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  • enzyme
  • In enzymology, a ceramide kinase, also abbreviated as CERK, (EC 2.7.1.138) is an enzyme that catalyzes the chemical reaction: ATP + ceramide ⇌ {\displaystyle \rightleftharpoons } ADP + ceramide 1-phosphate Thus, the two substrates of this enzyme are ATP and ceramide, whereas its two products are ADP and ceramide-1-phosphate. (wikipedia.org)
  • This enzyme is also called acylsphingosine kinase. (wikipedia.org)
  • CDK4
  • Induced by mitogenic signals cyclins of the D-type family (D1, D2, and D3) are synthesized and bind and activate CDK4 and CDK6 . (proteinkinase.biz)
  • 1992) "Identification and properties of an atypical catalytic subunit (p34PSK-J3/cdk4) for mammalian D type G1 cyclins. (proteinkinase.biz)
  • Lukas J, Bartkova J, Rohde M, Strauss M, Bartek J (1995) "Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. (proteinkinase.biz)
  • gene
  • The cyclin D1 gene is amplified and/or overexpressed in various human cancers. (proteinkinase.biz)
  • In normal cells, CpG islands preceding gene promoters are generally unmethylated, and tend to be transcriptionally active, while other individual CpG dinucleotides throughout the genome tend to be methylated. (wikipedia.org)
  • downstream
  • 2000 ). Furthermore, in the absence of Mos, a CSF effect could also be obtained by microinjection of a constitutively active p90 Rsk1 isoform ( Gross et al , 1999 ), confirming that a p90 Rsk isoform acts downstream of Mos. (embopress.org)
  • This results in activated c-jun and its downstream targets such as RACK1 and cyclin D1. (wikipedia.org)
  • mitotic
  • In vertebrates, there are five cyclin B isoforms (B1, B2, B3, B4, and B5), but specific role of each of these isoforms in regulating mitotic entry is still unclear. (wikipedia.org)
  • sequence
  • A second form of cyclin A, named cyclin A1 because of its high sequence homology to Xenopus cyclin A1, is most highly expressed in germ cells. (acris-antibodies.com)
  • One of them, the L12 helix that comes just before the T-loop in the primary sequence, becomes a beta strand and helps rearrange the T-loop, so it no longer blocks the active site. (wikipedia.org)
  • CERK shares sequence homology with sphingosine kinase type I, including an N-terminal pleckstrin homology (PH) domain and a diacylglycerol kinase domain. (wikipedia.org)
  • Interacts
  • Cyclin F/FBXO1 Interacts with HIV-1 Viral Infectivity Factor (Vif) and Restricts Progeny Virion Infectivity by Ubiquitination and Proteasomal Degradation of Vif Protein through SCFcyclin F E3 Ligase Machinery. (ebi.ac.uk)