Activation laminin receptors receptors laminin. Medical search. Frequent questions

Whereas endothelial cells plated on fibronectin or fibrinogen activate NF-κB in response to flow, cells on collagen or laminin do not. (rupress.org)
Furthermore, altering the extracellular matrix to promote p38 activation in cells on fibronectin suppresses NF-κB activation, suggesting a novel therapeutic strategy for treating atherosclerosis. (rupress.org)
Polyclonal and monoclonal antibodies raised against chicken gizzard 5′-nucleotidase were tested in adhesion assays of embryonic chicken fibroblasts (CEF) for their ability to interfere with the adhesion process of these cells on either laminin or fibronectin substrata. (morulaivf.com)
The initial attachment process of CEF on fibronectin and laminin substrata was not influenced by preincubating these cells with antibodies against chicken gizzard 5′-nucleotidase. (morulaivf.com)
The major components of the ECM are interstitial collagens (types I and III), membrane collagen (type IV), and non-collagenous glycoproteins, such as laminin and fibronectin. (vin.com)
During liver fibrosis, the composition of the ECM changes from one dominated by collagen IV and laminin [ 4 ], to one of fibrillar collagen, predominantly collagen I and III, as well as fibronectin [ 5 ]. (biomedcentral.com)
These chondrocyte/ECM interactions are regulated by a large family of transmembrane glycoproteins whereby beta 1 integrins are the most widely expressed and interact with several matrix proteins such as collagen, fibronectin, vitronectin and laminin [ 4 ]. (biomedcentral.com)
Previous studies have implicated β1 integrins in cancer since they regulate cell adhesion and migration/invasion on tumor stroma proteins such as fibronectin laminin and collagen (33). (biotech-angels.com)

Flow-induced NF-κB activation is downstream of conformational activation of integrins, resulting in new integrin binding to the subendothelial extracellular matrix and signaling. (rupress.org)
The flow-dependent adhesion of platelets to those and other extracellular matrix components is stabilized by a panel of integrins, including integrin α 2 β 1 , α IIb β 3 , and α 6 β 1 (adhesive platelet population), while the initial activation of platelets is achieved by signaling via the collagen/laminin receptor, glycoprotein VI (GPVI). (frontiersin.org)
Given the multi-domain architecture of Ln5, it seems conceivable that other receptors in addition to integrins interact with one of its many potential ligand sites to mediate its diverse cellular functions, including activation of EGFR signaling. (spandidos-publications.com)
Turning depended on the activation of integrins-the LN1 receptors. (rupress.org)
Moreover, integrins, laminins, NF-κB and other regulative molecules were found as crucial proteins. (nature.com)
This could be considered to be part of a feedback loop as changes in ECM composition results in changes in HSC cell surface receptors, particularly integrins indicating that the ECM should not be regarded simply as an inert physical scaffold but a dynamic structure that is able to influence the phenotype of HSCs [ 2 , 8 , 9 ]. (biomedcentral.com)
The region of sdc-1 that associates with 31 and 64 integrins is called the co-receptor binding website. (monossabios.com)
sdc-1 null fibroblasts AG-1478 enzyme inhibitor have reduced activation of v integrins on their surface (4) which may contribute to delayed wound healing in sdc-1 null mice since several v integrin heterodimers including v5, v6, and v8 mediate TGF1 activation. (monossabios.com)
The latent website of AG-1478 enzyme inhibitor TGF1 has an v integrin binding site and studies have suggested that v integrins sequester latent TGF1 to the cell surface and control its activation locally (11). (monossabios.com)
Tyrosine kinase receptors and integrins play essential roles in tumor cell invasion and metastasis. (biotech-angels.com)
in vivo yet does not influence primary tumor growth or activation of other integrins on these cells. (biotech-angels.com)

The subsequent activation of focal adhesion kinases might activate or recruit myosin II. (rupress.org)
Interaction with ECM is a major driver of HSC morphology [ 11 ], and signal transduction from integrin activation occurs at least partly through aggregation and subsequent activation of focal adhesion kinases (FAKs) by autophosphorylation of tyrosine 397 (Y397). (biomedcentral.com)

The process of thrombus formation is considered to be initiated by von Willebrand factor (VWF) binding to exposed collagen or laminin in the damaged vessel wall, followed by shear-dependent platelet binding to VWF through the glycoprotein (GP)Ib-V-IX complex ( 1 , 3 , 4 ). (frontiersin.org)

These findings demonstrate crosstalk between a tyrosine kinase receptor and an integrin involved in carcinoma cell invasion and metastasis and may explain in part how inhibitors of EGFR impact malignant disease. (biotech-angels.com)

Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. (joplink.net)
Laminin-332 (laminin-5) is a basement membrane heterotrimeric protein composed of alpha-3, beta-3 and gamma-2 laminin chains. (morulaivf.com)
In five dogs, IgG variably recognized the basement membrane of laminin-332-deficient human skin (three dogs negative, two dogs positive). (morulaivf.com)
These observations establish laminin-332 as a novel basement membrane antigen in dogs with autoimmune blistering diseases with variable clinical phenotypes. (morulaivf.com)
Laminins are multifunctional basement membrane glycoproteins composed of a, b, and g polypeptide chains. (mirnamimic.com)

Laminin 5 (Ln5) is an extracellular matrix protein that plays an important role in cell migration and tumor invasion. (spandidos-publications.com)

Ligation of integrin α2β1 on collagen prevents flow-induced NF-κB activation through a p38-dependent pathway that is activated locally at adhesion sites. (rupress.org)
The activities of adhesion and signaling receptors in platelets are controlled by several mechanisms. (frontiersin.org)
KEGG pathways enrichment and PPI network indicate four major pathways, including extracellular matrix -receptor interaction, focal adhesion, phosphatidylinositol 3-kinase (PI3K)-Protein kinase B (Akt), and Ras signaling pathways were involved in the degeneration of cartilage. (nature.com)
Regulation of adhesion of mouse bone marrow-derived mast cells to laminin. (aai.org)
In experiments probing for a role of PKCa in human laminin-2-integrin-mediated cell adhesion and spreading of PC12 cells, we observed unexpected enhancements of adhesion, spreading and stress fiber formation to 1 mM Go¨6976 with concomitant increase in membrane translocation of PKCd and autophosphorylation of focal adhesion kinase (FAK). (mirnamimic.com)
Go¨6976 also induced laminin-dependent cell adhesion in NIH/3T3 and CV-1 fibroblasts, suggesting of a mechanism that may be common to multiple cell-types. (mirnamimic.com)
A specific inhibitor of PKCd, rottlerin, completely abrogated Go¨6976-dependent increase in PC12 cell adhesion to laminin as well as the activation of small GTPases, Rac1 and Cdc42, that are downstream of PKCd in adhesion receptor signaling. (mirnamimic.com)
Biological activities of laminin are mediated through binding to a subset of integrin family of cell adhesion receptors, a3b1, a6b1, a6b4, and a7b1 [2]. (mirnamimic.com)
Synthetic peptides or recombinant fragments containing bio- logically active motifs have been shown to partially mimic the effects of native laminin in various cellular functions, such as cell adhesion, spreading, migration, neurite outgrowth, and tumor metastasis [6-10], suggesting that laminin-derived-short peptide- modified biomaterials may have therapeutic potential in tissue regeneration applications. (mirnamimic.com)
PKC activation by phorbol myristate acetate has been shown to induce the adhesion, spreading, and migration of cells [12]. (mirnamimic.com)
P-selectin, soluble endothelial protein C receptor, soluble thrombomodulin, plasminogen activator inhibitor 1, ADAMTS-13, von Willebrand factor, tissue factor, soluble intercellular adhesion molecule 1, and vascular cell adhesion molecule 1 were more elevated in LF patients than in controls. (cdc.gov)
Endothelial protein C receptor, thrombomodulin, intercellular adhesion molecule 1, plasminogen activator inhibitor 1, D-dimer, and hepatocyte growth factor were higher in fatal than nonfatal LF cases. (cdc.gov)
Our results demonstrate that cytoglobin expression is correlated with a more quiescent phenotype of stellate cells in culture and that cytoglobin is regulated by the extracellular matrix through integrin signalling dependent on activation of focal adhesion kinase. (biomedcentral.com)
Adhesion to anti-β1 led to Rac1 and Rap1 activity impartial of EGF stimulation whereas cells attached to anti-αvβ5 showed strong EGF-dependent activation of Rac1 or Rap1 (Fig. 1A). (biotech-angels.com)

An opioid agonist/antagonist, nalbuphine stimulates kappa opioid receptor in the CNS, which causes inhibition of ascending pain pathways. (medscape.com)
Codeine binds to opiate receptors in the CNS, causing inhibition of ascending pain pathways, altering perception and response to pain. (medscape.com)

In vitro assays demonstrated a competition of laminin and this monoclonal antibody for the binding site on purified 5′-nucleotidase. (morulaivf.com)
It was also abolished by the glucocorticoid receptor inhibitor, mifepristone, and a monoclonal antibody against the receptor. (uea.ac.uk)

