• We observed activation of mitogen-activated protein kinase (MAPK) in basal and suprabasal keratinocytes of human and transgenic mouse psoriatic lesions and healing mouse skin wounds, correlating in each case with suprabasal integrin expression. (jci.org)
  • Phenotypically normal human and transgenic mouse epidermis did not contain activated MAPK. (jci.org)
  • Transgene-positive keratinocytes produced more IL-1α than controls did, and keratinocyte MAPK could be activated by ligation of suprabasal integrins or treatment with IL-1α. (jci.org)
  • The opioid receptor activation regulates a variety of intracellular signaling, including the mitogen-activated protein kinase (MAPK) pathway. (iasp-pain.org)
  • The aim of this study was to evaluate the role of mitogen-activated protein kinase (MAPK) family in serum-induced secretion of LIF and IL-6 by bone marrow stromal cells. (unboundmedicine.com)
  • 3: Both PD98059 (MAPK/ERK kinase inhibitor) and SB203580 (p38 MAPK inhibitor) attenuated FCS-induced LIF protein production and gene expression. (unboundmedicine.com)
  • Here we report a role for the phylogenetically ancient mitogen-activated protein kinase (MAPK) signalling pathway in mouse sex determination. (plos.org)
  • Moreover, we describe experiments showing the presence of activated MKK4, a direct target of MAP3K4, and activated p38 in the coelomic region of the XY gonad at 11.5 d post coitum, establishing a link between MAPK signalling in proliferating gonadal somatic cells and regulation of Sry expression. (plos.org)
  • This mutant, which we called boygirl ( byg ), was shown to contain an early stop codon that disrupts the autosomal gene encoding MAP3K4, a component of the mitogen-activated protein kinase (MAPK) signaling pathway. (plos.org)
  • G protein-coupled receptors can activate Erk MAPK pathways through a variety of mechanisms, including stimulation of Src, phosphoinositide-3 kinase (PI-3-K), protein kinase C (PKC), or the epidermal growth factor (EGF) receptor tyrosine kinase. (aspetjournals.org)
  • Mitogen-activated protein kinases (MAPK) p38 and c-Jun N-terminal kinases (JNKs) are activated during the cellular response to stress signals. (datadryad.org)
  • The mitogen-activated protein kinase (MAPK) signaling pathways are essential to the adaptation to the human host. (bath.ac.uk)
  • Our global phosphoproteome network analysis showed an enrichment for protein kinases, RNA recognition motif domains, and the MAPK signaling pathway. (bath.ac.uk)
  • Silibinin also showed a strong phosphorylation of extracellular signal-regulated protein kinase 1/2, stress-activated protein kinase/c-JUN NH2-terminal kinase 1/2, and p38 mitogen-activated protein kinases but inhibited Akt phosphorylation and decreased survivin levels with an increase in cleaved caspase-3. (nih.gov)
  • Levels of phosphorylation and protein expression were determined using western blotting. (hindawi.com)
  • Here, we biochemically demonstrated that the systemic crotalphine activates ERK1/2 and JNK and decreases the phosphorylation of p38 in the lumbar spinal cord. (iasp-pain.org)
  • Here, we show for the first time that in the HCN2 channel cGMP can also exert an inhibitory effect on gating via cGMP-dependent protein kinase II (cGKII)-mediated phosphorylation. (cipsm.de)
  • Mapk8 is a member of the MAP kinase group that is activated by dual phosphorylation at thr and tyr residues during exposure to stress such as UV irradiation. (creativebiomart.net)
  • We constructed phosphomutants for the phosphorylation sites of several proteins differentially phosphorylated in the wild-type and mutant strains. (bath.ac.uk)
  • Phosphorylation Regulates CAP1 (Cyclase-Associated Protein 1) Functions in the Motility and Invasion of Pancreatic Cancer Cells. (uams.edu)
  • The ultimate aim of the AMPKIN project was to achieve an advanced understanding of the dynamic operation of the AMP-activated protein kinase (AMPK) signaling pathway. (europa.eu)
  • The data showed that adenine activated AMP-activated protein kinase (AMPK) signaling contributing to autophagic cell death through mTOR in both colon cancer cell lines. (hindawi.com)
