Activities in human cells. Medical search. Frequent questions

Interactome analysis combined with ex vivo and in vitro validation revealed that T cell activity within subepithelial niches is controlled by distinct molecular pathways during PI16 + RC-lymphocyte interaction. (nih.gov)
Our study is aimed at investigating whether precursors of myeloid angiogenic cells (PACs) treated with known pharmaceuticals would produce media with better proangiogenic activity in vitro and if such media can be used to stimulate blood vessel growth in vivo . (hindawi.com)
The only stimulant that enhanced PAC paracrine angiogenic activity was atorvastatin, which also had ability to stabilize endothelial tubes in vitro . (hindawi.com)
Concluding, high concentrations of atorvastatin stabilize tubes and enhance the paracrine angiogenic activity of human PAC cells in vitro . (hindawi.com)
Methods The effects of combining HexaBody-CD27 with anti-PD-(L)1 antibodies (pembrolizumab, nivolumab, and atezolizumab) on human CD8 + T-cell proliferation and effector functions were investigated in vitro . (bmj.com)
and ginger ( Zingiber officinale Roscoe), respectively, against all four serotypes of DENV infecting human lung epithelial carcinoma (A549) cell line in vitro. (ugm.ac.id)
This study examined the effects of 3 flavonoid-enriched fractions (a crude fraction, an anthocyanin-enriched fraction, and a proanthocyanidin-enriched fraction), which were prepared from lowbush blueberries (Vaccinium angustifolium), on MMP activity in DU145 human prostate cancer cells in vitro. (canada.ca)
We investigated in vitro the paracrine effects of human adipose-derived stem cells (ADSCs) on wound healing mechanisms for human tympanic membrane-derived keratinocytes (hTM) and immortalized human keratinocytes (HaCaT). (oslomet.no)
Antiproliferative activity and cytotoxicity of Solanum jamesii tuber extracts on human colon and prostate cancer cells in vitro. (psu.edu)
The objective of this study was to investigate antiproliferative activity and cytotoxicity of tuber extracts from 15 Solanum jamesii accessions on human HT-29 colon and LNCaP prostate cancer cell lines in vitro. (psu.edu)
Dive into the research topics of 'Antiproliferative activity and cytotoxicity of Solanum jamesii tuber extracts on human colon and prostate cancer cells in vitro. (psu.edu)
In conclusion, CE activity appears to be associated with higher sensitivity to CPT-11 in human lung cancer cell lines and may partly explain the difference in the in vitro sensitivity to CPT-11 between SCLC and NSCLC cells. (johnshopkins.edu)
Following stimulation, iNOS induction was monitored via measurement of nitrite production and in vitro iNOS enzyme activity. (okstate.edu)
The purpose of this study was to evaluate the in vitro anticandidal activity of a methanolic extract of Syngonanthus nitens scapes against different Candida species and clinical isolates from patients with vulvovaginal candidiasis (VVC), and its effect in vivo in the treatment of vaginal infection. (who.int)

Since continual loss of telomeric DNA is predicted to eventually limit cell proliferation, activation of telomerase in cancer cells may represent an important step in the acquisition of the cell immortalization which occurs during tumor progression. (nature.com)
Human CD38, a surface molecule expressed by immature and activated T and B lymphocytes, has been characterized as a molecule transducing activation and proliferation signals, and intervening in adhesion to endothelium via its ligand CD31. (nih.gov)
Cdc37 Expression in Multiple Myeloma and Its Role in Cell Proliferation]. (nih.gov)
In preclinical studies, HexaBody-CD27 enhanced proliferation and effector functions of activated T cells. (bmj.com)
CD8 + T-cell proliferation and cytokine secretion were assessed in an antigen-specific assay using claudin-6 as a model antigen. (bmj.com)
Results Combination treatment with HexaBody-CD27 and all tested anti-PD-(L)1 antibodies enhanced proliferation and proinflammatory cytokine secretion of antigen-specific CD8 + T cells in coculture with cognate antigen-expressing dendritic cells, compared to the respective single-agent treatments. (bmj.com)
Cancer is a heterogeneous disease, two of whose characteristic features are uncontrollable cell proliferation and insufficient apoptosis. (ktu.edu.tr)
These results indicate that Turkish propolis is capable of reducing cancer cell proliferation and may have a promising role to play in the development of new anticancer drugs in the future. (ktu.edu.tr)
Its roles include regulation of proliferation, promotion of immune system and activation of apoptosis in B cells. (intechopen.com)
In these cells, IL-21 does not promote proliferation but enhances apoptosis and chemotaxis. (intechopen.com)
ADSC conditioned media (CMADSC) were assessed for paracrine activity on keratinocyte proliferation and migration, with hypoxic conditions for ADSC culture used to generate contrasting effects on cytokine gene expression. (oslomet.no)
The tuber extracts significantly inhibited proliferation of HT-29 and LNCaP cell lines and were not cytotoxic to the cells compared to the control (DMSO). (psu.edu)
In both HT-29 and LNCaP cells, there were no observable significant correlations between antioxidant activity (DPPH and ABTS) and inhibition of cell proliferation or between TP and cell proliferation inhibition. (psu.edu)
Also, glycoalkaloids did not exhibit significant correlations with the inhibition of cancer cell proliferation. (psu.edu)
Correlation results, along with cell proliferation data, suggest that not only the compounds measured in this study but also other bioactive compounds present in the matrix acting additively or synergistically may be more responsible for the antiproliferative effects of potato tuber extracts than higher concentrations of a single or group of compounds. (psu.edu)
The effects of the COX-2 inhibitor celecoxib and the 5-LOX inhibitor MK886 on prostaglandin E(2) and cysteinyl leukotriene production,tumor cell proliferation,cell apoptosis,and Bcl-2/Bax expression were evaluated in the Caco-2 and HT29 colon cancer cells. (unifi.it)
Combined treatment with 10 micromol/L celecoxib and MK886 could prevent this activation and had additive effects on inhibiting tumor cell proliferation,inducing cell apoptosis,decreasing Bcl-2 expression,increasing Bax expression,and determining mitochondrial depolarization in comparison with treatment with either inhibitor alone. (unifi.it)
Our results indicated that insulin induces cell proliferation in a dose-dependent fashion in the LNCaP, C4-2, and P69 cell lines. (scienceopen.com)

