucil, or a tumor necrosis factor (TNF)-alpha antagonist. (medscape.com)
- Working primarily in hospitals, outpatient care centers and physician offices, respondents reported that they collectively administered over 90 specific antineoplastic drugs in the past week, with carboplatin, cyclophosphamide and paclitaxel the most common. (cdc.gov)
Chemotherapeutic3
- Despite being the most effective broad-spectrum chemotherapeutic agent in cancer treatment, Bleomycin has limited uses due to poor drug delivery abilities and toxicity. (yashodahospitals.com)
- Caution: Irinotecan should be administered only under the supervision of a physician who is experienced in the use of cancer chemotherapeutic agents. (rxmed.com)
- 4. Pharmaceuticals used to destroy cancer cells are called anticancer, chemotherapeutic, antineoplastic, or cytotoxic 5. (studylib.net)
Drugs6
- Drugs used to manage connective tissue disease (CTD) associated with interstitial lung disease (ILD) (CTD-ILD) include nintedanib, corticosteroids, and antineoplastic agents. (medscape.com)
- Kinetics of DNAase I activity was studied in reaction mixtures containing tightly bound to DNA drugs used for study and treatment of cancer and some other diseases. (msk.ru)
- Adherence to safe handling guidelines by healthcare workers who administer antineoplastic drugs. (cdc.gov)
- The toxicity of antineoplastic drugs is well-documented. (cdc.gov)
- All respondents who indicated that they administered antineoplastic drugs in the past week were eligible to complete a hazard module addressing self-reported health and safety practices on this topic. (cdc.gov)
- Particular importance here is the biological applications of Pt NCs such as the bioimaging of various cells as a preferred fluorophore in contrast to traditional fluorescent markers (e.g., organic dye, semiconductor quantum dots, and fluorescent proteins), the usage of Pt NCs-based antitumour drugs as a new class chemotherapeutics for malignant tumour therapy, and the utilization of antibacteria as an alternative of Ag-based antibacterial agent. (hindawi.com)
Inhibit3
- These agents inhibit key factors involved in immune reactions. (medscape.com)
- Antineoplastic agents inhibit cell growth and proliferation. (medscape.com)
- These agents inhibit cell growth and proliferation. (medscape.com)
Anticancer agent1
- Recent reports have identified a redox-silent analogue of VE, α -tocopheryl succinate ( α -TOS), as a potent anticancer agent with a unique structure and pharmacokinetics in vivo . (nature.com)
Potent2
- In cell growth assays, BN80927 is a very potent antiproliferative agent as shown by IC 50 values consistently lower than those of SN38 in tumor cell lines as well as in their related drug-resistant lines. (aacrjournals.org)
- Arsenic trioxide (As 2 O 3 ) is an environmental toxicant and a potent antineoplastic agent. (springer.com)
Pharmacology3
- 12287987 NMNC 1230 Pharmacology Antineoplastic and Biological Response Modifiers Answer Key 1 Define the following terms: 1. (studylib.net)
- 12287987 NMNC 1230 Pharmacology Antineoplastic and Biological Response Modifiers Answer Key excretion of cellular breakdown products and to reduce the risk of hemorrhagic cystitis. (studylib.net)
- 12287987 NMNC 1230 Pharmacology Antineoplastic and Biological Response Modifiers Answer Key 3 greater, brimmed hats, and lightweight, long-sleeved shirts). (studylib.net)
Nitrogen1
- Information about other mustard agents, such as nitrogen mustard (HN), thickened mustard (HT), and lewisite, are not included in this document (see Chapter 4). (cdc.gov)
Antibiotic1
- Antineoplastic antibiotic obtained from Streptomyces peucetius. (lookformedical.com)
Compounds4
- Great hope has been given to micronutrients as anticancer agents, since they present natural compounds with beneficial effects for normal cells and tissues. (nature.com)
- The results presented in this study suggest these compounds warrant further development with a view to assessing their clinical activity. (hud.ac.uk)
