Activates the lectin pathway. Medical search. Frequent questions

[ 1 ] Neutrophils move to the site of invasion by means of chemotaxis, which occurs in response to microbial products, activated complement proteins, and cytokines. (medscape.com)
The complement system comprises a group of proteins which, when activated, provide one of the first lines of defence by promoting lysis and the removal of invading microbes. (hindawi.com)
Activation of the complement system in response to an infection or foreign antigen is achieved via three complement pathways, the classical pathway, which is activated by antigen-antibody complexes, the lectin pathway, which is activated by the interaction of microbial carbohydrates with mannose-binding proteins in the plasma and tissue fluids, and the alternative complement pathway, which is activated by C3b binding to microbial surfaces and to antibody molecules. (hindawi.com)
The complement system consists of more than 35 soluble and cell-bound proteins, 12 of which are directly involved in the complement pathways. (dadamo.com)
At that time, glycobiology, which is the study of carbohydrates and their recognition by motif-specific carbohydrate-binding proteins or lectins, lagged far behind the studies that defined the structural and cellular biology of cell death. (nature.com)
In a cascade of proteolytic cleavage events, MASP-2 activates complement proteins C4 and C2 to form C4b2a (classical C3 convertase), thereby converging the lectin pathway with the classical pathway of complement activation. (escholarship.org)
Further, MASP-2 activity is regulated by several factors, including the serine protease inhibitor C1INH and by interaction with other proteins of the lectin complement pathway. (escholarship.org)
It is composed of several proteins activated in a cascade that culminates with formation of the membrane attack complex and pathogen lysis. (fiocruz.br)
Complement activation proceeds in a sequential fashion through the proteolytic cleavage of a series of proteins leading to the generation of activated products that mediate various biological activities through their interaction with specific cellular receptors and other serum proteins. (eaglebio.com)
Mannose-binding lectin (MBL) and MBL-associated serine proteases 2 (MASP-2) are important proteins in the lectin pathway of the immune system. (biomedcentral.com)
for example, the proteins factor H and factor I inhibit the formation of the enzyme C3 convertase of the alternative pathway. (medscape.com)
Adult humans who are genetically deficient in one of the proteins that activate MASP-2 do not appear to be detrimentally affected by the deficiency. (omeros.com)
Omeros also believes that it has identified the proteins that activate the complement system's alternative pathway in humans, which is linked to a wide range of immune-related disorders. (omeros.com)
It consists of a tightly regulated network of proteins that are activated as a cascade of biological reactions via three different proteolytic pathways: the classical, alternative and lectin pathways ( Figure 1 ). (cic.vc)
The article mentions, "Complement activation may occur early during SARS-CoV-2 infection by the direct interaction of viral proteins with mannose- binding lectin and ficolin pathway. (acquaintpublications.com)
previously called L-ficolin or ficolin-B) is a member of the ficolin family of secreted pattern recognition proteins that participate in the lectin complement activation pathway (1‑4). (rndsystems.com)
Lectins are proteins that bind to carbohydrates or glycoproteins (carb-protein mixture) [ 1 ]. (selfhack.com)
Proteins termed lectins (from the Latin legere, "to select") have the ability to bind to specific carbohydrate molecules. (selfhack.com)
Plants also use lectins to communicate with their environment, for cell organization, and as reserve proteins, among other functions [ 3 ]. (selfhack.com)
Lectins are carb-binding proteins found in all living organisms. (selfhack.com)
On average, 15% percent of a bean's proteins are lectins. (selfhack.com)

All of the three pathways converge with the activation of the central C3 component. (hindawi.com)
Three activating pathways comprise the complement cascade (classical, mannose-binding lectin, and alternative), and all converge on the proteolytic cleavage of C3 to generate an arsenal of inflammatory mediators, including the opsonin C3b and the anaphylatoxin C3a. (molvis.org)
The classical pathway of complement and the mannose-binding lectin (MBL) activation pathway converge at C4. (creative-biolabs.com)
The three pathways, designated classical, lectin and alternative pathway, converge at a central component into a final common pathway. (eaglebio.com)
The complement cascade consists of 3 separate pathways that converge in a final common pathway. (medscape.com)
These 3 pathways converge at the component C3. (medscape.com)
The classical, lectin, and alternative pathways converge into a final common pathway when C3 convertase (C3 con) cleaves C3 into C3a and C3b. (msdmanuals.com)

