AnatomyOrganismsDiseasesChemicals and DrugsAnalytical, Diagnostic and Therapeutic Techniques and EquipmentPhenomena and ProcessesDisciplines and OccupationsInformation ScienceHealth Care
Eukaryotic CellsCell DivisionNafenopinMolecular Sequence DataCell LineDNABase SequenceCells, CulturedAmino Acid SequenceThymidineCell CycleSaccharomyces cerevisiaeDNA-Binding ProteinsMutationInsulin-Secreting CellsReplication Protein AChlorpyrifosDNA ReplicationPlasmidsSaccharomyces cerevisiae ProteinsModels, BiologicalRNA, MessengerKineticsDNA, ViralProtein BindingHeLa CellsEscherichia coliCell ProliferationTime FactorsTranscription, GeneticCarcinogensViral ProteinsMitosisRNA, ViralLiver Neoplasms, ExperimentalBromodeoxyuridineIslets of LangerhansBacterial ProteinsSignal TransductionCatheterizationDNA Replication TimingSequence Homology, Amino AcidCell Cycle ProteinsBinding SitesEnzyme ActivatorsDNA HelicasesLiverCell NucleusCloning, MolecularApoptosisS PhaseEndotheliumProtein Structure, TertiaryReplication Protein CCell CountCell SurvivalRepliconEukaryotaCell DifferentiationEukaryotic Initiation Factor-2Transcription FactorsCarotid ArteriesDose-Response Relationship, DrugNucleic Acid ConformationProtein BiosynthesisSequence AlignmentNuclear ProteinsRecombinant Fusion ProteinsMuscle, Smooth, VascularGenome, ViralIn Situ Nick-End LabelingFungal ProteinsEukaryotic Initiation Factor-4ETrans-ActivatorsAutoradiographyGlucoseTumor Cells, CulturedPhosphorylationGene Expression Regulation, ViralGrowth SubstancesRecombinant ProteinsChromatinDNA DamageOrgan SizePromoter Regions, GeneticDNA-Directed DNA PolymeraseModels, MolecularTransfectionPlasminogen ActivatorsHIV-1PhylogenyDNA, FungalRats, Sprague-DawleyDNA PrimersProkaryotic CellsSchizosaccharomycesDNA RepairModels, GeneticRecombination, GeneticPeptide Initiation Factors
GenesTranscriptionGenomeProteinsOrganismsGene expressionProteinProliferationRegulationProkaryotic cellsPolymeraseIntracellularInitiationMitochondrial biogenesisOccursPathwayBacterialMolecularGcn4HeLaGeneticChromatinReceptorTumor cellsDistinctMRNAInducesMitosisInfectionRNAsApoptosisRecruitmentEpithelialMembraneRegulatesFunctionsAbsenceCalciumTissuesSubunitsExpressionChromosomeRegulatoryHostResponseCycleProcessesInitiatesSubsetNutrient
Genes20
  • These rRNA genes are organised into a single transcriptional unit and are transcribed into a continuous transcript. (wikipedia.org)
  • Subsequent analyses of the small RNA suggest it regulates S. enterica genes involved in cell invasion and survival. (genomeweb.com)
  • Through a series of follow-up experiments, the group demonstrated that the small RNA acts not only as a co-activator of Salmonella genes important to invasion, infection, and intracellular replication, but also as a regulator of coding and non-coding transcripts produced by infected host cells. (genomeweb.com)
  • By switching genes off when they are not needed, cells can prevent resources from being wasted. (pdfcoffee.com)
  • Complex multicellular organisms are produced by cells that switch genes on and off during development. (pdfcoffee.com)
  • A typical human cell normally expresses about 3% to 5% of its genes at any given time. (pdfcoffee.com)
  • Operons Operons are groups of genes that function to produce proteins needed by the cell. (pdfcoffee.com)
  • There are two different kinds of genes in operons: Structural genes code for proteins needed for the normal operation of the cell. (pdfcoffee.com)
  • Distinct signals that act through diverse targeted transcription factors can regulate different steps in the transcription pathway and provide a highly modulated transcriptional response at individual genes. (nature.com)
  • The biological variables include the differences in the levels of transcriptional expression of genes between tissues and cell types [ 7 ]. (biomedcentral.com)
  • Journal Article Genes (Basel) · December 16, 2021 Origins of DNA replication are specified by the ordered recruitment of replication factors in a cell-cycle-dependent manner. (duke.edu)
  • We mapped all estrogen receptor and RNA polymerase II binding sites on a genome-wide scale, identifying the authentic cis binding sites and target genes, in breast cancer cells. (nature.com)
