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  • overexpression
  • In the rat kidneys with transfection of a dominant-active Vav2 variant (onco-Vav2), we found that overexpression of Vav2 led to significant increases in Rac1 activity, superoxide production, and glomerular injury, which was similar to that induced by hyperhomocysteinemia. (ahajournals.org)
  • Overexpression of this phosphatase is reported to activate the expression of the tumor suppressor gene TP53/p53, which leads to G2/M cell cycle arrest and apoptosis. (acris-antibodies.com)
  • activation
  • 10 Chen et al 11 have also reported that constitutive upregulation of Rac1 because of activation of Vav2 and resulting enhancement of reactive oxygen species production are a hallmark of renal diseases characterized by irreversible fibrosis and sclerosis. (ahajournals.org)