This leads to a final common pathway with assembly of the C5-C9 components to form a cell surface transmembrane pore (membrane attack complex) [ 22 , 23 ]. (hindawi.com)

One such pattern-recognition molecule is M-ficolin, which is capable of activating the complement system through the lectin pathway. (nih.gov)
We detected rapid binding of mannan-binding lectin, H-ficolin, and L-ficolin to the surface of T. cruzi, and found that serum depleted of these molecules failed to kill parasites. (herts.ac.uk)
Alterations in the alternative pathway, like properdin or ficolin deficiency, increase the susceptibility to infection. (eaglebio.com)

and the alternative pathway by spontaneous hydrolysis of the C3 thioester bond that results in the formation of a fluid phase convertase capable of cleaving C3 to C3b, which is then deposited on nearby cellular or acellular surfaces. (cic.vc)
The three pathways all generate homologous variants of the protease C3-convertase . (wikidoc.org)
In all three pathways, a C3-convertase cleaves and activates component C3 , creating C3a and C3b and causing a cascade of further cleavage and activation events. (wikidoc.org)

Degradation of C3b by fI abrogates the action of this protein in the C3 pathway [ 27 ]. (hindawi.com)
MASP-2 (mannose/mannan binding lectin (MBL) associated serine protease-2) is a serum protein predominantly synthesized by the liver as a ~75kDa protein and is one of the key molecules of the innate immune system. (escholarship.org)
In addition, we demonstrate that the infectious stage of T. cruzi inhibits the lectin pathway activation and complement killing expressing the complement C2 receptor inhibitor trispanning (CRIT) protein. (herts.ac.uk)
Mannose-binding lectin (MBL) deficiency, defined as MBL protein level of less than 100 ng/ml, is present in about 5% of people of European descent and in about 10% of sub-Saharan Africans. (nih.gov)
People with this condition have low levels (deficiency) of an immune system protein called mannose-binding lectin in their blood. (nih.gov)
Mannose binding lectin (MBL) is a liver derived protein which plays an important role in innate immunity. (springeropen.com)
Mannose binding lectin (MBL) is a liver derived acute phase protein. (springeropen.com)
Protein MASP-2 and MAp19 encoded by MASP-2 genes both can bind with MBL, generate MBL-MASP compound, and then activate C4-C9 components in the complement system, generating membrane attack complex and opsonin as well as other inflammatory cytokines promoting the killing of pathogenic microorganisms [ 10 , 11 ]. (biomedcentral.com)
The classical pathway is triggered by interaction of the Fc portion of an antibody (immunoglobulin [Ig] M, IgG1, IgG2, IgG3) or C-reactive protein with C1q. (medscape.com)
We were able to identify several classes of antimicrobial peptides, such as buforins, peroniins and brevinins, as well as PLA 2 , lectins and galectins, combining protein sequencing and RNA-seq analysis for the first time. (biomedcentral.com)
C4b-binding protein (C4BP) is the major soluble inhibitor of the classical and lectin pathways whereas factor H (FH) inhibits the alternative route. (lu.se)
The viral nucleocapsid protein binds to a mannose-binding protein-associated serine protease 2 (MASP-2), a key protease of the MBL pathway leading to overactivation of the complement system and worsening of lung injury. (acquaintpublications.com)
Following activation, C3, the central protein of the complement system, is cleaved to form C3b, which is bound to the surface of the microbe where the complement is activated, and C3a, which is systemically released and acts as a chemoattractant for inflammatory cells. (medscape.com)
In mammals , complement component C3 is the most important protein of the complement system as it is activated by all three pathways (classical, lectin, and alternative pathways), and its various activation products are crucial for mediating, directly or indirectly, virtually all biological functions of complement. (expasy.org)
GSE162556 Abstract Translation-dependent quality control pathways such as no-go decay (NGD), non-stop decay (NSD), and nonsense-mediated decay (NMD) govern protein synthesis and proteostasis by resolving non-translating ribosomes and preventing the production Shh of potentially harmful peptides derived from faulty and aberrant mRNAs. (antiviralbiologic.com)
It is a glycan binding protein which can exert its functions within cells or exogenously by binding cell surface ligands, acting as a molecular bridge or activating signalling pathways. (ox.ac.uk)
They are activated when complexed with the MANNOSE-BINDING LECTIN, therefore also known as Mannose-binding protein-Associated Serine Proteases (MASPs). (bvsalud.org)
The high mobility of hydration water ensures that all thermally activated processes at the protein-water interface, such as binding, recognition and catalysis, can proceed at high rates. (lu.se)

