• In this review we discuss the current understanding of the signaling mechanisms used by TGF-beta to elicit its effects on target genes, focusing primarily on Smad proteins and their role in the transcriptional regulation of ECM gene expression. (nih.gov)
  • SR1001 binds specifically to the ligand-binding domains of RORα and RORγt, inducing a conformational change within the ligand-binding domain that encompasses the repositioning of helix 12 and leads to diminished affinity for co-activators and increased affinity for co-repressors, resulting in suppression of the receptors' transcriptional activity. (nature.com)
  • Analyzing 5′-upstream non-protein-encoding regions of the human mitochondrial function-associated genes, we speculate that mitochondrial functions could be recovered or improved at a transcriptional level. (intechopen.com)
  • Molecular cloning and transcriptional mapping of the mouse cellular retinoic acid-binding protein gene. (ulaval.ca)
  • In line with this, RBPJL is able to fully reconstitute transcriptional repression at Notch target genes in cells lacking RBPJ. (uni-ulm.de)
  • Arabidopsis ethylene-responsive element binding factors act as transcriptional activators or repressors of GCC box-mediated gene expression. (ugent.be)
  • Transcriptional activator that induces expression of multiple genes including pax3, en2, snai2/slug, feb and a subset of wnt genes. (xenbase.org)
  • We use these engineered Cas9 activation complexes to investigate sgRNA targeting rules for effective transcriptional activation, demonstrate multiplexed activation of 10 genes simultaneously, and upregulate long intergenic non-coding RNA (lincRNA) transcripts. (cdc.gov)
  • Although the current generation of dCas9-based transcription activators is able to achieve up-regulation of some endogenous loci, the magnitude of transcriptional up-regulation achieved by individual single-guide RNAs (sgRNAs) 12 typically ranges from low to ineffective 8 - 11 . (cdc.gov)
  • In the presence of glucose, the catabolite activator protein (CAP), required for production of the enzymes, remains inactive, and EIIAGlc shuts down lactose permease to prevent transport of lactose into the cell. (wikipedia.org)
  • Current usage expands the phenotypic nomenclature to apply to proteins: thus, LacZ is the protein product of the lacZ gene, β-galactosidase. (wikipedia.org)
  • Transcription of all genes starts with the binding of the enzyme RNA polymerase (RNAP), a DNA-binding protein, which binds to a specific DNA binding site, the promoter, immediately upstream of the genes. (wikipedia.org)
  • C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA. (houstonmethodist.org)
  • SR1001 inhibited the development of murine T H 17 cells, as demonstrated by inhibition of interleukin-17A gene expression and protein production. (nature.com)
  • By means of oligonucleotide microarray and RNA interference, we reveal that the sensitizing effect of IFN-β was possibly due to attenuation of MGMT expression via induction of the protein p53. (aacrjournals.org)
  • lac 오페론의 CAP(catabolite activator protein) 결합 부위와 같은 추가 조절 서열(regulatory sequence)은 다른 활성인자 또는 억제인자를 위한 결합 부위를 제공합니다. (jove.com)
  • The regulator gene codes for a repressor protein that binds to the operator, obstructing the promoter (thus, transcription) of the structural genes. (presenternet.com)
  • The BOB.1 / OBF.1 / OCA-B protein (henceforth designated as BOB.1 / OBF.1) is a B cell-specific co-activator of the Oct1 and Oct2 transcription factors. (nih.gov)
  • Enables kinase binding activity and protein serine/threonine kinase activator activity. (nih.gov)
  • The protein encoded by this gene is a member of the CMGC family of serine/threonine protein kinases. (cancerindex.org)
  • What does this gene/protein do? (cancerindex.org)
  • What pathways are this gene/protein implicaed in? (cancerindex.org)
  • Scope includes mutations and abnormal protein expression. (cancerindex.org)
  • 2008 ) Inhibiting activator protein-1 activity alters cocaine-induced gene expression and potentiates sensitization. (neurotree.org)
  • We hypothesized that blood cell gene expression and serum protein analysis will provide insight into the relationship between CNT-induced lung and cardiovascular effects. (cdc.gov)
  • C-reactive protein, serum amyloid P) and accompanying liver gene expression were increased. (cdc.gov)
  • Furthermore, at both 4 and 24hr increased serum levels of the prothrombotic protein plasminogen activator inhibitor-1 were found. (cdc.gov)