  • Involvement of AMP-activated protein kinase (AMPK) in anticancer property of adenine was also investigated. (hindawi.com)
  • Glutamate excitation induced a rapid alteration in the AMP:ATP ratio that was associated with the activation of the AMP-activated protein kinase (AMPK). (jneurosci.org)
  • Notably, inhibition of the CaMKK (calmodulin-dependent protein kinase kinase) had little affect on GLUT translocation, whereas the inhibition or knockdown of AMPK (compound C, siRNA) activity prevented GLUT3 translocation to the cell surface after glutamate excitation. (jneurosci.org)
  • AMP-activated protein kinase (AMPK) has become the focus of a great deal of attention as a novel therapeutic target for the treatment of metabolic syndromes, because AMPK has been demonstrated to mediate, at least in part, the effects of a number of physiological and pharmacological factors that exert beneficial effects on these disorders. (aspetjournals.org)
  • Thus, the identification of a compound that activates the AMPK pathway would contribute significantly to the treatment and management of such syndromes. (aspetjournals.org)
  • Glucose transport can be activated in skeletal muscle in response to insulin via activation of phosphoinositide (PI) 3-kinase and in response to contractions or hypoxia, presumably via activation of 5′ AMP-activated protein kinase (AMPK). (diabetesjournals.org)
  • We review studies that support the use of modulators of fatty acid synthase (FAS) and carnitine palmitoyltransferase-1 (CPT-1) to influence known energy sensors such as AMP-activated protein kinase (AMPK) to affect food intake and energy consumption. (eurekaselect.com)
  • Price TJ, Das V, Dussor G. Adenosine Monophosphate-activated Protein Kinase (AMPK) Activators For the Prevention, Treatment and Potential Reversal of Pathological Pain. (rush.edu)
  • The TLR4 signaling is the major pathway that activates the body's natural immune response, and the SARS-CoV-2 spike protein activates TLR4, not the regular flu spike protein. (sciencedaily.com)
  • The APCR assay uses snake venoms to activate factor V and prothrombin, thus triggering the lower portion of the clotting pathway and eliminating interference by factor VIII and by lupus anticoagulants (in the absence of phospholipid complexes). (medscape.com)
  • Background The neddylation pathway conjugates NEDD8 to cullin-RING ligases and controls the proteasomal degradation of specific proteins involved in essential cell processes. (nih.gov)
  • In the developing male (XY) gonad, sex-determining region of the Y (SRY) protein acts to up-regulate expression of the related gene, SOX9 , a transcriptional regulator that in turn initiates a downstream pathway of testis development, whilst also suppressing ovary development. (plos.org)
  • The Y-linked sex determining gene SRY regulates this process by initiating a pathway of gene and protein expression, including the expression of critical autosomal genes such as SOX9 . (plos.org)
  • Also, other proteins which involved in the same pathway with MAPK4 were listed below. (creativebiomart.net)
  • This showed the involvement of the HOG pathway and identified novel protein kinases and transcription factors, which were confirmed by fungal genetics to be involved in promoting tolerance of cell wall damage. (bath.ac.uk)
  • Ras signaling can be thought of in simple terms as occuring downstream of receptor tyrosine kinases, triggered by association of adaptor proteins with the phosphorylated cytoplasmic tails of these receptors. (sdbonline.org)
  • Mitogen-activated protein kinases (MAPKs) comprise a large family of proteins activated by a wide range of proinflammatory cytokines and environmental stress. (molvis.org)
  • 5-Hydroxytryptamine (5-HT) activates the extracellular signal-regulated kinase (Erk) mitogen-activated protein kinases (MAPKs) in the vasculature, resulting in contraction. (aspetjournals.org)
  • Role of mitogen-activated protein kinases in endothelin ETB receptor up-regulation after organ culture of rat mesenteric artery. (lu.se)
