Activating the transcriptional. Medical search. Frequent questions

Genotoxic damage causes robust alterations to pathways associated with B cell activation and increased proliferation, suggesting that genotoxic damage initiates not only the normal B cell maturation processes but also mimics activated B cell response to antigenic agents. (biomedcentral.com)
Significantly differentially expressed (SDE) immunological genes and transcription factor (TF) were selected for functional pathways and transcriptional signaling identification. (frontiersin.org)
Ly6C high MC exhibited activated neutrophil degranulation, lysosome, cytokine production/receptor interaction and myeloid cell activation pathways, and Ly6C low MC presented features of lymphocyte immunity pathways in both mice. (frontiersin.org)
Twenty-four potential transcriptional regulatory pathways were identified based on SDE TFs matched with their corresponding SDE immunological genes. (frontiersin.org)
Ly6C low MC manifested activated T-cell signaling pathways and potentially can adapt the function of lymphocytes. (frontiersin.org)
Here, we investigated the signaling pathways activated in response to the energetic stress created by transient glutamate excitation in cerebellar granule neurons. (jneurosci.org)
NF-κB pathways can be mainly activated by two pathways. (springer.com)
Transcriptional responses to pathways: roles in the causes and treatment of cancer Intra-cellular stress-response pathways are activated in response to potentially deleterious conditions in the cell's environment. (southampton.ac.uk)
Many current and prospective treatments for cancer work by either inhibiting, or re-activating stress response pathways.Our work focuses on the role of regulators of gene transcription in the response of cancer cells to stress. (southampton.ac.uk)
Transcriptional regulation of the genes in metabolic pathways is a highly successful strategy, which is virtually universal in microorganisms. (lu.se)
When a second nutrient and its metabolic pathway are introduced, the system must further decide whether and how to activate both pathways. (lu.se)
Citation: Troein C, Ahre´n D, Krogh M, Peterson C (2007) Is Transcriptional Regulation of Metabolic Pathways an Optimal Strategy for Fitness? (lu.se)
In this study, we showed that WC-Co nanoparticle s at 5 ug/cm2 induced reactive oxygen species (ROS) production which activated AKT and ERK signal pathways in a lung epithelial cell line. (cdc.gov)
In human breast epithelial cells Wnt-5a activates the canonical b-catenin pathway as well as the non-canonical Ca2+/calmodulin and planar cell polarity (PCP) pathways. (lu.se)

The Yes\associated protein (YAP) can be an important transcriptional co\activator that mediates the cellular response to mechanical and cytoskeletal cues. (rawveronica.com)
Ligand-activated transcriptional activator. (biolegend.com)
We have a long-standing interest in the p53 protein, a stress-activated transcriptional activator. (southampton.ac.uk)

Upstream activation sequences are a crucial part of induction, enhancing the expression of the protein of interest through increased transcriptional activity. (wikipedia.org)

Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. (biolegend.com)

One allele of REG1, the suppressor mutant sia1-1, was capable of suppressing the inositol auxotrophy, revealing a possible pathway for the repression of inositol-sensitive upstream activating sequence-containing genes of yeast. (wikipedia.org)
In the absence of retinoid acid, RARA is bound by nuclear corepressor factor, and this causes transcriptional repression. (medscape.com)

In this study, we developed a strategy for the isolation of polyphosphate-accumulating organisms (PAOs) by combining (i) nontoxic fluorescence staining of polyphosphate granules in viable microbial cells and (ii) fluorescence-activated cell sorting (FACS) for the rapid detection and collection of target cells. (frontiersin.org)
In this study, we propose a strategy for the isolation of polyphosphate-accumulating organisms (PAOs) by coupling (i) specific staining of an intracellular accumulate without compromising cell viability, and (ii) rapid detection and sorting of target cells by using fluorescence-activated cell sorting (FACS), for which wastewater sludge samples were utilized. (frontiersin.org)

Binds to the XRE promoter region of genes it activates. (biolegend.com)
The products of target genes it activates are required for differentiation and mitogenesis . (wikipedia.org)

Comparing these transcriptional responses provides a greater understanding of the mechanisms cells use in the differentiation between types of DNA damage and the potential consequences of different sources of damage. (biomedcentral.com)
Finally, we established 3 groups of transcriptional models to describe Ly6C high to Ly6C low MC subset differentiation, immune checkpoint regulation, Ly6C high MC to MΦ subset differentiation and Ly6C low MC to lymphocyte functional adaptation. (frontiersin.org)
In the presence of retinoic acid, RARA is activated and terminal differentiation of promyelocytes occurs. (medscape.com)
We have observed that metastatic melanomas consist of two distinct lineages characterized by activated or inactivated melanocyte differentiation transcriptional programs. (lu.se)

