• This complex attaches (binds) to other proteins called G protein coupled receptors. (medlineplus.gov)
  • The class-I and class-II proteins of the Major Histocompatibility Complex play an essential role in immune surveillance, by displaying epitopic peptides derived from the processing of aberrant proteins on the cell surface, where they can be recognized through interactions with specialized receptors on T cells and Natural Killer cells. (upenn.edu)
  • Only two PI3Ks are directly regulated downstream from G protein-coupled receptors (GPCRs): the class I enzymes PI3Kβ and PI3Kγ. (elsevierpure.com)
  • While some receptors selectively activate specific G protein families, others are more versatile, yielding diverse responses based on cell-specific G protein expression. (drgpcr.com)
  • Sphingosine 1-phosphate (S1P) receptors represent a novel subfamily of G-protein-coupled receptors binding S1P specifically and with high affinity. (mdc-berlin.de)
  • Here we show that S1 P4 couples directly to Gαi and even more effectively to Gα12/13-subunits of trimeric G-proteins, but notto Gαq unlike other S1P receptors. (mdc-berlin.de)
  • Binding of the trimeric TRAIL to its receptors TRAIL-R1 and TRAIL-R2 induces caspase activation and apoptosis [ 4 ], either through the extrinsic pathway alone or recruiting the intrinsic apoptotic pathway [ 5 ]. (biomedcentral.com)
  • Extracellular stimuli that activate cell surface receptors modulate glucocorticoid actions via as yet unclear mechanisms. (rupress.org)
  • The strong expression of ATP-gated P2X3 receptors by a subpopulation of sensory neurons indicates the important role of these membrane proteins in nociceptive signaling in health and disease, especially when the latter is accompanied by chronic pain syndromes. (gozmusic.org)
  • These receptors exist mainly as trimeric homomers, and, in part, as heteromers (assembly of two P2X3 subunits with one P2X2). (gozmusic.org)
  • Trimeric P2X3 receptors are rapidly activated by ATP and can be strongly desensitized in the continuous presence of the agonist. (gozmusic.org)
  • CDK-activating kinase (CAK) activates the cyclin-CDK complex by phosphorylating threonine residue 160 in the CDK activation loop. (wikipedia.org)
  • In vertebrates and Drosophila, CAK is a trimeric protein complex consisting of Cdk7 (a Cdk-related protein kinase), cyclin H, and Mat1. (wikipedia.org)
  • In budding yeast, CAK is a monomeric protein kinase and is referred to as Cak1. (wikipedia.org)
  • Pleckstrin, the protein where this domain was first detected, is the major substrate of protein kinase C in platelets. (embl.de)
  • How is a tyrosine kinase receptor activated? (flashcardmachine.com)
  • The AMP-activated protein kinase (AMPK) is known to be activated by the protein tyrosine phosphatase non-receptor type 12 (PTP-PEST) under hypoxic conditions. (bvsalud.org)
  • What are the independent variables of (0p 0T )v. A new human p34 protein kinase, CDK2, identified by complementation of opttion cdc28 mutation in Saccharomyces cerevisiae, is a homolog of Xenopus Eg1. (forex-consultant.com)
  • Applying FUSION evaluation to a little interfering RNA (siRNA) display NS13001 screen of genes encoding kinases, phosphatases, and related protein, a gene appearance signature quality of KSR1 disruption discovered PRKAG1, the gene encoding the 1 subunit of AMP-activated proteins kinase (AMPK), as an element of digestive tract tumor cell success. (researchatlanta.org)
  • Mechanistically, we found that AMPK activation increased, whereas AMPK inhibition decreased, the levels of mitogen-activated protein kinase phosphatase-1 (MKP-1), an inducible nuclear phosphatase, by regulating proteasome-dependent degradation of MKP-1. (diabetesjournals.org)
  • This work highlights both structural and mechanistic similarities with the small and trimeric G proteins and restricts the types of mechanisms responsible for the considerable enhancement of ATP hydrolysis associated with actin polymerization. (rcsb.org)
  • The unusually complex regulation of PI3Kβ by small and trimeric G proteins and RTKs leads to a rich landscape of signaling responses at the cellular and organismic levels. (elsevierpure.com)
  • The recruitment of specific cytosolic proteins to intracellular membranes through binding phosphorylated derivatives of phosphatidylinositol (PtdIns) controls such processes as endocytosis, regulated exocytosis, cytoskeletal organization, and cell signaling. (embl.de)