  • in the second, we are addressing the role of a sequence-specific DNA-binding histone acetylase, Spt10p, in the cell cycle-dependent regulation of the histone genes. (nih.gov)
  • An interferon regulatory factor that binds upstream TRANSCRIPTIONAL REGULATORY ELEMENTS in the GENES for INTERFERON-ALPHA and INTERFERON-BETA . (lookformedical.com)
  • It functions as a transcriptional activator for the INTERFERON TYPE I genes. (lookformedical.com)
  • In both cases, each genetically identical cell does not turn on, or express, the same set of genes. (pressbooks.pub)
  • DDX5 is required for cell proliferation by controlling the transcription of genes expressing DNA replication proteins in cancer cells in which the DDX5 locus is amplified, and this has uncovered a dependence on DDX5 for cell proliferation. (aacrjournals.org)
  • We describe the first report of RNA sequencing of 5' capped (Pol II) RNAs isolated from acutely hepatitis C virus (HCV) infected Huh 7.5 cells that provides a general approach to identifying differentially expressed annotated and unannotated genes that participate in viral-host interactions. (mdpi.com)
  • Deletions of multiple GID subunits compromise cell proliferation, and this defect is accompanied by deregulation of critical cell cycle markers such as the retinoblastoma (Rb) tumor suppressor, phospho-Histone H3 and Cyclin A. We identify the negative regulator of pro-proliferative genes Hbp1 as a bonafide GID/CTLH proteolytic substrate. (elifesciences.org)
  • In yet another coup for a research concept known as "big data," researchers at the Stanford University School of Medicine have developed a computerized algorithm to understand the complex and rapid choreography of hundreds of proteins that interact in mindboggling combinations to govern how genes are flipped on and off within a cell. (pharmaceuticalintelligence.com)
Transcription17
  • Eukaryotic transcription is the elaborate process that eukaryotic cells use to copy genetic information stored in DNA into units of transportable complementary RNA replica. (wikipedia.org)
  • Gene transcription occurs in both eukaryotic and prokaryotic cells. (wikipedia.org)
  • A eukaryotic cell has a nucleus that separates the processes of transcription and translation. (wikipedia.org)
  • Eukaryotic transcription occurs within the nucleus where DNA is packaged into nucleosomes and higher order chromatin structures. (wikipedia.org)
  • Eukaryotic transcription proceeds in three sequential stages: initiation, elongation, and termination. (wikipedia.org)
  • Crystal structures of RNA polymerases I and II provide an opportunity to understand the interactions among the subunits and the molecular mechanism of eukaryotic transcription in atomic detail. (wikipedia.org)
  • Including the mitochondrial DNA (mtDNA) replication and transcription devices possess distinct evolutionary roots in bacteriophage8-10 whereas the mitochondrial translational equipment has a very clear evolutionary romantic relationship to bacterias11. (academicediting.org)
  • In this closed state, chromatin structure becomes an obstacle for eukaryotic transcription by impeding the interaction of RNA polymerase machinery and most transcription factors (TFs). (cytoskeleton.com)
  • This subset of transcription factors, known as pioneer transcription factors (PTFs), possess the ability to engage closed chromatin that is not accessible by other types of transcription factors, establish gene expression, and elicit cell reprogramming. (cytoskeleton.com)
  • Nrf2 is a master eukaryotic redox-active factor and belongs to Cap 'n' Collar (Cnc)-bZIP (basic leucine zipper) family of transcription factors. (springer.com)
  • In a living cell, it is unlikely that the transcription of any gene is resistant to changes in the cell cycle or in the levels of nutrients. (biomedcentral.com)
  • Animations provided deal with topics such as protein purification, transcription, splicing reactions, cell division and DNA replication and SDS-PAGE. (vet-ebooks.com)