Other unusual features of the receptor include its ability to engage classes of molecules, rather than individual ligands, and its enhanced surface expression in environments rich in RAGE ligands. (jci.org)
HSCs express numerous cell surface receptors including both discoidin domain receptors (DDRs)-which are receptors for collagen I and many of the integrin subunits, which are a major family of cell surface receptors for extracellular molecules and play a critical role in many biological functions [ 7 , 10 ]. (biomedcentral.com)
Otiz-Urda and colleagues (7) showed the development of human being epidermal squamous cell carcinomas required the interaction between the two extracellular matrix molecules laminin 332 (LM332) and type VII collagen and recent studies show that this interaction is definitely mediated by signaling through integrin mediated adhesions. (monossabios.com)

EGFR is a key mediator of oncogenesis in NSCLCs, with its activation inducing tumor proliferation and growth, angiogenesis, invasion and metastasis, and inhibiting apoptosis ( 10 ). (spandidos-publications.com)
10 11 The hypothesis of a causal part of uPA-catalyzed plasminogen activation and plasmin proteolytic activity in main tumor growth local invasion and/or metastasis was recently strongly supported by studies with tumors growing on mice with targeted disruption of the uPA or plasminogen genes 3 including a study having a genetically induced mammary carcinoma. (tam-receptor.com)
Fig. 1 (A) EGF induces avβ5-mediated Rap1 activation and cell metastasis Fig. 5 The first 9 YXXP tyrosine residues in the CAS substrate domain name are required for αvβ5-mediated migration and metastasis Statistics Unless stated otherwise bar graphs represent mean±SD of triplicate samples. (biotech-angels.com)
Since αvβ5 requires activation to promote cell migration we considered whether EGF and integrin αvβ5 could coordinately influence the spontaneous metastasis of FG HIF-C2 cells in vivo. (biotech-angels.com)
Src activation downstream of EGFR is required for αvβ5-mediated carcinoma cell invasion and metastasis EGF receptor ligation and Src activation have been linked to the growth and malignant properties of many tumors (2 4 To assess whether HIF-C2 EGF-mediated migration was Src-dependent FG cells had been treated using a Src kinase inhibitor (SKI-606) ahead of EGF excitement. (biotech-angels.com)

Increased mRNA expression of a laminin-binding protein in human colon carcinoma: complete sequence of a full-length cDNA encoding the protein. (joplink.net)
Treating small skeletal muscle fibre bundles with the synthetic glucocorticoid, beclomethasone dipropionate, increased the phosphorylation (=activation) of extracellular-signal regulated kinase 1&2, c-Jun N-terminal kinase and p38 mitogen-activated protein kinase. (uea.ac.uk)
RAF265 uPA catalyzes the transformation from the inactive zymogen plasminogen towards the energetic broad-spectrum protease plasmin which can degrade many extracellular protein eg fibrin and laminin. (tam-receptor.com)
5 6 uPA-directed activation of plasminogen takes place mainly over the cell surface area after concomitant binding of uPA to its particular receptor uPAR and of plasminogen to protein with C-terminal lysines. (tam-receptor.com)

Polyclonal and monoclonal antibodies against chicken gizzard 5 '-nucleotidase inhibit the spreading process of chicken embryonic fibroblasts on laminin substratum. (morulaivf.com)
Laminin-332 polypeptides are targeted by auto-antibodies in human patients with mucous membrane (cicatricial) pemphigoid or, more rarely, subepidermal vesicular diseases that resemble epidermolysis bullosa acquisita (EBA) or bullous pemphigoid (BP). (morulaivf.com)
In all nine dogs, IgG auto-antibodies detected purified human laminin-332 by immunoblotting. (morulaivf.com)
Adherence was inhibited by antibodies to laminin and laminin receptor and was calcium ion and temperature dependent. (aai.org)

Myosin II pulls growth cones in the right direction, as shown by Stephen Turney and Paul Bridgman (Washington University, St. Louis, MO).Growing neurons in the developing embryo are directed by guidance cues such as laminin-1 (LN1), which steer the extension of neurite growth cones. (rupress.org)

We show that the absence of Yap and Taz causes a severe peripheral neuropathy due to a developmental impairment in axonal sorting, and that Yap/Taz-Tead1 are required for the transcriptional regulation of laminin receptors in Schwann cell. (holyexperiment.org)

