Treatment of rats with APAP at the dose of 20 mg/kg led to an increase in the level of lipid peroxidation and significant reduction of the oxidative markers such as reduced glutathione, catalase, superoxide dismutase, glutathione peroxidase, glutathione reductase and microsomal aniline hydroxylase. (jru-b.com)
Spd also inhibited the accumulation of oxidative stress products malondialdehyde (MDA) and hydrogen peroxide (H2O2) by increasing the ascorbic acid (ASA) and glutathione (GSH) content and peroxidase (POD) activity, whereas the effects on root activity and superoxide dismutase (SOD) activity were not significant. (bvsalud.org)
Aminopyrine N-demethylase2
The effects on aniline-p-hydroxylase, acetanilide-hydroxylase, and aminopyrine-N- demethylase activity were investigated. (cdc.gov)
IPI and CPI competitively inhibited aniline-p- hydroxylase and acetanilide-hydroxylase and noncompetitively inhibited aminopyrine-N-demethylase, IPI being the more potent. (cdc.gov)
Cytochrome2
Liver microsomes from four rats of each sex per group were assayed for protein and cytochrome P450 content, and the activities of UDP-glucuronyltransferase and several monooxygenases were determined (Vermeir, 1996). (inchem.org)
females) in aniline hydroxylase activity, cytochrome P-450 content, and cytochrome c reductase activity. (mun.ca)
Compound1
SUN11602 is a novel aniline compound, which mimics the neuroprotective mechanisms of basic fibroblast growth factor. (dcchemicals.com)
Organic1
The most significant part of the GO enrichment analysis shifted from responding to organic cyclic compounds and aldehyde/ketone group transferase activity to responding to trivalent iron ions and 2'-deoxymugineic-acid 2'-dioxygenase activity. (bvsalud.org)
Significantly1
Of the hydroxylations of testosterone, we demonstrate that castration on day 55 results in significantly higher specific activities of these isozymes, then castration on day 70. (mun.ca)
Enzyme activities2
Puberty is also a time when these basal enzyme activities, as well as the responsiveness of EMDM to adult testosterone therapy, can be permanently defeminized, in the absence of neonatal defeminization. (mun.ca)
Less ROS accumulation, upregulation of ROS signaling genes and higher antioxidant enzyme activities post BNS resulted in resistance. (nature.com)
Demonstrate1
ML216 was discovered to possess powerful (1-3 ?M) inhibition from the DNA unwinding activity of BLM induce sister chromatid exchanges and demonstrate selective antiproliferative activity in BLM-positive cells.17 Herein we details the medicinal chemistry initiatives that resulted in the nomination of ML216 being a chemical substance probe and offer selectivity details and ADME data for extra analogs. (immune-source.com)
Compounds3
Screening of compounds obtained from plants for their pharmacological activity has resulted in the isolation of innumerable therapeutic agents. (scialert.net)
By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS. (lookformedical.com)
Furthermore these compounds confirmed mobile activity by inducing sister chromatid exchanges a hallmark of Bloom symptoms. (immune-source.com)
Antioxidant1
It exhibits antioxidant activity by virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus. (lookformedical.com)
Inhibition2
As well, data showed a gilteritinib-driven inhibition of the receptor tyrosine kinase AXL which is known to modulate the activity of FLT3 in acute myeloid leukemia. (drugbank.com)
4 The activity of gilteritinib permits an inhibition of the phosphorylation of FLT3 and its downstream targets such as STAT5, ERK and AKT. (drugbank.com)
Gene expression1
Down-regulation of photosynthesis-related gene expression and decreased photosynthetic activity is in line with other studies that have reported the effects of biotic stress on photosynthesis. (biomedcentral.com)
Selective1
BGJ398 (NVP-BGJ398) is a potent and selective FGFR inhibitor for FGFR1/2/3 with IC50 of 0.9 nM/1.4 nM/1 nM, >40-fold selective for FGFR versus FGFR4 and VEGFR2, and little activity to Abl, Fyn, Kit, Lck, Lyn and Yes. (dcchemicals.com)
ACID1
It is the lactone of 2,3-DIKETOGULONIC ACID and has antiscorbutic activity in man on oral ingestion. (lookformedical.com)