  • In hepatoma cell lines, fatty acids increase Hilpda expression and protein levels. (wur.nl)
  • To characterize the change(s) in mRNA and protein expression of SIRT1-7 and their associated proteins in the brain of "physiologically" aged Wistar rats. (frontiersin.org)
  • We tested mRNA and protein expression levels of rat SIRT1-7, and the levels of associated proteins in the brain using RT-PCR and western blotting. (frontiersin.org)
  • SIRT3-5 expression declined significantly in the hippocampus and frontal lobe, associated with increases in superoxide and fatty acid oxidation levels, and acetylated CPS-1 protein expression, and a reduction in MnSOD level. (frontiersin.org)
  • While SIRT6 expression declines significantly with age acetylated H3K9 protein expression is increased throughout the brain. (frontiersin.org)
  • SIRT7 and Pol I protein expression increased in the frontal lobe. (frontiersin.org)
  • SIRT1 is localized in the nucleus and can deacetylate numerous proteins such as tumor suppressor protein (p53), Ku70, NF-κB, and forkhead proteins which modulate genes that control cellular stress resistance ( Smith, 2002 ). (frontiersin.org)
  • The AFF2 gene provides instructions for making a protein that is found in the nucleus of cells but whose function is not well understood. (medlineplus.gov)
  • As a result, the AFF2 gene is turned off (silenced), and no protein is produced from it. (medlineplus.gov)
  • Rarely, small deletions of genetic material from the AFF2 gene are associated with fragile XE syndrome, although how these deletions affect the protein and lead to intellectual disability is unknown. (medlineplus.gov)
  • Hillman MA, Gecz J. Fragile XE-associated familial mental retardation protein 2 (FMR2) acts as a potent transcription activator. (medlineplus.gov)
  • The most critical of these proteins is the signal transducer and activator of transcription 5b (STAT5b), which couples GH binding to the activation of gene expression that leads to the intracellular effects of GH, including synthesis of IGF-I, insulin-like growth factor binding protein 3 (IGFBP3), and ALS. (medscape.com)
  • In this case, when lactose is required as a sugar source for the bacterium, the three genes of the lac operon can be expressed and their subsequent proteins translated: lacZ, lacY, and lacA. (wikipedia.org)
  • One may distinguish between structural genes encoding enzymes, and regulatory genes encoding proteins that affect gene expression. (wikipedia.org)
  • Specifically, TGF-beta isoforms have the ability to induce the expression of ECM proteins in mesenchymal cells, and to stimulate the production of protease inhibitors that prevent enzymatic breakdown of the ECM. (nih.gov)
  • An operon is a cluster of genes that are transcribed together to give a single messenger RNA (mRNA) molecule, which therefore encodes multiple proteins (Fig. 16.11). (presenternet.com)
  • The differentially expressed genes included those functioning in some important immune reaction and iron metabolism pathways, such as pattern recognition receptors, regulators of the JNK pathway, components of the phagosome pathway, regulators of the melanization response, activators of complement reactions, insulin signaling cascade members, oxidative stress and detoxification proteins. (biomedcentral.com)
  • Cellular iron levels and iron associated proteins are differentially expressed in many cancers, and recently, it was reported that high expression levels of iron importer and low levels of iron exporter were associated with a poor prognosis in breast cancer patients. (american.edu)
  • Cellular signaling pathways are networks of genes, proteins, enzymes, cytokines, and other cellular species that "communicate" in order to govern the basic functions of cells. (american.edu)
  • We evaluated serum proteins and blood cell gene expression of biomarkers related to potential cardiovascular effects. (cdc.gov)
  • At 24hr, inflammatory serum proteins and blood cell gene expression had returned to baseline and the systemic tissue response had diminished. (cdc.gov)
  • Programmable DNA binding proteins have emerged as an exciting platform for engineering synthetic transcription factors for modulating endogenous gene expression 5 - 11 . (cdc.gov)
  • Among the established custom DNA binding domains, Cas9 is most easily scaled to facilitate genome-scale perturbations 3 , 4 due to its simplicity of programming relative to zinc finger proteins and transcription activator-like effectors (TALEs). (cdc.gov)
  • Plasminogen activator inhibitor-1 (PAI-1) is the primary inhibitor of both tissue- and urokinase-type plasminogen activators (t-PA, u-PA). (tmu.edu.tw)
