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Transcription FactorsTranscription, GeneticPromoter Regions, GeneticDNA-Binding ProteinsGene Expression RegulationMolecular Sequence DataSp1 Transcription FactorBase SequenceTranscriptional ActivationTrans-ActivatorsBinding SitesRNA, MessengerProtein BindingNuclear ProteinsTranscription Factor AP-1Cell LineRepressor ProteinsBasic Helix-Loop-Helix Transcription FactorsAmino Acid SequenceSignal TransductionDNAMutationHomeodomain ProteinsGene Expression Regulation, DevelopmentalForkhead Transcription FactorsSp3 Transcription FactorTransfectionSTAT3 Transcription FactorCell NucleusBasic-Leucine Zipper Transcription FactorsTranscription Factor AP-2Transcription Initiation SiteGenes, ReporterHeLa CellsTranscription Factors, TFIICells, CulturedCell DifferentiationChromatin ImmunoprecipitationTranscription Factor TFIIDKruppel-Like Transcription FactorsRNA Polymerase IIReverse Transcriptase Polymerase Chain ReactionPlasmidsCloning, MolecularYY1 Transcription FactorRegulatory Sequences, Nucleic AcidElectrophoretic Mobility Shift AssayEnhancer Elements, GeneticNF-kappa BNFATC Transcription FactorsRecombinant Fusion ProteinsTranscription Factor TFIIBGATA4 Transcription FactorZinc FingersActivating Transcription Factor 3Gene ExpressionActivating Transcription Factor 2Gene Expression Regulation, FungalGene Expression ProfilingSTAT1 Transcription FactorPaired Box Transcription FactorsPhosphorylationLuciferasesE2F1 Transcription FactorProtein Structure, TertiarySaccharomyces cerevisiaeChromatinBasic Helix-Loop-Helix Leucine Zipper Transcription FactorsSaccharomyces cerevisiae ProteinsCell Line, TumorDNA-Directed RNA PolymerasesGene Expression Regulation, BacterialMEF2 Transcription FactorsTCF Transcription FactorsGATA1 Transcription FactorTATA BoxSequence Homology, Amino AcidGATA3 Transcription FactorGATA2 Transcription FactorGATA Transcription FactorsTumor Cells, CulturedModels, BiologicalBlotting, WesternActivating Transcription FactorsTranscription Factor RelATissue Plasminogen ActivatorOligonucleotide Array Sequence AnalysisDown-RegulationMicrophthalmia-Associated Transcription FactorCyclic AMP Response Element-Binding ProteinE2F Transcription FactorsModels, GeneticBacterial ProteinsProto-Oncogene ProteinsHelix-Loop-Helix MotifsProto-Oncogene Proteins c-junMice, KnockoutHistonesGene Expression Regulation, PlantUp-Regulation
Cyclin dependent kinaseInhibitorGenesProteinsProto-oncogeneProteinActivatesCREBNuclear factorGene expressionRegulationTumorVirulenceRegulatesHelicaseCellHumansTargetCellsSiteFamilyDownloadSourceSpecificityRepressorMediateSubunitZinc-finger transcriptionBasalRegulate transcriptionReceptorOsteoblastsTranscriptionalRecruitmentVEGFChromosomeEstrogenEnzymeHumanSurvivalExpressionStudiesDevelopmentGrowth
Cyclin dependent kinase1
  • This was accompanied by increased manifestation of cyclin-dependent kinase inhibitor p27 with Sp3 knockdown [54-56]. (tam-receptor.com)
Inhibitor3
  • In the present study, autophagy activator and inhibitor were used to demonstrate the impact of autophagy on the catabolic effect induced by TNF‑α. (spandidos-publications.com)
  • In addition, nuclear factor κB (NF‑κB), c‑Jun N‑terminal kinase (JNK), extracellular signal‑regulated kinases and p38 mitogen‑activated protein kinase inhibitors and TNF‑α were used to determine the molecular mechanism of autophagy during the inflammatory conditions, and only the NF‑κB and JNK inhibitor were found to enhance the autophagy of rat NP cells. (spandidos-publications.com)
  • Chlorambucil-conjugated PI-polyamides (Chb-M'), a transcription inhibitor of RUNX family, has an anti-tumor activity against SHH-type medulloblastoma with p53 mutation. (atlasgeneticsoncology.org)
Genes7
  • Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. (wikipedia.org)
  • Gene transcription is mainly regulated by transcription factors (TFs) that bind to specific DNA sequences (called motifs) located in the promoter regions of genes [ 1 ]. (biomedcentral.com)
  • PGCs express several pluripotency-related TFs such as NANOG, POU5F3 , and SOX2 , and their expression controls transcription of germness-related genes in these cells [ 11 , 29 ]. (biomedcentral.com)
  • transcription factor (activator) for various hematopoietic-specific genes. (atlasgeneticsoncology.org)
