• We found that CTL responses against MVA-produced antigens were dominated by cross-priming in vivo , despite the ability of the virus to efficiently infect professional antigen-presenting cells (APC) such as dendritic cells (DC). (uniklinik-duesseldorf.de)
  • Current ideas concerning various aspects of the biology of dendritic cells (DC) were presented, including subdivision on two subsets and follow-ups of their activation. (pbkom.eu)
  • IL-1 signaling in dendritic cells (DCs) promoted radiation-induced antitumor immunity by enhancing the cross-priming activity of DCs. (elsevierpure.com)
  • Multimodal immunogenic cell death (ICD) together with autophagy often induced by OVs not only presents potent danger signals to dendritic cells but also efficiently cross-present tumor-associated antigens from cancer cells to dendritic cells to T cells to induce adaptive antitumor immunity. (biomedcentral.com)
  • Enhanced apoptosis of BCG-infected macrophages potentiates dendritic cells- mediated priming of CD8T-cells, a process defined as "cross-priming", while inhibition of IL-10 signalling, during BCG vaccination, confers higher protection against Mtb through a sustained Th1 and Th17 responses. (validate-network.org)
  • Mechanistic investigation defined that Axl inhibition reprograms the immunological microenvironment leading to the increased proliferation, activation and effector function of tumor-infiltrating CD4 + and CD8 + T cells possibly through preferential accumulation and activation of CD103 + cross-presenting dendritic cells. (oncotarget.com)
  • Many methodologies have already been utilized to handle this problem including shot of RNA or DNA in to the pores and skin, usage of live viral vectors or launching of dendritic cells and upregulation from the activation markers Compact disc69 and Compact disc25 (shape?2). (euromedh2020.com)
  • LH-RH, human (elicits Compact disc8 T cell priming, most likely through the traditional pathway of cross-presentation on MHC course I by specific dendritic cells. (euromedh2020.com)
  • The aim of this project is to address the most important of these questions:1)To characterize, in depth CD8 memory cells ge nerated against soluble proteins by cross-priming compared to those generated after viral or bacterial infection against the same antigen2) To study the effect of antigen localisation on the development of memory CD8 T cells. (europa.eu)
  • Moreover, stable mature protein was preferred to pre-processed antigen or antigen fragments as the substrate for cross-priming. (uniklinik-duesseldorf.de)
  • SR-717 displayed antitumor activity, promoted the activation of CD8+ T cells and facilitated antigen cross-priming. (ifmthera.com)
  • In conclusion, our final results offer evidence that the fucoidan developed by Fucus vesiculosus is really a novel adjuvant, which can stimulate DC maturation, CTL activation, Th1 H2 Receptor Agonist web immune responses, antigen particular antibody production and memory T cell generation. (bcrablinhibitor.com)
  • This Pik3r1 study shows that SMIP2.1 could assist in the generation of antigen specific CTL along with the robust activation of CD4+ T cells, and thus could be exploited in the design of effective adjuvants for antitumor and antiviral vaccines. (cckn-ia.org)
  • The Cross-Modal Priming Task (CMPT), developed by David Swinney, is an online measure used to detect activation of lexical and syntactic information during sentence comprehension. (wikipedia.org)
  • Friedmann, Taranto, Shapiro & Swinney ( 2008 ) conducted a cross-modal lexical priming experiment in English and found that subjects of unaccusatives reactivate after the verb, whereas subjects of unergatives do not. (glossa-journal.org)
  • By blocking the negative immune regulatory signals mediated by PD-1/PD-L1 pathway, these drugs remove the inhibition of T-cell activation and effector function and vigorously restore antitumor immune responses [ 3 ]. (oncotarget.com)
  • One possible solution would be to modify these vaccines so that they prime cross-reactive CD8 + cytotoxic T lymphocytes (CTL) cell-mediated immunity directed at conserved viral epitopes. (elsevierpure.com)
  • Dijke, P. ten & Cruz, L.J. (2023), Enhancing anti-tumor immunity through liposomal oxaliplatin and localized immunotherapy via STING activation, Journal of Controlled Release 357: 531-544. (universiteitleiden.nl)
  • Therefore, one focus of our work is the identification of key mechanisms essential for the efficient generation (priming) and expansion (recall) of anti-viral or vaccine-induced T cell responses. (uniklinik-duesseldorf.de)