  • When binding to the receptor complex, Jak1 and Tyk2 will be activated, and leads to subsequent tyrosine phosphorylation of the IFN-λR1 (intracellular domain, Tyr406 and Tyr343, Tyr517), and activation of STAT1 and STAT2. (medchemexpress.com)
  • The metabolic abnormalities of type 2 diabetes, including hyperglycemia, dyslipidemia, and insulin resistance, activate the Janus kinases/signal transducer and activator of transcription (JAK/STAT) signaling pathway, a major intracellular inflammatory cascade that transmits the intracellular signaling to the nucleus ( 2 ), promoting inflammatory response, inducing insulin resistance ( 3 ), and accelerating the development of cardiovascular complications ( 4 ). (diabetesjournals.org)
  • To gain insight into the intracellular fluxes of subpopulations and their interplay within such mixed cultures, we developed here a (13)C flux analysis approach based on affinity purification of the recombinant fusion glutathione S-transferase (GST) and green fluorescent protein (GFP) as a reporter protein. (gozmusic.org)
  • As a member of the G Protein-coupled receptor family, the topology of TGR5 displays the characteristic seven transmembrane helices, three extracellular loops contributing to ligand binding, and an intracellular carboxy tail that associates with trimeric G proteins. (indigobiosciences.com)
  • Different oligomeric complex of Adiponectin activates different signaling pathways and exerts distinct functions. (prospecbio.com)
  • The activated Gαq protein then separates from the protein complex and activates signaling pathways that help to regulate the development and function of blood vessels. (medlineplus.gov)
  • It then reattaches to the trimeric G protein complex, turning off the signaling pathways. (medlineplus.gov)
  • As a result, the protein is always active, and signaling pathways controlled by it are constantly turned on. (medlineplus.gov)
  • The AAA-ATPase (ATPases associated with diverse cellular activities) valosin-containing protein (VCP), is essential for many cellular pathways including but not limited to endoplasmic reticulum-associated degradation (ERAD), DNA damage responses, and cell cycle regulation. (portlandpress.com)
  • VCP primarily identifies ubiquitylated proteins in these pathways and mediates their unfolding and degradation by the 26S proteasome. (portlandpress.com)
  • Valosin-containing protein (VCP, also p97, or Cdc48p in yeast) is an evolutionarily conserved, homo-hexameric, ubiquitin-selective, AAA-ATPase that functions in numerous ubiquitin-dependent protein quality control pathways. (portlandpress.com)
  • Through these interactions, PH domains play a role in recruiting proteins to different membranes, thus targeting them to appropriate cellular compartments or enabling them to interact with other components of the signal transduction pathways. (embl.de)
  • What two pathways do PTKs activate? (flashcardmachine.com)
  • Previous reports have demonstrated that this channel type can be inhibited via two pathways that involve syntaxin 1 and G-protein. (jneurosci.org)
  • Prolonged chronical UPR may activate apoptotic pathways and cause cell death. (eurekaselect.com)
  • In this context, a new molecule, B-cell activating factor (BAFF), has emerged as a positive regulator of B cell survival and differentiation functioning through various signaling pathways and potentiating the activity of various receptor complexes through pleiotropic means. (medsci.org)
  • When the protein complex is bound to a receptor, the Gαq protein binds to a molecule called GTP and is turned on (activated). (medlineplus.gov)
  • Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. (embl.de)
  • However, PI3Kβ is also regulated by direct interactions with receptor tyrosine kinases (RTKs) and their tyrosine phosphorylated substrates, and similar to the class II and III PI3Ks, it binds activated Rab5. (elsevierpure.com)
  • It is disclosed herein that the HIV-1 envelope protein gp120 binds to α4β7 integrin on CD4+ T-cells, natural killer (NK) cells and CD8+ T-cells. (justia.com)
  • Activated adenylate cyclase results in the production of cAMP, which binds the transcription factor CREB (cAMP Response Element-Binding Protein). (indigobiosciences.com)