  • Recent breakthroughs have uncovered more and more DNA replication licensing machinery proteins (ORC, Cdc6, Cdt1, geminin, etc.) functioning in other cell cycle events, including centrosome replication, mitotic events, transcription and so on. (intechopen.com)
  • PHOSPHORYLATION of IRF-3 causes the protein to be translocated from the CYTOPLASM to CELL NUCLEUS where it binds DNA , and activates transcription. (lookformedical.com)
  • A signal transducer and activator of transcription that mediates cellular responses to INTERFERONS . (lookformedical.com)
  • 7) A mutation that inactivates the regulatory gene of a repressible operon in an E. coli cell would result in A) continuous transcription of the structural gene controlled by that regulator. (easynotecards.com)
  • The download Sarkozy, Israël et by which cell transcription nurses are from an ER molecule is also thus as identified. (erik-mill.de)
Genome8
  • The complexity of the eukaryotic genome necessitates a great variety and complexity of gene expression control. (wikipedia.org)
  • What remains in human cells is a small approximately 16 kilobase circular genome which is present in cells in a vast excess of copies relative to nuclear chromosomes. (academicediting.org)
  • DNA present within cells, collectively known as the genome, is the instruction manual read by the cellular machinery to live and function. (ccmb.res.in)
  • Despite having an identical genome, cells can be regulated differently via epigenetic mechanisms that result in cell specific gene expression patterns. (ccmb.res.in)
  • Journal Article Genome Res · June 2021 Though the sequence of the genome within each eukaryotic cell is essentially fixed, it exists within a complex and changing chromatin state. (duke.edu)
  • Journal Article · June 29, 2020 AbstractThough the sequence of the genome within each eukaryotic cell is essentially fixed, it exists within a complex and changing chromatin state. (duke.edu)
  • HPV promotes latency and consequently does not cause a disease phenotype following initial infection by an immune evasion response reaction, featuring binding to epithelial cells and integrating into the host genome, resulting in the proliferation of epidermal cells containing the viral genome and neovascularization ( 3 ). (spandidos-publications.com)
  • Shortening of the 5'-terminus of the daughter strand, caused by the removal of the terminal RNA-primer and the subsequent incomplete replication of linear DNA molecules, is observed during the genome replication occurring upon cell fission. (actanaturae.ru)
Proteins16
  • We speculated that the defect of protein synthesis attenuated expression of other exoglucanases or glucan synthesis-related proteins, and then induced release of Xog1p to the cell wall. (ncl.edu.tw)
  • The tasks of mitochondrial particular ribosomal proteins aren't realized but these protein are thought to get evolved to modify the coordination of mitochondrial translation with extra-mitochondrial pathways in eukaryotic cells. (academicediting.org)
  • The nucleus-encoded proteins that define a lot of the mitochondrial proteome are translated on cytosolic ribosomes and positively brought in and sorted into mitochondrial sub-compartments by external and internal membrane translocase devices in a fashion that is dependent for the electrochemical potential14 15 Transcriptional posttranscriptional and post-translational settings of regulation can BMS-790052 be found for nucleus-encoded mitochondrial proteins. (academicediting.org)
  • Roquin proteins preclude spontaneous T cell activation and aberrant differentiation of T follicular helper (Tfh) or T helper 17 (Th17) cells. (cipsm.de)
  • In addition, numerous important cellular proteins, such as B-cell lymphoma-2 homologous antagonist/killer, Myc proto-oncogene protein, cyclin-dependent kinase inhibitor 1B, DNA replication licensing factor MCM-7, retinoblastoma 1 and Annexin A1, are degenerated through the UBE3A-mediated ubiquitin proteasome pathway ( 7 ). (spandidos-publications.com)
  • By modified iPOND (isolation of proteins on nascent DNA) assay and telomere assay, we demonstrated that the p53S could promote the recruitment of those helicases to the DNA replication forks, facilitated the maintenance of telomere, and prevent the telomere dysfunction induced by G4 stabilizer. (bvsalud.org)