Previously, we showed that exosomes derived from human adipose tissue-derived mesenchymal stem cells (ASC-exosomes) attenuate AD-like symptoms by reducing multiple inflammatory cytokine levels. (mdpi.com)
Adipose tissue-derived mesenchymal stem cells (AD-MSC) show great potential to treat inflammatory and degradative processes in OA and have demonstrated paracrine effects in chondrocytes. (karger.com)
Matearnal obesity alters fatty acid oxidation, AMPK activity, and associated DNA methylation in mesenchymal stem cells from human infants. (ucdenver.edu)

Mechanisms involved in the cytotoxic action of EEP on A549 cells were then investigated in terms of apoptosis, mitochondrial membrane potential and cell cycle using flow cytometry, endoplasmic reticulum stress using RT-PCR, and caspase activity using luminometric analysis. (ktu.edu.tr)
We determined that EEP arrested the cell cycle of A549 cells at the G(1) phase, induced endoplasmic reticulum stress, caspase activity, and apoptosis and reduced mitochondrial membrane potential. (ktu.edu.tr)
Accordingly, cell viability and apoptosis were measured using MTT and flow cytometry assays, respectively. (ac.ir)
Especially at the concentration of 20 ug/ml, the apoptosis rate was remarkably high in AGS (P-value= 0.003) and SW480 cells (P-value= 0.0007). (ac.ir)
Of the 18 cancer cell lines treated with oh 8 dG, 3 cell lines (H9, CEM-CM3, and Molt-4) were found to be committed to apoptosis, and all of these showed very low OGG1 activity and a marked increase in the concentration of oh 8 Gua in DNA. (ewha.ac.kr)
These observations indicate that in addition to its mutagenic action, oh 8 Gua in DNA disturbs cell viability by inducing apoptosis. (ewha.ac.kr)
The possibility that cytotoxic effects were due to apoptosis was indicated by significant time- and dose-dependent induction of caspase-3/7 activity in both HepG2 cells and human hepatocytes. (cdc.gov)

In humans, mRNA expression of hTERT ( hEST2 ), the candidate telomerase catalytic subunit gene, appears to parallel the levels of telomerase enzyme activity, suggesting that induction of hTERT is necessary and perhaps sufficient for expression of telomerase activity in tumor cells. (nature.com)
Cytotoxic activity of claudin-6-specific human CD8 + T cells towards MDA-MB-231 tumor cells expressing cognate antigen was analyzed using real-time analysis of tumor cell mass, along with flow cytometric analysis of granzyme B and CD107a expression on CD8 + T cells. (bmj.com)
Furthermore, the combination increased granzyme B and CD107a expression by antigen-specific CD8 + T-cells and enhanced CD8 + T-cell-mediated cytotoxic activity towards cognate antigen-expressing tumor cells. (bmj.com)
More recently, a number of studies have focused on the procoagulant mechanisms exhibited by tumor cells. (scielo.br)
It was observed that tumor cells strongly accelerate plasma coagulation as a result of: i) expression of the blood clotting initiator protein, a tissue factor, as shown by flow cytometry and functional assays (factor Xa formation in the presence of cells and factor VIIa), and ii) direct activation of prothrombin to thrombin by cells, as evidenced by hydrolysis of the synthetic substrate, S-2238, and the natural substrate, fibrinogen. (scielo.br)
Moreover, a monoclonal antibody against bovine factor Xa reduced the prothrombin-converting activity of tumor cells. (scielo.br)

