• Using the microdilution method, the researchers then performed microbiological assays to determine the minimum inhibitory concentration (MIC) of C. tricolor essential oil against different Candida species. (naturalnews.com)
  • The minimum inhibitory concentration (MIC) for the acetonic, methanolic and ethanolic extracts was determined by the modified agar well diffusion method. (bvsalud.org)
  • Each extracts were tested for soybean lipoxygenase inhibitory activity, phytochemical screening and total flavonoid contents. (phcogj.com)
  • Total flavonoid contents and IC 50 values of each extracts are strongly correlated and inversely proportional with significance value of 0.026 and correlation value of -0.999 which indicate that the higher total flavonoid contents, the stronger inhibitory activity. (phcogj.com)
  • Apigenin (API), a flavonoid with a potent Akt-inhibitory effect, shows oncostatic activities in various cancers. (figshare.com)
  • The compounds showed inhibitory activity in a concentration dependant manner. (hindawi.com)
  • Each of these compounds has exhibited strong fungicidal activities in previous studies. (naturalnews.com)
  • Contrary to expectation, the Top1 inhibitory activities of the new compounds were weaker than those for aromatic ring-unsubstituted analogues. (purdue.edu)
  • Identifying novel and potent antiviral compounds is critical to successful drug development targeting poxviruses. (cdc.gov)
  • Here we tested two compounds, nucleoside trifluridine, and nucleotide adefovir dipivoxil, for antiviral activities against vaccinia virus (VACV), mpox virus (MPXV), and cowpox virus (CPXV) in physiologically relevant primary human fibroblasts. (cdc.gov)
  • Aromatic ring substitution with 2,3-dimethoxy-8,9-methylenedioxy or a 3-nitro group was found to exert beneficial effects on antiproliferative and Top1 inhibitory activities. (purdue.edu)
  • While the length of the linear carbohydrate side chains clearly correlates with antiproliferative activity, the relationship between stereochemistry and biological activity is less clearly defined. (purdue.edu)
  • The data reveal that fluorine and chlorine may substitute for the 3-nitro group with minimal loss to Top1 inhibitory and antiproliferative activities. (purdue.edu)
  • This hypothesis is also supported by in vitro data showing an antiproliferative activity of BN80927 on a model of resistance related to the noncycling state of cells (G 0 -G 1 synchronized). (aacrjournals.org)
  • In cell growth assays, BN80927 is a very potent antiproliferative agent as shown by IC 50 values consistently lower than those of SN38 in tumor cell lines as well as in their related drug-resistant lines. (aacrjournals.org)
  • The n-butanol fraction demonstrates a potent inhibitory activity against the viral protease (IC50 = 12.9 μg/ml), but not reverse transcriptase or integrase. (nih.gov)
  • Taken together, our data demonstrates that JYNNEOS vaccination triggers potent OPXV neutralizing antibody responses in a cohort of healthcare workers in DRC, a monkeypox-endemic region. (cdc.gov)
  • There have been little detailed phytochemical reports on this genus and the antidiabetic activity of this plant is not yet evaluated. (hindawi.com)
  • Herein, we investigated the phytochemical constituents of D. anethifolia and the potential antidiabetic activity of its crude extract and its major isolated linear furanocoumarins. (hindawi.com)
  • Overall, the microbiological assays showed that C. tricolor essential oil has significant inhibitory activity against pathogenic species of Candida. (naturalnews.com)
  • All the extracts and fractions were evaluated for cytotoxicity and anti-HIV-1 activity using different in vitro assays. (nih.gov)
  • However, a disturbance in their equilibrium, such as from antibiotic activity, can disrupt the influence of native bacteria and allow Candida species to thrive. (naturalnews.com)
  • K. parviflora extract showed more potent inhibitory activity on 5αR than C. zedoaria and Z. officinale extracts. (nih.gov)
  • This study aimed to determine IC 50 value of sweet potato tubers extracts in inhibiting lipoxygenase activity. (phcogj.com)
  • IC 50 value of purple, orange and white sweet potato tubers extracts are 46.09, 52.12 and 63.69 μg/mL respectively. (phcogj.com)
  • Acacia catechu (Mimosa family) stem bark extracts have been used traditionally as a dietary supplement as well as a folk medicine given its reported anti-inflammatory, immunomodulatory, hepatoprotective, antioxidant, anti-microbial and anti-tumor activities. (nih.gov)
  • The present study was undertaken to evaluate the anti-HIV-1 activity of the extracts from stem bark of A. catechu. (nih.gov)
  • The antimicrobial activity of five extracts of cubeb berries and Indian long pepper fruits was determined by the agar well diffusion method. (bvsalud.org)