  • Proteins secreted by vertebrate cells in response to a wide variety of inducers. (lookformedical.com)
  • Non-antibody proteins secreted by inflammatory leukocytes and some non-leukocytic cells, that act as intercellular mediators. (lookformedical.com)
  • Only a subset of proteins in a cell at a given time is expressed. (pressbooks.pub)
  • Whereas regulating gene expression in multicellular organisms allows for cellular differentiation, in single-celled organisms like prokaryotes, it primarily ensures that a cell's resources are not wasted making proteins that the cell does not need at that time. (pressbooks.pub)
  • Whereas events for free janes battles with the luftwaffe the bomber campaign against germany modeling are Subsequently released in the proteins, for book, models that are sample integrase and be reversible of every including event have incorrectly supported as T7 cells. (scoutconnection.com)
  • LPLI-induced cell cycle progression can be regulated by the activation or elevated expressions of cell cycle-specific proteins. (biomedcentral.com)
  • Recently, a large number of signaling proteins reported play an important key role in the process of LPLI-induced cell proliferation, probably due to the fact that the molecular events they are involved in are the basic response of the cells to extracellular stimuli. (biomedcentral.com)
  • Cellular proteostasis involves the coordinated and compensatory action of pathways that control biogenesis, folding, trafficking and breakdown of proteins allowing the cell to adapt to physiological or pathological environmental changes. (elifesciences.org)
  • Previously, researchers could only analyze two to three proteins and DNA sequences at a time, and were unable to see the true complexities of the interactions among proteins and DNA that occur in living cells. (pharmaceuticalintelligence.com)
  • The proteins of such MAPKs increased and were then repress UniProt differential download Sarkozy, Israël et whereby steps include to the spliced group before any further cell. (erik-mill.de)
Organisms4
  • A]s bacterial infections of eukaryotic cells involve two interacting organisms with profoundly different transcriptomes, RNA-seq studies are commonly restricted to either the pathogen or host after their physical separation," the authors wrote. (genomeweb.com)
  • In eukaryotic organisms, there is a multitude of specialized, differentiated cells that are formed by specific gene programs. (cytoskeleton.com)
  • Single cells and organisms may adapt to harmful oxidative stress conditions, through stress-activated factors. (springer.com)
  • Describe the general process of sexual reproduction, and how it relates to the definition of species in eukaryotic organisms. (qubeshub.org)
Gene expression6
  • Converts phosphorylated eIF-2-alpha/EIF2S1 either to a competitive inhibitor of the translation initiation factor eIF-2B, leading to a global protein synthesis repression, and thus to a reduced overall utilization of amino acids, or to a translational initiation activation of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. (avivasysbio.com)
  • The analysis of gene expression using quantitative real-time polymerase chain reaction (qPCR) has become increasingly important as biological research has focused on developing insights into the complex regulatory networks that exist within cells [ 1 ]. (biomedcentral.com)
  • it allows the simultaneous analysis of gene expression in a number of different samples and as a result of the high dynamic range, this technique is suitable even when only a few cells are available. (biomedcentral.com)
  • Using single cell genomic technologies, we analyze the gene expression and epigenetic profiles of various cells to understand cell heterogeneity. (ccmb.res.in)
  • MicroRNA (miRNA) molecules, a series of single-stranded non-coding RNA chains measuring 20-25 nucleotides in length, regulate gene expression at the transcriptional level by complementary pairing with target gene mRNA ( 5 ). (spandidos-publications.com)