Peroxisome proliferator-activated receptor gamma (PPARgamma) and liver X receptor alpha (LXRalpha) have been linked to the regulation of these processes. (nih.gov)
The defects Anacetrapib (MK-0859) are so severe that it is difficult to understand from studying these mutants the functional role of mesenchymal progenitors and the stroma they give rise to in nephrogenesis.1 4 We therefore tested the hypothesis that deletion of the miRNA activating enzyme in stromal progenitors may define the importance of post-transcriptional regulation by miRNAs in the stromal tissues during kidney organogenesis. (immune-source.com)
Classically or alternatively activated macrophages (M1 and M2, respectively) play distinct and important roles for microbiocidal activity, regulation of inflammation and tissue homeostasis. (edu.sa)
RNA-binding proteins (RBPs) play key roles in RNA metabolism and post-transcriptional regulation. (buyresearchchemicalss.net)
Thus locating all RNA-binding proteins (RBPs) in a genome and determining protein-RNA complex structures are key steps for understanding the mechanism of post-transcriptional regulation and for mapping the network of protein-RNA interactions. (buyresearchchemicalss.net)
These activate the ""late"" transcriptional reprogramming influencing DNA repair, cell cycle regulation and apoptosis. (europa.eu)
a potential mechanism is ARE-mediated transcriptional up-regulation of antioxidant enzymes by compounds such as sulforaphane (Sf). (usda.gov)
The transcriptional repressor HBP1 is a target of the p38 mitogen-activated protein kinase pathway in cell cycle regulation. (nih.gov)
SOX17 modulates transcriptional regulation via WNT3A and inhibits Wnt signaling. (thermofisher.com)
Mair Lab identifies that CRTC-1 in aging suppresses longevity when AMPK is activated while promoting longevity through epigenetic regulation. (harvard.edu)
With a minimalist model of metabolism, cell growth and transcriptional regulation in a microorganism, we explore how the interaction between environmental conditions and gene regulation set the growth rate of cells in the phase of exponential growth. (lu.se)
INTRODUCTION broken, which in realistic situations can severly constrain the Transcriptional regulation of effector genes is a highly successful regulatory options. (lu.se)
We provide a new mechanism for the regulation of heart development by PITX2 isoforms through the regulation of ANF and PLOD1 gene expression and Nkx2.5 transcriptional activity. (lu.se)
Although the current generation of dCas9-based transcription activators is able to achieve up-regulation of some endogenous loci, the magnitude of transcriptional up-regulation achieved by individual single-guide RNAs (sgRNAs) 12 typically ranges from low to ineffective 8 - 11 . (cdc.gov)

HBP1 inhibits the development of type 2 diabetes mellitus through transcriptional activation of the IGFBP1 gene. (nih.gov)
RGX-104 inhibits tumor angiogenesis and depletes myeloid derived suppressor cells (MDSC), thereby activating cytotoxic T-lymphocytes. (biospace.com)
This ERK5-SUMOylation happens at the K6 and K22 sites on the N-terminal region of ERK5, and inhibits ERK5 transcriptional activity. (mdanderson.org)
Furthermore, his next study showed that diabetes activates p90RSK, which directly inhibits the transcriptional activity of ERK5, an atheroprotective non-classical MAP kinase. (mdanderson.org)

Activated miRNAs are loaded into a complex including the Argonaute protein which enables the miRNA to bind by sequence complementarity to mRNA.9 13 A single miRNA can bind to 50-100 functionally related mRNA. (immune-source.com)
The sequence identified overlapped a binding site for GAL4 protein, which is a positive regulator for transcription which coincides with the function of upstream activating sequences. (wikipedia.org)
In conclusion, the finding of novel motifs, TFs and protein-coding and lncRNA genes is an important step forward to fully understand the transcriptional machinery of macrophage activation. (edu.sa)
They further link to the activation of protein kinase C- (PKC-) induced generation of reactive oxygen species (ROS) [ 6 , 7 ], which further mediates the activation of downstream transcription factor nuclear factor kappa-light-chain enhancer of activated B cells (NF- κ B). Thus, the main treatments of DN refer to modulate glycemic and blood pressure through insulin and RAS inhibitors. (hindawi.com)
Glutamate excitation induced a rapid alteration in the AMP:ATP ratio that was associated with the activation of the AMP-activated protein kinase (AMPK). (jneurosci.org)
It is a nuclear protein and functions as a transcriptional regulator. (wikipedia.org)
The ASXL1 protein can turn on (activate) or turn off (repress) HOX genes depending on when they are needed. (medlineplus.gov)
Despite the co-expression, loss of Wnt-5a and Syk protein appear to be regulated at the translational and transcriptional levels, respectively. (lu.se)

