ras Guanine Nucleotide Exchange FactorsSon of Sevenless Proteinsras Proteinsras-GRF1Genes, rasGuanine Nucleotide Exchange FactorsGRB2 Adaptor ProteinAmino Acid MotifsProto-Oncogene Proteins p21(ras)Oncogene Protein p21(ras)Molecular Sequence Dataras GTPase-Activating ProteinsAmino Acid SequenceProtein BindingBase SequenceNucleotide MotifsMutationProtein Structure, TertiarySignal TransductionProto-Oncogene Proteins c-rafKineticsModels, MolecularDeuterium Exchange MeasurementSequence Homology, Amino AcidBinding SitesCell LinePulmonary Gas ExchangeGuanosine TriphosphateExchange Transfusion, Whole BloodGuanosine DiphosphateSister Chromatid ExchangeRecombinant Fusion ProteinsProteinsTransfectionDNA-Binding ProteinsRecombinant ProteinsGTPase-Activating ProteinsMutagenesis, Site-DirectedTranscription FactorsEnzyme ActivationImmunoglobulin A, SecretorySequence AlignmentConserved SequencePhosphorylationCloning, MolecularCarrier Proteins3T3 CellsDNACell Transformation, Neoplasticral Guanine Nucleotide Exchange FactorEscherichia coliGTP-Binding ProteinsPromoter Regions, GeneticModels, BiologicalProto-Oncogene ProteinsProtein Interaction Domains and MotifsCrystallography, X-RayCells, CulturedProtein Structure, SecondaryGTP PhosphohydrolasesSaccharomyces cerevisiaeTranscription, GeneticStructure-Activity RelationshipHydrogenMembrane ProteinsCOS Cellsraf KinasesFarnesolSodium-Hydrogen AntiporterMagnetic Resonance SpectroscopyProtein ConformationFungal ProteinsGene Expression RegulationChromatography, Ion ExchangeMitogen-Activated Protein KinasesPeptidesBacterial ProteinsSaccharomyces cerevisiae ProteinsSubstrate SpecificityProtein-Serine-Threonine KinasesMAP Kinase Signaling SystemHydrogen-Ion ConcentrationCell MembraneHeLa CellsMonomeric GTP-Binding ProteinsDNA PrimersNuclear Proteinsral GTP-Binding ProteinsRNA, MessengerSodiumRho Guanine Nucleotide Exchange FactorsSOS1 ProteinNeurofibromin 1Helix-Turn-Helix MotifsPeptide FragmentsCalciumDeuteriumMutagenesisCalcium-Calmodulin-Dependent Protein KinasesConsensus Sequence