  • Thus, although most regulation of gene expression occurs through transcriptional control in prokaryotes, regulation of gene expression in eukaryotes occurs at the transcriptional level and post-transcriptionally (after the primary transcript has been made). (pressbooks.pub)
Protein20
  • A novel protein call AnkA in A. phagocytophilum is translocated from the bacterium within a host vacuole into the host nucleus, where it forms complexes with heterochromatin and is largely responsible for many host transcriptional changes by directly binding to regulatory regions of the DNA. (cdc.gov)
  • Moreover, C. albicans Hom6p affects expression of the cell wall protein Xog1p which is a major exoglucanase and is found to be involved in cell adhesion. (ncl.edu.tw)
  • C. albicans Hom6p thus had an effect on cell survival and cell adhesion by maintaining protein synthesis and cell wall function. (ncl.edu.tw)
  • Transcriptional mechanisms control the synthesis of mRNA and translational mechanisms control the synthesis of protein after mRNA has been produced. (pdfcoffee.com)
  • Positive control mechanisms require the presence of an activator protein before RNA polymerase will attach. (pdfcoffee.com)
  • The activator protein itself must be bound to an inducer molecule before it attaches to mRNA. (pdfcoffee.com)
  • eIF-2-alpha kinase GCN2;Eukaryotic translation initiation factor 2-alpha kinase 4;GCN2;GCN2 eIF2alpha kinase;GCN2-like protein;general control nonderepressible 2;PVOD2. (avivasysbio.com)
  • Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2 (eIF-2-alpha/EIF2S1) on 'Ser-52' in response to low amino acid availability (PubMed:25329545). (avivasysbio.com)
  • Involved in cell cycle arrest by promoting cyclin D1 mRNA translation repression after the unfolded protein response pathway (UPR) activation or cell cycle inhibitor CDKN1A/p21 mRNA translation activation in response to amino acid deprivation (PubMed:26102367). (avivasysbio.com)
  • Journal Article Nucleic Acids Res · August 20, 2021 Chromatin is a tightly packaged structure of DNA and protein within the nucleus of a cell. (duke.edu)
  • Journal Article · June 4, 2020 AbstractChromatin is the tightly packaged structure of DNA and protein within the nucleus of a cell. (duke.edu)
  • The precise regulations of pre-RC protein levels and assembly are effective ways to prevent reassembly of de novo MCM2-7 onto the replicated origins to re-license and re-replicate the genomic DNA in the subsequent phases of the same cell cycle ( Figure 1) . (intechopen.com)
  • The overexpression of miRNA‑375 significantly increased caspase‑3 and caspase‑9 activities, induced B‑cell lymphoma 2 (Bcl‑2)/Bcl‑2‑associated X protein, tumor protein 53 and cyclin‑dependent kinase inhibitor 1 protein expression and suppressed cyclin D1 and survivin protein expression in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
  • The overexpression of miRNA‑375 significantly suppressed the levels of protein expression of ubiquitin‑protein ligase E3A (UBE3A) and Insulin‑like growth factor‑1 receptor (IGF‑1R) in HPV‑18(+) cervical cancer cells. (spandidos-publications.com)
  • UBE3A is associated with cervical cancer and may combine with the E6 proto-oncogene encoded by HPV16 within cervical cancer cells to form the E6/E6-AP protein complex through the ubiquitin proteasome pathway ( 4 ). (spandidos-publications.com)
  • Some of the tumor cells were positive for p40 and p63, and the sustentacular cells showed the expression of S-100 protein. (bvsalud.org)
  • MARV assembles and buds from the host cell plasma where MARV matrix protein (mVP40) dimers associate with anionic lipids at the plasma membrane inner leaflet and undergo a dynamic and extensive self-oligomerization into the structural matrix layer. (uci.edu)
  • DEC-205 (CD205), a member of the macrophage mannose receptor protein family, is the prototypic endocytic receptor of dendritic cells, whose ligands include phosphorothioated cytosine-guanosine (CpG) oligonucleotides, a motif often seen in bacterial or viral DNA. (uci.edu)
  • Wu then performed immunoprecipitation experiments, which use antibodies to identify protein interactions in the cell nucleus. (pharmaceuticalintelligence.com)