- There is a growing body of anecdotal and scientific evidence that the "major cannabinoids" tetrahydrocannabinol (THC) and cannabidiol (CBD), certain "minor cannabinoids" (some without a name), and other cannabis compounds have antineoplastic action against cancer cells. (projectcbd.org)
- Although most of the studies presented here demonstrated the antineoplastic effects of individual or isolated cannabinoids, most of this research points to what lay healers and patients who make and use their own cannabis oil already know: the whole cannabis plant, including hemp varieties, every part of them, contain antineoplastic compounds that together kill cancer. (projectcbd.org)
Toxicity1
- Warfarin (war' far in) was discovered after identification of the hemorrhagic activity that caused toxicity and bleeding in cattle after eating spoiled, sweet clover silage. (nih.gov)
Topoisomerase2
- Preclinical data reported here show that BN80927 retains Topo I poisoning activity in cell-free assay (DNA relaxation) as well as in living cells, in which in vivo complexes of topoisomerase experiments and quantification of DNA-protein-complexes stabilization, have confirmed the higher potency of BN80927 as compared with the Topo I inhibitor SN38. (aacrjournals.org)
- Irinotecan HCl trihydrate is an antineoplastic agent of the topoisomerase I inhibitor class. (rxmed.com)
Inhibitor3
- This agent is pharmacologically classified as a human epidermal growth factor receptor type 1/epidermal growth factor receptor (HER1/EGFR) tyrosine kinase inhibitor. (medscape.com)
- Duvelisib, also known as IPI-145 and INK-1197, is a small-molecule inhibitor of phosphoinositide-3 kinases that was designed initially to prove that simultaneous inhibition of the isoforms delta and gamma can produce a broad adaptative and innate immune cell inhibitory activity. (drugbank.com)
- Gemzar [gemcitabine hydrochloride (HCL)] is a nucleoside metabolic inhibitor that exhibits antitumor activity. (transparencymarketresearch.com)
Cell's1
- A combined effect is attributed to its antineoplastic activity inhibiting the cell's uncontrolled cell division. (yashodahospitals.com)
Tumors3
- The cytotoxic activity of SAR408701 was assessed in CEACAM5-expressing tumor cell lines and using patient-derived xenograft mouse models of CEACAM5-positive tumors. (nih.gov)
- It inhibits DNA metabolism and is used as an antineoplastic, especially for solid tumors. (lookformedical.com)
- The anthracycline age began over half century ago, when a soil sample harvested near the Castel del Monte in Italy revealed Streptomyces peucetius , a new bacterial strain producing a bright red pigment that was found to have good activity against murine tumors. (mhmedical.com)
Primarily2
- The study population primarily included members of professional practice organizations representing healthcare occupations which routinely use or come in contact with selected chemical agents. (cdc.gov)
- An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease. (lookformedical.com)
Efficacy3
- Both in vitro and in vivo evaluations showed that SAR408701 has cytotoxic activity, leading to in vivo efficacy in single and repeated dosing. (nih.gov)
- High unmet needs in this area and poor efficacy of current treatments in pancreatic cancer, which are mostly chemotherapies, have prompted developers to explore improved versions of branded gemcitabine agents. (transparencymarketresearch.com)
- DOXO has an exceptional chemical reactivity and is able to react with several molecules within the cell, leading to a variety of toxic effects, all of which contribute to its unique antineoplastic efficacy. (mhmedical.com)
Inhibits3
- This agent inhibits prostaglandin synthesis. (medscape.com)
- It inhibits inflammatory reactions and pain by decreasing the activity of cyclooxygenase, which is responsible for prostaglandin synthesis. (medscape.com)
- It has been shown that, due to its α -tocopheryl moiety, the agent activates protein phosphatase-2A that, in turn, inhibits protein kinase C (PKC). (nature.com)
Inhibitors1
- Which medications in the drug class Antineoplastic Agents, mTOR Kinase Inhibitors are used in the treatment of Non-Hodgkin Lymphoma (NHL)? (medscape.com)
Immune3