  • Activated CREB binds to CRE sequences, seeding the formation of a complete transcription complex that drives luciferase gene expression. (indigobiosciences.com)
  • TNF superfamily member (TRAIL) is a type II transmembrane protein and is responsible for initiating apoptosis. (ekb.eg)
  • According to sequence based predictions Sig-1R is a 223 amino acid protein with two transmembrane (2TM) domains. (eurekaselect.com)
  • The X-ray structure of the Sig-1R [1] showed a membrane-bound trimeric assembly with one transmembrane (1TM) region. (eurekaselect.com)
  • The trimeric, transmembrane spike (S) glycoprotein of the virus, SARS-2-S, includes two main functional subunits: S1 and S2. (pubannotation.org)
  • Table of Cdk-activating Kinases http://www.oup.com/uk/orc/bin/9780199206100/resources/figures/nsp-cellcycle-3-3-3_7.jpg. (wikipedia.org)
  • Ser/Thr protein kinases such as the Akt/Rac family, the beta-adrenergic receptor kinases, the mu isoform of PKC and the trypanosomal NrkA family. (embl.de)
  • Tyrosine protein kinases belonging to the Btk/Itk/Tec subfamily. (embl.de)
  • GPCR kinases (GRKs) and β-arrestins are activated by agonist-bound GPCRs and interact with the receptor cavity. (drgpcr.com)
  • TRAIL-R1 can be activated by soluble or memTRAIL, whereas TRAIL-R2 only responds to memTRAIL. (biomedcentral.com)
  • CD40L is produced as homotrimeric membrane anchored protein each of the three membrane proximal stalk regions can be sequentially proteolyzed to generate the soluble trimeric protein which retains full binding activity to its receptor, CD40. (abbiosciences.com)
  • Leptin and adiponectin can augment the oxidation of fatty acid in liver by activating the nuclear receptor super-family of transcription factors, namely peroxisome proliferator-activated receptor (PPAR)-α. (wjgnet.com)
  • Our lab's principal efforts focus on mechanistic, structural and functional studies of protein complexes, with emphasis on the development of an iterative experimental / computational approach. (upenn.edu)
  • These syntaxin 1 protein complexes may play distinct roles in presynaptic biology. (jneurosci.org)
  • Conventional coimmunoprecipitation (coIP) and pull-down assays were used to test for stable protein complexes. (jneurosci.org)
  • Both enzymes produce phosphatidylinositol 3,4,5-trisposphate in vivo and are regulated by both heterotrimeric G proteins and small GTPases from the Ras or Rho families. (elsevierpure.com)
  • Further characterization uncovered that a complicated of the trimeric AMPK incorporating the two 2 and 2 subunits combined with the 1 subunit was vital to human digestive tract tumor cell success. (researchatlanta.org)
  • Single-chain antibodies (scFv) take an important role in the field, because they are less immunogenic than whole antibodies, their smaller size allows faster and deeper penetration into solid tumors, and are by definition recombinant proteins, therefore easier to produce and modify. (biomedcentral.com)
  • Sig-1R exists in oligomeric structures (dimer-trimer-octamer-multimer) and this fact may explain interaction with diverse proteins. (eurekaselect.com)
  • The Gαq protein converts GTP to a similar molecule called GDP, which turns off (inactivates) the protein. (medlineplus.gov)
  • Roles of T cell-B-cell-activating molecule (5c8 antigen) and CD40 in contact-dependent help. (abbiosciences.com)
  • IFN-lambda 2/IL-28A Protein shows anti-viral, anti-tumor and immune stimulatory properties. (medchemexpress.com)
  • Fas/APO-1/CD95, member of the tumor necrosis factor (TNF) receptor superfamily, is a widely expressed cell surface receptor that can initiate apoptosis when activated by its ligand (FasL). (ac.ir)
  • Recent advances in understanding the molecular events underlying hypohidrotic ectodermal dysplasia (HED) caused by mutations of the genes encoding proteins of the tumor necrosis factor α (TNFα)-related signaling pathway have been presented. (springer.com)
  • Our detailed biophysical characterization of the molecular chaperone TAPBPR provided us with a high-resolution view of peptide exchange on MHC-I proteins and led to the development a high-throughput methodology for generating barcoded MHC tetramer libraries encompassing hundreds of unique antigen specificities. (upenn.edu)
  • CD40 ligand (CD40L or CD154), a type II membrane glycoprotein and a member of the TNF superfamily, is known for its transient expression on activated CD4+ T lymphocytes which is responsible for the helper T cells' function on resting B cells in a non-antigen-dependent as well as non-major histocompatibility complex-restricted fashions. (abbiosciences.com)