The uPA converts cell surface-bound plasminogen to plasmin, a process that is regulated by the binding of plasminogen to specific receptors on the cell surface, however, the identity of the plasminogen receptors that function in this capacity is unclear. (oncotarget.com)
Plasminogen receptor profiling revealed RAS-dependent increases in both S100A10 and cytokeratin 8. (oncotarget.com)

Laminin receptors are overexpressed in a large number of human tumors and the high in vivo affinity of EGCG toward Laminin receptors has allowed to develop Laminin receptor specific radioactive gold nanoparticles to achieve tumor specificity (14). (sbbn.org.br)

The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives. (neurotree.org)

A synthetic opioid analgesic that is primarily a mu receptor agonist, fentanyl is 50-100 times more potent than morphine. (medscape.com)

Finally, interaction with the basal lamina during radial sorting is mediated by laminin receptors 7, but what controls their expression is also not known. (holyexperiment.org)
In contrast, in the submucosa, laminin was exclusively found in the basal lamina of blood vessels where many adherent mast cells were seen. (bmj.com)

There was an increase in mRNA levels of the TGF-β1 ligand and the two receptors. (vin.com)

Here, we review current knowledge how proteases act on platelet receptors and the platelet membrane surface. (frontiersin.org)
The names 'acquired junctional epidermolysis bullosa', 'anti-laminin-332 mucous membrane pemphigoid (MMP)' and 'mixed auto-immune subepidermal blistering dermatosis' are proposed for dogs with clinical signs reminiscent of EBA, MMP or BP respectively. (morulaivf.com)
A number of studies have previously proposed the existence of glucocorticoid receptors on the plasma membrane of many cell types including skeletal muscle fibres. (uea.ac.uk)

Expanded manifestation of 64 within papillomas undergoing premalignant progression arising from 2-stage chemical carcinogenesis is associated with variations AG-1478 enzyme inhibitor in the connection of cells with laminin in their matrix (5,6). (monossabios.com)

An opioid analgesic, morphine interacts with endorphin receptors in the CNS. (medscape.com)

An important way of regulation is provided by proteolytic cleavage of several of these receptors, leading to either a gain or a loss of platelet function. (frontiersin.org)

Yap/Taz Cyclothiazide activation results in their retention within the nucleus where they regulate gene manifestation that promotes proliferation or differentiation with regards to the cell type 8. (holyexperiment.org)
In SB 202190 price fact, he interned in a variety of techniques, flies and people Lich has become proven that, when new neurons within the cell cycle, the end result of t degeneration is convinced that the proliferation and cell activation is neuronal ectopic cycle rather alien on the degeneration sen. (alksignaling.com)
Transduces a signal that results in the proliferation, differentiation, and functional activation of hematopoietic cells. (cusabio.com)
In the current study, we investigated the role of different extracellular matrix proteins in stellate cell proliferation, activation (alpha smooth muscle actin expression and retinoic acid uptake) and cytoglobin expression. (biomedcentral.com)

In this study, we demonstrate that the cross-linking of cell surface high-affinity IgE-R on mast cells derived from mouse bone marrow cultured for 3 wk in the presence of WEHI-3-conditioned media acts as a highly sensitive physiologic stimulus for this attachment and that receptor activation is also induced by calcium ionophore A23187. (aai.org)
Hence, the high-affinity IgE-R on the mast cell functions not only in exocytosis but also facilitates the process of mast cell adherence to laminin. (aai.org)
Low affinity receptor for granulocyte-macrophage colony-stimulating factor. (cusabio.com)
Conformational changes in the GM-CSF receptor suggest a molecular mechanism for affinity conversion and receptor signaling. (cusabio.com)

These 2 members mediate leukocyte adhesions to endothelial cells but they also serve as receptors for iC3b (inactivated C3b). (medscape.com)

Activation of Akt (murine thymoma viral oncogene homolog) is one of the mechanisms that mediate the effects of EGFR ( 11 ). (spandidos-publications.com)

The colocalisation with laminin indicates a mechanism of interaction between smooth muscle cells and mast cells that may be important in the role of mast cells in the process of fibrosis. (bmj.com)

14 In addition the value of PAI-1 like a predictor of poor prognosis in breast cancer is self-employed of tumor size and of estrogen receptor status 15 and the prognostic value of combined measurement of uPA and PAI-1 levels in tumor extracts is independent of the prognostic value of HER2 status. (tam-receptor.com)