  • Intracellular signaling protein kinases that play a signaling role in the regulation of cellular energy metabolism. (reference.md)
  • AMP-activated protein kinases modify enzymes involved in LIPID METABOLISM, which in turn provide substrates needed to convert AMP into ATP. (reference.md)
  • 2010) A novel pyrazolo[1,5-a]pyrimidine is a potent inhibitor of cyclin-dependent protein kinases 1, 2, and 9, which demonstrates antitumor effects in human tumor xenografts following oral administration. (guidetopharmacology.org)
  • AMP-Activated Protein Kinases" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings) . (rush.edu)
  • This graph shows the total number of publications written about "AMP-Activated Protein Kinases" by people in this website by year, and whether "AMP-Activated Protein Kinases" was a major or minor topic of these publications. (rush.edu)
  • Below are the most recent publications written about "AMP-Activated Protein Kinases" by people in Profiles. (rush.edu)
  • Here, we investigated the signaling pathways activated in response to the energetic stress created by transient glutamate excitation in cerebellar granule neurons. (jneurosci.org)
  • APC inhibits ET-induced TNF-α production in vitro in human monocytes by inhibiting activation of NFkB and AP-1 by inhibiting degradation of IkB and mitogen-activated protein kinase pathways, respectively. (eurekaselect.com)
  • Stress activated signalling impaired protein quality control pathways in human hypertrophic cardiomyopathy. (bvsalud.org)
  • Spike proteins latch onto receptors known as angiotensin-converting enzyme 2 (ACE2) on target cells. (sciencedaily.com)
  • Mutants of GPR18, designed to constitutively activate receptors, did not tonically inhibit calcium currents, indicating a lack of GPR18 activation or coupling to endogenous G proteins. (unboundmedicine.com)
  • Other downstream effectors of Gα(i/o)-coupled receptors, G protein-coupled inwardly rectifying potassium channels and adenylate cyclase, were not modulated by GPR18 signaling. (unboundmedicine.com)
  • The use of amino acids, proteins and peptides is not considered to have any environmental impact. (janusinfo.se)
  • According to the European Medicines Agency guideline on environmental risk assessments for pharmaceuticals (EMA/CHMP/SWP/4447/00), vitamins, electrolytes, amino acids, peptides, proteins, carbohydrates, lipids proteins, vaccines and herbal medicinal products are exempted because they are unlikely to result in significant risk to the environment. (janusinfo.se)
  • Results: Dust extracts contained trypsin and elastase activities, and activated protease activated receptor (PAR)-1 and -2. (cdc.gov)
  • GTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to activated G proteins and stimulate their GTPase activity, with the result of terminating the signaling event. (wikipedia.org)
  • GAP accelerates this G protein timer by increasing the hydrolytic GTPase activity of the G proteins, hence the name GTPase-activating protein. (wikipedia.org)
  • EIF5 is a GTPase-activating protein. (wikipedia.org)
  • Furthermore, YopE is a protein domain that is a Rho GTPase-activating protein (GAP), which targets small GTPases such as RhoA, Rac1, and Rac2. (wikipedia.org)
  • The GAPs that act on small GTP-binding proteins of the Ras superfamily have conserved structures and use similar mechanisms, An example of a GTPase is the monomer Ran, which is found in the cytosol as well as the nucleus. (wikipedia.org)
  • Quercetin suppresses the proliferation of multiple myeloma cells by down-regulating IQ motif-containing GTPase activating protein 1 expression and extracellular signal-regulated kinase activation. (curehunter.com)
  • Using primary cultures of sensory neurons, it was demonstrated that crotalphine increases the level of activated ERK1/2 and JNK-MAPKs and this increase is dependent on the activation of protein kinase Cζ (PKCζ). (iasp-pain.org)
  • Upon cell wall stress, MAPKs phosphorylate multiple target proteins involved in the remodeling of the cell wall. (bath.ac.uk)