  • De novo design of a homo-trimeric amantadine-binding protein. (upenn.edu)
  • Moreover, with advances in the computational design of protein folding and protein-protein interfaces, considerable progress has recently been made in the de novo design of protein assemblies. (springeropen.com)
  • A better understanding of the proteins contributes to designing new supramolecular structures from rational design to de novo design. (springeropen.com)
  • Recently, the de novo design of proteins that start from scratch can create a new topology beyond experimentally determined structures. (springeropen.com)
  • De novo design generates a building block based on the basic physical principle of protein by using computational power. (springeropen.com)
  • Receptor binding activates proteases that can carry out proteolytic cleavage of the S protein. (pubannotation.org)
  • These entry-activating SARS-CoV proteases include the TMPRSS2 cell surface protease and the cathepsin lysosomal proteases. (cd-genomics.com)
  • Cytoskeletal proteins such as dynamin (see IPR001401 ), Caenorhabditis elegans kinesin-like protein unc-104 (see IPR001752 ), spectrin beta-chain, syntrophin (2 PH domains) and S. cerevisiae nuclear migration protein NUM1. (embl.de)
  • Consequently, CHO-K1 cells ectopically expressing S1P4 potently activate the small GTPase Rho and undergo cytoskeletal rearrangements, inducing peripheral stress fiber formation and cell rounding, upon S1P stimulation. (mdc-berlin.de)
  • In this paper, we will discuss about the component of supramolecular protein assembly and classify their conformation according to structural dimensionality. (springeropen.com)
  • The GNAQ gene provides instructions for making a protein called guanine nucleotide-binding protein G(q) subunit alpha (Gαq). (medlineplus.gov)
  • Regulators of small G-proteins like guanine nucleotide releasing factor GNRP (Ras-GRF) (which contains 2 PH domains), guanine nucleotide exchange proteins like vav, dbl, SoS and Saccharomyces cerevisiae CDC24, GTPase activating proteins like rasGAP and BEM2/IPL2, and the human break point cluster protein bcr. (embl.de)
  • Here, we report that the guanine nucleotide-binding protein (G protein)-coupled receptor-activated WD-repeat Gβ interacts with the glucocorticoid receptor (GR), comigrates with it into the nucleus and suppresses GR-induced transactivation of the glucocorticoid-responsive genes. (rupress.org)
  • Both trimeric light-harvesting complex II (LHCII) and monomeric LHC proteins have been indicated as site(s) of the heat-dissipative reactions. (lu.se)
  • Here, we report on the construction of a mutant lacking all monomeric LHC proteins but retaining LHCII trimers. (lu.se)
  • Trimeric LHCII was responsible for the slowly activated quenching component whereas inclusion in supercomplexes was not required. (lu.se)
  • In the following, we refer to pump of halophilic archaebacteria, has become the these as the extracellular (EC) channel and the paradigm of membrane proteins in general and ion cytoplasmic (CP) channel. (lu.se)
  • TSC is characterized by autosomal-dominant mutations in the TSC1 or TSC2 genes (encoding for the protein Hamartin on chromosome 9q34 and Tuberin on chromosome 16q13 respectively) leading to overactivation of the mTOR (mechanistic target of rapamycin) pathway with increased cell proliferation and a range of other consequences. (uspharmacist.com)
  • In the past decade, yeast have been frequently employed to study the molecular mechanisms of human neurodegenerative diseases, generally by means of heterologous expression of genes encoding the relevant hallmark proteins. (microbialcell.com)
  • In this respect, although obviously lacking a brain with a multicellular neuronal network, simple unicellular yeast are of great value to investigate the effects of overexpression and single point-mutations in genes encoding key proteins on cell physiology and on the function of conserved signaling cascades. (microbialcell.com)
  • Intro A third of all human cancers, including a substantial percentage of colorectal, lung, and pancreatic cancers, are driven by activating mutations in Ras genes. (researchatlanta.org)