- Matched Description: … produce a broad adaptative and innate immune cell inhibitory activity. (drugbank.com)
- Risk of additive immune system effects with etrasimod has not been studied in combination with antineoplastic, immune-modulating, or noncorticosteroid immunosuppressive therapies. (medscape.com)
- The severe immune plants is that suppression of the patients in whom it has been used deficiency that is characteristic of immune response can allow occult as an antineoplastic agent ( IARC, AIDS results from a deficiency in tumours or metastatic tumour cel s 2012b ). (who.int)
Analogues1
- The molecule of α -TOS may be modified so that analogues with higher activity are generated. (nature.com)
Exhibits1
- CBD exhibits apoptotic, anti-proliferative, and anti-invasive activity. (projectcbd.org)
Therapies2
- Siponimod is one of several disease-modifying therapies used in the management of relapsing forms of MS. Although not curative, these therapies have all been shown to modify several measures of disease activity, including relapse rates, new or enhancing MRI lesions, and disability progression. (drugs.com)
- Consider potential additive immunosuppressive effects in patients receiving or who previously received antineoplastic, immunosuppressive, or immunomodulating therapies. (drugs.com)
Medication1
- Severe bleeding episodes can be caused by administration of another medication that prolongs its half-life or activity. (nih.gov)
Clinical1
- Clinical Trials: Data from 3 single-agent studies, involving a total of 304 patients support the use of irinotecan in the treatment of patients with metastatic cancer of the colon or rectum that has recurred or progressed following treatment with 5-FU-based therapy. (rxmed.com)
Disease3
- Selective sphingosine 1-phosphate (S1P) receptor modulator with immunomodulatory and disease-modifying activity in multiple sclerosis (MS). (drugs.com)
- The American Academy of Neurology (AAN) recommends that disease-modifying therapy be offered to patients with relapsing forms of MS who have had recent relapses and/or MRI activity. (drugs.com)
- The hydrochloride is an antineoplastic agent used to treat HODGKIN DISEASE and LYMPHOMA. (lookformedical.com)
Mineralocorticoid activity1
- Prednisone has very little mineralocorticoid activity. (pharmacycode.com)
Inhibition2
- Their mechanism of action may be inhibition of cyclo-oxygenase (COX) activity and prostaglandin synthesis. (medscape.com)
- Beginning with polymerase inhibition and DNA intercalation and ending with perturbation of calcium homeostasis, DOXO finds itself a place in most antineoplastic combo regimens. (mhmedical.com)
Resistance1
- This hypothesis is also supported by in vitro data showing an antiproliferative activity of BN80927 on a model of resistance related to the noncycling state of cells (G 0 -G 1 synchronized). (aacrjournals.org)
Drug3
- Here, we describe preclinical data for a novel antibody-drug conjugate (ADC), SAR408701, which consists of an anti-CEACAM5 antibody (SAR408377) coupled to a maytansinoid agent DM4 via a cleavable linker. (nih.gov)
- Significant activity was also shown against the slower growing MAC 26 tumour for LS 4577 (the soluble pro-drug of LS 4559). (hud.ac.uk)
- suppression, often in concert with planted with maintenance of func- This drug has very marked immuno- other Group 1 agents, especial y tion that may continue for a normal suppressive properties. (who.int)
Dosage1
- 22, 24 The degree of tissue damage depends on the specific agent, dosage, dosage schedule, and patient-related variables. (dentalcare.com)
Effect2
- Fedorova T.M., Ashmarin I.P. (1980) Effect of DNA-tropic antineoplastic and antiparasitic agents on DNAase I activity. (msk.ru)
- 6,7 Although CBD does not bind directly to the CB1 or CB2 receptors, it also has a powerful antineoplastic effect. (projectcbd.org)
Cell5
- It may decrease inflammation by reversing increased capillary permeability and suppressing polymorphonuclear cell activity. (medscape.com)
- Agents in this class halt the cell cycle at the G1 phase in tumor cells. (medscape.com)
- Deferiprone, a bidentate iron chelator, has been shown to have antiproliferative and cytotoxicity activities in neuroblastoma cell lines [ 7 ]. (biomedcentral.com)