An upstream activating sequence or upstream activation sequence (UAS) is a cis-acting regulatory sequence. (wikipedia.org)
Transcription factor (TF) binding motif activity analysis revealed four motifs, NFKB1_REL_RELA, IRF1,2, IRF7 and TBP that are commonly activated but have distinct activity dynamics in M1 and M2 activation. (edu.sa)
Since tumor behavior isn't just INNO-406 inhibitor database affected by biophysical cues but also by metabolic stress, hormones, inflammation, it is?likely the mechanosignaling\induced activation of transcriptional co\activators cooperates with additional transcriptional regulators with the task to integrate almost all environmental cues into growth\ and migration\promoting signaling outputs, a realistic possibility awaiting long term scrutiny. (rawveronica.com)
Gene activation is dependent on cell-specific transcription factors that recognize transcriptional enhancer sequences. (imperial.ac.uk)
RGX-104 is a small-molecule LXR agonist that modulates innate immunity via transcriptional activation of the ApoE gene. (biospace.com)
We describe structure-guided engineering of a CRISPR-Cas9 complex to mediate efficient transcriptional activation at endogenous genomic loci. (cdc.gov)
We use these engineered Cas9 activation complexes to investigate sgRNA targeting rules for effective transcriptional activation, demonstrate multiplexed activation of 10 genes simultaneously, and upregulate long intergenic non-coding RNA (lincRNA) transcripts. (cdc.gov)
Tiling a given promoter region with several sgRNAs can produce more robust transcriptional activation 9 - 11 , but this requirement presents enormous challenges for scalability, and in particular for establishing pooled, genome-wide GOF screens. (cdc.gov)

A growing body of literature implicates the peroxisome proliferators-activated receptors (PPARs) in the pathogenesis and treatment of NAFLD. (wjgnet.com)

The transcriptional regulator LysG (Rv1985c) of Mycobacterium tuberculosis activates lysE (Rv1986) in a lysine-dependent manner. (helmholtz-hzi.de)

MicroRNAs activated by the enzyme Dicer1 control post-transcriptional gene expression. (immune-source.com)
In vitro studies and gene expression profiles showed that the transcriptional changes by the activated Ahr are ligand specific and are highly cell specific. (biolegend.com)
Proteins that enhance gene expression when associated with ligand bound activated NUCLEAR RECEPTORS. (bvsalud.org)

They are involved in a range of cellular processes, depending upon the transcriptional repressor that recruits them to DNA, and they suppress the transcription of genes that cause apoptosis (reviewed in Bergman et al, 2006a). (southampton.ac.uk)

Hence, the suppression of oncogene\induced mammary tumors upon gene deletion in mice (Chen (2017) display that MRTFs promote the transcriptional activity of the TEAD\YAP complex self-employed of SRF and canonical Hippo signaling, as neither SRF was required for the induction of the transcriptional system nor TAZ manifestation or YAP phosphorylation and localization changed in MRTF\A\ and MRTF\B\manipulated cells. (rawveronica.com)

In summary, the two papers from your Lim laboratory demonstrate that ECM rigidity and cytoskeletal dynamics INNO-406 inhibitor database control not only the nuclear translocation but also the assembly of transcriptional co\activators into large transcriptional complexes, which in turn INNO-406 inhibitor database induce the manifestation of gene programs that promote invasion and metastasis as well TPOR as expert genes such as to promote cell cycle progression. (rawveronica.com)
Alternatively nuclear receptor coactivators can function as adaptor proteins that bring nuclear receptors into close proximity with transcriptional complexes. (bvsalud.org)

We show that long-lived CAR-T cells developed a CD4/CD8 double-negative phenotype with an exhausted-like memory state and distinct transcriptional signature. (nature.com)
The blood microvascular endothelium consists of a heterogeneous population of cells with regionally distinct morphologies and transcriptional signatures in different tissues and organs. (researchgate.net)

By contrast, the transcriptional programs that specify the laterality of commissural axons, and furthermore, whether a global regulatory mechanism operates for diverse commissural neurons, are little understood. (biorxiv.org)
Despite this, their transcriptional regulatory dynamics are poorly understood. (edu.sa)
Transcriptional Control of Regulatory T Cells in Cancer: Toward Therapeutic Targeting? (mdpi.com)