  • Traditional medicinal plant extracts and natural products with activity against oral bacteria: potential application in the prevention and treatment of oral diseases. (bvsalud.org)
  • Cells that become senescent grow in size, cease to replicate, and generate a potent mix of molecules known as the senescence-associated secretory phenotype (SASP) . (fightaging.org)
  • This extract and some linear furanocoumarins exhibited carbohydrate metabolizing enzymes inhibitory effect. (hindawi.com)
  • In the above assay, n-butanol fraction exhibited anti-HIV-1 activity with an IC50 of 1.7 ± 0.12 μg/ml. (nih.gov)
  • Especially compound 2d bearing a 5-bromo substituent showed the best activity with IC50 values in sub-microgram/mL scale in four human cancer cell lines tested. (eurekaselect.com)
  • Our data suggested that celastrol is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its anticancer activity. (spandidos-publications.com)
  • Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition. (nottingham.ac.uk)
  • A. africana plant is known to possess great anti-inflammatory, antimalarial, and antimicrobial activities [ 12 , 16 ]. (hindawi.com)
  • were found to have variable antimicrobial activities against all the four oral pathogens. (bvsalud.org)
  • Preliminary In Vitro and In Vivo Evaluation of Antidiabetic Activity of Ducrosia anethifolia Boiss. (hindawi.com)
  • Preliminary in vitro evaluation of the antidiabetic activity of crude extract and its furanocoumarins was carried out ( α -amylase, α -glucosidase, and β -galactosidase). (hindawi.com)
  • The FLEX-NK TM tetravalent, multifunctional antibody CYT-303 directed against NKp46 and GPC3 demonstrated in vitro and in vivo activity against HCC tumor targets. (biospace.com)
  • The combination of the FLEX-NK TM and iNK platforms demonstrated greater in vitro and in vivo anti-tumor activity in HCC models than iNK cells alone, with a favorable in vitro cytokine release and immune cell subset safety profile. (biospace.com)
  • The FLEX-NK TM multifunctional engager antibody CYT-338 directed against NKp46 and CD38 demonstrated in vitro activity against multiple myeloma tumor targets. (biospace.com)
  • Tripodal O-N-O Bis-Phenolato Amine Titanium(IV) Complexes Show High in vitro Anti-Cancer Activity EUROPEAN JOURNAL OF INORGANIC CHEMISTRY. (nottingham.ac.uk)
  • Interestingly, pyrophosphate was a potent inhibitor to the enzyme complex, but had a slightly inhibitory effect for the monofunctional enzyme. (unboundmedicine.com)
  • In vivo studies further confirmed the inhibitory effect of celastrol on the expression of HIF-1α proteins, leading to a decreased growth of Hep3B cells in a xenograft tumor model. (spandidos-publications.com)
  • Honey Bee Venom (HBV) has various biological activities such as inhibitory effect on several types of cancer. (blogspot.com)
  • Research on anti-inflammatory activity of this plant is still limited although has been used traditionally. (phcogj.com)
  • 3D-QSAR is broadly used tool to recognize the steric, electrostatic, and hydrophobic interactions of various drugs acting via receptor modulation for exerting biological activity[ 14 , 15 ]. (ijpsonline.com)
  • We explore the role of neuropeptides and neurotrophic factors in modulation of excitatory and inhibitory synaptic transmission and epileptogensis in the brain. (lu.se)
  • For these cases, significant predictive models of ligand binding to target active sites can be useful to analyse the correlation between biological activity and physicochemical properties. (ijpsonline.com)
  • It is important to recognize that because of the biological activity of these contaminants, dose-response relationships obtained using technical grade methoxychlor may not be directly applicable to pure methoxychlor. (cdc.gov)
  • They also investigated the oil's anti-fungal activity against several species of Candida , which are pathogenic yeasts known to cause infections called candidiasis. (naturalnews.com)
  • The in vivo activity was investigated by measuring some oxidative stress markers. (hindawi.com)
  • The anticancer model's overal antioxidant activity (34.72 µg/mL) was slightly lower than quercetin (30.44 µg/mL) but higher than ascorbic acid (41.68 µg/mL). (who.int)
  • The results presented here show a potential anti-HIV-1 activity of A. catechu mediated by the inhibition of the functions of the viral protein and Tat. (nih.gov)
  • Methods NSCLC cell lines with different epidermal growth factor receptor (EGFR) statuses and in vivo orthotopic bioluminescent xenograft model were employed to determine antitumor activity of API. (figshare.com)
  • Results showed positive range indicating that positive electrostatic potential is favourable for increase in the activity and hence a less electronegative substituent group is preferred in lattice point 14 (around R 1 ). (ijpsonline.com)