  • preferentially, post-translational amino-acid JmjC increases are activated provided and conserved to regulate pentose cell polysaccharides with antimicrobial program protein and Clot positions. (erik-mill.de)
Proliferation13
Regulation5
  • Lis, J. Promoter-associated pausing in promoter architecture and postinitiation transcriptional regulation. (nature.com)
  • It can influence numerous functions of the cells involved in the regulation of immune response and hematopoiesis including macrophages, dendritic cells, T lymphocytes, B lymphocytes and endothelial cells. (justia.com)
  • We hypothesized that IL-22 regulation would occur at the interface between cancer cells and immune cells. (cipsm.de)
  • Here we described a molecular strategy that cells developed to overcome the DNA replication stress via DNA helicase regulation. (bvsalud.org)
  • Gene regulation involves a complex web of interactions within a given cell among signals from the cell's environment, signalling molecules within the cell, and the cell's DNA. (pressbooks.pub)
Prokaryotic cells1
Polymerase2
  • All three eukaryotic polymerases have five core subunits that exhibit homology with the β, β', αI, αII, and ω subunits of E. coli RNA polymerase. (wikipedia.org)
  • We identify an important role for DDX5 in G 1 -S-phase progression where it directly regulates DNA replication factor expression by promoting the recruitment of RNA polymerase II to E2F-regulated gene promoters. (aacrjournals.org)
Intracellular2
  • Using an approach known as dual RNA-seq, researchers from Germany, Austria, and the US characterized host transcripts and pathogen messenger RNAs in tandem over time in a human cell line infected with Salmonella enterica from the Typhimurium serovar, an intracellular pathogen known for producing a large repertoire of small regulatory RNAs. (genomeweb.com)
  • Topics in Splines and ApplicationsDownloaded: human soluble cells for comparable patients and intracellular experiments are as developed HIV-infected Adenine in other and dynamic aspects. (scoutconnection.com)
Initiation3
Mitochondrial biogenesis1
  • Herein, we address the complex crosstalk that involves mitochondrial biogenesis, mitochondrial destabilization accompanied by mitophagy, and cell death. (hindawi.com)
Occurs3
Pathway3
  • Examples of signal transduction systems are the GAMMA-AMINOBUTYRIC ACID-postsynaptic receptor-calcium ion channel system, the receptor-mediated T-cell activation pathway, and the receptor-mediated activation of phospholipases. (lookformedical.com)
  • To conclude, it was identified that the probable anti‑CA mechanism of miRNA‑375 modulates HPV through the UBE3A and IGF‑1R pathway in cervical cancer cells. (spandidos-publications.com)
  • cycle, lymphoblastic pathway, and Replication plasma as Strategic Technology Director at actin. (erik-mill.de)
Bacterial4
  • In an effort to simultaneously assess coding and non-coding transcripts in a bacterial pathogen and affected host, the researchers relied on dual RNA-seq, a strategy that uses green fluorescent-tagged Salmonella to identify infected human host cells from a HeLa cell line. (genomeweb.com)
  • The origin from the mitochondrial proteome can be an assortment of 'older' bacterial and 'fresh' eukaryotic-derived proteins2. (academicediting.org)
  • Similarly, all cells in two pure bacterial cultures inoculated from the same starting colony contain the same DNA, with the exception of changes that arise from spontaneous mutations. (pressbooks.pub)
  • Similarly, how is it that the same bacterial cells within two pure cultures exposed to different environmental conditions can exhibit different phenotypes? (pressbooks.pub)
Molecular3
  • These potent effects are driven by curcumin's ability to induce G2/M cell cycle arrest, induce autophagy, activate apoptosis, disrupt molecular signaling, inhibit invasion and metastasis, and increase the efficacy of current chemotherapeutics. (hindawi.com)
  • The estrogen receptor is the master transcriptional regulator of breast cancer phenotype and the archetype of a molecular therapeutic target. (nature.com)
  • Specific molecular sites or structures on or in cells with which interferons react or to which they bind in order to modify the function of the cells. (lookformedical.com)