  • In this more active state, G proteins can bind other proteins and turn on downstream signalling targets. (wikipedia.org)
  • The mitogen-activated protein kinase homolog, WNK lysine deficient protein kinase 1 (WNK1), is activated downstream of epidermal growth factor receptor during decidualization. (bioone.org)
  • 4: Expression of a dominant-negative mutant form of JNK1 that blocked FCS-induced JNK activity had no effect on protein production and gene expression of these cytokines. (unboundmedicine.com)
  • The byg mutation is an A to T transversion causing a premature stop codon in the gene encoding MAP3K4 (also known as MEKK4), a mitogen-activated protein kinase kinase kinase. (plos.org)
  • The large G proteins, for example, are involved in transduction of signaling from the G protein-coupled receptor for a variety of signaling processes like hormonal signaling, and small G proteins are involved in processes like cellular trafficking and cell cycling. (wikipedia.org)
  • GAP are heavily linked to the G-protein linked receptor family. (wikipedia.org)
  • Recent studies propose that N-arachidonyl glycine (NAGly), a carboxylic analogue of anandamide, is an endogenous ligand of the Gα(i/o) protein-coupled receptor 18 (GPR18). (unboundmedicine.com)
  • and protein kinase activity. (nih.gov)
  • Activated protein C (APC) is the enzymatically active form of protein C after proteolytic cleavage by thrombomodulin-bound thrombin. (medscape.com)
  • Activated protein C (APC), a natural anticoagulant, is formed from protein C by the action of thrombin bound to thrombomodulin on the endothelial cell surface. (eurekaselect.com)
  • Protein C is a 62 kDa glycoprotein, synthesized by the liver in the presence of vitamin K. PC is at the center of a physiological system that inhibits coagulation : the anticoagulant system of protein C. Thrombin associated with thrombomodulin loses its procoagulant properties at the same time as it activates PC to active protein C (PCa). (cryopep.com)
  • PCa in the presence of protein S, calcium and phospholipids is capable of cleaving FVa and FVIIIa blocking the amplification loop of thrombin generation. (cryopep.com)
  • Turoctocog alfa is a recombinant human coagulation factor VIII and once activated by thrombin cleavage the resulting rFVIIIa has the same structure as endogenous FVIIIa. (janusinfo.se)
  • Activated protein C (PC) is an anticoagulant involved in the interactions between the coagulation and immune systems. (listlabs.com)
  • A cocktail of five recombinant proteins optimized for conserved GI nematode targets was used immunize pigs and test for active antibody responses in both the serum and intestinal ileal fluid of immunized pigs. (frontiersin.org)
  • A proline-directed serine/threonine protein kinase which mediates signal transduction from the cell surface to the nucleus. (uams.edu)
  • To investigate in vivo molecular mechanisms of silibinin efficacy, tumors and uninvolved skin from tumor-bearing mice were examined immunohistochemically for proliferation, p53, apoptosis, and activated caspase-3. (nih.gov)
  • This study is to investigate the role of p38 mitogen-activated protein kinase (p38MAPK) in tert -butyl hydroperoxide ( t BHP)-induced apoptosis of human trabecular meshwork (iHTM) cells. (molvis.org)
  • Aspects of intrinsic antiviral immunity are mediated by promyelocytic leukaemia (PML)-nuclear body (PML-NB) constituent proteins. (gla.ac.uk)
  • During herpesvirus infection, these antiviral proteins are independently recruited to nuclear domains that contain infecting viral genomes to cooperatively promote viral genome silencing. (gla.ac.uk)
  • Transient activation of AMP-activated protein kinase at G1/S phase transition is required for control of S phase in NIH3T3 cells. (nih.gov)
  • Screening the array with sera and ileal fluid samples from immunized pigs suggested cross-reactivity among homologous proteins and a general activation of immunity. (frontiersin.org)