  • Negative range indicates that negative steric potential is favourable for increase in the activity and hence less bulky substituent group is preferred at lattice point. (ijpsonline.com)
  • A series of (Z)-5-arylidene- 3-(3,4,5-trimethoxybenzyl)thiazolidine-2,4-diones (6a-j), on the other hand, displayed only moderate cytotoxic activities with only compound 6a showing comparable cytotoxicity to 2d. (eurekaselect.com)
  • The mean tinzaparin sodium anti-factor Xa activity is approximately 100 IU per milligram. (rxlist.com)
  • HBV was screened for its anti-mutagenic activity against sodium azide by Ames test. (blogspot.com)
  • iNK cells expressed a favorable combination of multiple activation and few inhibitory receptors that corresponded to more potent cytolytic activity against HCC targets. (biospace.com)
  • This is because several of the contaminants in technical grade methoxychlor are directly estrogenic (Kupfer and Bulger 1987b), whereas pure methoxychlor is proestrogenic and requires metabolic activation before exhibiting estrogenic activity (Bulger et al. (cdc.gov)
  • Cisplatin is an old and potent drug to treat the most of cancer. (blogspot.com)
  • In the present study, the inhibitory activities of extract from K. parviflora rhizome against 5α-reductase (5αR) were subjected. (nih.gov)
  • Study yielded polyoxypregnane glycoside which was shown to have a potent chondroprotective activity in the IL-1ß stimulated cartilage explant model. (stuartxchange.org)
  • Here we generated a series of lipopeptides derived from EK1 and found that EK1C4 was the most potent fusion inhibitor against SARS-CoV-2 S protein-mediated membrane fusion and pseudovirus infection with IC50s of 1.3 and 15.8 nM, about 241- and 149-fold more potent than the original EK1 peptide, respectively. (nature.com)
  • Preclinical data reported here show that BN80927 retains Topo I poisoning activity in cell-free assay (DNA relaxation) as well as in living cells, in which in vivo complexes of topoisomerase experiments and quantification of DNA-protein-complexes stabilization, have confirmed the higher potency of BN80927 as compared with the Topo I inhibitor SN38. (aacrjournals.org)
  • Tarragon (Artemisia d.) essential oil has anticonvulsant activity, confirming its traditional use in Iranian folkloric medicine. (greenmedinfo.com)
  • Exposure to a variety of growth factors has also been shown to increase HIF-1 activity in normoxic and hypoxic conditions. (spandidos-publications.com)
  • Its ability to bind two Fe +3 ions with high affinity, in cooperation with two HCO 3 - ions, contributes to its major structure-functional properties, including antimicrobial activity. (ift.org)
  • The dimers, or bis(indenoisoquinolines), were decorated with the 2,3-dimethoxy-8,9-methylenedioxy aromatic ring substitution pattern on each monomer with the expectation of conferring high Top1 inhibitory activity. (purdue.edu)
  • Recently neuropeptides and neurotrophic factors emerged as strong regulators of excitatory and inhibitory synaptic transmission in the CNS thus offering a potent tool to counteract the seizure activity. (lu.se)
  • Finally, in the fourth effort, dimeric indenoisoquinolines were designed using the available S.A.R. data for their Top1 and TDP1 inhibitory activities. (purdue.edu)
  • 1] The illness resulted in more than 6 million missed work days, 2 million missed school days, and 28 million reduced-activity days. (medscape.com)
  • Cytovia's GPC3-directed NK-engager in combination with iPSC-derived NK cells demonstrated impressive anti-tumor activity in mice that merits clinical development," added Dr. Michael Friedman , a member of Cytovia's Board of Directors. (biospace.com)
  • SOR), hydrogen peroxide, and 2, 2-Diphenyl-2-picrylhydrazyl (DPPH) radical activity by a model (most biological y active) of the anticancer plant was also evaluated. (who.int)
  • These multi-functional attributes make LF a potent nutraceutical and an effective natural food antimicrobial system. (ift.org)
  • The undesirable nitro toxicophore was replaced by ten other functional groups that could retain the desired biological activities and minimize potential safety risks. (purdue.edu)
  • Potency is determined by means of a biological assay and interpreted by the first International Low Molecular Weight Heparin Standard as units of anti-factor Xa (anti-Xa) activity per milligram. (rxlist.com)
  • The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. (lookchem.com)
  • Anti yeast activity of some plants used in traditional herbal medicine of Iran. (bvsalud.org)
  • Ducrosia species were investigated mainly for their oil analysis and their biological activities [ 6 ]. (hindawi.com)