Wutz, A. Haploid mouse embryonic stem cells: rapid genetic screening and germline transmission. (nature.com)
Leeb, M. & Wutz, A. Derivation of haploid embryonic stem cells from mouse embryos. (nature.com)
Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. (nature.com)
Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. (nature.com)
Androgenetic haploid embryonic stem cells produce live transgenic mice. (nature.com)
Genetic modification and screening in rat using haploid embryonic stem cells. (nature.com)
Generation of haploid embryonic stem cells from Macaca fascicularis monkey parthenotes. (nature.com)
Derivation and differentiation of haploid human embryonic stem cells. (nature.com)
Previous work in the embryonic rodent brain suggested that the preferential inheritance of the pre-existing (older) centrosome to the self-renewed progenitor cell is required to maintain stem cell properties, ensuring proper neurogenesis. (elifesciences.org)
Using a novel, recombination-induced tag exchange-based genetic tool to birthdate and track the segregation of centrosomes over multiple cell divisions in human embryonic stem cell-derived regionalised forebrain organoids, we show the preferential inheritance of the older mother centrosome towards self-renewed NPCs. (elifesciences.org)
Research Objective We will produce a universal donor cell (UDC) line by gene editing an embryonic stem cell line. (ca.gov)

Impact Our proposal will optimize the generation and viability of an unlimited, reproducible source of human engineered islets for transplantation. (ca.gov)
After three days of treatment with sFzd7, the viability of AGS and SW480 cell lines was decreased in a dose-dependent manner. (ac.ir)
The A549 cell line was the most sensitive of the cell lines tested with a significant reduction in viability observed at 40 µg/mL. (scielo.br)
Alterations in cell viability and metabolic activity were determined. (lu.se)
Fipronil mediated activation of caspase-3/7 in concurrence with compromised ATP production and viability are attributed to apoptotic cell death. (cdc.gov)

Conditioned media from such cells were then used to stimulate human aortic endothelial cells (HAoECs) to enhance tube-like structure formation in a Matrigel assay. (hindawi.com)
Then, we used atorvastatin-stimulated cells or conditioned media from them in the Matrigel plug in vivo angiogenic assay. (hindawi.com)
dCK activity of the cells was determined by an enzyme activity assay. (biomedcentral.com)
Cytotoxic activity of EEP on A549 cells was revealed using the MTT assay. (ktu.edu.tr)
Antiproliferative activity, expressed as IC 50 values, was determined using the MTT assay. (johnshopkins.edu)
Cell metabolic activity was measured using the alamarBlue assay. (molvis.org)
Effects of EGCG on mitogen-activated protein kinase (MAPK) phosphorylation were determined by cell-based enzyme-linked immunosorbent assay (ELISA) and western blotting. (molvis.org)
Effects of EGCG on nuclear factor kappa B (NFκB) and activator protein-1 (AP-1) transcriptional activity were assessed by reporter gene assay. (molvis.org)
The cytotoxicity on different cell lines was assayed using the 3-(4, 5-dimethylthiazol-2yl)-2, 5-diphenyltetrazolium bromide (MTT) assay which measures survival based on the detection of mitochondrial activity and by the crystal violet assay, which measures survival based on the ability of cells to remain adherent to microplates. (scielo.br)
Conversion of DHEAS to DHEA was assessed in luteinized granulosa cells by tritiated steroid assay following incubation with or without LH or insulin and steroid accumulation in the medium measured by RIA. (ox.ac.uk)
Exposure of human hepatocytes to doses of fipronil (5-amino-1-[2,6-dichloro-4-(trifluoromethyl)phenyl]-4-[(trifluoromethyl) sulfinyl]-1H-pyrazole-3-carbonitrile) ranging from 0.1 to 25 µM resulted in a dose dependent increase in CYP1A1 mRNA expression (3.5 to approximately 55-fold) as measured by the branched DNA assay. (cdc.gov)

Neither AT alone in control media nor conditioned media nor AT-stimulated cells affected numbers of endothelial cells in the plug or plug's vascularization. (hindawi.com)
The process of neovascularization can be influenced not only by the residual endothelial cells but also by the circulating cells. (hindawi.com)

However, the features initially ascribed to endothelial progenitor cells, i.e ., phenotype, expression of endothelial markers, and ability to form tube-like structures on Matrigel, can be mimicked by blood monocytes [ 3 ]. (hindawi.com)
We investigated the effects of monocyte-activating stimuli (IFN-gamma, IL-2, LPS, TNF-alpha, and GM-CSF) on the expression and function of CD38, starting from the observation that human monocytes and the derived lines U937, THP-1, and Mono-Mac-6 bear the molecule on their surface. (nih.gov)
Treatment with IFN-gamma produced a dose- and time-dependent up-regulation of CD38 in monocytes and monocytic lines, which was paralleled by increased ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase activities. (nih.gov)
However, we know less about the biological effects of IL-21 and its signaling mechanisms in leukemia cells and monocytes. (intechopen.com)
The researchers studied the uptake of these nanoparticles by three different types of immune cells: Monocytes (large phagocytic white blood cells), macrophages (large phagocytic cells found to be stationary in tissues or as a mobile white blood cell at sites of infection) and neutrophils (neutrophilic white blood cells). (indiatimes.com)

