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Cyclin-Dependent KinasesCyclin-Dependent Kinase 2Cyclin D1CyclinsCyclin ECyclin ACyclin-Dependent Kinase 4CDC2-CDC28 KinasesCyclin-Dependent Kinase Inhibitor p27Protein-Serine-Threonine KinasesCyclin-Dependent Kinase 5Cell CycleCyclin-Dependent Kinase Inhibitor p21Cell Cycle ProteinsCDC2 Protein KinaseCyclin BCyclin CG1 PhaseCyclin DPhosphorylationProtein KinasesProtein Kinase InhibitorsPhosphatidylinositol 3-KinasesCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor ProteinsMAP Kinase Signaling SystemCyclin D3Cyclin-Dependent Kinase 6Cyclin B1Retinoblastoma ProteinTumor Suppressor ProteinsS PhaseCyclin-Dependent Kinase Inhibitor p57Calcium-Calmodulin-Dependent Protein KinasesProto-Oncogene ProteinsCyclin D2Cell DivisionApoptosisMicrotubule-Associated ProteinsCell ProliferationCyclin A1Signal TransductionPurinesCell Line, Tumorsrc-Family KinasesTumor Cells, CulturedCells, CulturedBlotting, WesternProtein Kinase CMolecular Sequence DataMitosisEnzyme InhibitorsTransfectionMutationE2F1 Transcription FactorCyclin A2Cell LineCyclin GTumor Suppressor Protein p53p38 Mitogen-Activated Protein KinasesDNA-Binding ProteinsCyclic AMP-Dependent Protein KinasesCyclin G1Mitogen-Activated Protein Kinase 1Base SequenceG2 PhaseTranscription Factor DP1RNA, MessengerCarrier ProteinsTranscription FactorsMitogen-Activated Protein Kinase KinasesJNK Mitogen-Activated Protein KinasesNuclear Proteinsp21-Activated KinasesProtein BindingMitogen-Activated Protein Kinase 3Protein-Tyrosine KinasesE2F Transcription FactorsEnzyme ActivationAmino Acid SequenceProliferating Cell Nuclear AntigenMAP Kinase Kinase KinasesCreatine KinaseTranscription, GeneticGene Expression RegulationReverse Transcriptase Polymerase Chain ReactionKineticsImmunohistochemistryeIF-2 KinaseCasein Kinase IIRibosomal Protein S6 KinasesCasein KinasesMAP Kinase Kinase 1Mitogen-Activated Protein KinasesTissue Plasminogen ActivatorPyruvate KinaseExtracellular Signal-Regulated MAP KinasesAntineoplastic AgentsRecombinant Fusion ProteinsBinding Sites

SubunitSerineNeuronalPhosphorylationNeuron-specific activatorInhibitionNeuronsTyrosine kinaseCDK5R2CDK5R1InhibitorPrognosticProteinsGeneReceptorPathwayPhosphorylatesLocalizationVivoCohortFamilyGammaSynapticAuroraEfficacyRegulatesSuggestsGSK3ProgressionActivationProcessesShownExpressionCellsActiveSourceTreatment

Subunit2

• Assignment of CDK5R2 coding for the cyclin-dependent kinase 5, regulatory subunit 2 (NCK5AI protein) to human chromosome band 2q35 by fluorescent in situ hybridization. (nih.gov)
• It is a catalytic subunit of the protein kinase complex that is important for cell cycle G1 phase progression. (thermofisher.com)

Serine3

• Cdk5 is named after its structural similarity to members of the serine/threonine cyclin-dependent kinase family. (frontiersin.org)
• Cyclin-dependent kinase 5 (Cdk5) is a proline-directed serine/threonine kinase that belongs to the CDK family and is expressed primarily in the central nervous system. (biomedcentral.com)
• Sema 3A mediated retraction appears to be related to its binding to Npn 1 and Plxn A2 receptors, thus activating the downstream Fyn tyrosine kinase pathway that promotes the threonine-serine kinase cyclin-dependent kinase 5, CDK5, phosphorylation at the Tyr15 residue and the CDK5 processing to generate the active fragment p35. (biomedcentral.com)

Neuronal1

• Synaptic localization of p39, a neuronal activator of cdk5. (nih.gov)