This is the first report of a global transcriptional mechanism that controls the laterality of all floor plate-crossing commissural axons via activating Robo3 expression. (biorxiv.org)

In the late 1990s work from a number of groups, including Blaydes et al , demonstrated that HDM2 could be targeted in cancer cells to re-activate the p53 stress-response pathway. (southampton.ac.uk)

These results suggest genotoxic damage may induce a unique cancer-prone phenotype and processes mimicking activated B cell response to antigenic agents, as well as the normal B cell maturation processes. (biomedcentral.com)
Restitution of Wnt-5a signalling in breast tumour cells confer better adhesion and ability to activate DDR1 as well as a less malignant-looking phenotype. (lu.se)

Using promoter-level expression profiling by non-biased deepCAGE we have studied the transcriptional dynamics of classically and alternatively activated macrophages. (edu.sa)
Differential responses of murine alveolar macrophages to elongate mineral particles of asbestiform and non-asbestiform varieties: Cytotoxicity, cytokine secretion and transcriptional changes. (cdc.gov)
Alveolar macrophages (AM) are the first responders to inhaled particulates, participating in clearance and activating other resident and recruited immunocompetent cells, impacting the long-term outcomes. (cdc.gov)
At infection sites, activated T cells secrete cytokines (eg, interferon-gamma [IFN-gamma]) that induce production of macrophage migration inhibitory factor, preventing macrophages from leaving. (msdmanuals.com)
M1, "classically activated," pro-inflammatory macrophages are stimulated by cytokines such as IFN-gamma and by various microbial components (eg, lipopolysaccharide). (msdmanuals.com)
M2 "alternatively activated" anti-inflammatory macrophages are stimulated predominantly by cytokines such as IL-4 and IL-13. (msdmanuals.com)

Aberrant vascular remodeling contributes to the progression of many aging-associated diseases, including idiopathic pulmonary fibrosis (IPF), where heterogeneous capillary density, endothelial transcriptional alterations and increased vascular permeability correlate with poor disease outcomes. (researchgate.net)

We previously showed that physiologic breaks initiate lymphocyte development-specific transcriptional programs. (biomedcentral.com)
We identified a central lymphocyte-specific transcriptional response common to both physiologic and genotoxic breaks, which includes many lymphocyte developmental processes. (biomedcentral.com)
While it is known that genotoxic agents, such as IR, activate transcriptional programs involved in maintaining the integrity of the genome, we also want to investigate whether or not the genotoxic breaks could affect lymphocyte-specific maturation transcriptional responses similar to those we observed following RAG-induced physiological DSBs. (biomedcentral.com)

Due to its essential role in activating transcription, the upstream activating sequence is often considered to be analogous to the function of the enhancer in multicellular eukaryotes. (wikipedia.org)
PML-RARA represses genes responsible for hematopoiesis and activates super-enhancer genes responsible for specific characteristics of APL. (medscape.com)

These data suggest that Sf accounts for most of the ARE-activated transcriptional induction of antioxidant genes by broccoli. (usda.gov)

Recent studies have recognized important functions for post transcriptional regulators including miRNAs in podocytes 14 15 juxtaglomerular (JG) cells 16 nephron epithelium and collecting duct system of the developing kidney17 18 and in epithelial and stromal cells during adult kidney diseases.10 19 20 However the importance of miRNAs in Anacetrapib (MK-0859) stromal cells has not been explored during kidney development. (immune-source.com)

Therefore, the gene cannot be activated with physiologic doses of retinoic acid. (medscape.com)

PITX2A, PITX2B, and PITX2C isoforms differentially activate the ANF promoter. (lu.se)

In this project, I will employ biochemical, cell, systems biology and computational approaches to study the relevance of post-transcriptional regulators such as RNA-binding proteins and microRNAs in DDR. (europa.eu)

In this technique, four related binding sites between the GAL10 and GAL1 loci in Saccharomyces cerevisiae serve as an Upstream Activating Sequences (UAS) element through GAL4 binding. (wikipedia.org)