Results1
We do not attribute the above results to differences in P-450 content or reductase activity. (mun.ca)
Effects3
Rat liver microsomes were treated with IPI and metyrapone and the effects on epoxide-hydrase activity using cyclohexene-oxide and styrene -oxide as substrates were determined. (cdc.gov)
Among other effects, this combining activity protects pancreatic islets against damage by cytokines and prevents myocardial and pulmonary perfusion injuries. (lookformedical.com)
Specific activities of Catechol-2,3-dioxygenase and effects of temperature and pH and their stabilities on the enzyme relative activities were observed. (openmicrobiologyjournal.com)
Time1
The pH and temperature range with time for the enzyme activity were 6.0-8.0 and 30 o C-50 o C respectively. (openmicrobiologyjournal.com)
Specific2
We studied the ability of testicular secretions to either defeminize (represented as an increase in basal specific activity), or masculinize (represented as an ability to respond to adult testosterone administration), the sex-specific P-450s 2C11 and 3A2, in the absence of neonatal defeminization. (mun.ca)
The permanent increase in EMDM basal activity, is most likely completed by day 55, as there was no difference in specific activity between the day 55 castrate, and the day 70 castrate. (mun.ca)
Growth1
FGF401 is an inhibitor of human fibroblast growth factor receptor 4 (FGFR4), with potential antineoplastic activity. (dcchemicals.com)
Free1
The present study was divided into three parts, including (1) measurement of free radical scavenging and choleretic activity, (2) evaluating of effective dose of SD (1, 2, 4 ml/kg, p.o.) against APAP exposure (2 g/kg. (jru-b.com)
Analysis1
A comprehensive analysis of the dynamic changes in primary metabolism was performed, which included whole transcriptome analysis, nontargeted proteomics, and photosynthetic activity measurements in potato cv. (biomedcentral.com)
Hepatic4
8-MOP administered orally to CD-1 mice daily for 6 days caused 2-3 fold increases in hepatic aryl hydrocarbon hydroxylase (AHH), ethylmorphine N-demethylase and cytochrome P-450. (cdc.gov)
In addition, PCB-pretreated, propylene-exposed rats exhibited a decrease in the specific activity of hepatic microsomal aniline hydroxylase. (nih.gov)
However, there was no change in activities of either hepatic microsomal aminopyrine demethylase or glucose-6-phosphatase. (nih.gov)
A preclinical study in rats demonstrated that single doses of garlic oil (500 mg/kg intraperitoneally [i.p.]) resulted in a significant depression of hepatic CYP450, aminopyrine N-demethylase, and aniline hydroxylase activity. (medscape.com)
Enzyme6
Four-hour inhalation exposure to 50,000 ppm propylene increased liver weight/body weight ratios and elevated serum enzyme activities in PCB-pretreated animals. (nih.gov)
Administration of SKF-525A to PCB-pretreated rats immediately prior to propylene exposure completely prevented elevations in serum enzyme activities and liver weight/body weight ratios. (nih.gov)
This enzyme, encoded by CYP1A1 gene, can be measured by using ethoxyresorufin as a substrate for the ethoxyresorufin O-deethylase activity. (nih.gov)
Specific activities of Catechol-2,3-dioxygenase and effects of temperature and pH and their stabilities on the enzyme relative activities were observed. (openmicrobiologyjournal.com)
The pH and temperature range with time for the enzyme activity were 6.0-8.0 and 30 o C-50 o C respectively. (openmicrobiologyjournal.com)
Liver microsomes from four rats of each sex per group were assayed for protein and cytochrome P450 content, and the activities of UDP-glucuronyltransferase and several monooxygenases were determined (Vermeir, 1996). (inchem.org)
137 Folic acid 138 Large-scale laboratory 138 Germ-free program 138 Laboratory of physical biology 139 Physiology 139 Molecular structure 139 Protein structure, activity, synthesis 140 Biological energy 140 Laboratory of chemistry 141 Rotatory dispersion of nucleosides 141 Cz's-nucleosides 141 Octuloses and nonuloses 142 Anhydroheptuloses 142 Rearrangements of cyclitols 142 Glycosyl cyanides 142 Benzomorphans 142 Phenolic hydroxyl in a- and ^-benzomorphans. (nih.gov)