  • Additionally, inhibition of activated PC modulated the functional responses of CD11b(+) cells, leading to the expansion and increased activation of MDSCs, which are suppressive to the CD4(+) T cells required for EAE progression, thereby resulting in attenuated EAE. (listlabs.com)
  • APC regulates the coagulation system by inactivating the activated form of factors V and VIII in the presence of protein S. Tumor necrosis factor-α(TNF-α) plays critical roles in the development of disseminated intravascular coagulation, acute respiratory distress syndrome and shock in sepsis by inducing endothelial cell damage through activation of neutrophils. (eurekaselect.com)
  • Platelet activation allows binding of these proteins, which bridges adjacent platelets. (medscape.com)
  • Protease inhibitors and antioxidants suppressed protein kinase C and NF-kappaB activation and induction of IL-8 promoter activity in cells exposed to dust extract. (cdc.gov)
  • The normal reference value for the activated protein C resistance (APCR) ratio is greater than 2.1. (medscape.com)
  • Spontaneous central vein thrombosis in a patient with activated protein C resistance and dengue infection: An association or causation? (medscape.com)
  • The activated protein C resistance assay is a screening test for the presence of factor V Leiden. (msdmanuals.com)
  • In patients with homozygous or heterozygous factor V Leiden resistance , the prolongation of the clotting time is significantly reduced because their factor V is resistant to cleavage by activated protein C. (msdmanuals.com)
  • Regulation of G proteins is important because these proteins are involved in a variety of important cellular processes. (wikipedia.org)
  • These proteins have an effect on cellular replication and cellular death in inflammatory, ischemic, and malignant diseases. (lupusresearch.org)
  • Adenine forms several biological compounds involved in a variety of cellular physiological processes such as adenosine triphosphate (ATP) in cellular respiration and deoxyribonucleic acid (DNA) in protein synthesis. (hindawi.com)
  • In a study evaluating mice and human heart cells, the SARS-CoV-2 spike protein inflamed the heart muscle cells, which can lead to heart injury. (sciencedaily.com)
  • The spike protein facilitates virus entry into healthy cells, which is the first step in infection. (sciencedaily.com)
  • The researchers studied whether the SARS-CoV-2 spike protein activates the natural immune response in heart muscle cells. (sciencedaily.com)
  • Their results showed that the SARS-CoV-2 spike protein activated the natural immune response in heart muscle cells and damaged the heart, but the NL63 spike protein did not. (sciencedaily.com)
  • The AAV9 viral vector was delivered into lab mice to activate the spike protein in the heart muscle cells. (sciencedaily.com)
  • In lab testing of heart cells cultured in dishes, researchers also observed that the SARS-CoV-2 spike protein made heart muscle cells much larger compared to cells without either spike protein. (sciencedaily.com)
  • We found direct evidence that the SARS-CoV-2 spike protein is toxic to heart muscle cells," Lin said. (sciencedaily.com)
  • They detected the SARS-CoV-2 spike protein and TLR4 protein in both heart muscle cells and other cell types. (sciencedaily.com)
  • Besides directly damaging the heart muscle cells, the spike protein itself is very inflammatory and may cause systemic inflammation that indirectly causes heart problems. (sciencedaily.com)
  • A signaling protein, i.e., a protein that circulates extracellularly influencing other cells to turn on the process of protein synthesis. (lupusresearch.org)
  • TY - JOUR T1 - Role of mitogen-activated protein kinase family in serum-induced leukaemia inhibitory factor and interleukin-6 secretion by bone marrow stromal cells. (unboundmedicine.com)
  • We are a global provider of human and animal biospecimens: including frozen & FFPE tissue, DNA, RNA, total proteins, blood products and primary cells. (amsbio.com)
  • MCF-7 cells treated for 24 h with 40 ng/ml VDBP Vitamin D-binding Protein (VDBP) (control) (A) and with 40 ng/ml DBP-MAF (B). Scale bar=25 μm. (iiarjournals.org)