Gcn41
  • In the absence of the Gcn4 activator, the HIS3 gene is organized into a dominant nucleosomal array. (nih.gov)
HeLa1
  • The addition of a cloned and purified recombinant PLD to HeLa cells resulted in substantial remodeling of the host membrane architecture, as measured by lipid raft formation. (cdc.gov)
Genetic1
Chromatin5
Receptor2
  • Figure 7: Assessment of estrogen receptor binding properties in different cell systems. (nature.com)
  • A expression V load is the package to exist to a eukaryotic receptor code. (scoutconnection.com)
Tumor cells3
  • A cell line derived from cultured tumor cells. (lookformedical.com)
  • Previous studies have identified that UBE3A exhibits abnormal expression in numerous tumor cells, including prostate, cervical and breast cancer ( 6 , 7 ). (spandidos-publications.com)
  • Microscopically, the tumor cells were arranged in solid, nested or lobulated patterns with occasional palisading around the solid nests. (bvsalud.org)
Distinct1
  • Competing occupation for the sinks by different sources leads to distinct states of genomic equilibrium in differentiated cells. (biologists.com)
MRNA2
  • We speculate that by coupling RNA processing to the status and activity of Pol II itself, the cell ensures that nascent RNA is properly protected from degradation and efficiently matures into a functional mRNA. (nature.com)
  • impairs early viral mRNA translation of the incoming genomic virus RNA, thus preventing alphavirus replication (By similarity). (avivasysbio.com)
Induces1
  • The G-rich DNA, such as telomere, tends to form G-quadruplex (G4) structure, which slows down the replication fork progression, induces replication stress, and becomes the chromosome fragile sites. (bvsalud.org)
Mitosis2
  • Cancer cells have lost their ability to regulate mitosis, resulting in uncontrolled cell division. (pdfcoffee.com)
  • This mode of cell death serves as a balance to mitosis in regulating the size of animal tissues and in mediating pathologic processes associated with tumor growth. (lookformedical.com)
Infection4
  • In the process, they narrowed in on a small RNA called PinT that is activated by Salmonella upon host cell infection. (genomeweb.com)
  • After isolating cells four hours and 24 hours post-infection, the team used the Illumina HiSeq 2000 instrument to generate tens of millions of reads from total RNA present in the samples. (genomeweb.com)
  • Cell adhesion is the first step in C. albicans infection of epithelia. (ncl.edu.tw)
  • Host transcriptional response to SARS-CoV-2 infection in COVID-19 patients. (ccmb.res.in)
RNAs4
  • More abundantly made are the so-called non-coding RNAs account for the large majority of the transcriptional output of a cell. (wikipedia.org)
  • But PinT also appears to influence host transcriptional patterns, leading to shifts in representation by several long, non-coding RNAs as well as enhanced activation of JAK-STAT signaling pathways. (genomeweb.com)
  • These human RNAs Do a removing download Ethos and see cities, overhangs, cells, ATPases operators, 7SL RNA, 7SK RNA, the RNA cell of RNase transfer RNA, the RNA number of RNase MRP, and the RNA molecule of conservation. (evakoch.com)
  • longitudinal contradictions use a free janes battles to be points of alternative tissues and RNAs on prediction P and modification with observations rational in recipients eukaryotic to outcomes on containing. (scoutconnection.com)
Apoptosis1
  • Apoptosis is the mechanism responsible for the physiological deletion of cells and appears to be intrinsically programmed. (lookformedical.com)
Recruitment1
  • Journal Article · November 18, 2021 ABSTRACTOrigins of DNA replication are specified by the ordered recruitment of replication factors in a cell cycle dependent manner. (duke.edu)
Epithelial1
  • We find that the DDX5 locus is frequently amplified in breast cancer and that breast cancer-derived cells with amplification of DDX5 are much more sensitive to its depletion than breast cancer cells and a breast epithelial cell line that lacks DDX5 amplification. (aacrjournals.org)
Membrane1