Using our recently established haploid human pluripotent stem cells (hPSCs), we generated a genome-wide loss-of-function library targeting 18,166 protein-coding genes to define the essential genes in hPSCs. (nature.com)
Research Objective Functional human islet like organoids differentiated from human pluripotent stem cells. (ca.gov)
Research Objective Universal Pluripotent Liver Failure Therapy (UPLiFT) is composed of 2 lines- UPLiFT0 ( from LiPSC-GR1.1) and UPLiFT1 which will be derived from gene edited universal human pluripotent stem cells. (ca.gov)

To test this model directly, we ectopically expressed an epitope-tagged version of hTERT in telomerase-negative cells and show that telomerase activity was induced to levels comparable to those seen in immortal telomerase-positive cells and that the expressed hTERT protein was physically associated with the cellular telomerase activity. (nature.com)
We conclude that synthesis of the hTERT telomerase subunit represents the rate-limiting determinant of telomerase activity in these cells and that this protein, once expressed, becomes part of the functional telomerase holoenzyme. (nature.com)
The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. (nih.gov)
This protein is a molecular chaperone with specific function in cell signal transduction. (nih.gov)
The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. (nih.gov)
The dCK activity of our cell lines varied considerably and differed up to three fold from 5 to 15 pmol/h/mg protein between the tested cell lines. (biomedcentral.com)
p53 is a key protein that is altered in all cancer cells. (who.int)
Protein expression was investigated by ELISA and immunofluorescence, transcription factor-DNA binding by ELISA, gene expression by real-time PCR, prostaglandin E 2 (PGE 2 ) by radioimmunoassay, and matrix metalloproteinase (MMP) activity and nitric oxide (NO) production by fluorometry. (karger.com)
Aberration of asymmetric segregation of centrosomes by genetic manipulation of the centrosomal, microtubule-associated protein Ninein alters fate decisions of NPCs and their maintenance in the VZ of human cortical organoids. (elifesciences.org)
The antiproliferative effects of CPT-11 and SN-38, CE-activity and topoisomerase I protein expression were investigated in five human small-cell lung cancer (SCLC) cell lines and four human non-small-cell lung cancer (NSCLC) cell lines. (johnshopkins.edu)
Western blotting experiments showed topoisomerase I protein expressions within a factor of 2, and a granular nuclear staining was detectable in all cell lines by immunocytochemistry of cytospins. (johnshopkins.edu)
A novel recombinant human Frizzled-7 protein exhibits anti-tumor activity against triple negative breast cancer via abating Wnt/β-catenin pathway. (ac.ir)
Methods: A172 cells were analyzed immunohistochemically for the astrocyte markers, glial fibrillary acidic protein (GFAP) and S-100β. (okstate.edu)

The expression of telomerase, the enzyme that synthesizes telomeric DNA de novo , is suppressed in normal somatic human cells but is reactivated during tumorigenesis. (nature.com)
One unit of 110a/p85a kinase activity is defined as the amount of enzyme required to produce 1 pmol of Phosphoinositol-3, 4,5-Trisphosphate/min at 37°C. (sigmaaldrich.com)
In contrast, prothrombin activation was not observed when cells were previously incubated with DEGR-factor Xa, an inactive derivative of the enzyme. (scielo.br)
Nitrite production was greatest over the initial 24 hr of stimulation with iNOS enzyme activity peaking at 12 hr. (okstate.edu)
Ethanol had no direct effect on the catalytic activity of the enzyme. (okstate.edu)
Confirmation of bDNA results were sought through western blotting and/or enzyme activity assays. (cdc.gov)
Likewise, activity levels for a CYP1A1-specific substrate, luciferin CEE, demonstrated that CYP1A1 enzyme activities were maximally induced by 1 µM fipronil followed by dramatically declining activity measurements at 10 and 25 µM. (cdc.gov)

The antiproliferative activity exhibited by tuber extracts was not due to necrosis, because the amount of lactate dehydrogenase (LDH) released from cells incubated with the extracts was not significantly different from that released from cells incubated without extracts (control). (psu.edu)

Together with gene regulation associated with hypoxia in ADSCs, this study has provided several strong leads for a stem cell-derived approach to TM wound healing. (oslomet.no)
The active role of dendrites in the regulation of magnocellular neurosecretory cell behavior. (wikipedia.org)
Down-regulation of frizzled-7 expression decreases survival, invasion and metastatic capabilities of colon cancer cells. (ac.ir)