CR1 on erythrocytes may bind circulating immune complexes (that had activated complement) and transport them to the liver where the immune complexes are partially degraded and thus become more soluble. (dadamo.com)
Binding of these complexes to their appropriate pathogenic ligands auto-activates MASP-1. (escholarship.org)
The classical pathway is initiated by binding of C1q to antibody complexes, whereas the alternative and lectin pathway are activated in an antibody-independent fashion through the interaction of complement components with respectively specific carbohydrate groups and lipopolysaccharides (LPS) on the surface of foreign pathogens. (eaglebio.com)
Most inhibitors act on complement convertases through increased dissociation of these enzymatic complexes (acceleration of decay) or through promoting enzymatic cleavage of activated complement factors C3b or C4b by a serine proteinase factor I (FI). (lu.se)
The complement system is activated via 3 different mechanisms: (1) the classical pathway, which is activated by antibody-antigen complexes, (2) the alternative pathway, which is activated by microbial cell surfaces in the absence of antibodies, and (3) the lectin pathway, which is activated by mannose residues on microbes. (medscape.com)
Pattern-recognition molecules such as mannose-binding lectin (MBL), collectins, and ficolins-collectively termed lectins-bind to DAMPs on injured host cells, forming activation complexes with MBL-associated serine proteases 1, 2, and 3 (MASP-1, MASP-2, and MASP-3). (biomedcentral.com)
Activated JNK in turn phosphorylates c-jun in its N terminus, activating the c-jun-containing AP-1 complexes.34 Activation of AP-1 transcription factor eventually results in increased IL-2 transcription. (syksignaling.com)

As proteínas do soro MBL (Mannan binding lectin), L-ficolina e H-ficolina ligam a carboidratos na superfície dos tripomastigotas metacíclicos. (fiocruz.br)
There are three types of complement cascade, the classical and alternative pathways and the Mannan-binding lectin pathway. (vetsci.co.uk)
Mannan-binding lectin associated serine protease (MASP-2) is homologous to MASP-1 and the two C1q-associated serine proteases C1r and C1s. (lu.se)
When mannan-binding lectin binds to carbohydrate structures on microorganisms, the manan-binding lectin pathway of the complement system is activated. (lu.se)
According to research findings, after the pathogenic microorganism invades the body, mannose-binding lectin (MBL) binds with mannan residues on its surface, and activate MBL-associated serine Proteases (MASPs) and the lectin pathway of the complement system, generating non-specific immune responses [ 8 , 9 ]. (biomedcentral.com)
OMS721 is the company's lead human monoclonal antibody targeting mannan-binding lectin-associated serine protease-2 (MASP-2), the key regulator of the lectin pathway of the immune system. (omeros.com)
Molecular representation of the interface between mannan-binding lectin and MASP-1. (le.ac.uk)