  • Fucoidan stimulates macrophage and DC activation by means of scavenger receptor-A (SR-A) in in vitro research [19,23,32], and it truly is likely that fucoidan may possibly stimulate in vivo spleen cDCs by engaging SR-A. Activation of SR-A benefits in human peripheral blood DC (PBDC) maturation that subsequently promotes Th1 responses [23]. (bcrablinhibitor.com)
  • DCs are identified to prime CTL responses upon activation by ligands targeting several PRRs, including toll-like receptors and Dectin-1 [33,34]. (bcrablinhibitor.com)
  • Our futurestudies will straight test regardless of whether fucoidan can activate SR-A and whether activation of SR-A signaling in DCs can promote CLR responses in vivo by utilizing SR-A-knock out mouse. (bcrablinhibitor.com)
  • Prime Joint Support Formula also contains the powerful antioxidant Pycnogenol®, which science has shown help maintain the body's natural defenses by inhibiting metabolic responses associated with the normal aging process. (tlsslim.com)
  • BCG failure to induce long-term protection has been endowed to its mild activation of CD8-T cell responses along with the induction of the immunosuppressive cytokine IL-10. (validate-network.org)
  • Alternative vaccine adjuvants aimed at eliciting both antibody and cellular responses are based on the activation of receptors of the innate immune system, such as TLRs. (cckn-ia.org)
  • Heat shock proteins (HSPs) are required for the successful activation of anti-tumor immune responses. (celljournal.org)
  • TRALI has two proposed pathophysiologic mechanisms: the antibody hypothesis and the neutrophil priming hypothesis. (medscape.com)
  • Interestingly, ProIFN-treated mice show enhanced DC cross-priming and significant increased CD8(+) infiltration and effector function in the tumor microenvironment. (acir.org)
  • Overall, we demonstrated that radiation-induced activation of the AIM2 and NLRP3 inflammasomes coordinate to induce some of the antitumor effects of radiation by triggering IL-1 signaling in DCs, leading to their activation and cross-priming. (elsevierpure.com)
  • Citation: Chickarmane V, Enver T, Peterson C (2009) Computational Modeling of the Hematopoietic Erythroid-Myeloid Switch Reveals Insights into Cooperativity, Priming, and Irreversibility. (lu.se)
  • We demonstrate that treatment with TAK-981 results in IFN1-dependent macrophage and natural killer (NK) cell activation, promoting macrophage phagocytosis and NK cell cytotoxicity in ex vivo assays. (bvsalud.org)
  • Pachamama also received another powerful activation on the Ring of Fire with a magnitude 5.8 earthquake in Japan at 22:48 UTC. (primedisclosure.com)
  • This type of hyperinflammatory state is reminiscent of 2 rheumatologic disorders known as macrophage activation syndrome and hemophagocytic lymphohistiocytosis, which are characterized by macrophage and T-cell activation. (cdc.gov)
  • An evaluation of 2 cohorts of patients with EVD revealed that a marker of macrophage activation (sCD163) but not T-cell activation (sCD25) was associated with severe and fatal EVD. (cdc.gov)
  • These data suggest that host macrophage activation contributes to EVD pathogenesis and that directed antiinflammatory therapies could be beneficial in the treatment of EVD. (cdc.gov)
  • Glycoprotein 96 (gp96) is a well-known HSP that promotes the cross-presentation of tumor antigens. (celljournal.org)
  • Understanding the interaction between BAF and cGAS adds a new layer of control to prevent aberrant innate immune system activation, and therefore, may enable the development of more precise treatment options for autoimmune or autoinflammatory diseases. (ifmthera.com)
  • Subliminal priming reveals cross-notation and cross-modality effects, contrary to CK&W's prediction that automatic activation is modality and notation-specific. (cambridge.org)
  • That unmatched legacy continues with the recent reveals of the all-new 2023 Prius and 2023 Prius Prime. (toyota.com)
  • Moreover, MVA is reconsidered as prime candidate vaccine for safer protection against orthopoxvirus infections. (uniklinik-duesseldorf.de)
  • This has provided hope for the design of a universal vaccine able to prime against diverse influenza virus strains and subtypes. (mdpi.com)
  • At both 2 and 10 ng dosages of vaccine, DC15 conjugation induced excellent Compact disc8 T cell activation weighed against VHHcont (shape?3at low dosages and will not need B cells. (euromedh2020.com)
  • Cross-language syntactic activation during bilingual reading: Eye movement evidence from adjective-noun constructions. (uwo.ca)
  • Axl receptor tyrosine kinase critically involves in the carcinogenesis of multiple cancers due to its dual roles in both promoting cancer invasion and metastasis and suppressing myeloid cell activation and function. (oncotarget.com)