In the present study, the relation between deoxycytidine kinase (dCK) activity and the radiosensitising effect of gemcitabine was investigated in eight different human tumour cell lines. (biomedcentral.com)
Cell cycle analysis of the activity, subcellular localization, and subunit composition of human CAK (CDK-activating kinase). (rupress.org)
We now demonstrate that the tyrosine kinase activity of p56lck is increased within seconds following CD2 triggering. (pasteur.fr)
EGCG significantly inhibited phosphorylation of the MAPKs p38 and c-Jun N-terminal kinase (JNK), and NFκB and AP-1 transcriptional activities. (molvis.org)
Cytotoxic effects of fipronil and fipronil sulfone were examined using the adenylate kinase and the trypan blue exclusion assays in HepG2 cells and human hepatocytes. (cdc.gov)
A significant time- and dose-dependent induction of adenylate kinase activity in HepG2 cells was noted from 0.1 to 12.5 µM fipronil followed by decreasing activities at 25 and 50 µM. (cdc.gov)

abstract = "Irinotecan (CPT-11) is a semisynthetic camptothecin derivative with a broad spectrum of anti-tumour activity. (johnshopkins.edu)

Both compounds generated cell cytotoxicity to A549 cells at CC50 values of 108 µM for curcumin and 210 µM for 6‐gingerol. (ugm.ac.id)
The purpose of this study was to show the cytotoxic effects, and possible mechanisms involved, of ethanolic extract of Turkish propolis (EEP) on the human lung cancer (A549) cell line. (ktu.edu.tr)
EEP exhibited selective toxicity against A549 cells compared to normal fibroblast cells. (ktu.edu.tr)
In the present study, the venoms from five sea anemones (Heteractis crispa, Heteractis magnifica, Heteractis malu, Cryptodendrum adhaesivum and Entacmaea quadricolor) were obtained by the milking technique, and the potential of these venoms to kill cancer cells was tested on three cell lines (A549 lung cancer, T47D breast cancer and A431 skin cancer). (scielo.br)

In MLR assays of human CD8 + T cells and allogeneic dendritic cells, the combination of HexaBody-CD27 and pembrolizumab synergistically enhanced IFN-γ secretion. (bmj.com)

We used G-CSF-mobilized CD34 + HSPCs, FACS-sorted from healthy donor peripheral blood mononuclear cells (PBMCs). (hindawi.com)

No induction of either necrotic or apoptotic cell death was noted in these cells in response to treatment with the blueberry fractions. (canada.ca)

However, increased levels of telomerase activity were detected in alpha-particle survivors while robust telomerase activity was seen in the tumorigenic cell lines. (duke.edu)

Natural and synthetic ERα ligands are classified as agonists (17β-estradiol/E2), selective estrogen receptor modulators (SERMs: Tamoxifen/Tam and Raloxifene/ Ral), and pure antagonists (ICI 182,780-Fulvestrant/ ICI), according to the response they elicit in hormone responsive cells. (unina.it)
Background Activation of the T-cell co-stimulatory receptor CD27 and blockade of the PD-1:PD-L1 axis can augment antitumor immune responses through distinct mechanisms. (bmj.com)
HexaBody ® -CD27 (GEN1053/BNT313) is a novel CD27 human monoclonal antibody with a functionally inert IgG1 Fc domain harboring a hexamerization-enhancing mutation to induce CD27 activation independently of Fc gamma receptor crosslinking, while also avoiding T-cell depletion. (bmj.com)
Human iPSC-derived chimeric antigen receptor expressing macrophages for improved cancer treatment. (ca.gov)
The effect of sFzd7 was evaluated on AGS gastric and SW480 colon cancer cell lines expressing high levels of Fzd7 receptor. (ac.ir)
sFzd7 decoy receptor inhibits tumor cell progression by attenuating the Wnt pathway through inhibiting Fzd7 receptors and Wnt ligand interaction. (ac.ir)

The activity of magnocellular neurosecretory cells is regulated by local glial cells as well as through themselves (intrinsically). (wikipedia.org)
Background: Glial cells are critical in the functioning of the central nervous system (CNS), including responsiveness to injury and immunocompetence. (okstate.edu)
Previously, we have demonstrated that ethanol inhibits cytokine-induced iNOS expression and activity in rat glial cells. (okstate.edu)
Evidence of ethanol-induced effects on iNOS in human glial cells is nonexistent. (okstate.edu)
Conclusions: The present study is the first published report of ethanol-induced modulation of iNOS expression in human glial cells. (okstate.edu)

The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. (nih.gov)

