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  • CycA2
  • In the process of searching for regulatory factors of endoreduplication, the promoter of an Arabidopsis thaliana cyclin A gene, CYCA2;3 , was revealed to be active in developing trichomes during the termination period of endoreduplication as well as in proliferating tissues. (plantcell.org)
  • Taking advantage of the situation that plants encode highly redundant cyclin A genes, we were able to perform functional dissection of CYCA2;3 using null mutant alleles. (plantcell.org)
  • gene
  • The cyclin D1 gene is amplified and/or overexpressed in various human cancers. (proteinkinase.biz)
  • Lukas J, Bartkova J, Rohde M, Strauss M, Bartek J (1995) "Cyclin D1 is dispensable for G1 control in retinoblastoma gene-deficient cells independently of cdk4 activity. (proteinkinase.biz)
  • In normal cells, CpG islands preceding gene promoters are generally unmethylated, and tend to be transcriptionally active, while other individual CpG dinucleotides throughout the genome tend to be methylated. (wikipedia.org)
  • regulate
  • Rather than imiquimod activity being mediated by induction of various cytokines, including interferon (IFN)-á, IFN-ã, tumor necrosis factor-á (TNFá) interleukin (IL)-1á, and IL-12 as currently thought, an entirely new pathway - native to body chemistry - has been discovered to regulate cell proliferation by imidazoquinolines. (medicalxpress.com)
  • securin
  • Thus, securin and cyclin B1 destruction have very similar properties. (rupress.org)
  • Moreover, we find that both cyclin B1 and securin have to be degraded before sister chromatids can separate. (rupress.org)
  • pathway
  • In PRR, there are two sub-pathways: (1) a translesion pathway, which is carried out by specialised DNA polymerases that are able to incorporate damaged DNA bases into their active sites (unlike the normal replicative polymerase, which stall), and hence bypass the damage, and (2) a proposed "template switch" pathway that is thought to involve damage bypass by recruitment of the homologous recombination machinery. (wikipedia.org)
  • Subsequently
  • The temporal expression of cyclins is tightly regulated and subsequently plays a critical role in controlling the enzymatic activity of cdk's. (biotium.com)