The lectin pathway is multifaceted with activities spanning from complement activation to coagulation, autoimmunity, ischemia-reperfusion injury and embryogenesis. (nih.gov)
Furthermore, lectin pathway activation by T. cruzi required the MBL-associated serine protease 2 (MASP2) activity resulting in C2 factor cleavage. (herts.ac.uk)
Our findings establish that the complement lectin pathway recognizes T. cruzi and provide molecular insights into how the infectious stage inhibits this activation to resist complement system killing. (herts.ac.uk)
The bound C3b activates the next complement component C5, which again splits up into the subcomponents C5a and C5b upon activation. (vetsci.co.uk)
2008). Genetic Heterogeneity of Lectin Complement Activation Pathway Defects See also LCAPD2 (613791), caused by variation in the MASP2 gene (605102) on chromosome 1p36, and LCAPD3 (613860), caused by variation in the FCN3 gene (604973) on chromosome 1p36. (nih.gov)
The C4d activation fragment of C4 is an excellent marker for the activation of the classical complement pathway and MBL pathway. (creative-biolabs.com)
The Mouse Alternative Complement Pathway ELISA Assay Kit is a qualitative/ semiquantitative ELISA to be used for the in vitro determination of activation of the alternative pathway of the complement system in serum and plasma samples. (eaglebio.com)
We advise to include in your study your own reference sample for 100% complement activity and negative control (e.g. non-preserved activated serum) to determine the level of activation of your samples. (eaglebio.com)
Activation of C3 initiates the alternative pathway and the formation of the membrane-attack complex. (lu.se)
Platelet activation pathways. (medscape.com)
MASP-2 appears to be unique to, and required for the function of, one of the principal complement activation pathways, known as the lectin pathway. (omeros.com)
Importantly, inhibition of MASP-2 does not appear to interfere with the antibody-dependent classical complement activation pathway, which is a critical component of the acquired immune response to infection, and its abnormal function is associated with a wide range of autoimmune disorders. (omeros.com)
In addition to its lectin pathway inhibitors, the Company is advancing the development of antibodies that block activation of the alternative pathway. (omeros.com)
In turn, activation of the lectin pathway causes more damage to endothelial cells, fueling a dangerous positive feedback loop. (medecon.org)
2 While the classical and lectin pathways are triggered by the recognition of 'foreign' signals, the alternative pathway of activation remains constitutively active, probing all surfaces with which it comes into contact. (cic.vc)
Activation of the classical complement pathway by therapeutic anti-thymocyte globulin preparations rapidly enhances monocyte tissue factor procoagulant activity, according to the article. (acquaintpublications.com)
Based on an article by Maurizio Costabile, the classical complement activation is measured by the 50 % complement hemolytic assay ( CH 50) which tests the functional capacity of serum complement components of the classical pathway to lyse sheep red blood cells pre- coated with rabbit anti-sheep red blood cell antibody [3] . (acquaintpublications.com)
Pulmonary findings were consistent with significant deposits of terminal complement C5b-9, C4d, and MBL associated serum protease in the microvasculature consistent with sustained systemic activation of complement pathways [7] . (acquaintpublications.com)
Activation of the lectin pathway may also trigger the coagulation cascade via MASP-2 cleavage of prothrombin to thrombin. (biomedcentral.com)
Endothelial injury triggers activation of the complement system-significantly through the lectin pathway-via altered cell-surface patterns on injured endothelial cells, initiating an inflammatory response [ 7 ]. (biomedcentral.com)
Here we discuss evidence for the role of lectin pathway activation in endothelial injury-associated complications of HSCT and how targeting complement activity may provide therapeutic benefit for patients with HSCT-TMA. (biomedcentral.com)
The classical complement pathway typically requires antibodies for activation (specific immune response), while the alternative and mannose-binding lectin pathways can be activated by C3 hydrolysis or antigens without the presence of antibodies (non-specific immune response). (wikidoc.org)
The classical pathway is triggered by activation of the C1-complex (which consists of one molecule C1q and two molecules C1r and C1s), either by C1q's binding to antibodies from classes M and G, complexed with antigens , or by its binding C1q to the surface of the pathogen. (wikidoc.org)
In T cells, productive antigen stimulation triggers the activation of MAPK including extracellular signal-regulated kinase, p38 and JNK.33 The JNK is activated through the dual phosphorylation of its Thr and Tyr residues by mitogen-activated kinase kinase Pembrolizumab 4 (MKK4) and MKK7. (syksignaling.com)
I'm a biochemist interested in understanding the molecular changes that occur during initiation of the classical and lectin pathways of complement activation. (le.ac.uk)
In addition to our work on complement activation, we are also interested in other host-pathogen interactions associated with disease, including the mechanism of action of the pore forming toxin, pnemolysin, of Streptococcus pneumoniae, with Professor Peter Andrew (Respiratory Sciences) and Dr Andrew Hudson (LISCB) and enzymes and signalling pathways of Mycobacterium tuberculosis and Gram +ve bacteria, with Drs Helen O'Hare, Galina Mukamolova, Ed Galyov and Hasan Yesilkaya (Respiratory Sciences). (le.ac.uk)
Related effects on signaling pathways, including mTOR activation, the translatome and mouse cerebellar development were observed upon deletion of the NMD element and resulted in strikingly similar effects within the translatome, signaling pathways, and neurogenesis. (antiviralbiologic.com)
C1 inhibitor deficiency or dysfunction not only affects complement activation but also results in increased levels of bradykinin because C1 inhibitor inhibits activated kallikrein (required for the generation of bradykinin) in the kinin system pathway. (msdmanuals.com)