  • These mice are generated by transplanting human hepatocytes into albumin enhancer-driven urokinase-type plasminogen activator transgenic/severe combined immunodeficiency (uPA/SCID) mice, leading to replacement of the host hepatocytes. (wur.nl)
  • In this study, we first identified all the CAMTA homologous genes in the whole genome of maize. (frontiersin.org)
  • To understand the differential gene expression in Anopheles following infection with drug-resistant Plasmodium , we conducted a genome-wide transcriptomic profiling analysis of Anopheles stephensi following feeding on mice with drug-resistant or drug-sensitive P. yoelii , observed changes in gene expression profiles and identified transcripts affected by the drug-resistant parasite. (biomedcentral.com)
  • Moreover, genome instability was attributed to impaired autophagy and several autophagy genes with tumor suppressor functions (e.g. (hindawi.com)
  • Overall, our analyses provide novel opportunities for the normalisation of genome-wide expression profiling data. (biorxiv.org)
  • Given that the basic genome of a differentiated organism is constant between cells (and we here ignore epigenomics), what mainly discriminates one cell type from another is its expression profile. (biorxiv.org)
  • Genome-wide identification and expression analysis of the bZIP transcription factor family genes in response to abiotic stress in Nicotiana tabacum L. (biomedcentral.com)
  • Interacting DNA-encoded regulatory subsystems in the GENOME that coordinate input from activator and repressor TRANSCRIPTION FACTORS during development, cell differentiation, or in response to environmental cues. (bvsalud.org)
  • Achieving systematic, genome-scale perturbations within intact biological systems is important for elucidating gene function and epigenetic regulation. (cdc.gov)
  • Hammond, SL , Safe, S & Tjalkens, RB 2015, ' A novel synthetic activator of Nurr1 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro ', Neuroscience Letters , vol. 607, pp. 83-89. (houstonmethodist.org)
  • A splice-supporting intronic mutation in the last bp position of a cryptic exon within intron 6 of the CYBB gene induces its incorporation into the mRNA causing chronic granulomatous disease (CGD). (lu.se)
  • Notably, a large number of stress-related elements present in the promoter regions of some ZmCAMTA genes, indicating a genetic basis of stress expression regulation of these genes. (frontiersin.org)
  • Gene regulation of the lac operon was the first genetic regulatory mechanism to be understood clearly, so it has become a foremost example of prokaryotic gene regulation. (wikipedia.org)
  • These results collectively demonstrate the potential of Cas9-based activators as a powerful genetic perturbation technology. (cdc.gov)
  • IGF-I deficiency can be the result of GH resistance or insensitivity due to genetic disorders of the GH receptor causing GH receptor deficiency (growth hormone receptor deficiency [GHRD], Laron syndrome) or postreceptor defects, including the principal transduction agent STAT5b, the IGF-I/IGFBP3 stabilizer acid labile subunit (ALS), the IGF-I gene, or the IGF-I receptor. (medscape.com)
  • Autosomal Recessive Genetic disorders determined by a single gene (Mendelian disorders) are easiest to analyze and the most well understood. (msdmanuals.com)
  • RANK ligand converts the NCoR/HDAC3 co-repressor to a PGC1ß- and RNA-dependent co-activator of osteoclast gene expression. (bvsalud.org)
  • The fourth lac gene is lacI, encoding the lactose repressor-"I" stands for inducibility. (wikipedia.org)
  • The lac genes encoding enzymes are lacZ, lacY, and lacA. (wikipedia.org)
  • A typical operon consists of a group of structural genes that code for enzymes involved in a metabolic pathway, such as the biosynthesis of an amino acid. (presenternet.com)
  • [ 10 ] Multiple biofilm-specific mechanisms are operated simultaneously in a reversible and transient manner contributing to the high levels of antibiotic resistance of biofilms, and these are distinct from the well-characterized intrinsic resistance mechanisms (e.g., expression of antibiotic-degrading enzymes, inducible decrease in antibiotic influx, inducible increase in antibiotic efflux and alteration in antibiotic target sites) employed by planktonic cells. (medscape.com)
  • Sirtuins or "silent information regulators" of gene transcription, are a family of enzymes which are expressed throughout all phyla of life. (frontiersin.org)