Role of CtBP transcriptional repressors in cancer cell proliferation and survival In common with p53, CtBP1 and CtBP2 proteins were discovered through their physical association with a viral oncoprotein. (southampton.ac.uk)
A ) Levels of SAMHD1, phosphorylated SAMHD1, CDK1 and CDK2 proteins in activated or unsimulated, unfractionated PBMCs treated with carrier, AhR agonist or antagonist. (elifesciences.org)
B ) Levels of SAMHD1, phosphorylated SAMHD1, CDK1 and CDK2 proteins in activated or unstimulated purified CD4+ T cells treated with carrier, AhR agonist or antagonist. (elifesciences.org)
Alternatively it may activate HLA class II transcription by modifying proteins that bind to the MHC class II promoter. (lu.se)

When compared to the native GPD promoter, the presence of UASG caused the transcriptional activity to remain equivalently enhanced under induced conditions. (wikipedia.org)
Mechanical cues can promote MRTF\mediated recruitment of NCOA3 towards the TEAD\YAP complicated also, which can fortify the TEAD\YAP\mediated transcriptional activity further. (rawveronica.com)
When activated p90RSK associated with ERK5, this association inhibited ERK5 transcriptional activity and up-regulated VCAM-1 expression. (mdanderson.org)

One study explored the interaction between Ino4p and Ino2p in more depth, examining the dimerization that takes place between the two prior to binding to the promoter of the INO1 gene and activating transcription. (wikipedia.org)

AB - Lineage-selective expression of developmental genes is dependent on the interplay between activating and repressive mechanisms. (imperial.ac.uk)
Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene). (biolegend.com)
We found that loss of PTEN and TP53 induced B7-H3 expression by activating transcriptional factor Sp1. (urotoday.com)
DNA, is preferred when demand for expression is rare, whereas an sources present at levels that are perturbed at some point in time activating mode is preferred in the opposite situation [8]. (lu.se)

The Aryl hydrocarbon receptor (AHR) is a member of the basic helix-loop-helix-PER- ARNT-SIM (bHLH-PAS) subgroup of the bHLH superfamily of transcription factors and is the only member of this family known to be activated by ligands. (biolegend.com)

Here we compare transcriptional responses to physiological DNA breaks with responses to genotoxic DNA damage induced by ionizing radiation. (biomedcentral.com)
These genome wide transcriptional responses are very tightly regulated and complex. (biomedcentral.com)
By comparing the transcriptional responses to both types of DNA damage, we can compare the similarities in the responses to damage as well as the differences induced by genotoxic damage. (biomedcentral.com)
Moreover, activating SREBPs resulted in remodelling the lipidome, decreased hepatocellular damage, and improved wound-healing responses. (nih.gov)

In this study, we identified a pair of highly-related basic helix-loop-helix (bHLH) transcription factors, Nhlh1 and Nhlh2, as such a transcriptional program. (biorxiv.org)

These findings raise the possibility that a universal transcriptional signature of clinically effective, persistent CD19 CAR-T cells exists. (nature.com)
Mature Notch receptors are activated by binding to ligands (Jagged-1, -2 and Delta-like -1, -3, and -4) located on adjacent signal-presenting cells. (mskcc.org)
genic models are inadequate for number of activated CD8-positive T LMP1 was strongly expressed in the understanding the cancer etiology in cells increased considerably in the lymphoma tissues but was hardly the context of natural viral infection. (who.int)
Dendritic cells in the skin act as sentinel APCs, taking up antigen, then traveling to local lymph nodes where they can activate T cells. (msdmanuals.com)

It promotes degradation of activated CTNNB1. (thermofisher.com)

However, for an immediate and effective response, global post-transcriptional control of mRNA stability, splicing and translation may be crucial during "immediate-to-early" DDR. (europa.eu)
As a consequence, these tumors are characterized as a constitutively activated hypoxic response program. (lu.se)

In parallel, substantial advancements have been made in describing the transcriptional programs of normal nephron cell types and how they respond to renal insults. (lu.se)

However, our lab has uncovered a new non-transcriptional role of HIF-1α interacting with and activating γ-secretase. (mskcc.org)

Pathways14

Activator3

Increased transcriptional activity1

Mediated transcriptional activation1

Repression2

Fluorescence Activated Cell Sorting2

Genes it activates2

Differentiation4

Regulation14

Inhibits4

Protein8

Activation8

Peroxisome1

Regulator1

Gene expression3

Repressor1

Signaling1

Complexes2

Distinct2

Regulatory3

Mechanism1

Pathway1

Phenotype2

Macrophages6

Endothelial1

Lymphocyte3

Enhancer2

Induction1

Epithelial1

Physiologic1

Isoforms1

MicroRNAs1

Sequences1

Proteins4

Activity3

Interaction1

Expression4

Receptor1

Responses4

Transcription factors1

Cells4

Degradation1

Response2

Cell1

Role1