Two decades later, pioneering studies suggested that lectin-like molecules constitutively expressed on the surface of macrophages can selectively recognize changes on glycans decorating the surface of apoptotic thymocytes, 4 , 5 although these studies likewise did not provide substantial insight into the mechanisms by which lectin-glycan interactions regulate cell death. (nature.com)
C3b is able to activate a number of C5 molecules like this. (vetsci.co.uk)
The system consist of three defined pathways which are activated by a pathway specific panel of molecules. (eaglebio.com)

A monoclonal antibody called narsoplimab inhibits the lectin pathway by blocking the MASP-2 enzyme, offering a way to interrupt the injurious process described above, in critically ill COVID-19 patients. (medecon.org)

However in the alternative pathway the complement cascade does not require that an antibody binds to the antigen. (vetsci.co.uk)
TDM binds to the receptor Mincle and activates macrophage C-type lectin, thereby inducing the Syk-Card9-Bcl1-Malt1 signaling pathway and a strong Th1/Th17 immune response in vivo . (bioglyco.com)

We focused on 8 single-nucleotide polymorphisms (SNPs) in 2 candidate genes important in the innate immune response to influenza infection and for which national prevalence estimates were available: the gene for tumor necrosis factor superfamily, member 2 (official symbol TNF ) and the mannose-binding lectin gene (official symbol MBL2 ). (cdc.gov)
Major functions include forming pores in mammalian cell membranes and activating the complement cascade to divert the host's immune system. (le.ac.uk)
Mannose-binding lectin deficiency is a condition that affects the immune system. (nih.gov)
As a very early event in COVID-19 infection, the first damage to endothelial cells activates an enzyme called MASP-2 and the body's lectin pathway - a part of the complement system that helps the immune system respond to infection. (medecon.org)
Complement activates as soon as a pathogen enters the body and serves to neutralise the threat via lysis or opsonisation (where the pathogen is tagged for destruction by host phagocytic cells) and prepare the body against further assault by stimulating and directing inflammatory and adaptive immune responses. (le.ac.uk)
Mincle, a C-type lectin on innate immune cells, was identified as a receptor for TDM and its analogs. (bioglyco.com)
In the blood, lectins may stimulate the immune system and modify hormone functions, or get deposited in blood and lymphatic walls [ 9 , 10 ]. (selfhack.com)

KLRF1, an activating homodimeric C-type lectin-like receptor (CTLR), is expressed on nearly all natural killer (NK) cells and stimulates their cytoxicity and cytokine release (Kuttruff et al. (nih.gov)
Activated complement factor 3, specifically, stimulates platelets through C3a receptor signaling and thereby amplifies thrombus formation. (acquaintpublications.com)