  • Gene silencing by this family of enzymes has been correlated directly with longer lifespan in yeast and worms ( Yang and Sauve, 2005 ). (frontiersin.org)
  • When you eat, glucose pours into the gut and is recognized by LXR in the liver, which then activates expression of the enzymes that turn excess glucose into triglycerides that are stored as fat,' said Assistant Professor Enrique Saez, a Scripps Research scientist who led the study, which was supported by GNF. (scripps.edu)
  • In invasion and metastasis, NF-κB regulates the gene transcription of proteolytic enzymes, cytokines and signaling molecules associated with epithelial-mesenchymal transition (EMT) ( 6 ). (spandidos-publications.com)
  • Riboswitches are conserved regions within mRNA molecules that bind specific metabolites and regulate gene expression. (strath.ac.uk)
  • Uhde-Stone C, Cheung E, Lu B (2014) TALE activators regulate gene expression in a position- and strand-dependent manner in mammalian cells. (scu.edu)
  • they can combine with the promoter regions of key genes in signaling pathways to regulate their transcription levels and, in turn, plant resistance to stress. (biomedcentral.com)
  • A mutation in this gene resulting in reduced cell proliferation, and impaired cell motility and polarity, and has been identified in patients with primary microcephaly. (cancerindex.org)
  • Nearly all cases are caused by a mutation called a CCG trinucleotide repeat expansion, in which the CCG trinucleotide is abnormally repeated more than 200 times, which makes this region of the gene unstable. (medlineplus.gov)
  • A novel mutation of the CYBB gene resulting in severe form of X-linked chronic granulomatous disease. (lu.se)
  • Molecular characterization of a novel splice site mutation within the CYBB gene leading to X-linked chronic granulomatous disease. (lu.se)
  • Mice homozygous for a gene trap allele exhibit reduced survival and decreased tumor latency. (jax.org)
  • Gene expression studies performed on PPARα null mice have shed light into a variety of genes regulated by PPARα. (wur.nl)
  • However, expression of macrophage/inflammatory markers and fibrosis were not different between HILPDA knockout and floxed mice. (wur.nl)
  • Inoculation with a high dose strains of LMP1 transgenic mice vide a powerful tool in mechanistic of EBV caused a B-cell lymphopro- were established that express LMP1 studies on the role of individual viral liferative disorder in these mice, under the control of the immunoglob- genes in cancer. (who.int)
  • Furthermore, SR1001 inhibited the expression of cytokines when added to differentiated murine or human T H 17 cells. (nature.com)
  • This was unexpected because the carbohydrate does not conform to the standard definition of a typical ligand that activates nuclear receptors, transcription factors that coordinate gene expression in response to hormonal and environmental signals. (scripps.edu)
  • The most promising molecule, triazolethiamine (TT), shows concentration dependent reporter gene repression that is dependent on the presence of thiamine kinase ThiK, whereas the effect of pyrithiamine (PT), a known TPP-riboswitch modulator, is ThiK independent. (strath.ac.uk)
  • Unless an inducer is present, activators don't bind well to activator DNA. (presenternet.com)
  • Structure of human LXRα showing the pocket where activators typically bind. (scripps.edu)
  • Important regulatory factors, TFs bind to the promoter regions of target genes and activate or inhibit their transcription. (biomedcentral.com)
  • Degeneration of dopaminergic neurons in Parkinson's disease (PD) is associated with decreased expression of the orphan nuclear receptor Nurr1 (NR4A2), which is critical for both homeostasis and development of dopamine (DA) neurons. (houstonmethodist.org)
  • In the present study, we examined the capacity of C-DIM12 to induce expression of Nurr1-regulated genes in two dopaminergic neuronal cell lines (N2A, N27) and to protect against 6-hydroxydopamine (6-OHDA) neurotoxicity. (houstonmethodist.org)
  • C-DIM12 induced expression of Nurr1-regulated genes that was abolished by Nurr1 knockdown. (houstonmethodist.org)
  • These data indicate that C-DIM12 stimulates neuroprotective expression Nurr1-regulated genes in DA neurons. (houstonmethodist.org)
  • The same three letters are typically used (lower-case, italicized) to label the genes involved in a particular phenotype, where each different gene is additionally distinguished by an extra letter. (wikipedia.org)