  • Novel data were reviewed and discussed on the structure and functions of the components of TNFα-related signaling pathway, the consequences of mutations of the genes encoding these proteins, and the prospect for further investigations, which might elucidate the origin of HED. (springer.com)
  • Mutations of these genes are responsible for systemic tooth agenesis, in addition to the defects of other ectodermal structures, and this review is limited to description of the function of their protein products. (springer.com)
  • This is followed by their culture on extracellular matrix (ECM) protein coated tissue culture flasks in presence of endothelial cell growth medium. (bvsalud.org)
  • Protein substrates bind to the entrance of the active site cleft. (wikipedia.org)
  • VCP identifies ubiquitylated substrates through numerous dedicated adaptor proteins and unfolds substrates by threading them through a central pore in the hexamer ( Figure 1 ). (portlandpress.com)
  • VCP interacts with adaptor proteins to identify ubiquitylated substrates for degradation by the proteasome. (portlandpress.com)
  • Apoptosis is a genetically programmed form of cell death that is mediated by the activation of the caspase cascade and results in the cleavage of protein substrates and oligonucleosomal fragmentation of DNA. (ac.ir)
  • GPCR signaling is a complex process modulated by protein conformational states. (drgpcr.com)
  • Proteolytic cleavage of the S protein causes conformational changes so that they cannot revert to the original structure and profound enough to prime the S2 subunit for the fusion of viral and cellular membranes. (pubannotation.org)
  • Upon binding to bile acid ligands, TGR5 undergoes a conformational change that triggers the activation of Gas proteins via an exchange of GDP with GTP, followed by the activation of adenylate cyclase and the production of cAMP. (indigobiosciences.com)
  • Subsequent movement of the S4 helix from the intermediate state to the activated state then triggers conformational change of the pore from the IO state to the AO state. (elifesciences.org)
  • An order-to-disorder structural switch activates the FoxM1 transcription factor. (upenn.edu)
  • The SARS-CoV-2 genome contains a single 29,903 bp RNA strand that codes for replicase-transcriptase, and spike, envelope, membrane, and nucleocapsid structural proteins. (cd-genomics.com)
  • The genomic areas which code for structural proteins are subsequently transcribed by this complex. (cd-genomics.com)
  • The GNAQ gene mutation associated with Sturge-Weber syndrome changes a single building block (amino acid) in the Gαq protein. (medlineplus.gov)
  • The GNAQ gene mutations in uveal melanoma result in an overactive protein, which leads to excessive signaling. (medlineplus.gov)
  • Activating K-Ras mutations are present in 35 to 40% of colon tumors and are thought to be both drivers of tumorigenesis and determinants of restorative regimens (1). (researchatlanta.org)
  • Despite the detailed in vitro characterization of the enzymatic properties of yeast Sac1p, the exact cellular function of this protein has remained obscure. (embl.de)
  • Despite their contributions, these methods often lack cellular auxiliary structures and proteins. (drgpcr.com)
  • Instead of detecting the (13)C labeling patterns in the typically used amino acids from the total cellular protein, our method detects these (13)C patterns in amino acids from the reporter protein that has been expressed in only one species of the consortium. (gozmusic.org)
  • TRAIL can either be secreted as a dissolved protein or hydrophobic amino acids can attach it to the membrane. (ekb.eg)
  • Proteins were resolved using SDS-PAGE and transferred to nitrocellulose membranes, clogged in Odyssey obstructing buffer (Li-Cor), hybridized with main and secondary antibodies in Tris-buffered saline (TBS)C0.1% Tween 20, and recognized using an Odyssey imaging system (Li-Cor). (researchatlanta.org)
  • Trimeric form of Adiponectin Human trimeric form was expressed in HEK293 cells. (prospecbio.com)
  • Other adipokines, such as leptin and adiponectin and, to a lesser extent, resistin and retinol binding protein-4 are also involved. (wjgnet.com)
  • From the MRD data, the rotational correlation time of detergent-solubilized BR was determined to 35 ns at 300 K, con- sistent with a monomeric protein in complex with about 150 detergent molecules. (lu.se)
