AspirinPlatelet Aggregation InhibitorsAnti-Inflammatory Agents, Non-SteroidalBiotransformationTiclopidineProdrugsPlatelet AggregationThromboxane B2Chromatography, High Pressure LiquidDose-Response Relationship, DrugCyclooxygenase InhibitorsPlatelet Function TestsDrug InteractionsSalicylatesAdministration, OralDrug Therapy, CombinationMicrosomes, LiverBlood PlateletsCamptothecinArea Under CurveHalf-LifeIsoxazolesCytochrome P-450 Enzyme SystemSodium SalicylateGlucuronidesThiophenesTime FactorsCytochrome P-450 CYP2D6Chromatography, LiquidFibrinolytic AgentsPurinergic P2Y Receptor AntagonistsDouble-Blind MethodGas Chromatography-Mass SpectrometryTriethylenephosphoramideTandem Mass SpectrometryCross-Over StudiesMass SpectrometryCalcitriolHemorrhageProstaglandin-Endoperoxide SynthasesAsthma, Aspirin-InducedCyclooxygenase 1HydroxybutyratesAnticoagulantsWarfarinTablets, Enteric-CoatedAntineoplastic Agents, PhytogenicNordazepamAryl Hydrocarbon HydroxylasesThromboxanesDrug ResistanceCanrenoneCytochrome P-450 CYP3APhosphoramide MustardsThromboxane A2Arachidonic AcidDrug Administration ScheduleIbuprofenPlatelet ActivationButyrophenonesGlucuronosyltransferaseBleeding TimeHydroxylationGastrointestinal HemorrhageTramadolTreatment OutcomeAniline CompoundsMorphine DerivativesMetabolomicsBiological AvailabilityCyclooxygenase 2Receptors, Purinergic P2Y12MetabolomeRats, Sprague-DawleyAcetaminophenCarbamazepineMagnetic Resonance SpectroscopyCyclooxygenase 2 InhibitorsTopoisomerase I InhibitorsBenzamidinesDealkylationIndomethacinStereoisomerismThrombosisPiperazinesEthylene ChlorohydrinMetabolic Clearance RateLiverInjections, IntravenousDipyridamoleSarcinaLipoxinsProstaglandinsCrotonatesEnzyme InhibitorsProspective StudiesGlucuronatesProguanilKineticsRisk Factors