  • Naser Al Deen N, Nassar F, Nasr R, Talhouk R. Cross-roads to drug resistance and metastasis in breast cancer: miRNAs regulatory function and biomarker capability. (celljournal.org)
  • Activation of MAPK is initiated by one of the four ErbB receptors (ErbB1/epidermal growth factor receptor (EgfR), ErbB2-4), which leads to signaling through Raf (RAF proto-oncogene serine/threonine-protein kinase), Mek (mitogen-activated protein kinase kinase 1/2) and Erk. (biomedcentral.com)
  • Likewise, upon stimulation with SMIP2.1, human PBMCs were able to cross-present the CMV pp65 protein to human CMV (HCMV)-primed CD8+ T cells. (cckn-ia.org)
  • In addition, the ErbB receptors integrate a diverse array of signals, both at the cell surface level and through cross-talk with other pathways, such as the phosphoinositide 3-kinase (Pi3k) pathway [ 11 ]. (biomedcentral.com)
  • Activation of guinea pig eosinophils by human recombinant IL-5. (pasteur.fr)
  • IFNγ exerts immunoregulatory, anti-proliferative, anti-viral, and proinflammatory activities and plays an important role in activation, growth, and differentiation of T and B lymphocytes, macrophages, NK cells and other non-hematopoietic cell types. (bioxcell.com)
  • We previously reported that apoptosis of BCG-infected macrophages relies on activation of FOXO3, a transcription factor negatively regulated by the pro-survival Akt kinase. (validate-network.org)
  • After validating a system of filovirus-specific indirect ELISAs utilizing infectious-based virus antigens for detection of virus-specific IgG antibodies from bat sera, we assess the level of serological cross-reactivity between the virus-specific antisera and heterologous filovirus antigens. (cdc.gov)
  • 2007 ) in English, and Shetreet, Friedmann & Hadar ( 2009 ) in Hebrew, using fMRI, revealed distinct activations for unaccusatives and unergatives. (glossa-journal.org)
  • The current study investigates cross-linguistic influence of second language (L2) learning on native language (L1) processing of morphosyntactic variation in proficient L2 learners immersed in their L1. (cambridge.org)
  • In a cross-sectional study design, 47 female football and handball players were randomly assigned to receive app instruction (APP group) or on-site instruction provided by a physiotherapist (PHY group) while performing five lower extremity injury preventive exercises. (unboundmedicine.com)
  • they conducted a reaction time study in Spanish to explore whether the trace left by the argument of unaccusative verbs in the complement of V position, argued to be an anaphor ( Chomsky 1981 ), would prime semantically related nouns as overt anaphors do. (glossa-journal.org)
  • Here, we generate filovirus-specific antisera by prime-boost immunization of groups of captive ERBs with all seven known culturable filoviruses. (cdc.gov)
  • The 2023 Prius Prime also adds to the innovative nameplate. (toyota.com)
  • Without question, both the 2023 Prius and 2023 Prius Prime are key vehicles in Toyota's diverse electrified portfolio as the company works to achieve carbon neutrality. (toyota.com)
  • Read on to learn about the top five things that make the 2023 Prius and 2023 Prius Prime innovative additions to the eco-sensitive Prius family. (toyota.com)
  • The 2023 Prius will be available in LE, XLE and Limited grades, and the 2023 Prius Prime will be available in SE, XSE and XSE Premium grades, respectively. (toyota.com)
  • With an aerodynamic flair, the 2023 Prius and Prius Prime feature a roofline 2 inches lower compared to the prior generation for a more athletic look. (toyota.com)
  • For both the 2023 Prius and Prius Prime, the position of the battery is also optimized, with placement under the rear seat for enhanced luggage capacity. (toyota.com)
  • Drivers can expect enhanced acceleration and effortless handling when they get behind the wheel of both the 2023 Prius and 2023 Prius Prime. (toyota.com)
  • The 2023 Prius and 2023 Prius Prime are designed and equipped with the tools to make life easier and more convenient - thanks to the available 12.3-inch Toyota Audio Multimedia system feature. (toyota.com)
  • Their observations, published in Nature, revealed that male patients showed higher plasma levels of innate immune cytokines such as IL-8 and IL-18, while female patients mounted significantly more robust T cell activation than male patients during SARS-CoV-2 infection. (ifmthera.com)
  • The TNF-family member Receptor Activator of NF-kappaB (RANK) is known for its role in bone homeostasis and is increasingly recognized as a central player in immune regulation and epithelial cell activation. (cnrs.fr)
  • Such ``priming'' is also clear that both GATA-1 and PU.1 cross-antagonize each behavior for progenitors could allow for rapid deployment of other's activity. (lu.se)