  • Members of a subfamily of these enzymes share a specific domain that was first identified in the yeast Sac1 protein [1]. (embl.de)
  • My research focuses on understanding the intricate molecular mechanisms that determine the vast repertoire of peptide antigens displayed by the proteins of the Major Histocompatibility Complex for immune surveillance by T cells and Natural Killer cells. (upenn.edu)
  • We conclude that non-photochemical quenching is catalysed by two independent mechanisms, with the fastest activated response catalysed within monomeric LHC proteins depending on both zeaxanthin and lutein and on the formation of a radical cation. (lu.se)
  • These findings provide insight into the molecular basis for human antibody recognition of paramyxovirus surface proteins and the mechanisms of SOSV neutralization. (cdc.gov)
  • Presynaptic Ca V 2.2 (N-type) calcium channels are subject to modulation by interaction with syntaxin 1 and by a syntaxin 1-sensitive Gα O G-protein pathway. (jneurosci.org)
  • that allow interaction with trimeric G proteins, which regulate second messengers like cAMP or Ca2+. (drgpcr.com)
  • Msc6 and Msc2 complex not only activates cell cycle Cdks but also regulates gene expression because it is part of the transcription factor TFIIH. (wikipedia.org)
  • The Gαq protein is part of a group of proteins called the trimeric G protein complex. (medlineplus.gov)
  • The above findings could be explained if syntaxin 1 was a key element of a protein complex at the transmitter release site that included N-type Ca channels and Gα O . The primary motivation for this study was to test this hypothesis. (jneurosci.org)
  • It does not address the more fundamental question of whether the intensity of staining for the two proteins vary in synchrony, as would be predicted if they are components of the same complex. (jneurosci.org)
  • Activated STAT1 and STAT2 together with IRF-9 (p48) form a trimeric transcription factor complex (ISGF3). (medchemexpress.com)
  • Using Argonaute CLIP-seq data, Dr. Rigoutsos and colleagues showed that similar percentages of the two sets of microRNAs were in complex with Argonaute proteins. (pharmaceuticalintelligence.com)
  • 2 SARS-CoV2 cell entry is not complex Fig. 1 is a schematic illustration of the minimum proteins required to mediate the SARS-CoV2 cell entry. (pubannotation.org)
  • The light harvesting complex is composed of trimeric and monomeric antenna proteins containing Chlorophyll a and b pigments and Carotenoids. (unine.ch)
  • Various proteins form one complex structure to control detailed reactions. (springeropen.com)
  • Supramolecular assembly is a very common phenomena in nature and these natural supramolecular proteins have various structures, from simple structures to complex structures [ 1 , 2 ]. (springeropen.com)
  • In co-cultures with K V 10.1-positive cancer cells the fusion protein also induced apoptosis in bystander K V 10.1-negative cancer cells, while normal prostate epithelial cells were not affected when present as bystander. (biomedcentral.com)
  • IFN-lambda 2/IL-28A Protein, Human (HEK293, His) is a recombinant human IFN-lambda 2 (V26-V200) with C-terminal 6*His tag, which is expressed in HEK293. (medchemexpress.com)
  • Several S. cerevisiae proteins involved in cell cycle regulation and bud formation like BEM2, BEM3, BUD4 and the BEM1-binding proteins BOI2 (BEB1) and BOI1 (BOB1). (embl.de)
  • TRAIL promotes cell death by attaching to and activating trimeric death receptor. (ekb.eg)
  • Fig. 1 Proteins required for the SARS-CoV2-cell entry. (pubannotation.org)
  • In addition HIV-1 Vpr protein alters the cell-cycle regulation by hijacking centrosome functions. (biomedcentral.com)
  • This is an all-inclusive cell-based luciferase reporter assay kit targeting the Human G Protein Coupled Bile Acid Receptor 1 (GPBAR1), also commonly referred to as the Takeda G-protein-coupled receptor 5 (TGR5). (indigobiosciences.com)
  • The spike protein is present as a trimer in mature viruses, with three receptor binding S1 heads lying on top of the S2 stalk of a trimeric membrane fusion. (cd-genomics.com)
  • In recent work, our team found that the dynamic plasticity of MHC-I proteins, occurring over a range of timescales from microseconds to milliseconds, plays an essential role in their peptide selector function though the sampling of minor, "excited-state" conformations. (upenn.edu)