Using gelatin gel electrophoresis, MMP activity was evaluated from cells after 24-hr exposure to blueberry fractions. (canada.ca)
Bengaluru: A team from Indian Institute of Science ( IISc ), in a new study has found how the functioning of immune cells in the human body could alter in the advent of increased exposure to nanoparticles used for medical purposes. (indiatimes.com)
The amount of formaldehyde exposure did not appear to correlate with AGT activity. (cdc.gov)
The authors conclude that AGT activity was reduced among students with embalming experience, but that no link to formaldehyde exposure could be made with the data. (cdc.gov)
Acute (6-24 hr) exposure of activated cells to 50 mM ethanol enhanced iNOS activity recovered from the cytosol, whereas 200 mM ethanol decreased it. (okstate.edu)
Public health officials and others concerned with appropriate actions to take at hazardous waste sites may want information on levels of exposure associated with more subtle effects in humans or animals (LOAEL) or exposure levels below which no adverse effects (NOAELs) have been observed. (cdc.gov)
Estimates of exposure levels posing minimal risk to humans (Minimal Risk Levels or MRLs) have been made for di-n-butyl phthalate. (cdc.gov)
An MRL is defined as an estimate of daily human exposure to a substance that is likely to be without an appreciable risk of adverse effects (noncarcinogenic) over a specified duration of exposure. (cdc.gov)
As these kinds of health effects data become available and methods to assess levels of significant human exposure improve, these MRLs will be revised. (cdc.gov)
Early diagnosis of human rabies infection might be hampered by delayed recognition, given the rarity of the disease, nonspecific initial symptoms, and difficulty in obtaining animal exposure history once the patient is in the later stages of illness. (cdc.gov)

Despite their important role in steering innate and adaptive immunity, the age- and inflammation-associated changes in the molecular identity and functional properties of human FRCs have remained largely unknown. (nih.gov)
In sum, the topological and molecular definition of the human tonsillar stromal cell landscape reveals PI16 + RCs as a specialized FRC niche at the core of mucosal immune responses in the oropharynx. (nih.gov)
This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. (nih.gov)
In the present study, we dissected the molecular mechanisms responsible for the procoagulant activity of MV3, a highly aggressive human melanoma cell line. (scielo.br)
If asymmetric segregation of centrosomes occurs in NPCs of the developing human brain, which depends on unique molecular regulators and species-specific cellular composition, remains unknown. (elifesciences.org)
Appreciating the similarities and differences between cell types is particularly important to the fields of cell and molecular biology as well as to biomedical fields such as cancer research and developmental biology. (phys.org)
Hence, research in cell biology is closely related to genetics, biochemistry, molecular biology and developmental biology. (phys.org)
Vasopressin is produced from the vasopressin-producing cells via the AVP gene, a molecular output of circadian pathways. (wikipedia.org)

Inhibition of either COX-2 or 5-LOX alone resulted in activation of the other pathway in colon cancer cells. (unifi.it)
In conclusion,our study showed that inhibition of 5-LOX by MK886 could augment the antitumor activity of celecoxib in human colorectal cancer. (unifi.it)
When cells were treated with IL-1β and EGCG or hyperosmolarity and EGCG there was a dose-dependent reduction in release of these cytokines/chemokines, with significant inhibition observed at 3-30 µM. (molvis.org)

This may have an important impact in understanding the biology of wild-type p53 in cancer-transformed cells. (who.int)
Cell biology (formerly cytology , from the Greek kytos , "container") is an academic discipline that studies cells - their physiological properties, their structure, the organelles they contain, interactions with their environment, their life cycle, division and death. (phys.org)
Cell biology research encompasses both the great diversity of single-celled organisms like bacteria and protozoa, as well as the many specialized cells in multicellular organisms like humans. (phys.org)

Here, we draw upon studies that have shed light on the initiation and progression of islet autoimmunity from the point of view of the beta cell. (springer.com)
Scholars@Duke publication: Chromosome end-to-end associations and telomerase activity during cancer progression in human cells after treatment with alpha-particles simulating radon progeny. (duke.edu)
Helicobacter pylori evolution during progression from chronic atrophic gastritis to gastric cancer and its impact on gastric stem cells. (medscape.com)

The expression/activity of COX-2 and 5-LOX were assessed in 24 human colorectal cancer specimens. (unifi.it)

Cell Stem Cell 19 , 569-572 (2016). (nature.com)
A cross-sectional study was performed on 12,249 asymptomatic examinees who underwent an NK cell activity test, between January 2016 and May 2017. (jcpjournal.org)
Appraisal (JA) 2015 and 2016 was that inadequate human resource in numbers/capacity at various levels i.e. (who.int)

Colon cancer cells were more responsive to tuber extract treatment than prostate cancer cells. (psu.edu)

Type 1 diabetes results from the poorly understood process of islet autoimmunity, which ultimately leads to the loss of functional pancreatic beta cells. (springer.com)
Type 1 diabetes results from organ-specific autoimmunity, which eliminates most of the insulin-producing pancreatic beta cells. (springer.com)
Research Objective Development of hESC-derived pancreatic beta cells that are protected from allogeneic and autoimmune attack into a cell therapy for type 1 diabetes (T1D) Impact Cell therapy of T1D is challenged by immune rejection. (ca.gov)