  • Upon binding of the estrogen ligand, the receptor is translocated to the nucleus and binds to the DNA of target genes that promote tumorigenesis but also regulate transcription of the receptor itself [ 1 ]. (oncotarget.com)
  • To this effect our laboratory has focused on specificity protein (Sp) transcription factors (TFs) since Sp1 and additional Sp TFs regulate manifestation of multiple genes that are important for malignancy cell growth and survival and Sp TFs can be efficiently targeted by numerous anti-cancer providers. (tam-receptor.com)
  • Ethyl 2-((2 3 bis(nitrooxy)propyl)disulfanyl)benzoate (GT-094) a novel nitro-NSAID induced ROS and decreased mitochondrial membrane potential (MMP) in SW480 and RKO colon cancer cells and treatment with antioxidants GSH and DTT inhibited ROS generation prevented the loss of MMP and reversed the effects on downregulation of Sp1 Sp3 and Sp4 proteins and Sp dependent genes [42]. (tam-receptor.com)
Proteins2
  • The transcription factors, stimulatory proteins 1 and 3 (Sp1 and Sp3), nuclear factor Y (NF-Y), upstream stimulatory factor (USF) and sterol regulatory element binding protein-1 (SREBP-1) have cognate binding sites on the promoter of the FAS gene. (hw.ac.uk)
  • RNA interference (RNAi) studies carried out in pancreatic malignancy cells shows that Sp1 Sp3 and Sp4 proteins are involved in VEGF VEGFR1 and VEGFR2 manifestation and knockdown of Sp1 Sp3 and Sp4 by RNAi also affected pancreatic malignancy cell growth and cell cycle progression with a decreased percentage of cells in G2/M and S and improved percentage of cells in G0/G1 phase. (tam-receptor.com)
Proto-oncogene1
  • Here we describe the role of BCL9-2, a proto-oncogene previously characterized as co-activator of Wnt/ß-catenin signaling, for mammary tumorigenesis in mice and human. (oncotarget.com)
Protein3
  • Helicobacter pylori activates the histidine decarboxylase promoter through a mitogen-activated protein kinase pathway independent of pathogenicity island-encoded virulence factors. (mpg.de)
  • Reverse transcription quantitative PCR results demonstrated high expression of an actin-binding Rho-activating protein in the latter stages of virus-infected cells, and molecular docking, cell transfection and coimmunoprecipitation experiments confirmed that it interacted with the ORF55 protein. (biomedcentral.com)
  • One of the most important regulators of ER transcription is Sp1 (specificity protein 1) that is overexpressed in human ER positive (ER+) breast cancers [ 4 ]. (oncotarget.com)
Activates1
  • p21-activated kinase 1 activates the nuclear factor kappa B (NF-kappa B)-inducing kinase-I kappa B kinases NF-kappa B pathway and proinflammatory cytokines in Helicobacter pylori infection. (mpg.de)
CREB1
  • Helicobacter pylori stimulates host cyclooxygenase-2 gene transcription: critical importance of MEK/ERK-dependent activation of USF1/-2 and CREB transcription factors. (mpg.de)
Nuclear factor3
  • Nuclear factor-kappa B directs carcinoembryonic antigen-related cellular adhesion molecule 1 receptor expression in Neisseria gonorrhoeae-infected epithelial cells. (mpg.de)
  • Nuclear factor-kappa B activation and innate immune response in microbial pathogen infection. (mpg.de)
  • In cultured keratinocytes, CWO stimulated calcium signaling, resulting in calcineurin-dependent activation of nuclear factor of activated T cells (NFAT). (biorxiv.org)
Gene expression2
  • Helicobacter pylori stimulates host vascular endothelial growth factor-A (vegf-A) gene expression via MEK/ERK-dependent activation of Sp1 and Sp3. (mpg.de)
  • The factors responsible for the postnatal and starvation-associated induction of HMGCS2 gene expression have been identified and shown to involve changes in circulating hormone and fatty acid levels. (aacrjournals.org)
Regulation3
  • cAMP regulation is mediated via the inverted CAAT element (ICE) at -99 to -92, which binds NF-Y. The FAS insulin-responsive element 3 (FIRE3)-binding site at -71 to -52 is capable of binding NF-Y, USF and SREBP-1, and is required for the sterol response in conjunction with the co-activator NF-Y around -100. (hw.ac.uk)
  • Regulation of the NANOG gene by TFs, epigenetic factors, and autoregulatory factors is well characterized in ESCs, and transcriptional regulation of NANOG is well established in these cells. (biomedcentral.com)