  • Therefore, it might be likely that stimulation of SR-A on DCs by fucoidan results in the crosspriming of OVA-specific CTLs. (bcrablinhibitor.com)
  • This Scoping Parameter excludes any Second-generation Data exported through pre-built destination connectors, as described in the Audience Activation Static Limit below. (adobe.com)
  • He is also the author of studies and expert opinions commissioned by: the Chancellery of the Prime Minister of Poland, the Institute of Public Affairs, the Batory Foundation, the United States Agency for International Development (US AID), and the East Europe Democratic Centre. (who.int)
  • WHO Regional Director for Eastern Mediterranean together with the Regional Emergency Director visited Lebanon and met with the Prime Minister, the Minister of Health, UN partners, and WHO staff to reinforce health system preparedness for a potential escalation of the conflict. (who.int)
  • Users can interact with the system through intuitive touch and voice activation controls. (toyota.com)
  • In addition, activation of the renin-angiotensin system, through the action of angiotensin II on angiotensin I receptors, leads to growth of interstitium and cell matrix components. (medscape.com)
  • GATA-1 and PU.1 then initiate the presumed cascade of It governs the erythroid - myeloid lineages and demonstrates both transcriptional changes that culminate in the specification of the commitment as well as priming features [6,7]. (lu.se)
  • Significantly, the levels of peptide found in these cocultures had been below that necessary for the activation of OT-I T cells by surface area launching onto MHC course I, as evidenced by minimal activation induced by DC15 admixed with free of charge peptide at concentrations less than 300 pM (shape?2, blue pubs). (euromedh2020.com)
  • The dynamics of cross-language phonological activation in bilinguals: Evidence from event related potentials. (uwo.ca)
  • Swinney claimed that if a person activates both meanings of an equibiased ambiguous word simultaneously, then the response times should be the same regardless of which meaning is primed by the stimulus. (wikipedia.org)
  • This algorithmic machine- PMMM, encapsulated a bunch of propensity (response, activation, right time to call) and predictive (probability of default, spending) models. (scienaptic.ai)
  • The deployed expert is working closely with the PHEOC team at the MoPH to strengthen preparedness, readiness, and response capacities to emergencies in addition to providing technical guidance in relation to Incidence Management Structure during activation. (who.int)
  • While it is already known that DCs can cross-present exogenous antigens, the role of B cells in this process is less clear.19-21 Using transnuclear B cells that express a BCR specific for OVA, we demonstrated for the first time that B cells can cross-present OVA upon TLR2 stimulation. (cckn-ia.org)
  • Understanding the underlying molecular circuitry in terms of how it governs both a primed state and, at the other extreme, a committed state is of relevance not only to hematopoiesis but also to developmental systems in general. (lu.se)
  • An interesting fallout from this architecture is that suppression of the cofactor through external means can lead to a loss of cooperativity, and hence to a primed state for PU.1 and GATA-1. (lu.se)
  • The genetic switch, which handles the erythroid-myeloid lineage decision, is an example of a network that implements both a primed and a committed state by regulating cooperativity through recruitment of cofactors. (lu.se)
  • Due to the artificial nature of drug/chemical-T-cell epitopes, it is not clear whether thymic selection of drug/chemical-specific T cells is a common phenomenon or remains limited to few donors or simply does not exist, suggesting T-cell receptor (TCR) cross-reactivity with other antigens. (frontiersin.org)
  • The remainder cross the tunnel of Corti to innervate the outer hair cells. (medscape.com)
  • The test assumed that multiple meanings are activated at the moment an ambiguity is encountered in a sentence, which primes related concepts. (wikipedia.org)
  • Countries have the necessary legal and regulatory processes to allow for rapid national or cross-border deployment and receipt of public health, medical personnel and logistics and supplies during emergencies. (who.int)
  • You prime the PMMM with existing credit card customer data and come up with target lists to cross sell unsecured loans. (scienaptic.ai)
  • We investigated which APCs populations could be the target for SMIP2.1-induced cross-presentation and showed that both CD8+ and CD8? (cckn-ia.org)