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  • synthesis
  • Experiments using the glutamate-cysteine ligase modifier subunit knockout mice Gclm(-/-), which are severely impaired in glutathione synthesis, show that BHMT activity is reduced about 75% in Gclm(-/-) compared to Gclm(+/+) mice. (labome.org)
  • metabolism
  • Using IDO1-expressing MCF-7 and SGC-7901 cells, we found that exogenous H 2 S inhibited IDO1 expression by blocking STAT3 and NF-κB pathways, and decreased IDO1 activity via H 2 S/NO crosstalk, and combinedly decreased the tryptophan metabolism. (biomedcentral.com)
  • enzymes
  • The following assays were performed in the hepatic tissue (a) antioxidant enzymes such as superoxide dismutase and catalase, (b) cytochrome P450 content, (c) glutathione-metabolizing enzymes such as glutathione peroxidase, glutathione reductase, glutathione-S-transferase and glucose 6-phosphate dehydrogenase, and (d) low molecular weight antioxidants (reduced glutathione, ascorbic acid) and protein carbonyl content. (anabolicminds.com)
  • It was also observed that the activities of antioxidant enzymes and glutathione-metabolizing enzymes were considerably stabilized in mice pretreated with taurine. (anabolicminds.com)
  • This metabolite is then free to react with key hepatic enzymes, therefore damaging hepatocytes. (chemicalbook.com)
  • The activity of GSTs is dependent upon a steady supply of GSH from the synthetic enzymes gamma-glutamylcysteine synthetase and glutathione synthetase, as well as the action of specific transporters to remove conjugates of GSH from the cell. (wikipedia.org)