  • The K V 10.1-specific scFv62 antibody -TRAIL fusion protein was expressed in CHO-K1 cells, purified by chromatography and tested for biological activity. (biomedcentral.com)
  • The co-expression of the CD40L and the FcγRIIA on the surface of the activated platelets has been implicated for the thrombogenic activity of the anti-CD40L antibody in human. (abbiosciences.com)
  • TRAIL is normally present as a membrane protein (memTRAIL) on immune effector cells, like natural killer cells. (biomedcentral.com)
  • This is exemplified by the neuronal tau proteins, which are critically involved in a class of neurodegenerative diseases collectively called tauopathies and which includes Alzheimer's disease (AD) as its most common representative. (microbialcell.com)
  • ED1 , encoding a ligand-ectodysplasinA-A1 (EDA-A1), EDAR , coding for ectodysplasinA-A1 receptor, EDARADD , programming the structure of EDAR-associated death domain protein and NEMO whose protein product, NFκB essential modulator (NEMO), is necessary for an indirect activation of nuclear factor κB (NFκB). (springer.com)
  • Here we show, using X-ray crystallography, molecular dynamics simulations and in vitro and in vivo functional assays, that MlaA is a monomeric α-helical OM protein that functions as a phospholipid translocation channel, forming a ~20-Å-thick doughnut embedded in the inner leaflet of the OM with a central, amphipathic pore. (nature.com)
  • The principal application of this assay is in the screening of test samples to quantify any functional activity, either activating or inhibitory, that they may exert against human TGR5. (indigobiosciences.com)
  • We isolated six mAbs recognizing the functional attachment protein hemagglutinin-neuraminidase (HN) and 18 mAbs against the fusion (F) protein. (cdc.gov)
  • Both endogenous and enhanced green fluorescent protein (EGFP)-fused Gβ2 and Gγ2 proteins were detected in the nucleus at baseline, whereas a fraction of EGFP-Gβ2 and DsRed2-GR comigrated to the nucleus or the plasma membrane, depending on the exposure of cells to dexamethasone or somatostatin, respectively. (rupress.org)
  • The PCM is an ordered lattice that anchors a large number of microtubule (MT)-associated proteins, many of which bear putative coiled-coil domains, a tertiary structure known to facilitate protein-protein interactions [ 4 ]. (biomedcentral.com)
  • In addition to its expression on activated T cells, CD40 ligand can be efficiently translocated the surface of activated platelets. (abbiosciences.com)
  • Within the last 10 years significant progress has been made in understanding the pathogenesis of HED and this is mainly due to the discovery of unknown proteins and the elucidation of their function in signal transduction via the TNFα-related pathway. (springer.com)
  • While the locations and inferred H-bond connec- water molecules in a membrane protein, despite tivities of these internal water molecules are essen- being deeply buried and extensively H-bonded to tial, one would also like to quantify their mobility. (lu.se)
  • Apart from G proteins, GPCRs engage other effectors for signaling modulation. (drgpcr.com)
  • The conservation of functionalities involved in nucleotide binding and catalysis also provide insights into the mechanistic features of members of the family of actin-related proteins. (rcsb.org)
  • MlaA represents a lipid transport protein that selectively removes outer leaflet phospholipids to help maintain the essential barrier function of the bacterial OM. (nature.com)
  • A lentiviral p201-green fluorescent protein (GFP) empty create was a kind gift from Manabu Furukawa. (researchatlanta.org)
  • Protein modules such as FVYE domains and PH domains that bind specifically to PtdIns 3-phosphate (PtdIns-3-P) and polyphosphoinositides, respectively, can direct such membrane targeting. (embl.de)
  • The domain family possesses multiple functions including the abilities to bind inositol phosphates, and various proteins. (embl.de)
  • What proteins does IRS-1 bind to in order to activate Raf-1? (flashcardmachine.com)
  • Computational design of closely related proteins that adopt two well-defined but structurally divergent folds. (upenn.edu)
  • Crowding of asymmetric proteins results in an asymmetric lateral pressure across the membrane which can be used by cells in a number of biological processes involving membrane remodeling. (portlandpress.com)