  • Currently, 17 murine and human KLFs are known to play crucial roles in the regulation of transcription, cell proliferation, cellular differentiation, stem cell maintenance, and tissue and organ pathogenesis. (mdpi.com)
Tumor4
  • The constitutive photomorphogenesis 9 signalosome directs vascular endothelial growth factor production in tumor cells. (mpg.de)
  • Proteoglycan degradation contributing to the pathogenesis of intervertebral disc (IVD) degeneration is induced by inflammatory cytokines, such as tumor necrosis factor‑α (TNF‑α) and interleukin‑1β (IL‑1β). (spandidos-publications.com)
  • Inflammatory cytokines, such as tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), are highly expressed in degenerative IVDs and contribute to a degenerative IVD phenotype by inhibiting the production of ECM ( 3 , 4 ). (spandidos-publications.com)
  • Evidence from studies carried out in this laboratory and others show that Sp transcription factors are overexpressed in several tumor cell lines including colon bladder pancreatic prostate breast thyroid and esophageal malignancy cell lines and play a crucial part in tumor growth development and metastasis Semagacestat [48-53]. (tam-receptor.com)
Virulence1
  • The CyHV-2 gene encoding thymidine kinase (TK) is an important virulence-associated factor. (biomedcentral.com)
Regulates2
  • Therefore, we investigated the mechanism that regulates transcription of the chicken NANOG ( cNANOG) gene in PGCs and ESCs. (biomedcentral.com)
  • Finally, we describe a novel mechanism, how BCL9-2 regulates ER transcription by interaction with Sp1 through the proximal ESR1 gene promoter. (oncotarget.com)
Helicase1
  • Helicase-like transcription factor is an enzyme that in humans is encoded by the HLTF gene. (wikipedia.org)
Cell4
  • The primary microRNA (Pri-miRNA) is produced in the cell nucleus through the transcription of a DNA strand mediated by RNA polymerase II [ 2 ]. (archivesofmedicalscience.com)
  • Furthermore, small interfering RNA-mediated knockdown demonstrated that POU5F3 , SOX2 , and CEBP played a role in cell type-specific transcription of cNANOG . (biomedcentral.com)
  • We show for the first time that different trans -regulatory elements control transcription of cNANOG in a cell type-specific manner. (biomedcentral.com)
  • Similarly ascorbic acid (vitamin C) which induced hydrogen peroxide decreased SW480 and RKO colon cancer cell proliferation and induced apoptosis and necrosis and this was accompanied by downregulation of Sp1 Sp3 and Sp4. (tam-receptor.com)
Humans1
  • In the present study we used Affymetrix oligonucleotide microarrays to produce gene transcription profiles for the major leukocyte types in humans. (gsea-msigdb.org)
Target1
  • R CH2-C6H5 : 2-(benzylethylamino)-1-(3- hydroxyphenyl)ethanone (benzyletilefrone), B. BeginProcessRequest: Preparing to invoke the BeginXXX web method on the web service else { Create an instance of the web service IDisposable target Activator. (banglaforexacademy.com)
Cells1
  • NANOG is a core transcription factor (TF) in embryonic stem cells (ESCs) and primordial germ cells (PGCs). (biomedcentral.com)
Site2
  • Competitive gel shift and supershift assays indicated that Sp2 and Sp3 were bound to an Sp1 site (-40/-31), and activating transcription factor-2 and c-Jun were bound to a CRE site. (eurekamag.com)
  • We first identified the transcription start site of cNANOG by 5′-rapid amplification of cDNA ends PCR analysis. (biomedcentral.com)
Family2
  • Sp Transcription Factors Members of the Sp/KLF family have a highly conserved DNA binding website that consists of three contiguously placed C2H2-type zinc fingers that are located in the C-terminal region. (tam-receptor.com)
  • Members of the family bind to GC boxes (GGGGCGGGG) GT/CACCC Semagacestat boxes (GGTGTGGGG) and fundamental transcription elements to regulate gene transcription [44-47]. (tam-receptor.com)
Download1
  • If you want to create only single installation disk of all the previous updates including SP3, go to this link to download an ISO image. (club1.com.ua)
Source1
Specificity3
  • Involvement of a specificity proteins-binding element in regulation of basal and estrogen-induced transcription activity of the BRCA1 gene. (nih.gov)
  • Background Curcumin inhibits development of several cancer tumor cell lines and research in this lab in bladder and pancreatic LY-411575 cancers cells present that curcumin downregulates specificity proteins (Sp) transcription elements Sp1 Sp3 and Sp4 and pro-oncogenic Sp-regulated genes. (health-ground.com)