- Basal oxidative activity related to cell size/morphology, small granular cells showed lower activity. (ed.ac.uk)
- ROS may have a role in AA induced cell death and anti-tumour activity of AA in glioma. (ed.ac.uk)
Varied metabolic1
- These agents have anti-inflammatory properties and cause profound and varied metabolic effects. (medscape.com)
Pancreatic cancer2
- The most active agents for pancreatic cancer have been 5-fluorouracil (5-FU) and gemcitabine. (medscape.com)
- For instance, Pancreatic Cancer Action Network hosts Pancreatic Cancer Awareness Month in November, every year, in order to donate and participate in fundraising and support legislation for research and other activities. (transparencymarketresearch.com)
Administration2
- Gingival enlargement may be associated with the administration of calcium-channel blocking agents, phenytoin, and cyclosporine. (dentalcare.com)
- Comment: Palifermin should not be administered within 24 hr before, during infusion of, or within 24 hr after administration of antineoplastic agents. (medscape.com)
Effects2
- Importantly, coumarin itself does not have anticoagulant activity but is used as an antineoplastic agent, and has different effects and side effects than its derivatives. (nih.gov)
- The abolition of the antineoplastic DFX effects when cells were co-treated with ferric ammonium sulfate supports the hypothesis that its effects result from its ability to chelate iron. (biomedcentral.com)
Widely2
- Gemcitabine is widely used as an antitumor agent in research labs and clinics. (transparencymarketresearch.com)
- CP is one of the most widely used antineoplastic agents. (comu.edu.tr)
Anti-inflammatory2
- These agents have analgesic, anti-inflammatory, and antipyretic activities. (medscape.com)
- Anti-inflammatory activity results from lymphocyte transformation suppression. (medscape.com)
Antimicrobial1
- Recio M, Rios J, and Villar A. Antimicrobial activity of selected plants employed in the Spanish Mediterranean area. (medlineplus.gov)
Infectious agents4
- The Guideline for Isolation Precautions: Preventing Transmission of Infectious Agents in Healthcare Settings 2007 builds upon a series of isolation and infection prevention documents promulgated since 1970. (cdc.gov)
- The information also will be useful for other healthcare personnel, healthcare administrators, and anyone needing information about infection control measures to prevent transmission of infectious agents. (cdc.gov)
- Much of the evidence cited for preventing transmission of infectious agents in healthcare settings is derived from studies that used "quasi-experimental designs", also referred to as nonrandomized, pre- post-intervention study designs 2 . (cdc.gov)
- In addition to oncogenic infectious agents. (who.int)
Antioxidant activity2
- Inhibitory potential of some Romanian medicinal plants against enzymes linked to neurodegenerative diseases and their antioxidant activity. (medlineplus.gov)
- The idea has been attractive, as VE is a micronutrient with high antioxidant activity. (nature.com)
Antibacterial2
- 21,22,24 Antibacterial agents kill bacteria allowing candidal species to successfully compete for nutrients. (dentalcare.com)
- Antibacterial Agent-induced Pseudomembranous Candidiasis. (dentalcare.com)
Irinotecan1
- The precise contribution of SN-38 to the activity of irinotecan in humans has not been completely defined. (rxmed.com)
Cells1
- The anticancer activities of iron depletion are based on the fact that neoplastic cells require more iron than normal cells for proliferation [ 2 ]. (biomedcentral.com)
Enzymatic1
- Carnosine plays a part in neurotransmission, it is a heavy metal binder (chelates ionic metals) and modulates enzymatic activities. (natmedtalk.com)
Acute2
- We aimed to confirm the activity and safety profile of blinatumomab for acute lymphoblastic leukaemia. (nih.gov)
- Single-agent blinatumomab showed antileukaemia activity in adult patients with relapsed or refractory B-precursor acute lymphoblastic leukaemia characterised by negative prognostic factors. (nih.gov)