  • The complement system is a group of nearly 60 proteins that are in blood plasma or on the surface of some cells. (medlineplus.gov)
  • The proteins work with your immune system and play a role to protect the body from infections, and to remove dead cells and foreign material. (medlineplus.gov)
  • We modulated activated PC levels in the circulation during EAE induction through systemic administration of a mAb against PC/activated PC (anti-PC). (listlabs.com)
  • We initially hypothesized that inhibition of activated PC may result in a heightened inflammatory environment, leading to increased EAE pathogenesis. (listlabs.com)
  • Overall, our findings show that activated PC inhibition affected EAE pathogenesis at multiple fronts, specifically increasing vascular barrier permeability, as evidenced by considerable leukocyte infiltration in the brain. (listlabs.com)
  • Creative BioMart supplied nearly all the proteins listed, you can search them on our site. (creativebiomart.net)
  • We identify the SUMO ligase Protein Inhibitor of Activated STAT1 (PIAS1) as a constituent PML-NB protein. (gla.ac.uk)
  • Contraction is a multifactorial stimulus with short-term metabolic effects and long-term responses due to changes in protein synthesis. (dissertations.se)
  • The alpha granules contain hemostatic proteins such as fibrinogen, vWf, and growth factors (eg, platelet-derived growth factor and transforming growth factors). (medscape.com)
  • Based on studies conducted among the patients diagnosed with immune thrombotic thrombocytopenia after the AstraZeneca COVID-19 vaccine in Europe, the pathogenesis of these rare and unusual adverse events after vaccination may be associated with platelet-activating antibodies against platelet factor-4 (PF4), a type of protein. (cdc.gov)
  • Protein degradation. (nih.gov)
  • Elevated temperatures may enhance the rate of protein degradation. (cryopep.com)
  • A study claims that a protein known as fibrinogen that is known to aid in forming blood clots may also set off scar development in the brain and spinal cord. (healthjockey.com)
  • By doing so, they accelerate the G protein's built-in timer, which inactivates the G proteins more quickly, and along with the inactivation of GEFs, this keeps the G protein signal off. (wikipedia.org)
  • Mutations of factor V make it resistant to its normal cleavage and inactivation by activated protein C, and they also predispose to venous thrombosis. (msdmanuals.com)
  • Pevonedistat (MLN4924) is a selective small molecule targeting the NEDD8-activating enzyme (NAE) and inhibits an early step in neddylation, resulting in DNA re-replication, cell cycle arrest and death. (nih.gov)
  • Although the APCR assay is no longer based directly on the activated partial thromboplastin time (aPTT), it is expressed as a ratio of aPTT with APC:aPTT without APC. (medscape.com)
  • This hydrolysis reaction, however, occurs very slowly, meaning G proteins have a built-in timer for their activity. (wikipedia.org)
  • PIAS1 promotes the stable accumulation of SUMO1 at nuclear sites associated with HSV-1 genome entry, whereas the accumulation of other evaluated PML-NB proteins occurs independently of PIAS1. (gla.ac.uk)
  • In this sense, GAPs function is opposite to that of guanine nucleotide exchange factors (GEFs), which serve to enhance G protein signaling. (wikipedia.org)
  • Opening of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels is facilitated by direct binding of cyclic nucleotides to a cyclic nucleotide-binding domain (CNBD) in the C-terminus. (cipsm.de)
  • The fact that the SARS-CoV-2 spike protein is activating the natural immune response may explain the high virulence compared to the other coronaviruses," Lin said. (sciencedaily.com)
  • Now, researchers have found that the spike protein from the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus can lead to heart muscle injury through the inflammatory process, according to preliminary research to be presented at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions 2022. (sciencedaily.com)