  • Both PLD and ALN are membrane-active toxins and contribute to the adhesion and invasion of A. hemolyticum to host cells. (cdc.gov)
Regulates1
  • In addition to antiviral activity, it activates NATURAL KILLER CELLS and B-LYMPHOCYTES , and down-regulates VASCULAR ENDOTHELIAL GROWTH FACTOR expression through PI-3 KINASE and MAPK KINASES signaling pathways. (lookformedical.com)
Functions3
  • ATP production their overall form and composition have been drastically altered and they have acquired myriad additional functions within the cell. (academicediting.org)
  • The electrochemical potential is harnessed for additional crucial mitochondrial functions such as buffering the signalling ion BMS-790052 Ca2+ through uptake by a uniporter in the inner membrane3 4 A reduction in the electrochemical potential of mitochondria in cells has evolved like a read-out for mitochondrial practical position which as talked about later creates indicators to activate pathways that restoration and/or eliminate faulty mitochondria. (academicediting.org)
  • The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. (lookformedical.com)
Absence2
  • Local nucleosome dynamics and eviction following a double-strand break are reversible by NHEJ-mediated repair in the absence of DNA replication. (duke.edu)
  • Somatic cells are usually characterized by the absence of telomerase activity. (actanaturae.ru)
Calcium2
  • At higher doses, cells undergo mitochondrial destabilization due to calcium release from the endoplasmic reticulum, and die. (hindawi.com)
  • Computer ScienceOverviewComputer Vision is a public and so describing calcium with eukaryotic cIAP2 cataracts that are initiated connected in new Defects. (erik-mill.de)
Tissues1
  • The light must be absorbed by the endogenous chromophores of cells or tissues for actions. (biomedcentral.com)
Subunits2
  • An identical ω-like subunit (RBP6) is used by all three eukaryotic polymerases, while the same α-like subunits are used by Pol I and III. (wikipedia.org)
  • The three eukaryotic polymerases share four other common subunits among themselves. (wikipedia.org)
Expression3
  • It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES. (lookformedical.com)
  • Expression of phosphorylation-defective PLIN5 S155A in Plin5 null cells resulted in decreased rates of lipolysis and triglyceride-derived fatty acid oxidation. (uci.edu)
  • Beyond this protective role, Mrr can inflict chromosomal DNA damage that elicits the SOS response in the host cell upon heterologous expression of specific methyltransferases such as M.HhaII, or after exposure to high pressure (HP). (uci.edu)
Chromosome1
  • It was revealed as early as in the 1930s that the behavior of the whole chromosome and its fragments in cells varies. (actanaturae.ru)
Regulatory1
  • Here we showed that deletion of Roquin-encoding alleles specifically in regulatory T (Treg) cells also caused the activation of conventional T cells. (cipsm.de)
Host1
  • The invention also relates to nucleic acid constructs, vectors, and host cells comprising the nucleic acid sequences as well as methods for producing the trichodiene synthases. (justia.com)
Response2
  • Plays a role as an activator of the integrated stress response (ISR) required for adapatation to amino acid starvation. (avivasysbio.com)
  • Frequently, low doses of natural chemical products activate an adaptive stress response, whereas high doses activate acute responses like autophagy and cell death. (hindawi.com)
Cycle1
  • Our biochemical and cellular analysis thus demonstrates that the GID/CTLH complex prevents cell cycle exit in G1, at least in part by degrading Hbp1. (elifesciences.org)
Processes1
Initiates1
  • Curcumin causes cell death and primarily initiates an autophagic step (mitophagy). (hindawi.com)
Subset1
  • Given the high frequency of DDX5 amplification in breast cancer, our results highlight DDX5 as a promising candidate for targeted therapy of breast tumors with DDX5 amplification, and indeed we show that DDX5 inhibition sensitizes a subset of breast cancer cells to trastuzumab. (aacrjournals.org)
Nutrient1
  • The UPS is also required for cells to adjust to different nutrient conditions such as limiting carbon sources. (elifesciences.org)