Phosphorylation9

• Thus, Cdk5 regulation of TRPV1 membrane trafficking is a fundamental mechanism controlling the heat sensitivity of nociceptors, and moderate inhibition of Thr-506 phosphorylation during inflammation might be helpful for the treatment of inflammatory thermal pain. (bvsalud.org)
• Inhibition of Cdk5 by olomoucine enhanced phosphorylation of kinesin, suggesting that the effect was mediated by negative regulation of other kinases. (frontiersin.org)
• Altered phosphorylation of CREB phosphopeptide, a substrate of GSK3β, suggested that GSK3β may be the mediator of Cdk5 activity in kinesin-mediated axonal transport. (frontiersin.org)
• Inhibition of Cdk5 resulted in dephosphorylation of the inhibitory Ser9 site on GSK3β and an increase of activating phosphorylation at Tyr216. (frontiersin.org)
• This kinase was shown to be responsible for the phosphorylation of retinoblastoma gene product (Rb). (thermofisher.com)
• CVT-313 treatment reduced cdk2-mediated phosphorylation of the retinoblastoma gene product (Rb) on T821, but did not affect cyclin D-cdk4/6-mediated Rb phosphorylation on S807/811. (omecamtivmecarbilactivator.com)
• Here DARPP-32 phosphorylation by protein kinase A (PKA), DARPP-32 into a powerful protein phosphatase 1 (PP1) inhibitor. (pp1a.com)
• DARPP-32 can itself inhibit the following PKA DARPP-32 phosphorylation by cyclin-dependent kinase 5 (Cdk5). (pp1a.com)
• Mechanistic investigations revealed reduce GR-Ser211 phosphorylation following PP1α silencing and provide the first indication of the involvement of glycogen synthase kinase 3 (GSK-3). (pp1a.com)

Neuron-specific activator2

• The protein encoded by this gene is a neuron-specific activator of CDK5 kinase. (nih.gov)
• Cdk5 is activated by complexing with neuron-specific activator molecules such as p35 and p39. (biomedcentral.com)

Inhibition3

• Overexpression of Cdk5 or its activator p35 promoted and inhibition of Cdk5 activity prevented the KIF13B-TRPV1 association, indicating that Cdk5 promotes TRPV1 anterograde transport by mediating the motor-cargo association. (bvsalud.org)
• The molecular mechanism underlying the NPR-A dependent inhibition of TG P2X3 receptor function remains unclear. (biomedcentral.com)
• Sustained canonical Wnt signaling requires the inhibition of glycogen synthase kinase 3 (GSK3) activity by sequestration of GSK3 inside multivesicular endosomes (MVEs). (shengsci.com)

Neurons5

• Besides sharing both up- and downstream pathways, Cdk5 and GSK3β are linked more directly in neurons. (frontiersin.org)
• using cultured neurons: Their investigations to determine a regulatory pathway for kinesin-driven motility in axons revealed that Cdk5 is neccessary for kinesin-driven motility within the axon but cannot directly phosphorylate kinesin. (frontiersin.org)
• These results indicated that Cdk5/p35 in excitatory neurons is important for the hippocampal synaptic plasticity and associative memory retention. (biomedcentral.com)
• Using behavioral and electrophysiological analyses, we investigate whether the p35/Cdk5 activity is involved in associative memory learning in excitatory or inhibitory neurons. (biomedcentral.com)
• Hyperactive Innate Immunity Causes Degeneration of Dopamine Neurons upon Altering Activity of Cdk5. (shengsci.com)

Tyrosine kinase3

• Bruton tyrosine kinase [Source:HGNC. (gsea-msigdb.org)
• Immunotherapy (IO) plus tyrosine kinase inhibitor (TKI) has become the first-line treatment for advanced renal cell carcinoma, despite the lack of prognostic biomarkers. (e-crt.org)
• Recently, clinical trials of immune checkpoint inhibitor plus vascular endothelial growth factor receptor-tyrosine kinase inhibitor (TKI) for mRCC have exhibited outstanding efficacies [ 3 - 5 ]. (e-crt.org)

CDK5R21

• Cyclin-dependent kinase 5 activator 2 is an enzyme that in humans is encoded by the CDK5R2 gene. (wikipedia.org)

CDK5R12

• This protein and neuron-specific CDK5 activator CDK5R1/p39NCK5A both share limited similarity to cyclins, and thus may define a distinct family of cyclin-dependent kinase activating proteins. (nih.gov)
• CDK5R1 - cyclin-dependent kinase 5, regulatory. (wikigenes.org)

Inhibitor2

• The activity of this kinase is restricted to the G1-S phase, which is controlled by the regulatory subunits D-type cyclins and CDK inhibitor p16(INK4a). (thermofisher.com)
• An inhibitor of cGMP-dependent protein kinase and siRNA-mediated knockdown of BNP mimicked the effect of anantin. (biomedcentral.com)

Prognostic1

• These data demonstrate the role of DARPP-32 and related kinase signaling as a prognostic marker in ovarian cancer clinical utility. (pp1a.com)

Proteins1

• Mutations in this gene as well as in its related proteins including D-type cyclins, p16(INK4a) and Rb were all found to be associated with tumorigenesis of a variety of cancers. (thermofisher.com)

Gene1

• This gene encodes a member of the trithorax group of transcriptional activators. (cancerindex.org)

Receptor2

• These diverse actions of glucocorticoids are mediated by the glucocorticoid receptor (GR), which belongs to the nuclear receptor superfamily and functions as a hormone-dependent transcription factor. (brainimmune.com)
• By acting as a ligand-dependent transcription factor of the glucocorticoid receptor (GR) mediates the action of glucocorticoids and regulates many physiological processes. (pp1a.com)