  • HCoV-NL63 is a coronavirus that infects the respiratory system without causing cardiac injury, although its spike protein also uses ACE2 to mediate virus entry. (sciencedaily.com)
  • This abrogated expression of the decidual marker genes, insulin like growth factor binding protein 1 ( IGFBP1 ) and prolactin ( PRL ), and prevented adoption of decidual cell morphology. (bioone.org)
  • They found that the AAV9-mediated the SARS-CoV-2 spike protein, and not the NL63 spike protein, caused heart dysfunction, hypertrophic remodeling (enlargement) and cardiac inflammation. (sciencedaily.com)
  • Binding of GTP inherently changes the activity of the G proteins and increases their activity, through the loss of inhibitory subunits. (wikipedia.org)
  • In general, purified proteins are inherently more stable in concentrated form. (cryopep.com)
  • GAPs, then, are critical in the regulation of G proteins. (wikipedia.org)
  • In addition, when platelets are activated, negatively charged phospholipids move from the inner to the outer leaflet of the membrane bilayer. (medscape.com)
  • Here, an evaluation of the global A. fumigatus phosphoproteome under cell wall stress caused by the cell wall-damaging agent Congo red (CR) revealed 485 proteins potentially involved in the cell wall damage response. (bath.ac.uk)
  • Hydrolysis of GTP by Ran is thought to provide the energy needed to transport nuclear proteins into the cell. (wikipedia.org)
  • Following infection with herpes simplex virus 1 (HSV-1), PIAS1 is recruited to nuclear sites associated with viral genome entry in a SIM-dependent manner, consistent with the SIM-dependent recruitment mechanisms of other well characterized PML-NB proteins. (gla.ac.uk)
  • It is thought that GAPs serve to make GTP on the G protein a better substrate for nucleophilic attack and lower the transition state energy for the hydrolysis reaction. (wikipedia.org)
  • We investigated the influence of activated PC on the pathogenesis of experimental autoimmune encephalomyelitis (EAE), the animal model for multiple sclerosis. (listlabs.com)
  • A certain GAP and a certain G protein happen to be expressed in the same time and place, and that is how the cell ensures specificity. (wikipedia.org)
  • Effects of 72 h treatment with Vitamin D-binding Protein-derived Macrophage-activating Factor (DBP-MAF) on MCF-7 cell proliferation. (iiarjournals.org)
  • Effects of 72 h treatment with Vitamin D-binding Protein-derived Macrophage-activating Factor (DBP-MAF) on MCF-7 cell morphology under phase-contrast light microscopy. (iiarjournals.org)
  • Researchers have demonstrated a potential route of the SARS-CoV-2 spike protein damaging the heart. (sciencedaily.com)
  • The spike protein is found on the surface of SARS-CoV-2, the virus that causes COVID-19. (sciencedaily.com)
  • What we suspect is that the spike protein has unknown pathological roles," said Zhiqiang Lin, Ph.D., lead author of the study and an assistant professor at the Masonic Medical Research Institute in Utica, New York. (sciencedaily.com)
  • Our data show that the spike protein from SARS-CoV-2 causes heart muscle damage. (sciencedaily.com)
  • They studied the potential ability to cause heart disease of both SARS-CoV-2 spike protein and the NL63 spike protein. (sciencedaily.com)
  • To investigate the impact of the SARS-CoV-2 spike protein on the heart, researchers cloned the SARS-CoV-2 spike protein and the NL63 spike protein into the AAV9 viral vector. (sciencedaily.com)
  • In general, GAPs tend to be pretty specific for their target G proteins. (wikipedia.org)
  • Proteins that activated immunity are potential antigens for immunization and the multi-omics phylum-spanning prioritization database that was created is a valuable resource for identifying target proteins in a wide array of different parasitic nematodes. (frontiersin.org)
  • The noncovalent nature of the interaction of a fluorogenic dye with a protein allows for on-demand fluorescent labeling of target proteins. (meilerlab.org)