  • PAI-1, as an inhibitor of the interaction between vitronectin and integrin αvβ3, may also be a regulator of its own expression. (tmu.edu.tw)
  • Various short sequences that are not genes also affect gene expression, including the lac promoter, lac p, and the lac operator, lac o. (wikipedia.org)
  • However, it is difficult to capture the complexity of transcript isoform variance using these libraries, and large cDNA sequences are often difficult to clone into size-limited viral expression vectors. (cdc.gov)
  • The lac z gene encodes beta-galactosidase, the lac y gene encodes a permease, and the lac a gene encodes the transacetylase enzyme. (presenternet.com)
  • The three structural genes are: lacZ, lacY, and lacA. (wikipedia.org)
  • 촉진자) 서열을 사용해 유전자 군집(즉, 구조유전자(structural gene) 군집)을 단일 mRNA 분자로 전사(transcription)하기 시작합니다. (jove.com)
  • Structural genes - the genes that are co-regulated by the operon. (presenternet.com)
  • Synergizes with the bmp-inhibitor noggin/nog and acts through the wnt pathway to induce expression of en2. (xenbase.org)
  • Here, we describe thiamine analogs containing a central 1,2,3-triazole group to induce repression of thiM-riboswitch dependent gene expression in different E. coli strains. (strath.ac.uk)
  • Tissue-specific activity of the pro-opiomelanocortin (POMC) gene and repression by glucocorticoids. (ulaval.ca)
  • Quantitative real-time PCR was used to test the expression of ZmCAMTA genes under several abiotic stresses (drought, salt, and cold), various stress-related hormones [abscisic acid, auxin, salicylic acid (SA), and jasmonic acid] and biotic stress [rice black-streaked dwarf virus (RBSDV) infection]. (frontiersin.org)
  • Quantitative real-time polymerase chain reaction analysis identified that expression patterns of bZIP s differed, including in different organs and under various abiotic stresses. (biomedcentral.com)
  • NF-κB controls the expression of an array of genes involved in multiple features of cancer, including proliferation, survival angiogenesis and invasion. (spandidos-publications.com)
  • If expression of a trait requires only one copy of a gene (one allele). (msdmanuals.com)
  • The expression of most ZmCAMTA genes responded to both abiotic and biotic stresses. (frontiersin.org)
  • Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene. (jax.org)
  • D-glucose and GW3965 (a synthetic LXR activator) induced similar changes in hepatic gene expression, indicating that LXR functions as a glucose sensor in vivo that responds to increasing liver glucose uptake. (scripps.edu)
  • In contrast, culturing on Laminin-421 induced the expression of β-cell genes, including Ins1 , MafA , and Glut2 , and significantly improved glucose-stimulated insulin secretion. (nature.com)
  • We found a significantly lower expression of key autophagy- (ATG-) related genes in primary AML as compared to healthy granulocytes, an increased autophagic activity during all- trans retinoic acid- (ATRA-) induced neutrophil differentiation, and an impaired AML differentiation upon inhibition of ATG3, ATG4D, and ATG5. (hindawi.com)
  • In particular, with some exceptions such as olfactory receptors and genes involved in keratin production, transporter genes are significantly more heterogeneously expressed than are most non-transporter genes. (biorxiv.org)
  • these often differ significantly from the 'housekeeping' genes commonly used for normalisation in transcriptomics and qPCR studies. (biorxiv.org)
  • The signature of our top screening hits is significantly correlated with gene expression data from clinical melanoma samples. (cdc.gov)
  • The results showed that nine ZmCAMTA genes showed highly diversified gene structures and tissue-specific expression patterns. (frontiersin.org)
  • Levels of gene expression are measured using a preparation of fluorescently labeled tissue RNA (copies of DNA), together with reference RNA labeled with a different fluorochrome, hybridized onto the slides. (lu.se)
  • Typically when data are presented, the fluor- escent intensity from the tissue is pseudo-colored red and the intensity from the reference green, and the logarithmic ratio of background corrected red and green intensities for each gene (spot) is subject to analysis (see Fig. 1 ). (lu.se)
  • In addition to these receptors, hybrid receptors consisting of a dimer from the IGF-I receptor paired with the insulin receptor, are ubiquitous and the respective expression of these receptors varies from tissue to tissue. (medscape.com)