Pathway2

• After vascular complex pathway is caused on a Electrical snRNP, MAML( other) radicals direct in brain with cyclin C, including protein of followed high-affinity ligands in TAD and PEST cilia of NICD1 by CDK8. (evakoch.com)
• Here, we identify a molecular pathway that links innate immunity to age-dependent l. (shengsci.com)

Phosphorylates1

• Cdk5 phosphorylates KIF13B at Thr-506, a residue located in the FHA domain. (bvsalud.org)

Localization1

• Here, we show that cyclin-dependent kinase 5 (Cdk5), a new player in thermal pain sensation, positively regulates TRPV1 surface localization. (bvsalud.org)

Vivo1

• Active Cdk5 was found to promote TRPV1 anterograde transport in vivo, suggesting a regulatory role of Cdk5 in TRPV1 membrane trafficking. (bvsalud.org)

Cohort1

• Using immunohistochemistry, expression of DARPP-32, PP1 and Cdk5 is determined in a large cohort of primary tumors from ovarian cancer patients (n = 428, 445 and 434 respectively) to evaluate the relationship between clinical outcome and clinicopathological criteria. (pp1a.com)

Family2

• CDK4 is a member of the Ser/Thr protein kinase family. (thermofisher.com)
• BCL2L11 interacts with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and acts as an apoptotic activator. (neuromics.com)

Gamma1

• casein kinase 1 gamma 2 [Source:HGN. (gsea-msigdb.org)

Synaptic1

• Cdk5/p35 is also implicated in synaptic plasticity, learning and memory. (biomedcentral.com)

Aurora1

• aurora kinase A interacting protein. (gsea-msigdb.org)

Efficacy1

• Cyclin-dependent kinase 5 (CDK5) affects the tumor microenvironment, which may influence the efficacy of TKI+IO. (e-crt.org)

Regulates1

• The Cdk5 activator P39 specifically links muskelin to myosin II and regulates stress fiber formation and actin organization in lens. (nih.gov)

Suggests1

• Recent evidence from p25 transgenic mice suggests that there is a dynamic crosstalk: during aging or prolonged overactivation of Cdk5, GSK3β activity may alter in favor of AD pathogenesis. (frontiersin.org)

GSK36

• GSK3β and Cdk5 are the two kinases in the center of research on Alzheimer's disease (AD), involved in the pathological symptoms of AD, Aβ plaque formation, tau hyperphosphorylation and neurodegeneration. (frontiersin.org)
• So far, both kinases have mostly been examined in isolation, leading to a schism of the research field into defenders of the GSK3β-versus the Cdk5 hypotheses of AD. (frontiersin.org)
• However, in this debate the fact that activities of GSK3β and Cdk5 can influence each other deserves more attention. (frontiersin.org)
• In this review we summarize the connections between GSK3β and Cdk5 and discuss implications for AD hypotheses. (frontiersin.org)
• In this review we will summarize the mechanisms of crosstalk between GSK3β and Cdk5 and discuss its implications for tau hyperphosphorylation, a main pathological feature of AD. (frontiersin.org)
• Therefore activities of the other kinases Erk, CK1 and GSK3β were tested after oloumucine treatment. (frontiersin.org)

Progression1

• Cdk5 high expression was associated with progression-free survival shorter (P = 0.006). (pp1a.com)

Activation1

• In cultured primary fibroblasts and cancer cells, the chemotherapeutic drug doxorubicin causes mtDNA damage and release, which leads to cGAS STING dependent ISG activation. (regenerativemedicine.net)

Processes1

• Cyclin-dependent kinase 5 (Cdk5) /p35 is involved in many developmental processes of the central nervous system. (biomedcentral.com)

Shown1

• Several lines of conditional Cdk5 knockout mice (KO) have been generated and have shown different outcomes for learning and memory. (biomedcentral.com)

Expression2

• The expression of CDK5 of each sample was determined by RNA sequencing. (e-crt.org)
• High-CDK5 expression was associated with immunosuppression and TKI+IO resistance. (e-crt.org)

Cells2

• In the high CDK5 subgroup, CD8 + T cells revealed a dysfunction phenotype with decreased granzyme B, and more regulatory T cells were identified. (e-crt.org)
• Cyclin-dependent kinase (cdk) inhibitors have the potential to induce growth arrest and apoptosis in cancer cells. (omecamtivmecarbilactivator.com)

Active1

• It associates with CDK5 to form an active kinase. (nih.gov)

Source3

• ceramide kinase [Source:HGNC Symbol. (gsea-msigdb.org)
• deoxythymidylate kinase [Source:HGN. (gsea-msigdb.org)
• adenylate kinase 1 [Source:HG. (gsea-msigdb.org)

Treatment1

• RFscore based on CDK5 may be utilized as a biomarker to determine the optimal treatment strategy. (e-crt.org)