We have reported that mast cells adhere to laminin after activation with PMA. (aai.org)
however, culture of mast cells with TGF-beta 1 was determined to enhance IgE-mediated adherence to laminin. (aai.org)
All mast cells in the muscularis propria were colocalised with patches of laminin. (bmj.com)
These studies provide evidence that mast cells with their plethora of mediators may be involved in intestinal fibrosis, a notion supported by the observation of mast cell hyperplasia and activation in a variety of clinical and experimental situations in which fibrosis is prominent. (bmj.com)

Given the association between sdc-1 and integrin activation, binding of 3 integrin to LM332 and its part in carcinoma development (2, 6), and the modified rules of integrin and TGF1 signaling in sdc-1 null keratinocytes (3,17), we. (monossabios.com)

In this study, we investigated the localisation and the mechanism(s) underlying the non-genomic physiological functions of these receptors in mouse skeletal muscle cells. (uea.ac.uk)

Fibrosis is a physiological response to cellular injury in the liver and is mediated by the activation of hepatic stellate cells resulting in the replacement of hepatocytes with extracellular matrix comprised principally of collagen 1 to form a hepatic scar. (biomedcentral.com)

Tyrosine kinase inhibitors (TKIs) targeting epidermal growth factor receptor (EGFR), including gefitinib and erlotinib, have become the standard first-line therapy for patients with advanced non-small cell lung cancers (NSCLCs) harboring activating EGFR mutations ( 4 , 5 ). (spandidos-publications.com)

Spreading-arrested and rounded CEF do not develop prominent intracellular stress-fibers like control cells, instead they seem to concentrate their available actin in areas of presumptive initial contact with the laminin substratum. (morulaivf.com)

CYTOKINES, and expression of cell activation markers and is a critical regulator of SEPTIC SHOCK. (bvsalud.org)

From these results we conclude that the non-genomic/non-canonical physiological functions of glucocorticoids, in adult skeletal muscle fibres are mediated by a glucocorticoid receptor localised in the extracellular matrix, in satellite cells and close to mitochondria and involve activation of the MAPK pathway. (uea.ac.uk)

Little GTPase activation For Fig. 1 FG cells had been serum-starved trypsinized plated on meals covered with 10μg/ml P1F6 or P4C10 antibody and permitted to adhere for a quarter-hour. (biotech-angels.com)

In PC12 cells, we recently showed that the engagement of integrin a3b1 to a binding sequence within the human laminin a2 chain was sufficient to recruit PKCa and PKCd to the integrin receptor [6]. (mirnamimic.com)

Although these platelet activation processes are relatively well-studied as a function of the platelet environment, only since recently it is becoming clear that a multitude of proteases present in plasma or produced by platelets themselves are important for the distinct properties of platelet populations, often by cleaving specific receptors. (frontiersin.org)
In our continued efforts to apply Green Nanotechnology for the development of therapeutic radioactive gold nanoparticles, recently we have discovered that the high antioxidant capacity of Epigallocatechin gallate (EGCG), which is the most abundant catechin polyphenol in tea, can be used to convert radioactive Gold-198 precursor to the corresponding biocompatible radioactive gold nanoparticles functionalized with Laminin receptor specific EGCG. (sbbn.org.br)

Immunological investigations consisted of direct immunofluorescence (IF), indirect IF with intact and salt-split canine gingival, and salt-split normal or laminin-332-deficient human skin, immunoblotting with purified human laminin-332 and immunoblotting with recombinant NC1 domain of human collagen VII. (morulaivf.com)

The proteases involved are of different origins and types: (i) present as precursor in plasma, (ii) secreted into the plasma by activated platelets or other blood cells, or (iii) intracellularly activated and cleaving cytosolic receptor domains. (frontiersin.org)
Outcomes Activation of Taz and Yap i Schwann cells Yap and Taz are controlled from the Hippo pathway, but by mechanotransduction individually of Hippo 1 also. (holyexperiment.org)
However Yap/Taz activation did not correlate with myelination, because the nucleus of myelin-forming Schwann cells was devoid of Yap and Taz (Fig. 1a). (holyexperiment.org)
However, the subsequent spreading process of these cells was found to be inhibited for at least 2 h on a laminin substratum. (morulaivf.com)
The results show that the receptors were localised in the cytoplasm in myoblasts, in the nucleus in myotubes and in the extracellular matrix, in satellite cells and in the proximity of mitochondria in adult muscle fibres. (uea.ac.uk)

Neurotrophins bind two classes of receptors, the receptor tyrosine kinase family of Trk (A, B, and C) receptors and the p75 neurotrophin receptor (NTR). (jneurosci.org)

We investigated the role of the p75 neurotrophin receptor (p75 NTR ) in mediating neurotrophin-induced increases in filopodial length. (jneurosci.org)

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