Cell Stem Cell 9 , 563-574 (2011). (nature.com)
Cell Stem Cell 14 , 404-414 (2014). (nature.com)

The establishment, characterization, and tumorigenicity of a new epithelial cell line (PC-3) from a human prostatic adenocarcinoma metastatic to bone is reported. (scienceopen.com)
Metabolic activity was significantly increased by hypoxia in both epithelial cell types. (lu.se)

Comparative analyses of agonist (E2)- vs antagonist (Tam, Ral or ICI)-bound ERα interacting proteins reveal significant differences among ER ligands that relate with their biological activity, identifying novel functional partners of antiestrogen−ERα complexes in human BC cell nuclei. (unina.it)
We advance the hypothesis that antigen presentation by beta cells, their stress responses and functional heterogeneity are critical factors that will provide clues towards solving the enigma posed by islet autoimmunity in type 1 diabetes. (springer.com)
Finally, IR isoforms form heterodimers, IR-A/IR-B, and hybrid IR/IGF-IR receptors (HR-A and HR-B). The functional characteristics of such hybrid receptors and their role in physiology, in diabetes, and in malignant cells are not yet fully understood. (scienceopen.com)

Mutational Analysis of the VPREB1 Gene of Pre-BCR Complex in a Cohort of Sporadic Pediatric Patients With B-Cell Acute Lymphoblastic Leukemia. (nih.gov)
CRISPR/Cas9 mediated knock-out of VPREB1 gene induces a cytotoxic effect in myeloma cells. (nih.gov)
This gene is localized to human chromosome 3q. (sigmaaldrich.com)
Mutation in this gene leads to enhanced PI3K activity, and it is a candidate transforming oncogene. (sigmaaldrich.com)
Research Objective We propose to generate NK cells with enhanced immunity from gene-edited human PSCs and use the resultant NK cells to kill SARS-CoV-2-infected cells to combat against COVID-19. (ca.gov)

J Cell Biol (1994) 127 (2): 467-478. (rupress.org)

Therefore, the cells we used should be considered as hematopoietic precursors of myeloid angiogenic cells and are referred as PACs. (hindawi.com)
GFI1B-D262N promoted myelomonocytic versus erythroid output from primary human hematopoietic precursors and enhanced cell survival of both normal and MDS derived precursors. (lu.se)

Major Proposed Activities Fabrication and characterization of the injectable immunomodulating and pro-angiogenic material components: HA hydrogel, heparin nanoparticles and VEGF clusters. (ca.gov)
15. Schmuck R, Warneke V, Behrens H-M, Simon E, Weichert W, Röcken C. Genotypic and phenotypic characterization of side population of gastric cancer cell lines. (ac.ir)
Establishment and characterization of a human prostatic carcinoma cell line (PC-3). (scienceopen.com)

Myeloid angiogenic cells (MAC) derive from hematopoietic stem/progenitor cells (HSPCs) that are mobilized from the bone marrow. (hindawi.com)
Such myeloid angiogenic cells (MAC) [ 1 ] of bone marrow origin were known as endothelial progenitor cells (EPCs). (hindawi.com)
Cells previously known as endothelial progenitor cells are considered now to be rather myeloid angiogenic cells than endothelial precursors [ 4 ]. (hindawi.com)
In our study, we worked on cells derived from the CD34 + hematopoietic stem and progenitor cells, enriched with CD133 + population, and used culture media promoting growth of hematopoietic progenitors. (hindawi.com)
During human forebrain development, neural progenitor cells (NPCs) in the ventricular zone (VZ) undergo asymmetric cell divisions to produce a self-renewed progenitor cell, maintaining the potential to go through additional rounds of cell divisions, and differentiating daughter cells, populating the developing cortex. (elifesciences.org)
During human brain development, neural progenitor cells (NPCs) undergo two modes of cell division. (elifesciences.org)

The tumorigenic cells that were telomerase positive and had the highest frequency of cells with chromosome end-to-end associations were also metastatic. (duke.edu)

The GFI1B-D262N mutant functionally antagonizes the transcriptional activity of wild-type GFI1B. (lu.se)

Other partners of the intracellular metabolism of gemcitabine in relation to the cell cycle effects and DNA repair could be more responsible for the radiosensitising effect than dCK activity. (biomedcentral.com)
6. Sherwood V. WNT signaling: an emerging mediator of cancer cell metabolism? (ac.ir)

Recent studies have demonstrated the potential of pesticides to either inhibit or induce xenobiotic metabolizing enzymes in humans. (cdc.gov)

The peptidase inhibitor 16 (PI16)-expressing reticular cell (PI16 + RC) subset of adult tonsils exhibited the strongest inflammation-associated structural remodeling. (nih.gov)

Scientists can do some nifty things with microbes, including engineering bacterial cells to sense and signal the presence of specific compounds. (phys.org)