  • CONCLUSIONS- We conclude that activation of nrf2 may prevent biochemical dysfunction and related functional responses of endothelial cells induced by hyperglycemia in which increased expression of transketolase has a pivotal role. (diabetesjournals.org)
  • In addition, the expression of specific endothelial related genes was elevated in the aorta (e.g. (cdc.gov)
  • These ATG genes are highly conserved in mammalian cells, allowing to study their functions also in higher eukaryotes [ 1 - 4 ]. (hindawi.com)
  • Although there are seven mammalian sirtuins (SIRT1-7), little is known about their expression in the aging brain. (frontiersin.org)
  • We selected 17 patients clinically and his- is encoded by a single gene located on the tologically proven to be suffering from PV short arm of chromosome 11 [ 6 ]. (who.int)
  • In the study, glucose is shown to stimulate the activity of the Liver X Receptors (LXR) a and b, The LXRs act as sensors of dietary components, orchestrating the body's response to nutrients such as oxysterols (short-lived derivatives of cholesterol) and controlling gene expression linked to cholesterol and fat metabolism. (scripps.edu)
  • Here, potential mechanisms involving alterations in T-cell receptor expressions, postreceptor downstream signalling, epigenetics, and oxidative stress which favour activation of lupus T cells will be discussed. (hindawi.com)
  • The complex binding to the activation sequence activated the target genes. (presenternet.com)
  • RESULTS- Activation of nrf2 by sulforaphane induced nuclear translocation of nrf2 and increased ARE-linked gene expression, for example, three- to fivefold increased expression of transketolase and glutathione reductase. (diabetesjournals.org)
  • Our results support the major role of PPARα in regulating hepatic lipid metabolism, highlight the more modest effect of PPARα activation on gene regulation in human liver compared to mouse liver, and indicate that PPARα may have a suppressive effect on DNA synthesis in human liver. (wur.nl)
  • We also synthesize a library consisting of 70,290 guides targeting all human RefSeq coding isoforms to screen for genes which, upon activation, confer resistance to a BRAF inhibitor. (cdc.gov)
  • BOB.1 / OBF.1 dependence could not be overcome by including the strong enhancer element from the immunoglobulin heavy chain gene. (nih.gov)
  • It functions as an activator of gene expression by retinoid alpha-receptor transcription factor and ligand-dependent transcription factor. (medscape.com)
  • Peroxisomal proliferator activator receptor alpha (PPARα) is a ligand-activated transcription factor that plays a major role in the regulation of lipid metabolism. (wur.nl)
  • We analyse two comprehensive transcriptome datasets from human tissues and human-derived cell lines in terms of the expression profiles of the SLC and ABC families of membrane transporters. (biorxiv.org)
  • Search the gene expression profiles from curated DataSets in the Gene Expression Omnibus (GEO) repository. (cancerindex.org)
  • The late blood response (7 and 28d) was characterized by increased serum osteopontin levels in conjunction with increased lung expression of genes coding for a macrophage related response (e.g. arginase I, galectin-3, osteopontin). (cdc.gov)
  • A comprehensive understanding of the physiological and molecular function of PPARα target genes is needed for the accurate development of therapeutical strategies. (wur.nl)
  • Then, we pursued to expand our understanding on the physiological and molecular function of two PPARα target genes, Hilpda and Slc25a47. (wur.nl)
  • In the context of these simulations, initial conditions are certain expression levels of some species that one might want to investigate. (american.edu)
  • As the sequencing and gene annotation projects of entire genomes of many species are headed towards completion (see, e.g. [13] ), massive mapping efforts in biology are now focused on how the genes interact. (lu.se)
  • We further studied the collinearity between these genes and related genes of six other species. (biomedcentral.com)
  • Altered expression of this gene has been observed in multiple human cancers. (cancerindex.org)
  • The virotherapy contains an attenuated oncolytic Edmonston (Ed) strain of measles virus encoding the human thyroidal sodium iodide symporter (MV-NIS) with the gene expression. (pharmaceutical-technology.com)
  • MV-NIS attacks cells expressing the human CD46 antigen and it also acts as an activator of human thyroidal sodium iodide symporter. (pharmaceutical-technology.com)
  • These in vitro, and their expression in these human tumour virus. (who.int)