Some plant lectins, such as castor bean ricin and white kidney bean agglutinins, are very toxic to humans and rats. (selfhack.com)
Other plant lectins are less toxic, but they can cause damage in other ways. (selfhack.com)
Some plant lectins are extremely toxic, while others do milder harm. (selfhack.com)

The alternative pathway is activated in an antibody-independent manner. (medscape.com)

occurs by three pathways: the classical pathway, the lectin pathway, and the alternative pathway (or properdin system). (britannica.com)
and the alternative pathway, which is triggered by other means, including invading pathogens or tumour cells. (britannica.com)
The term alternative is something of a misnomer because this pathway almost certainly evolved before the classical pathway. (britannica.com)
Danger-associated molecular patterns (DAMPs) are endogenous ligands released from renal tubular cells following ischemia/reperfusion injury that activate the complement system through the classical, lectin and alternative pathways. (nature.com)
The complement system is the first line of defence against pathogen infection and can be activated by the classic, alternative and lectin pathways. (herts.ac.uk)
The complement system can be activated by the classical, lectin and alternative pathways. (fiocruz.br)
In a similar manner to the classical pathway, the alternative pathway works by forming the MAC (membrane attack complex). (vetsci.co.uk)
The Mouse Alternative Complement Pathway ELISA Assay Kit is for research use only and not to be used for diagnostic procedures. (eaglebio.com)
The Mouse Alternative Complement Pathway ELISA Assay Kit measures the alternative pathway activity mediated via LPS. (eaglebio.com)
The alternative pathway also acts as an amplification loop of the other pathways. (eaglebio.com)
A common way to measure the activity of the classical or alternative pathway is the hemolysis of erythrocytes. (eaglebio.com)
The Mouse Alternative Complement Pathway ELISA is a ready-to-use solid-phase enzyme-linked immunosorbent assay based on a sandwich principle with a working time of 3½ hours. (eaglebio.com)
Invading pathogens activate complement either spontaneously due to differences in envelope/membrane composition compared to host (alternative and lectin pathways) or through antibody binding (classical pathway). (lu.se)
The classical and alternative complement pathways. (wikidoc.org)

Activated B cells and memory T cells can recognize specific antigens on pathogens. (amboss.com)

This complex cleaves C4 to activate the complement pathway (4, 7, 8). (rndsystems.com)

Active MASP-1 in turn acts on its substrate, MASP-2, and thereby activates it. (escholarship.org)
The activated MASP-1 and MASP-2 cleave C4, resulting in the formation of C4a and C4b. (creative-biolabs.com)
The thioester formed between the side chains of Cys1010 and Gln1013 in the C4d region of the α chain mediates covalent attachment to the target surface with activated form of C1s or MASP. (creative-biolabs.com)

People with mannose-binding lectin deficiency can develop infections of the upper respiratory tract and other body systems. (nih.gov)
Infants and young children with mannose-binding lectin deficiency seem to be more susceptible to infections than affected adults, but adults can also develop recurrent infections. (nih.gov)

In particular, the lectin pathway of complement is activated by damage-associated molecular patterns (DAMPs) on the surface of injured endothelial cells. (biomedcentral.com)

These receptors trigger inflammation through the NFkB-dependent and interferon regulatory factor-dependent signaling pathway. (medscape.com)
Pathogenic mechanisms of bradykinin mediated diseases: dysregulation of an innate inflammation pathway. (mastattack.org)
The pathways that lead to fibrosis are not fully understood, although chronic non-resolving inflammation in the kidney is likely to drive the fibrotic response that occurs. (wjgnet.com)
Intracellular lectins and glycan-modifying enzymes mediate autophagy and control host immunity and inflammation. (nature.com)
If the lectin pathway is hyper-activated , it can lead to a dangerous cycle of damage to blood vessels, and to blood clots and inflammation. (medecon.org)
This post covers low-lectin and high-lectin foods, as well as other plant substances that may cause inflammation. (selfhack.com)

Lectins can withstand heat and digestion in both rats and humans. (selfhack.com)