  • Curcumin and RL197 inhibited RKO and SW480 cancer of the colon cell development and induced apoptosis which was followed by downregulation of specificity proteins (Sp) transcription elements Sp1 Sp3 and Sp4 and Sp-regulated genes like the epidermal development aspect receptor (EGFR) hepatocyte development element receptor (c-MET) survivin bcl-2 cyclin D1 and NFκB (p65 and p50). (health-ground.com)
Repressor1
  • Transcriptional factor that can act as an activator or repressor depending on isoform and/or post-translational modifications. (nih.gov)
Mediate1
Subunit2
  • 4. Laminin reduces expression of the human alpha6 integrin subunit gene by altering the level of the transcription factors Sp1 and Sp3. (nih.gov)
  • 16. Regulation of the integrin subunit alpha5 gene promoter by the transcription factors Sp1/Sp3 is influenced by the cell density in rabbit corneal epithelial cells. (nih.gov)
Zinc-finger transcription1
  • We show that two closely related buttonhead -like zinc-finger transcription factors, Sp8 and Sp9 , are expressed in the AER, and regulate Fgf8 expression and limb outgrowth. (biologists.com)
Basal2
  • 2. Sp1/Sp3 and DNA-methylation contribute to basal transcriptional activation of human podoplanin in MG63 versus Saos-2 osteoblastic cells. (nih.gov)
  • 9. Sp1 and Sp3 regulate the basal transcription of receptor activator of nuclear factor kappa B ligand gene in osteoblasts and bone marrow stromal cells. (nih.gov)
Regulate transcription2
  • Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. (wikipedia.org)
  • This gene belongs to a family of Sp1 related genes that encode transcription factors that regulate transcription by binding to consensus GC- and GT-box regulatory elements in target genes. (nih.gov)
Receptor2
  • 12. Gene expression of the human glucagon-like peptide-1 receptor is regulated by Sp1 and Sp3. (nih.gov)
  • 15. Sp1-mediated transcriptional control of fibroblast growth factor receptor 4 in sarcomas of skeletal muscle lineage. (nih.gov)
Osteoblasts2
  • 7. Sp1/Sp3 and the myeloid zinc finger gene MZF1 regulate the human N-cadherin promoter in osteoblasts. (nih.gov)
  • 10. Control of Fiat (factor inhibiting ATF4-mediated transcription) expression by Sp family transcription factors in osteoblasts. (nih.gov)
Transcriptional1
  • The C-terminal domain is required for the transcriptional activation of the sodium-dependent bile acid co-transporter (NTCP) gene and is therefore likely to be required for the activation of transcription in other contexts [ 28 , 29 ]. (biomedcentral.com)
Recruitment1
  • We previously reported that estrogen stimulated BRCA1 transcription through the recruitment of a p300/ER-alpha complex to an AP-1 site harbored in the proximal BRCA1 promoter. (nih.gov)
VEGF1
  • Other studies in colon cancer cells report similar responses and also show downregulation of cyclin D1 bcl-2 VEGF and p65 (NFκB) and other pro-oncogenic factors [15-19]. (health-ground.com)
Chromosome1
  • Transcription factor Sp1 regulates mitotic chromosome assembly and segregation. (nih.gov)
Estrogen1
  • Increased estrogen level has been regarded to be a risk factor for breast cancer. (nih.gov)
Enzyme2
  • Helicase-like transcription factor is an enzyme that in humans is encoded by the HLTF gene. (wikipedia.org)
  • lysosomal enzyme trafficking factor [S. (gsea-msigdb.org)
Human2
  • 1. Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells. (nih.gov)
  • 8. Sp1 and Sp3 transcription factors upregulate the proximal promoter of the human prostate-specific antigen gene in prostate cancer cells. (nih.gov)
Survival1
  • Profiling of multiple survival factors identified a critical role for the BH3-only member Bcl-2-modifying factor (Bmf). (oregonstate.edu)
Expression1
Studies1
  • 2011 . Coffee, broccoli and spices are strong inducers of electrophile response element-dependent transcription in vitro and in vivo-studies in electrophile response element transgenic mice. (nih.gov)
Development1
  • Curcumin and RL197 also induced reactive air varieties (ROS) and cotreatment using the antioxidant glutathione considerably attenuated curcumin- and RL197-induced development inhibition and downregulation of Sp1 Sp3 Sp4 and Sp-regulated genes. (health-ground.com)
Growth2