Hence, sFzd7 can be proposed as a candidate therapy for GC and CRC cells with high levels of Fzd7 expression. (ac.ir)
12. Cheng Y, Li L, Pan S, Jiang H, Jin H. Targeting frizzled-7 decreases stemness and chemotherapeutic resistance in gastric cancer cells by suppressing Myc expression. (ac.ir)
Herein, the conditions necessary for significant iNOS induction in human A172 astrocytoma cells have been characterized, and subsequently, the effects of ethanol on iNOS expression have been investigated. (okstate.edu)

Addition of DHEAS to granulosa cells caused a dose-dependent increase in oestradiol and androstenedione production with no change in progesterone concentration. (ox.ac.uk)

The degree of radiosensitisation was also cell line dependent and seemed to correlate with the sensitivity of the cell line to the cytotoxic effect of dFdC. (biomedcentral.com)

Cell survival was determined 7, 8, or 9 days after RT by the sulforhodamine B test. (biomedcentral.com)

In conclusion, the data strongly suggest that MV3 cells recruit factor Xa from the culture medium, triggering an uncommon procoagulant mechanism. (scielo.br)
In conclusion, insulin exhibits direct mitogenic activities in PCa cells, which are mediated exclusively through the INSR. (scienceopen.com)
Discussion: In conclusion, our data indicate that bronchial and alveolar epithelial cells respond differently to hypoxia and profibrotic stimuli. (lu.se)

Finally, the expressions of β-catenin (P-value= 0.01) and cyclin-D1 (P-value= 0.02) were obviously decreased in SW480 cells. (ac.ir)

In this range dCK activity was only weakly related to radiosensitisation (correlation coefficient 0.62, p = 0.11). (biomedcentral.com)
A significant correlation (r 2 = 0.52, P = 0.028) was observed between CE activity and chemosensitivity to CPT-11 but not to SN-38, and significantly higher CE activity was observed in SCLC compared with NSCLC cell lines (P = 0.025). (johnshopkins.edu)
2. The aim of this work was to investigate how hypoxia affects human lung epithelial cells in combination with profibrotic stimuli and its correlation to pathogenesis. (lu.se)

There was no effect of EGCG on cell metabolic activity at any of the doses tested (0.3-30 µM). (molvis.org)
In addition to its normal spectrum of metabolic effects, insulin can act as a growth factor and has the ability to promote mitogenic activity. (scienceopen.com)

The signaling mechanisms of IL-21 in different cell types have been identified. (intechopen.com)
The aims of this study were to investigate whether insulin can directly induce mitogenic activities in PCa-derived cell lines and to examine the mechanisms responsible for these actions. (scienceopen.com)

Oncogenic transformation was initiated using radon simulated alpha-particles and cells evaluated as primary, secondary and metastatic transformants. (duke.edu)

The assessment of CE activity in clinical material of lung cancer patients undergoing treatment with CPT-11 may be warranted. (johnshopkins.edu)

Hsp90 interacts with Cdc37, is phosphorylated by PKA/PKC, and regulates Src phosphorylation in human sperm capacitation. (nih.gov)
An early biochemical event associated with T cell activation is tyrosine phosphorylation. (pasteur.fr)
This activity decreases thereafter correlating with the appearance of changes in phosphorylation previously described. (pasteur.fr)

The aim of this study was to investigate human granulosa cells as a site of steroid sulphatase activity, to determine whether DHEAS can be utilized as a precursor for oestrogen synthesis and to investigate the inhibitory capacity of EMATE in these cells. (ox.ac.uk)

Anatomy36

Organisms16

Diseases8

Chemicals and Drugs85

Analytical, Diagnostic and Therapeutic Techniques and Equipment36

Phenomena and Processes87

Information Science3

Health Care2

Vitro14

Proliferation18

Mesenchymal stem3

Apoptosis7

Tumor cells6

Embryonic11

Viability5

Assay11

Endothelial cells2

Monocytes5

Pluripotent stem3

Protein13

Enzyme7

Antiproliferative1

Regulation3

Kinase6

Abstract1

A5494

Assays1

Peripheral blood mononuclear cells1

Apoptotic cell1

Levels of telomerase1

Receptor6

Glial cells5

Differentiation1

Exposure10

Molecular8

Inhibition3

Biology3

Progression3

Colorectal1

20163

Prostate cancer cells1

Pancreatic3

Stem Cell2

Epithelial cell2

Functional3

Gene5

Biol1

Hematopoietic precursors2

Characterization3

Progenitor cells6

Telomerase-positive1

Transcriptional activity1

Metabolism2

Inhibit1

Inflammation1

Bacterial cells1

Expression3

Dose-dependent1

Cytotoxic effect1

Survival1

Conclusion3

SW4801

Correlation3

Metabolic2

Mechanisms2

Metastatic1

Lung cancer1

Phosphorylation3

Study was to investigate1