We compared the prevalence of 8 polymorphisms in the tumor necrosis factor and mannose-binding lectin genes among 105 children and young adults with fatal influenza with US population estimates and determined in subanalyses whether these polymorphisms were associated with sudden death and bacterial co-infection among persons with fatal influenza. (cdc.gov)
Mannose binding lectin (MBL), a major component of the lectin pathway, is associated with bacterial, fungal and viral infection. (eaglebio.com)
The complement system plays a role in the inflammatory response and becomes activated as a result of tissue damage or microbial infection. (omeros.com)

Mannose binding lectin gene 2 ( MBL2 ) polymorphisms are reported to be associated with various diseases. (springeropen.com)

Furthermore, differential binding was observed also to known endogenous ligands C1q, mannose-binding lectin, and secretory IgA. (researchgate.net)

This cleavage activates the terminal complement pathway leading to eventually the formation of the terminal C5b-9 complement complex (TCC). (eaglebio.com)
CH 50 (total hemolytic complement assay) measures the ability of the serum test sample to lyse 50% of sheep RBCs coated with rabbit immunoglobulin, reflecting the functional status of the classical and terminal complement pathways. (medscape.com)

In addition, this lectin has been shown to bind to microorganisms. (ox.ac.uk)

Endogenous lectins and glycans are critical signals in the resolution of cell death. (nature.com)

C5b initiates the membrane attack pathway , which results in the membrane attack complex (MAC), consisting of C5b, C6 , C7 , C8 , and polymeric C9 . (wikidoc.org)

Here, we present the first evidence that T. cruzi activates the complement lectin pathway. (herts.ac.uk)
First, we identify for the first time that T. cruzi metacyclic trypomastigotes activate the complement lectin pathway. (fiocruz.br)

Several complement inhibitors targeting various complement pathways are in clinical trials for the treatment of HSCT-TMA. (biomedcentral.com)

Human dNK cell function is differentially regulated by extrinsic cellular engagement and intrinsic activating receptors in first and second trimester pregnancy. (nih.gov)

In the cascade once a component has been activated by a proteinase, the molecule itself which was activated becomes a proteinase for the next component of the cascade. (vetsci.co.uk)

We discuss here the contribution of glycan-lectin interactions to the initiation, execution and resolution of apoptosis and their emerging roles in other cell death programs including autophagy. (nature.com)

This also activates the complement cascade that assists in clearance of cells (9, 10). (rndsystems.com)

Opsonins are often antibodies or components of the complement pathway that bind to the surface of target organisms to facilitate this phagocytosis. (medscape.com)

How do C-type lectins tailor adaptive immunity following phagocytosis of apoptotic cells? (nature.com)

Lectins activate the lectin pathway in a manner similar to the antibody interaction with complement in the classical pathway. (medscape.com)

Deficiencies of an early component of the classical complement pathway (C1q, C1r, C1s, C2, C4) have been associated with lupus like autoimmune conditions. (mastattack.org)
Complement deficiencies or other defects in the complement system can easily be screened by running an assay for each pathway in parallel or separately. (eaglebio.com)
Complement pathways and deficiencies. (medscape.com)

Anatomy1

Organisms9

Diseases3

Chemicals and Drugs61

Analytical, Diagnostic and Therapeutic Techniques and Equipment5

Phenomena and Processes14

Technology, Industry, Agriculture1

Information Science3

Proteins21

Converge7

Final common pathway1

Ficolin3

Convertase3

Protein18

Complexes7

Mannan7

Activation28

Molecules3

Inhibits1

Binds2

Immune7

Receptor2

Plant lectins3

Antibody-independent1

Alternative14

Pathogens1

Cleaves1

MASP3

Deficiency2

Molecular1

Inflammation6

Humans1

Infection3

MBL21

Ligands1

Terminal complement2

Microorganisms1

Endogenous1

Membrane attack1

Cruzi2

Inhibitors1

Receptors1

Molecule1

Initiation1

Cascade1

Antibodies1

Phagocytosis1

Interaction1

Deficiencies3