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  • Tumor
  • Long-term alcohol and high fat diet feeding resulted in higher levels of serum alanine aminotransferase, impaired ER stress response, and higher incidence of liver tumor in older (aged 16 months) KO females than in either middle-aged (6 months) KOs or older (aged 16 months) wild type females. (frontiersin.org)
  • Tumor necrosis factor family member LIGHT acts with IL-1β and TGF-β to promote airway remodeling during rhinovirus infection. (nih.gov)
  • vascular
  • Clinical and experimental evidence indicates that inflammatory processes in the vascular wall are the decisive factor that accounts for the rate of lesion formation and clinical development in patients suffering from atherosclerosis [ 2 ]. (hindawi.com)
  • Tissues
  • Pubmed ID: 9576942 Basic fibroblast growth factor (FGF2) is a wide-spectrum mitogenic, angiogenic, and neurotrophic factor that is expressed at low levels in many tissues and cell types and reaches high concentrations in brain and pituitary. (jove.com)
  • type
  • However, lack of hot-spot BRAF , RAS , or NF1 driver mutations in the triple wild-type subtype accounting for 6-20% of melanomas [ 2 , 3 ], and variability of phenotype of patient-derived melanoma cell lines representing the same genetic subtype [ 4 ] enforce combining both genetic and phenotypic traits to achieve more accurately stratification of melanoma patients. (springer.com)
  • progression
  • Insulin resistance, often associated with obesity and physical inactivity, is a major factor in the progression of T2DM. (springer.com)
  • Genetic factors have an important role in its appearance and progression [ 10 - 12 ]. (hindawi.com)
  • several
  • The work is of translational relevance for OA, since several drugs that activate AMPK are already in the clinic for arthritis (for example, allosteric AMPK activators sodium salicylate and high dose aspirin, and methotrexate, which activates AMPK by generating AICAR). (biomedcentral.com)
  • stress response
  • The steps involved in the prosurvival (blue steps 1 to 6) and proapoptotic phases (red steps 5′ to 8′) of the ER stress response are shown. (ahajournals.org)
  • In general, during the prosurvival phase, components of the rapidly activated ER stress response contribute to restoring the ER luminal environment and resolving the ER stress, thus promoting survival. (ahajournals.org)